Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Pyridoxamine 5'-phosphate oxidase putative
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Major facilitator superfamily (MFS) profile
RNA polymerase sigma factor 70 region 4 type 2
Glycosyl transferase family 3 N-terminal
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Solute-binding protein family 3/N-terminal
Inosine/uridine-preferring nucleoside hydrolase
YbaK/aminoacyl-tRNA synthetase-associated
Putative oxidoreductase/dehydrogenase Rossmann-like
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Peptidase M10 metallopeptidase domain-containing protein
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Activator of Hsp90 ATPase homologue 1-like C-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Heat-inducible transcription repressor HrcA C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Putative Flp pilus-assembly TadG-like N-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Glycoside hydrolase family 42 N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-? in acceptor proteins)
ATP synthase F1 complex delta/epsilon subunit N-terminal
Survival protein SurE-like phosphatase/nucleotidase
Alpha-glycerophosphate oxidase C-terminal
DNA polymerase III delta subunit C-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Glycosyltransferase subfamily 4-like N-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Methionyl-tRNA synthetase anticodon-binding
Tryptophan synthase beta chain-like PALP
Cytochrome bc1 complex cytochrome c subunit
Peptidase M1 membrane alanine aminopeptidase
Peptidase S9 prolyl oligopeptidase catalytic
Tat pathway signal sequence domain protein
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Pyrroline-5-carboxylate reductase dimerisation
Phosphomannose isomerase type I catalytic
Cell envelope-related transcriptional attenuator
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Lantibiotic biosynthesis protein dehydration
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Glycine cleavage T-protein C-terminal barrel
Mandelate racemase/muconate lactonizing enzyme C-terminal
SsuA/THI5-like domain-containing protein
Endoribonuclease L-PSP/chorismate mutase-like
Alpha-D-phosphohexomutase alpha/beta/alpha
Schiff-base intermediate with substrate; via pyruvic acid
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
TetR transcriptional regulator Rv1219c-like C-terminal
BAAT/Acyl-CoA thioester hydrolase C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Phosphoadenosine phosphosulphate reductase
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
N,N-dimethylformamidase beta subunit-like C-terminal
Prokaryotic-type class I peptide chain release factors
O-(3'-phospho-DNA)-tyrosine intermediate
PhoD-like phosphatase metallophosphatase
Glutathionylspermidine synthase pre-ATP-grasp-like
Large ribosomal subunit protein uL2 C-terminal
Subtilisin-like protease fibronectin type-III
Moybdenum cofactor oxidoreductase dimerisation
Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase C-terminal
Peptidoglycan recognition protein family
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Sodium/calcium exchanger membrane region
SUF system FeS cluster assembly SufBD N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Esterase-like activity of phytase family protein
SGNH hydrolase-type esterase domain-containing protein
Penicillin-binding protein transpeptidase
Nucleophile; cysteine thiosulfonate intermediate
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Adaptive response protein AidB N-terminal
Polysaccharide biosynthesis protein C-terminal
Rhamnogalacturonan I lyase beta-sheet domain-containing protein
Anthranilate synthase component I N-terminal
Right handed beta helix domain-containing protein
NADH:ubiquinone oxidoreductase-like 20kDa subunit
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
Bacterial type II secretion system protein E
DNA primase/polymerase bifunctional N-terminal
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-104)
GxGYxYP putative glycoside hydrolase C-terminal
GxGYxYP putative glycoside hydrolase N-terminal
Alpha-galactosidase NEW3 domain-containing protein
Aconitase A/isopropylmalate dehydratase small subunit swivel
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Glycoside hydrolase family 31 N-terminal
Schiff-base intermediate with D-ribose 5-phosphate
TRAP C4-dicarboxylate transport system permease DctM subunit
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Reversibly protonated during proton transport
Polysaccharide biosynthesis protein CapD-like
Polysaccharide chain length determinant N-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Alpha-L-rhamnosidase six-hairpin glycosidase
Bacterial alpha-L-rhamnosidase N-terminal
Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
ABC transporter-associated repeat protein
Polymerase/histidinol phosphatase N-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Phosphoribosylformylglycinamidine synthase linker
Large ribosomal subunit protein uL30-like ferredoxin-like fold
NAD(P) transhydrogenase alpha subunit C-terminal
Chitin-binding type-3 domain-containing protein
AB hydrolase-1 domain-containing protein
Beta-hexosaminidase bacterial type N-terminal
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
Cytochrome oxidase subunit II copper A binding
Positions MEP for the nucleophilic attack
Myo-inositol-1-phosphate synthase GAPDH-like
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Gly-cisPro motif, important for rejection of L-amino acids
Transcription regulator AsnC/Lrp ligand binding
LPXTG-motif cell wall anchor domain protein
Peptide methionine sulphoxide reductase MsrA
6-phosphogluconate dehydrogenase C-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Basic secretory peptidase family protein
Ribosomal RNA adenine methylase transferase N-terminal
Trigger factor ribosome-binding bacterial
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Rv2525c-like glycoside hydrolase-like domain-containing protein
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
DNA topoisomerase I catalytic core eukaryotic-type
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Phosphatidic acid phosphatase type 2/haloperoxidase
Prepilin type IV endopeptidase peptidase
Membrane insertase YidC/Oxa/ALB C-terminal
Glycosyl transferase family 28 C-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
PknH-like extracellular domain-containing protein
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Glycoside hydrolase family 42 N-terminal domain-containing protein
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Peptidase M43 pregnancy-associated plasma-A
Peptidase M43 pregnancy-associated plasma-A domain-containing protein
Small ribosomal subunit protein uS4 N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Large ribosomal subunit protein uL15/eL18
NIF system FeS cluster assembly NifU N-terminal
Acyltransferase MbtK/IucB-like conserved
Plays an important role in substrate specificity
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
DNA-directed DNA polymerase family A palm
Glycosyl hydrolase-like 10 domain-containing protein
Ribose-phosphate pyrophosphokinase N-terminal
Alanyl-transfer RNA synthetases family profile
Bacterial transcription activator effector binding
Bacterial spore germination immunoglobulin-like
Glycosyltransferase family 28 N-terminal
Pseudouridine synthase I TruA alpha/beta
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Exonuclease VII large subunit C-terminal
Transglycosylase SLT domain-containing protein
Glycoside hydrolase family 38 N-terminal
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Cell wall-active antibiotics response LiaF-like C-terminal
CobB/CobQ-like glutamine amidotransferase
DNA-directed RNA polymerase RpoA/D/Rpb3-type
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Peptidase C39-like domain-containing protein
Thymidylate synthase/dCMP hydroxymethylase
Polysaccharide lyase 8 N-terminal alpha-helical
Polysaccharide lyase family 8 C-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Large ribosomal subunit protein uL6 alpha-beta
O-(5'-phospho-DNA)-tyrosine intermediate
Helix-hairpin-helix DNA-binding motif class 1
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Molybdopterin cofactor biosynthesis C (MoaC)
Calcineurin-like phosphoesterase N-terminal
D-inositol 3-phosphate glycosyltransferase
ABC transporter substrate-binding protein PnrA-like
Fibronectin type-III domain-containing protein
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase
Phosphatidate phosphatase APP1 catalytic
DNA replication/recombination mediator RecO N-terminal
Ionotropic glutamate receptor C-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Butirosin biosynthesis protein H N-terminal
EfeO-type cupredoxin-like domain-containing protein
Cyclobis-(1-6)-alpha-nigerosyl repressor
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
F420-dependent glucose-6-phosphate dehydrogenase
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
DnaJ homologue subfamily C member 28 conserved
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
ABC3 transporter permease protein domain-containing protein
Cytochrome C biogenesis protein transmembrane
ABC-type glycine betaine transport system substrate-binding
Aldehyde ferredoxin oxidoreductase N-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Calcium-dependent phosphoinositide phospholipase C
Sporulation stage II protein D amidase enhancer LytB N-terminal
Putative glycogen debranching enzyme N-terminal
RNA 2-O ribose methyltransferase substrate binding
Essential for prephenate dehydratase activity
Histidine-specific methyltransferase SAM-dependent
Proton acceptor; for glutaminase activity
Tricarboxylic transport membrane protein
Sporulation transcription regulator WhiA N-terminal
Arabinogalactan endo-beta-1,4-galactanase
Nitrite/Sulfite reductase ferredoxin-like
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Glycoamylase-like domain-containing protein
Shikimate dehydrogenase substrate binding N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Could play a key role in the communication between the regulatory and the substrate sites
Beta/gamma crystallin 'Greek key' domain-containing protein