Alpha-D-phosphohexomutase alpha/beta/alpha
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Release factor glutamine methyltransferase N-terminal
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase
Styrene monooxygenase StyA putative substrate binding
Bacterial bifunctional deaminase-reductase C-terminal
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Probable transposase IS891/IS1136/IS1341
Thiolase-like protein type 1 additional C-terminal
Transposase IS116/IS110/IS902 C-terminal
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Major facilitator superfamily (MFS) profile
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
Polymerase/histidinol phosphatase N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Glycoside hydrolase family 38 N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Glycosyltransferase subfamily 4-like N-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Penicillin-binding protein transpeptidase
Subtilisin-like protease fibronectin type-III
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
RNA polymerase sigma factor 70 region 4 type 2
SUF system FeS cluster assembly SufBD N-terminal
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Pyrimidine nucleoside phosphorylase C-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Pyrroline-5-carboxylate reductase catalytic N-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Positions MEP for the nucleophilic attack
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Acetylserotonin O-methyltransferase dimerisation
Peptidase S9 prolyl oligopeptidase catalytic
Histidine-specific methyltransferase SAM-dependent
SGNH hydrolase-type esterase domain-containing protein
Cell wall-active antibiotics response LiaF-like C-terminal
FtsX extracellular domain-containing protein
Mandelate racemase/muconate lactonizing enzyme C-terminal
Chitin-binding type-3 domain-containing protein
Myo-inositol-1-phosphate synthase GAPDH-like
Saccharopine dehydrogenase-like C-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Phosphotransferase system enzyme I N-terminal
6-phosphogluconate dehydrogenase NADP-binding
Tryptophan synthase beta chain-like PALP
Pyrroline-5-carboxylate reductase dimerisation
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
L-seryl-tRNA selenium transferase N-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Threonine/serine exporter-like N-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Polysaccharide biosynthesis protein CapD-like
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Cell envelope-related transcriptional attenuator
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase
Adaptive response protein AidB N-terminal
Subtilisin inhibitor domain-containing protein
Aminoacyl-transfer RNA synthetases class-II family profile
Glycosyltransferase family 28 N-terminal
Damage-control phosphatase ARMT1-like metal-binding
Fibronectin type-III domain-containing protein
Integral membrane protein YccS N-terminal
Prokaryotic-type class I peptide chain release factors
Alanyl-transfer RNA synthetases family profile
Superoxide dismutase copper/zinc binding
Erythromycin biosynthesis protein CIII-like central
Glycosyl transferase family 28 C-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Abnormal spindle-like microcephaly-associated protein ASH
Beta-hexosaminidase bacterial type N-terminal
Lactate utilization protein B C-terminal
RNA 2-O ribose methyltransferase substrate binding
AB hydrolase-1 domain-containing protein
Flagellar basal body rod protein N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Glycoside hydrolase family 13 N-terminal
DNA replication/recombination mediator RecO N-terminal
Chromosomal replication initiator DnaA C-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Reversibly protonated during proton transport
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Pyruvate phosphate dikinase AMP/ATP-binding
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
PknH-like extracellular domain-containing protein
NIF system FeS cluster assembly NifU C-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
2,4-diaminopentanoate dehydrogenase C-terminal
Dihydrodipicolinate reductase N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Translation elongation factor P/YeiP central
Tetrahydrodipicolinate-N-succinyltransferase chain A
N-sulphoglucosamine sulphohydrolase C-terminal
Transition state stabilizer; via amide nitrogen
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Actinobacteria/chloroflexi VLRF1 release factor
Phosphocysteine intermediate; for EIIB activity
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Membrane fusion protein biotin-lipoyl like
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Putative Flp pilus-assembly TadG-like N-terminal
Transcription regulator AsnC/Lrp ligand binding
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Coenzyme Q-binding protein COQ10 START domain-containing protein
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
N,N-dimethylformamidase beta subunit-like C-terminal
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Glycine cleavage T-protein C-terminal barrel
Peptidoglycan recognition protein family
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
NIF system FeS cluster assembly NifU N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Endoribonuclease L-PSP/chorismate mutase-like
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding domain-containing protein
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Right handed beta helix domain-containing protein
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Thymidylate synthase/dCMP hydroxymethylase
CobB/CobQ-like glutamine amidotransferase
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Butirosin biosynthesis protein H N-terminal
Large ribosomal subunit protein uL2 C-terminal
Glucose-methanol-choline oxidoreductase C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Glutathionylspermidine synthase pre-ATP-grasp-like
Bacterial transcription activator effector binding
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Biopterin-dependent aromatic amino acid hydroxylase family profile
Small ribosomal subunit protein uS4 N-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
DNA primase/polymerase bifunctional N-terminal
Polysaccharide lyase 8 N-terminal alpha-helical
Increases nucleophilicity of active site Cys
Glycosyl transferase family 3 N-terminal
Moybdenum cofactor oxidoreductase dimerisation
Membrane insertase YidC/Oxa/ALB C-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
DNA-directed DNA polymerase family A palm
Phosphatidic acid phosphatase type 2/haloperoxidase
Important for beta-aspartyl-AMP intermediate formation
PhoD-like phosphatase metallophosphatase
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Tetracyclin repressor-like C-terminal group 31
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein
4'-phosphopantetheinyl transferase N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
ABC-type nitrate/sulfonate/bicarbonate transport systems periplasmic components-like protein
2-oxoacid dehydrogenase acyltransferase catalytic
Cytochrome C biogenesis protein transmembrane
Ricin B lectin domain-containing protein
Sporulation transcription regulator WhiA N-terminal
ABC-type glycine betaine transport system substrate-binding
ABC3 transporter permease protein domain-containing protein
DNA polymerase III delta subunit C-terminal
Methylguanine DNA methyltransferase ribonuclease-like
Could play a key role in the communication between the regulatory and the substrate sites
L,D-transpeptidase catalytic domain-containing protein
Peptidase M17 leucyl aminopeptidase N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
NADH-rubredoxin oxidoreductase C-terminal
Dihydrodipicolinate reductase C-terminal
Cytochrome b/b6 N-terminal region profile
6-phosphogluconate dehydrogenase C-terminal
Polysaccharide lyase family 8 C-terminal
Helix-hairpin-helix DNA-binding motif class 1
CASTOR/POLLUX/SYM8 ion channel conserved
Gram-positive cocci surface proteins LPxTG domain-containing protein
Choloylglycine hydrolase/NAAA C-terminal
Putative adhesin domain-containing protein
Polysaccharide chain length determinant N-terminal
Peptidase M1 membrane alanine aminopeptidase
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
ATP synthase F1 complex delta/epsilon subunit N-terminal
Heparin-sulfate lyase N-terminal domain-containing protein
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
O-(5'-phospho-DNA)-tyrosine intermediate
Shikimate dehydrogenase substrate binding N-terminal
Extradiol ring-cleavage dioxygenase LigAB LigA subunit
Large ribosomal subunit protein uL15/eL18
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Bacterial type II secretion system protein E
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Integrin alpha beta-propellor repeat protein
Peptidase S1A alpha-lytic prodomain domain-containing protein
Polysaccharide biosynthesis protein C-terminal
Peptidase M6-like domain-containing protein
DnaJ homologue subfamily C member 28 conserved
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Alpha-glycerophosphate oxidase C-terminal
Resolvase/invertase-type recombinase catalytic
Methionyl-tRNA synthetase anticodon-binding
Glycoside hydrolase family 42 N-terminal
Glucosamine/galactosamine-6-phosphate isomerase
ABC-type sugar transport system periplasmic component-like protein
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Na+/H+ antiporter MnhB subunit-related protein
Heat-inducible transcription repressor HrcA C-terminal
Tricarboxylic transport membrane protein
Putative oxidoreductase/dehydrogenase Rossmann-like
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Exonuclease VII large subunit C-terminal
Endonuclease/exonuclease/phosphatase domain-containing protein
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Large ribosomal subunit protein uL30-like ferredoxin-like fold
N(4)-bis(aminopropyl)spermidine synthase C-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Anthranilate synthase component I N-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Plays an important role in substrate specificity
Essential for prephenate dehydratase activity
S-adenosyl-L-homocysteine hydrolase NAD binding
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
RND efflux pump membrane fusion protein barrel-sandwich
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Putative glycogen debranching enzyme N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Cysteine sulfenic acid (-SOH) intermediate
Ribosomal RNA adenine methylase transferase N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Fe/B12 periplasmic-binding domain-containing protein
Cation-transporting P-type ATPase N-terminal
Docks into pockets in the proteasome alpha-ring
Polyketide synthase phosphopantetheine-binding
Important for autoinhibition of adenylyltransferase activity
Beta-xylosidase C-terminal Concanavalin A-like
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Electron transfer via tryptophanyl radical
N6 adenine-specific DNA methyltransferase N-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
YVTN beta-propeller repeat-containing protein
Cellulase Ig-like domain-containing protein
Outer membrane lipoprotein-sorting protein
Fibronectin type III-like domain-containing protein
ABC transporter substrate-binding protein
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Alpha-L-rhamnosidase six-hairpin glycosidase
Bacterial alpha-L-rhamnosidase N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal