3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Translocation and assembly module subunit TamA
Carbamoyl-phosphate synthase small subunit N-terminal
Sodium/calcium exchanger membrane region
Major facilitator superfamily (MFS) profile
Phosphomannose isomerase type I C-terminal
Phosphomannose isomerase type I catalytic
Phosphomannose isomerase type I helical insertion
YbaK/aminoacyl-tRNA synthetase-associated
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Transposase IS116/IS110/IS902 C-terminal
Fimbrial biogenesis outer membrane usher protein
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Ribose-phosphate pyrophosphokinase N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
RND efflux pump membrane fusion protein barrel-sandwich
Pyridoxamine 5'-phosphate oxidase putative
Large ribosomal subunit protein uL15/eL18
Polymerase/histidinol phosphatase N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Cytochrome b561 bacterial/Ni-hydrogenase
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
TonB-dependent receptor-like beta-barrel
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Type III secretion system flagellar brake protein YcgR PilZN
Prepilin type IV endopeptidase peptidase
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Pyrimidine nucleoside phosphorylase C-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Cation-transporting P-type ATPase N-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
High-affinity branched-chain amino acid transport system permease LivHM N-terminal
Catalytic role in ketonization of the dienol substrate (substrate destabilization)
Membrane-bound lytic murein transglycosylase C
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Essential for prephenate dehydratase activity
Negative modulator of initiation of replication SeqA N-terminal
Replication modulator SeqA C-terminal DNA-binding
UDP N-acetylglucosamine O-acyltransferase C-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Shikimate dehydrogenase substrate binding N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Electron transfer via tryptophanyl radical
Involved in allosteric activation by GTP
Periplasmic binding protein/LacI sugar binding
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Alanyl-transfer RNA synthetases family profile
Flagellar hook-length control protein-like C-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Penicillin-binding protein transpeptidase
Phosphocysteine intermediate; for EIIB activity
RNA binding; important for wobble base 34 recognition
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Interaction with tRNA; Important for base-flipping
Pseudouridine synthase I TruA alpha/beta
Moves into active site upon enzyme activation, plays a role in electron transfer
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
Interaction with polymerase core subunit RpoC
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Disulphide bond isomerase DsbC/G N-terminal
Membrane fusion protein biotin-lipoyl like
Outer membrane protein assembly factor BamD
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Alpha-tubulin suppressor-like RCC1 family protein
Bacterial bifunctional deaminase-reductase C-terminal
Greasy slide, important in sugar transport
Major facilitator superfamily associated
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Integral membrane protein YccS N-terminal
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
L-seryl-tRNA selenium transferase N-terminal
Tryptophan synthase beta chain-like PALP
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Chromosome partition protein MukF C-terminal
Chromosome partition protein MukF middle
Chromosome partition protein MukF winged-helix
Flagellar assembly protein FliH/Type III secretion system HrpE
Lysidine-tRNA(Ile) synthetase C-terminal
Glycosyltransferase subfamily 4-like N-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Phosphoethanolamine transferase N-terminal
Choloylglycine hydrolase/NAAA C-terminal
Na(+)-translocating NADH-quinone reductase subunit A C-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Lipopolysaccharide export system protein LptA
Organic solvent tolerance-like N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
DNA polymerase III delta subunit C-terminal
FAD-dependent oxidoreductase 2 FAD binding
Interacts with tRNA; defines subfamily-specific binding signature
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Cytochrome c-type biogenesis protein CcmF C-terminal
Cob(I)alamin adenosyltransferase N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Prepilin peptidase dependent protein C-like C-terminal
Large ribosomal subunit protein uL6 alpha-beta
Survival protein SurE-like phosphatase/nucleotidase
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
D-galactose/methyl-galactoside binding periplasmic protein MglB
RNA polymerase sigma factor 70 region 4 type 2
Resolvase/invertase-type recombinase catalytic
Translation elongation factor P/YeiP central
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Nitrite/Sulfite reductase ferredoxin-like
Endolytic peptidoglycan transglycosylase RlpA
3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Schiff-base intermediate with acetaldehyde
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Outer membrane protein assembly factor BamB
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Beta-hexosaminidase bacterial type N-terminal
sn-glycerol-3-phosphate-binding periplasmic protein UgpB
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Gamma-glutamylcyclotransferase AIG2-like
Involved in tetramerization or stability of the tetramer
Required for zinc-mediated homotetramerization and catalytic activity
Helix-hairpin-helix DNA-binding motif class 1
Could be important to modulate the pK values of the two catalytic cysteine residues
Aconitase A/isopropylmalate dehydratase small subunit swivel
NADH:flavin oxidoreductase/NADH oxidase N-terminal
NIF system FeS cluster assembly NifU N-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Phosphotransferase system enzyme I N-terminal
4'-phosphopantetheinyl transferase N-terminal
Fimbrial-type adhesion domain-containing protein
RNA methyltransferase SpoU/TrmH type C-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Proline utilization A proline dehydrogenase N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Anthranilate synthase component I N-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Schiff-base intermediate with substrate; via topaquinone
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Glycoside hydrolase family 31 N-terminal
Glucose-6-phosphate isomerase prokaryote
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Type I restriction modification DNA specificity
Plays an important role in discriminating NADH against NADPH
NADH-rubredoxin oxidoreductase C-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Membrane insertase YidC/Oxa/ALB C-terminal
Carbamoyl-phosphate synthetase large subunit-like ATP-binding
Haem-binding uptake Tiki superfamily ChaN
Type VI secretion system IcmF C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Influences the redox potential of the prosthetic heme and FAD groups
Involved in heme-bound ligand stabilization and O-O bond activation
Membrane iron-sulfur containing protein FtrD-like
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Proton acceptor; for glutaminase activity
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Important for interaction with partner proteins
High-affinity zinc uptake system protein ZnuA
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Common pilus major fimbrillin subunit EcpA
Activator of Hsp90 ATPase homologue 1-like C-terminal
Nucleoside-specific channel-forming protein Tsx
Aspartate/homoserine dehydrogenase NAD-binding
Acyl-CoA dehydrogenase C-terminal bacterial-type
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
O-(phosphoribosyl dephospho-coenzyme A)serine
Tetrahydrodipicolinate-N-succinyltransferase chain A
Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H(+) and Cl(-) transport
Mediates proton transfer from the protein to the inner aqueous phase
HicB-like antitoxin of toxin-antitoxin system
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Exonuclease VII large subunit C-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
Flagella basal body P-ring formation protein FlgA
Polysaccharide biosynthesis protein C-terminal
Outer-membrane lipoprotein carrier protein
Molybdopterin cofactor biosynthesis C (MoaC)
Bacterial type II secretion system protein E
Glycosyl transferase family 3 N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Prokaryotic-type class I peptide chain release factors
Ribosomal RNA adenine methylase transferase N-terminal
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Required for dimer formation and molybdate binding
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Plays an important role in substrate specificity
Bacterial transcription activator effector binding
Phosphatidic acid phosphatase type 2/haloperoxidase
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Erythronate-4-phosphate dehydrogenase dimerisation
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
S-adenosyl-L-homocysteine hydrolase NAD binding
Aldehyde oxidase/xanthine dehydrogenase first molybdopterin binding
Aldehyde oxidase/xanthine dehydrogenase second molybdopterin binding
Lipocalin-like domain-containing protein
Transcriptional regulator SgrR N-terminal HTH
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS domain-containing protein
Gly-cisPro motif, important for rejection of L-amino acids
Large ribosomal subunit protein bL25 L25
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
DNA-directed DNA polymerase family A palm
Flagellar motor switch protein FliN N-terminal
Flagellar motor switch protein FliN-like C-terminal
Outer-membrane lipoprotein Wza C-terminal
Proton acceptor; for decarboxylase activity
Proton donor; for decarboxylase activity
Proton donor; for formyltransferase activity
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
DNA mismatch repair MutH/Type II restriction enzyme Sau3AI
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
N6 adenine-specific DNA methyltransferase N-terminal
DNA-directed DNA polymerase family B exonuclease
DNA-directed DNA polymerase family B multifunctional
6-phosphogluconate dehydrogenase C-terminal
Large ribosomal subunit protein uL2 C-terminal
Polysaccharide chain length determinant N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Acyltransferase MbtK/IucB-like conserved
Outer membrane assembly lipoprotein YfiO
Virulence factor membrane-bound polymerase C-terminal
Positions MEP for the nucleophilic attack
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
5-glutamyl coenzyme A thioester intermediate
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Chromosomal replication initiator protein DnaA
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
ATP synthase F1 complex delta/epsilon subunit N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Adaptive response protein AidB N-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Probable transposase IS891/IS1136/IS1341
The binding site for the sugar molecule has not yet been established, but C-87 may be involved
Small ribosomal subunit protein uS4 N-terminal
Chitobiase/beta-hexosaminidases N-terminal
ABC-type glycine betaine transport system substrate-binding
Nicotinamide phosphoribosyltransferase N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Type II secretion system protein GspI C-terminal
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Appears to be important in orienting the phosphate for catalysis
Inosine/uridine-preferring nucleoside hydrolase
YdgH/BhsA/McbA-like domain-containing protein
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
ABC-type transport auxiliary lipoprotein component
Release factor glutamine methyltransferase N-terminal
Guanylate kinase/L-type calcium channel beta subunit
Glycine cleavage T-protein C-terminal barrel
Type I restriction enzyme R protein N-terminal
Arginine decarboxylase C-terminal helical
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Important for beta-aspartyl-AMP intermediate formation
Molybdenum cofactor biosynthesis protein F N-terminal
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Penicillin-binding protein activator LpoA
Cysteine sulfenic acid (-SOH) intermediate
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
CobB/CobQ-like glutamine amidotransferase
NIF system FeS cluster assembly NifU C-terminal
Outer membrane protein assembly factor BamA
Integrative conjugative element protein, RAQPRD family
Could play a key role in the communication between the regulatory and the substrate sites
Polypeptide-transport-associated ShlB-type
Menaquinone biosynthesis protein MenD middle
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
For 3-hydroxyacyl-CoA dehydrogenase activity
DNA replication/recombination mediator RecO N-terminal
Quercetin 2,3-dioxygenase C-terminal cupin
Pyruvate phosphate dikinase AMP/ATP-binding
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Metallo-beta-lactamase domain-containing protein
Heme-copper oxidase subunit III family profile
Acyl-ester intermediate; for transpeptidase activity
Proton donor; for transglycosylase activity
Transglycosylase PBP1b N-terminal transmembrane
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
Thymidylate synthase/dCMP hydroxymethylase
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Important for substrate binding and specificity
Alpha-glycerophosphate oxidase C-terminal
Pectate lyase superfamily protein domain-containing protein
Type II secretion system protein GspC N-terminal
Outer membrane protein assembly factor BamC
Periplasmic nitrate reductase, electron transfer subunit
Non-canonical purine NTP phosphatase/PRRC1
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
TIGR03759 family integrating conjugative element protein
Reversibly protonated during proton transport
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
Peptide methionine sulphoxide reductase MsrA
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Outer membrane protein assembly factor BamE
Sugar fermentation stimulation protein C-terminal
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
Methylguanine DNA methyltransferase ribonuclease-like
Fe/B12 periplasmic-binding domain-containing protein
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Threonine/serine exporter-like N-terminal
Cytochrome C biogenesis protein transmembrane
Thiol:disulfide interchange protein DsbD N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Solute-binding protein family 3/N-terminal domain-containing protein
Glutathionylspermidine synthase pre-ATP-grasp-like
Putative regulatory protein FmdB Zinc ribbon
Superoxide dismutase copper/zinc binding
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Bacteriophage tail tape measure C-terminal
DNA mismatch repair proteins mutS family
Type II secretion system protein GspG C-terminal
Mechanosensitive ion channel inner membrane
DNA polymerase III subunit delta C-terminal
Thiol:disulfide interchange protein DsbD
RNA 2-O ribose methyltransferase substrate binding
Regulator of nucleoside diphosphate kinase N-terminal
SUF system FeS cluster assembly SufBD N-terminal
Pyruvate dehydrogenase E1 component middle
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Hypersensitivity response secretion-like HrpJ