TonB-dependent receptor-like beta-barrel
HicB-like antitoxin of toxin-antitoxin system
Porin opacity type domain-containing protein
Ribose-phosphate pyrophosphokinase N-terminal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Aminoacyl-transfer RNA synthetases class-II family profile
Alpha-D-phosphohexomutase alpha/beta/alpha
Solute-binding protein family 3/N-terminal
Release factor glutamine methyltransferase N-terminal
Major facilitator superfamily (MFS) profile
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
PBCV-specific basic adaptor domain-containing protein
C-type lysozyme inhibitor domain-containing protein
NIF system FeS cluster assembly NifU N-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal domain-containing protein
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Thymidylate synthase/dCMP hydroxymethylase
TolB N-terminal domain-containing protein
Probable transposase IS891/IS1136/IS1341
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Lipid/polyisoprenoid-binding YceI-like domain-containing protein
NIF system FeS cluster assembly NifU C-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Type VI secretion system-associated lipoprotein
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Ribosomal RNA small subunit methyltransferase E methyltransferase
Pyruvate dehydrogenase E1 component middle
Transposase IS116/IS110/IS902 C-terminal
Anthranilate synthase component I N-terminal
Solute-binding protein family 3/N-terminal domain-containing protein
Beta-lactamase hydrolase-like protein phosphatase-like
Ribosomal RNA adenine methylase transferase N-terminal
Peptide methionine sulphoxide reductase MsrA
Transferrin-binding protein B C-lobe handle
Transferrin-binding protein B C-lobe/N-lobe beta barrel
Transferrin-binding protein B N-lobe handle
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
O-(3'-phospho-DNA)-tyrosine intermediate
Septum formation inhibitor MinC C-terminal
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Aconitase A/isopropylmalate dehydratase small subunit swivel
S-adenosyl-L-homocysteine hydrolase NAD binding
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Glycine cleavage T-protein C-terminal barrel
Prokaryotic-type class I peptide chain release factors
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Tail specific protease domain-containing protein
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Pyruvate phosphate dikinase AMP/ATP-binding
RNA polymerase sigma factor 70 region 4 type 2
Molybdopterin cofactor biosynthesis C (MoaC)
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Cysteine sulfenic acid (-SOH) intermediate
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Resolvase/invertase-type recombinase catalytic
Tryptophan synthase beta chain-like PALP
Proline utilization A proline dehydrogenase N-terminal
Peptidase M15B domain-containing protein
Interacts with tRNA; defines subfamily-specific binding signature
DNA-directed DNA polymerase family A palm
Bacterial type II secretion system protein E
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Na(+)-translocating NADH-quinone reductase subunit C
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Secretin/TonB short N-terminal domain-containing protein
Formamidopyrimidine-DNA glycosylase catalytic
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Outer membrane protein assembly factor BamD
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Helix-hairpin-helix DNA-binding motif class 1
Type I restriction modification DNA specificity
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Polypeptide-transport-associated ShlB-type
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
RND efflux pump membrane fusion protein barrel-sandwich
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Penicillin-binding protein transpeptidase
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Large ribosomal subunit protein uL2 C-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Acyl-ester intermediate; for transpeptidase activity
Proton donor; for transglycosylase activity
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Membrane insertase YidC/Oxa/ALB C-terminal
Lipoprotein SmpA/OmlA domain-containing protein
CagE TrbE VirB component of type IV transporter system central
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Glycosyltransferase subfamily 4-like N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Ionotropic glutamate receptor C-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Cytochrome c-type biogenesis protein CcmF C-terminal
SGNH hydrolase-type esterase domain-containing protein
Important for substrate binding and specificity
Positions MEP for the nucleophilic attack
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Small ribosomal subunit protein uS4 N-terminal
UDP N-acetylglucosamine O-acyltransferase C-terminal
Tetrahydrodipicolinate-N-succinyltransferase chain A
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Threonine/serine exporter-like N-terminal
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
NADH:flavin oxidoreductase/NADH oxidase N-terminal
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Plays an important role in substrate specificity
O-(5'-phospho-DNA)-tyrosine intermediate
Ribosome maturation factor RimP N-terminal
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Interaction with polymerase core subunit RpoC
Type III restriction/modification enzyme methylation subunit
Restriction system protein Mrr-like N-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Essential for prephenate dehydratase activity
Organic solvent tolerance-like N-terminal
Translation elongation factor P/YeiP central
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Urease accessory protein UreH-like transmembrane
Type III restriction enzyme C-terminal endonuclease
Large ribosomal subunit protein uL15/eL18
Factor H binding protein C-terminal domain-containing protein
Alanyl-transfer RNA synthetases family profile
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Membrane fusion protein biotin-lipoyl like
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Restriction endonuclease type II DpnII-like
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
NADH:ubiquinone oxidoreductase 30kDa subunit
Exonuclease VII large subunit C-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Outer membrane protein assembly factor BamA
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
UDP-glucose/GDP-mannose dehydrogenase dimerisation
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Glycosyl transferase family 3 N-terminal
Na(+)-translocating NADH-quinone reductase subunit A C-terminal
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Polymerase/histidinol phosphatase N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Autotransporter domain-containing protein
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Proton acceptor; for glutaminase activity
Inner membrane protein YgaP-like transmembrane
Could be important to modulate the pK values of the two catalytic cysteine residues
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Cytochrome b561 bacterial/Ni-hydrogenase
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
ATP synthase F1 complex delta/epsilon subunit N-terminal
RlpA-like protein double-psi beta-barrel
RlpA-like protein double-psi beta-barrel domain-containing protein
RNA binding; important for wobble base 34 recognition
Toxin YqcG C-terminal domain-containing protein
Large ribosomal subunit protein uL6 alpha-beta
Lipopolysaccharide export system protein LptA
Prepilin type IV endopeptidase peptidase
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Pseudouridine synthase I TruA alpha/beta
Reversibly protonated during proton transport