Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Flagellar basal-body/hook protein C-terminal
Helix-hairpin-helix DNA-binding motif class 1
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
UDP N-acetylglucosamine O-acyltransferase C-terminal
Glycine-zipper-containing OmpA-like membrane
Interaction with polymerase core subunit RpoC
Mannose-6-phosphate isomerase type II C-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
RND efflux pump membrane fusion protein barrel-sandwich
Sodium/calcium exchanger membrane region
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Sugar fermentation stimulation protein C-terminal
Proline utilization A proline dehydrogenase N-terminal
PhoD-like phosphatase metallophosphatase
Flagellar basal body rod protein N-terminal
Prepilin type IV endopeptidase peptidase
Transcription elongation factor GreA/GreB C-terminal
Membrane fusion protein biotin-lipoyl like
Bacterial type II secretion system protein E
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Polymerase/histidinol phosphatase N-terminal
Flagellar motor switch protein FliN-like C-terminal
Flagellar hook-length control protein-like C-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Alpha-glycerophosphate oxidase C-terminal
Major facilitator superfamily (MFS) profile
Tryptophan synthase beta chain-like PALP
Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
TonB-dependent receptor-like beta-barrel
Protein-L-isoaspartate O-methyltransferase
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Release factor glutamine methyltransferase N-terminal
Putative ATP-dependent zinc protease domain-containing protein
Bacterial bifunctional deaminase-reductase C-terminal
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
ABC-type uncharacterised transport system
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Glycosyltransferase subfamily 4-like N-terminal
Thymidylate synthase/dCMP hydroxymethylase
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
Could play a key role in the communication between the regulatory and the substrate sites
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
May play a role in metal incorporation in vivo
SUF system FeS cluster assembly SufBD N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Thiol:disulfide interchange protein DsbD
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Alpha-ketoglutarate-dependent dioxygenase AlkB-like
Probable transposase IS891/IS1136/IS1341
Gfo/Idh/MocA-like oxidoreductase N-terminal
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
HicB-like antitoxin of toxin-antitoxin system
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Glycine cleavage T-protein C-terminal barrel
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Disulphide bond isomerase DsbC/G N-terminal
Mechanosensitive ion channel inner membrane
Phosphotransferase system enzyme I N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
DNA mismatch repair MutH/Type II restriction enzyme Sau3AI
Resolvase/invertase-type recombinase catalytic
Penicillin-binding protein transpeptidase
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Acyltransferase MbtK/IucB-like conserved
Small ribosomal subunit protein uS4 N-terminal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
CRISPR-associated protein Cas6 C-terminal
Reversibly protonated during proton transport
Lipocalin-like domain-containing protein
NIF system FeS cluster assembly NifU N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Putative regulatory protein FmdB Zinc ribbon
PEP-CTERM protein-sorting domain-containing protein
Putative Flp pilus-assembly TadG-like N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Aminoacyl-transfer RNA synthetases class-II family profile
Polysaccharide biosynthesis protein CapD-like
TRAP C4-dicarboxylate transport system permease DctM subunit
O-(5'-phospho-DNA)-tyrosine intermediate
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Large ribosomal subunit protein uL6 alpha-beta
DNA-directed DNA polymerase family A palm
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
1,4-alpha-glucan branching enzyme C-terminal
Glycoside hydrolase family 57 N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Nitrite/Sulfite reductase ferredoxin-like
Proton acceptor; for glutaminase activity
RNA binding; important for wobble base 34 recognition
Rap1a immunity protein domain-containing protein
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Peptide methionine sulfoxide reductase MsrB
Cytochrome b561 bacterial/Ni-hydrogenase
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Anthranilate synthase component I N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Alpha-D-phosphohexomutase alpha/beta/alpha
Polysaccharide biosynthesis protein C-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Type I restriction modification DNA specificity
DNA mismatch repair proteins mutS family
Phosphatidic acid phosphatase type 2/haloperoxidase
NADH:ubiquinone oxidoreductase 30kDa subunit
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
N6 adenine-specific DNA methyltransferase N-terminal
Electron transfer via tryptophanyl radical
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Major facilitator superfamily associated
Heme-copper oxidase subunit III family profile
Polysaccharide chain length determinant N-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Antitoxin Xre/MbcA/ParS-like toxin-binding
Tetrahydrodipicolinate-N-succinyltransferase chain A
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
tRNA(Met) cytidine acetyltransferase TmcA
Solute-binding protein family 3/N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Phage terminase large subunit GpA ATPase
Terminase large subunit GpA endonuclease
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Transcription elongation factor GreA/GreB N-terminal
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Molybdopterin cofactor biosynthesis C (MoaC)
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Arginine decarboxylase C-terminal helical
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Chromosomal replication initiator protein DnaA
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Large ribosomal subunit protein uL15/eL18
Positions MEP for the nucleophilic attack
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
6-phosphogluconate dehydrogenase C-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
ssDNA thymidine ADP-ribosyltransferase DarT
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Glutamate synthase alpha subunit C-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Plays an important role in substrate specificity
Histidine-specific methyltransferase SAM-dependent
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Ribosomal RNA adenine methylase transferase N-terminal
Pseudouridine synthase I TruA alpha/beta
Cytochrome P460 domain-containing protein
Gamma-butyrobetaine hydroxylase-like N-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Phosphoadenosine phosphosulphate reductase
Bacterial spore germination immunoglobulin-like
Bacterial spore germination immunoglobulin-like domain-containing protein
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Methylene-tetrahydromethanopterin dehydrogenase N-terminal
Ribulose bisphosphate carboxylase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
Outer membrane protein beta-barrel domain-containing protein
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Na+/H+ antiporter MnhB subunit-related protein
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Acyl-CoA dehydrogenase C-terminal bacterial-type
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
RNA polymerase sigma factor 70 region 4 type 2
N-end rule aminoacyl transferase C-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Schiff-base intermediate with substrate; via pyruvic acid
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
DnaJ homologue subfamily C member 28 conserved
Transglycosylase SLT domain-containing protein
Interacts with tRNA; defines subfamily-specific binding signature
Transposase IS204/IS1001/IS1096/IS1165 DDE
Flagellar assembly protein FliH/Type III secretion system HrpE
Type II secretion system protein GspG C-terminal
Prokaryotic-type class I peptide chain release factors
Membrane insertase YidC/Oxa/ALB C-terminal
Cation-transporting P-type ATPase N-terminal
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Pyruvate dehydrogenase E1 component middle
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
DNA replication/recombination mediator RecO N-terminal
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
ABC-type transport auxiliary lipoprotein component
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
S-adenosylmethionine-dependent methyltransferase
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Alpha-L-glutamate ligase-related protein ATP-grasp
Type 4 fimbrial biogenesis protein PilX N-terminal
Important for beta-aspartyl-AMP intermediate formation
Ribulose bisphosphate carboxylase small subunit
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Glycoside hydrolase family 31 N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Large ribosomal subunit protein uL2 C-terminal
ATP-dependent DNA helicase RecG C-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Acetylserotonin O-methyltransferase dimerisation
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Twin-arginine translocation signal domain-containing protein
Survival protein SurE-like phosphatase/nucleotidase
Essential for prephenate dehydratase activity
Alanyl-transfer RNA synthetases family profile
Lysidine-tRNA(Ile) synthetase C-terminal
Arsenosugar biosynthesis radical SAM protein ArsS-like C-terminal
ATPsynthase alpha/beta subunit N-terminal extension
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Myo-inositol-1-phosphate synthase GAPDH-like
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Moybdenum cofactor oxidoreductase dimerisation
Transposase IS116/IS110/IS902 C-terminal
Quinohemoprotein amine dehydrogenase alpha subunit haem binding
DNA polymerase III subunit delta C-terminal
Type III restriction enzyme C-terminal endonuclease
Translation elongation factor P/YeiP central
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Pyridoxamine 5'-phosphate oxidase putative
Organic solvent tolerance-like N-terminal
Important for interaction with partner proteins
CD-NTase-associated protein 12/Pycsar effector protein TIR
Putative auto-transporter adhesin head GIN
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Polyribonucleotide 5'-hydroxyl-kinase Clp1 P-loop
7 transmembrane helices usually fused to an inactive transglutaminase
Inactive transglutaminase fused to 7 transmembrane helices
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Hydrazine synthase alpha subunit middle domain-containing protein
Nucleophile; cysteine thiosulfonate intermediate
Heparin-sulfate lyase N-terminal domain-containing protein
Carboxypeptidase regulatory-like domain-containing protein
TonB system biopolymer transport component
Formylmethanofuran: tetrahydromethanopterin formyltransferase Ftr C-terminal
Formylmethanofuran: tetrahydromethanopterin formyltransferase Ftr N-terminal
Peptide methionine sulfoxide reductase MsrA
Peptide methionine sulphoxide reductase MsrA
PBS lyase HEAT domain protein repeat-containing protein
Cytochrome c-type biogenesis protein CcmF C-terminal
Glycosyl transferase family 3 N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Homogentisate 1,2-dioxygenase N-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Probable peptidoglycan glycosyltransferase FtsW
4'-phosphopantetheinyl transferase N-terminal
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase