DNA-directed DNA polymerase family A palm
ESX-1 secretion-associated protein EspA/EspE-like
Mycothiol-dependent maleylpyruvate isomerase metal-binding
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Pyrimidine nucleoside phosphorylase C-terminal
Lactate utilization protein B C-terminal
Anti-sigma-D factor RsdA sigma factor binding region
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Alanyl-transfer RNA synthetases family profile
RNA polymerase sigma factor 70 region 4 type 2
Major facilitator superfamily (MFS) profile
Inosine/uridine-preferring nucleoside hydrolase
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Phosphoribosylformylglycinamidine synthase linker
Important for beta-aspartyl-AMP intermediate formation
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Glycosyltransferase subfamily 4-like N-terminal
Beta-hexosaminidase bacterial type N-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Superoxide dismutase copper/zinc binding
Superoxide dismutase copper/zinc binding domain-containing protein
Membrane insertase YidC/Oxa/ALB C-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
SUF system FeS cluster assembly SufBD N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Alpha-D-phosphohexomutase alpha/beta/alpha
Carbamoyl-phosphate synthase small subunit N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Glycosyl transferase family 3 N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Proton acceptor; for glutaminase activity
Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase C-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Adaptive response protein AidB N-terminal
Putative Flp pilus-assembly TadG-like N-terminal
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Pyridoxamine 5'-phosphate oxidase putative
Myo-inositol-1-phosphate synthase GAPDH-like
DNA primase/polymerase bifunctional N-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Histidine-specific methyltransferase SAM-dependent
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Aconitase A/isopropylmalate dehydratase small subunit swivel
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Glycine cleavage T-protein C-terminal barrel
Tryptophan synthase beta chain-like PALP
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase
Peptidoglycan recognition protein family
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Mandelate racemase/muconate lactonizing enzyme C-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
NAD(P) transhydrogenase alpha subunit C-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Schiff-base intermediate with D-ribose 5-phosphate
Molybdopterin cofactor biosynthesis C (MoaC)
Translation elongation factor P/YeiP central
Essential for prephenate dehydratase activity
Gfo/Idh/MocA-like oxidoreductase N-terminal
Schiff-base intermediate with substrate; via pyruvic acid
L-seryl-tRNA selenium transferase N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
Cytochrome C biogenesis protein transmembrane
UDP-glucose/GDP-mannose dehydrogenase C-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Cytochrome bc1 complex Rieske iron-sulfur subunit
Transcription regulator AsnC/Lrp ligand binding
Cytochrome b/b6 N-terminal region profile
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Large ribosomal subunit protein uL2 C-terminal
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Bacterial type II secretion system protein E
Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-? in acceptor proteins)
Polymerase/histidinol phosphatase N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Cytochrome oxidase subunit II copper A binding
RNA 2-O ribose methyltransferase substrate binding
Prepilin type IV endopeptidase peptidase
Cell envelope-related transcriptional attenuator
Peptide methionine sulphoxide reductase MsrA
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase
Putative regulatory protein FmdB Zinc ribbon
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Exonuclease VII large subunit C-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Helix-hairpin-helix DNA-binding motif class 1
Gram-positive cocci surface proteins LPxTG domain-containing protein
SGNH hydrolase-type esterase domain-containing protein
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Penicillin-binding protein transpeptidase
Glutathionylspermidine synthase pre-ATP-grasp-like
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
6-phosphogluconate dehydrogenase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Heme-copper oxidase subunit III family profile
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Cell wall-active antibiotics response LiaF-like C-terminal
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
CobB/CobQ-like glutamine amidotransferase
Peptidase C39-like domain-containing protein
Prokaryotic-type class I peptide chain release factors
Docks into pockets in the proteasome alpha-ring
Ribosomal RNA adenine methylase transferase N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Gly-cisPro motif, important for rejection of L-amino acids
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Shikimate dehydrogenase substrate binding N-terminal
1,4-alpha-glucan branching enzyme C-terminal
Glycoside hydrolase family 57 N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Nicotinate phosphoribosyltransferase N-terminal
Transcription elongation factor GreA/GreB C-terminal
Endoribonuclease L-PSP/chorismate mutase-like
S-adenosyl-L-homocysteine hydrolase NAD binding
Phosphotransferase system enzyme I N-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
ABC-type glycine betaine transport system substrate-binding
SurA N-terminal domain-containing protein
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
Peptidase M1 membrane alanine aminopeptidase
Release factor glutamine methyltransferase N-terminal
D-inositol 3-phosphate glycosyltransferase
Prealbumin-like fold domain-containing protein
NADH:ubiquinone oxidoreductase 30kDa subunit
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Chromosomal replication initiator DnaA C-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Extradiol ring-cleavage dioxygenase LigAB LigA subunit
Pyruvate dehydrogenase E1 component middle
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Alpha-glycerophosphate oxidase C-terminal
Anthranilate synthase component I N-terminal
Heat-inducible transcription repressor HrcA C-terminal
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Sporulation transcription regulator WhiA N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
DNA replication/recombination mediator RecO N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Plays an important role in substrate specificity
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Formamidopyrimidine-DNA glycosylase catalytic
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Small ribosomal subunit protein uS4 N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
YbaK/aminoacyl-tRNA synthetase-associated
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Removed in mature form; by autocatalysis
Beta-xylosidase C-terminal Concanavalin A-like
Gram-positive cocci surface proteins LPxTG
NIF system FeS cluster assembly NifU N-terminal
Na+/H+ antiporter MnhB subunit-related protein
N(4)-bis(aminopropyl)spermidine synthase C-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Large ribosomal subunit protein uL15/eL18
Actinobacteria/chloroflexi VLRF1 release factor
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
ABC transporter substrate-binding protein PnrA-like
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
PsrA tetracyclin repressor-like C-terminal
Polysaccharide biosynthesis protein CapD-like
Integral membrane protein YccS N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Involved in ionization of N3 of dUMP, leading to its activation
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Large ribosomal subunit protein uL6 alpha-beta