Neurotransmitter-gated ion-channel ligand-binding
Neurotransmitter-gated ion-channel transmembrane
DNA/pantothenate metabolism flavoprotein C-terminal
TATA box binding protein associated factor (TAF) histone-like fold
YbaK/aminoacyl-tRNA synthetase-associated
G-protein coupled receptors family 2 profile 2
G-protein coupled receptors family 1 profile
Post-GPI attachment to proteins factor 3
SAM-dependent methyltransferase TRM5/TYW2-type
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Membrane fusion protein biotin-lipoyl like
Ribosome maturation protein SDO1/SBDS C-terminal
Ribosome maturation protein SDO1/SBDS N-terminal
Ribosome maturation protein SDO1/SBDS central
Anaphase-promoting complex subunit 4-like WD40
Cation channel sperm-associated protein subunit beta
Receptor ligand binding region domain-containing protein
G-protein coupled receptors family 1 profile domain-containing protein
Major facilitator superfamily associated
Peptidase M1 membrane alanine aminopeptidase
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Phosphatidic acid phosphatase type 2/haloperoxidase
RNA binding; important for wobble base 34 recognition
Major facilitator superfamily (MFS) profile
Potassium channel tetramerisation-type BTB
Tryptophan synthase beta chain-like PALP
Muscle M-line assembly protein unc-89-like
Thiamin pyrophosphokinase thiamin-binding
2-oxoacid dehydrogenase acyltransferase catalytic
Interaction with phosphoserine on interacting protein
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Translation initiation factor 3 N-terminal
Peptidase metallopeptidase domain-containing protein
Mediator complex subunit Med13 N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Large ribosomal subunit protein uL23 N-terminal
Telomere length regulation protein conserved
Zinc finger CCCH-type with G patch domain-containing protein
Interaction with galactose moiety of substrate glycoprotein
Vesicular, overexpressed in cancer, prosurvival protein 1
Glutamate receptor ionotropic, kainate 2
Ionotropic glutamate receptor C-terminal
Ionotropic glutamate receptor L-glutamate and glycine-binding
Tetratricopeptide repeat protein 36 homolog
Ribosomal RNA adenine methylase transferase N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Exosome complex component CSL4 C-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Phosphatidylserine amidated glycine; alternate
Clathrin/coatomer adaptor adaptin-like N-terminal
Coatomer gamma subunit appendage Ig-like subdomain
Alanyl-transfer RNA synthetases family profile
MD-2-related lipid-recognition domain-containing protein
SUEL-type lectin domain-containing protein
Platelet-derived growth factor (PDGF) family profile
Platelet-derived growth factor (PDGF) family profile domain-containing protein
Phosphatidylinositol-specific phospholipase C X
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Conserved oligomeric Golgi complex subunit 4
Inward rectifier potassium channel C-terminal
Potassium channel inwardly rectifying transmembrane
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Gamma tubulin complex component C-terminal
Gamma tubulin complex component protein N-terminal
Gamma-tubulin complex component 6 N-terminal
Origin recognition complex subunit 5 C-terminal
Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
BAAT/Acyl-CoA thioester hydrolase C-terminal
G-protein coupled receptors family 3 profile
Eukaryotic translation initiation factor 3 subunit M
Branched-chain-amino-acid aminotransferase
Endoplasmic reticulum vesicle transporter C-terminal
Endoplasmic reticulum vesicle transporter N-terminal
Transmembrane protein 127 transmembrane region
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Nascent polypeptide-associated complex subunit alpha-like UBA
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Saposin B-type domain-containing protein
NF-kappa-B-activating protein C-terminal
Transmembrane emp24 domain-containing protein
Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal
Glycosyl hydrolase family 13 catalytic domain-containing protein
Quinone oxidoreductase-like protein 2 homolog
Important for beta-aspartyl-AMP intermediate formation
NADH:ubiquinone oxidoreductase intermediate-associated protein 30
Inositol polyphosphate-related phosphatase
E3 ubiquitin-protein ligase CHFR cysteine rich
Large ribosomal subunit protein uL30 N-terminal eukaryotes
Large ribosomal subunit protein uL30-like ferredoxin-like fold
SAM-dependent MTase RsmB/NOP-type domain-containing protein
BLOC-1-related complex subunit 8 homolog
Poly (ADP-ribose) glycohydrolase (PARG) catalytic
Large ribosomal subunit protein uL15/eL18
Centriolar and ciliogenesis-associated protein HYLS1 C-terminal
Nucleophile or transition state stabilizer
Queuosine 5'-phosphate N-glycosylase/hydrolase
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Cysteine sulfenic acid (-SOH) intermediate
Chromosome segregation protein Spc25 C-terminal
Alpha-(1,6)-fucosyltransferase N- and catalytic
Glycoside hydrolase family 65 central catalytic
Glycoside hydrolase family 65 central catalytic domain-containing protein
LamG-like jellyroll fold domain-containing protein
Glycosyl-hydrolase family 116 N-terminal
Glycosyl-hydrolase family 116 catalytic region
Eukaryotic translation initiation factor 3 subunit H
Lipocalin/cytosolic fatty-acid binding domain-containing protein
Acetylserotonin O-methyltransferase dimerisation
Eukaryotic translation initiation factor 3 subunit E
Alpha galactosidase A C-terminal beta-sandwich
G-protein coupled receptors family 3 profile domain-containing protein
Eukaryotic translation initiation factor 3 subunit K
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Important for autoinhibition of adenylyltransferase activity
Nucleolus and neural progenitor protein-like N-terminal
Ragulator complex protein LAMTOR4 homolog
Multiple myeloma tumor-associated protein 2-like N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Fibronectin type-III domain-containing protein
Mandelate racemase/muconate lactonizing enzyme C-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
ATPsynthase alpha/beta subunit N-terminal extension
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial
C4-type zinc-finger of DNA polymerase delta
DNA-directed DNA polymerase family B exonuclease
DNA-directed DNA polymerase family B multifunctional
Cysteine/serine-rich nuclear protein N-terminal
Serine/threonine specific protein phosphatases
Iron/zinc purple acid phosphatase-like C-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Retinoblastoma-associated protein C-terminal
Retinoblastoma-associated protein N-terminal
Thymidylate synthase/dCMP hydroxymethylase
Gamma-butyrobetaine hydroxylase-like N-terminal
AB hydrolase-1 domain-containing protein
Schiff-base intermediate with acetaldehyde
Pituitary tumor-transforming gene 1 protein-interacting protein
Schiff-base intermediate with D-ribose 5-phosphate
CCR4-Not complex component Not N-terminal
E3 ubiquitin-protein ligase APD1-4 middle
L-2-hydroxyglutarate dehydrogenase, mitochondrial
Folate receptor-like domain-containing protein
Eukaryotic translation initiation factor 3 subunit J
Phosphomannose isomerase type I C-terminal
Phosphomannose isomerase type I catalytic
Phosphomannose isomerase type I helical insertion
FACT complex subunit Spt16 N-terminal lobe
Histone chaperone RTT106/FACT complex subunit SPT16-like middle
U3 small nucleolar RNA-associated protein 15 C-terminal
Nicotinate-nucleotide pyrophosphorylase [carboxylating]
Leucine-rich repeat protein soc-2 homolog
Peptide methionine sulphoxide reductase MsrA
Peptide-N-glycosidase F N-terminal domain-containing protein
Transforming acidic coiled-coil-containing protein C-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Non-structural maintenance of chromosomes element 1 RING C4HC3-type
Glucosamine/galactosamine-6-phosphate isomerase
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
Does not affect channel activity by ADP-ribose. Acquires sensitivity to oxidative stress.
Does not affect channel activity. Acquires sensitivity to oxidative stress.
Induces fast inactivation of the channel.
Induces transient spontaneous channel activity. Does not affect channel activity by ADP-ribose. Acquires sensitivity to oxidative stress. In response to oxidative stress, induces intracellular Ca(2+) oscillations instead of a sustained Ca(2+) increase.
Mild loss of Ca(2+) sensitivity and increased sensitivity to phosphatidylinositol 4,5-bisphosphate-mediated activation.
Severe loss of Ca(2+) sensitivity and increased sensitivity to phosphatidylinositol 4,5-bisphosphate-mediated activation.
Severe reduction in ADP-ribose-mediated channel activation.
Transient receptor potential cation channel subfamily M member-like 2
Chitin-binding type-2 domain-containing protein
Gamma-interferon-inducible lysosomal thiol reductase
Glutaminyl-tRNA synthetase class Ib non-specific RNA-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
vitamin-K-epoxide reductase (warfarin-sensitive)
U2A'/phosphoprotein 32 family A C-terminal
Pyrimidine nucleoside phosphorylase C-terminal
DET1- and DDB1-associated protein 1 N-terminal
Small ribosomal subunit protein uS15 N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Spermatogenesis-associated protein 1 C-terminal
von Willebrand factor A domain-containing protein 7
Telomeric single stranded DNA binding POT1/Cdc13
Translocon-associated protein subunit beta
Abscisic acid G-protein coupled receptor-like
Nuclear envelope integral membrane protein 1
Peptidase S9 prolyl oligopeptidase catalytic
Translocon-associated protein subunit delta
Sulfatase N-terminal domain-containing protein
Large ribosomal subunit protein uL2 C-terminal
Peptidase C1A papain C-terminal domain-containing protein
Small ribosomal subunit protein uS4 N-terminal
Sulfotransferase domain-containing protein
Transcription factor CBF/NF-Y/archaeal histone
Coiled-coil domain-containing protein 42 homolog
NAD-dependent epimerase/dehydratase domain-containing protein
Domain of unknown function with conserved HDNR motif
Thioredoxin domain-containing protein 12
Telomerase activating protein Est1-like N-terminal
Large ribosomal subunit protein uL18 C-terminal eukaryotes
Collagen triple helix repeat-containing protein 1-like
NIF system FeS cluster assembly NifU N-terminal
tRNA-splicing endonuclease subunit Sen15
Fibrinogen C-terminal domain-containing protein
Alpha galactosidase C-terminal beta sandwich
Carboxypeptidase activation peptide domain-containing protein
Protein phosphatase 1 regulatory subunit 35 C-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Multiple inositol polyphosphate phosphatase 1
Eukaryotic translation initiation factor 3 subunit F
Beta-hexosaminidase eukaryotic type N-terminal
6-phosphogluconate dehydrogenase C-terminal
Glycoside hydrolase family 5 domain-containing protein
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
Phosphorylated adapter RNA export protein RNA-binding
May act as a substrate filter by repelling compounds with a negatively charged alpha-carboxylate
Schwannomin interacting protein 1 C-terminal
FAD dependent oxidoreductase domain-containing protein
Deubiquitinating enzyme MINDY-3/4 conserved
Sodium/calcium exchanger membrane region
Casein kinase substrate phosphoprotein PP28
Sphingolipid delta4-desaturase N-terminal
DNA polymerase alpha/delta/epsilon subunit B
DNA polymerase epsilon subunit B N-terminal
DNA replication complex GINS protein SLD5 C-terminal
Seven cysteines N-terminal domain-containing protein
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Probable tRNA N6-adenosine threonylcarbamoyltransferase
Translation elongation factor IF5A C-terminal
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Glycine cleavage T-protein C-terminal barrel
Pseudouridine synthase I TruA alpha/beta
Inosine/uridine-preferring nucleoside hydrolase
receptor protein serine/threonine kinase
Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase
Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase domain-containing protein
Nuclear speckle splicing regulatory protein 1 N-terminal
Gamma-glutamylcyclotransferase AIG2-like
Alpha-N-acetylglucosaminidase C-terminal
Alpha-N-acetylglucosaminidase N-terminal
Alpha-N-acetylglucosaminidase tim-barrel
Cation-transporting P-type ATPase N-terminal
16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal
RNase L inhibitor RLI-like possible metal-binding
Thioredoxin-like fold domain-containing protein
Ribosomal RNA processing protein 36 homolog
Spo11/DNA topoisomerase VI subunit A N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Transcription initiation factor IIA gamma subunit C-terminal
Transcription initiation factor IIA gamma subunit N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Pre-mRNA processing factor 4 (PRP4)-like
DNA damage-regulated autophagy modulator protein 2
INO80 complex subunit B-like conserved region
Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central
Schiff-base intermediate with substrate; via topaquinone
ER membrane protein complex subunit 1 C-terminal
Transcription factor COE helix-loop-helix
Glycosyl hydrolase family 30 beta sandwich
Ragulator complex protein LAMTOR5 homolog
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
Choloylglycine hydrolase/NAAA C-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Alpha-2-macroglobulin receptor-associated protein
Hemimethylated DNA-binding domain-containing protein
UDP-xylose and UDP-N-acetylglucosamine transporter
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
CBF1-interacting co-repressor CIR N-terminal
Serine/threonine-protein kinase receptor
Methylcytosine dioxygenase TET1-3 oxygenase
Serine/threonine-protein kinase haspin C-terminal
3-beta hydroxysteroid dehydrogenase/isomerase
Potassium channel domain-containing protein
CSC1/OSCA1-like N-terminal transmembrane
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Large ribosomal subunit protein uL6 N-terminal
Guanylate kinase/L-type calcium channel beta subunit
Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain
Structure-specific endonuclease subunit SLX1 homolog
Biogenesis of lysosome-related organelles complex 1 subunit 5
Laminin EGF-like domain-containing protein
Formamidopyrimidine-DNA glycosylase catalytic
DNA-directed RNA polymerase RBP11-like dimerisation
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Glucose-induced degradation protein 8 homolog
RNA 3'-terminal phosphate cyclase insert
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Translation initiation factor beta propellor-like
tRNA-splicing endonuclease subunit Sen54 N-terminal
Succinate dehydrogenase assembly factor 3, mitochondrial
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Formiminotransferase C-terminal subdomain
Formiminotransferase N-terminal subdomain
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Alpha-ketoglutarate-dependent dioxygenase AlkB-like
Histone-binding protein RBBP4 N-terminal
Glycosyl transferase CAP10 domain-containing protein
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Eukaryotic translation initiation factor 3 subunit D
Pre-rRNA-processing protein Ipi1 N-terminal
Chitin-binding type-4 domain-containing protein
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Protein kinase domain-containing protein
Dickkopf N-terminal cysteine-rich domain-containing protein
ATP-grasp fold succinyl-CoA synthetase-type
Transcription initiation factor TFIID subunit 12
DNA-directed RNA polymerase subunit 2 hybrid-binding
Superoxide dismutase copper/zinc binding
Poly(A)-specific ribonuclease RNA-binding
Mediator of RNA polymerase II transcription subunit 25 von Willebrand factor type A
Specifically reduces 3'-3' linked cGAMP binding while retaining 2'-3' linked cGAMP recognition.
Eukaryotic translation initiation factor 3 subunit A
Fanconi Anaemia group E protein C-terminal
Sphingomyelin phosphodiesterase C-terminal
Tetratricopeptide repeat protein 5 OB fold
Anaphase-promoting complex subunit 4 long
ATP synthase F1 complex delta/epsilon subunit N-terminal
Glycosyl transferase family 28 C-terminal
Nuclear respiratory factor 1 NLS/DNA-binding dimerisation
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Large ribosomal subunit protein uL10-like insertion
Cytoplasmic polyadenylation element-binding protein ZZ
Histidine kinase/HSP90-like ATPase domain-containing protein
L-type lectin-like domain-containing protein
Coiled-coil domain-containing protein 22 homolog
Membrane insertase YidC/Oxa/ALB C-terminal
ABC-type uncharacterised transport system
Fanconi anemia core complex-associated protein 24 pseudonuclease
Loss of activity; when associated with A-131.
Loss of activity; when associated with A-133.
Small ribosomal subunit protein uS17 N-terminal
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Selenoprotein P N-terminal domain-containing protein
Hydroxymethylglutaryl-coenzyme A synthase C-terminal
Hydroxymethylglutaryl-coenzyme A synthase N-terminal
GDP-fucose protein O-fucosyltransferase 1
Integrator complex subunit 14 C-terminal
Integrator complex subunit 14 beta-barrel
Eukaryotic translation initiation factor 3 subunit I
Large ribosomal subunit protein uL4 C-terminal
Copper type II ascorbate-dependent monooxygenase C-terminal
Copper type II ascorbate-dependent monooxygenase N-terminal