D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Putative Flp pilus-assembly TadG-like N-terminal
Major facilitator superfamily (MFS) profile
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Glycine cleavage T-protein C-terminal barrel
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Peptidase S9 prolyl oligopeptidase catalytic
Cytochrome C biogenesis protein transmembrane
Phosphocysteine intermediate; for EIIB activity
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Release factor glutamine methyltransferase N-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Centromere-binding protein ParB C-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Polymerase/histidinol phosphatase N-terminal
Ribosomally synthesized peptide with SipW-like signal peptide
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Type II secretion system protein GspE N-terminal
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Glutathionylspermidine synthase pre-ATP-grasp-like
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
YbaK/aminoacyl-tRNA synthetase-associated
FAD-dependent oxidoreductase 2 FAD binding
RNA 2-O ribose methyltransferase substrate binding
O-(3'-phospho-DNA)-tyrosine intermediate
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
S-adenosyl-L-homocysteine hydrolase NAD binding
Aminoacyl-tRNA synthetase class I anticodon-binding
Gfo/Idh/MocA-like oxidoreductase N-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Ribosomal RNA small subunit methyltransferase H
Glycosyltransferase subfamily 4-like N-terminal
Methionyl-tRNA synthetase anticodon-binding
Pyrimidine nucleoside phosphorylase C-terminal
Gram-positive cocci surface proteins LPxTG domain-containing protein
Flagellar motor switch protein FliN-like C-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Flagellar basal-body/hook protein C-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Cytochrome b561 bacterial/Ni-hydrogenase
Ribose-phosphate pyrophosphokinase N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Peptidase M1 membrane alanine aminopeptidase
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase
Mandelate racemase/muconate lactonizing enzyme C-terminal
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Solute-binding protein family 3/N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Subtilisin inhibitor domain-containing protein
Pyridine nucleotide-disulphide oxidoreductase dimerisation
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Inosine/uridine-preferring nucleoside hydrolase
RNA polymerase sigma factor 70 region 4 type 2
N6 adenine-specific DNA methyltransferase N-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase
Penicillin-binding protein transpeptidase
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Ribosomal RNA small subunit methyltransferase G
Ribulose bisphosphate carboxylase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
N,N-dimethylformamidase beta subunit-like C-terminal
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Nicotinate phosphoribosyltransferase N-terminal
Cytochrome oxidase subunit II copper A binding
Beta-xylosidase C-terminal Concanavalin A-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Protein O-mannosyl-transferase C-terminal four TM
Putative glycogen debranching enzyme N-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Electron transfer via tryptophanyl radical
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Schiff-base intermediate with substrate; via topaquinone
Alpha-L-rhamnosidase six-hairpin glycosidase
Bacterial alpha-L-rhamnosidase N-terminal
Schiff-base intermediate with D-ribose 5-phosphate
RNA binding; important for wobble base 34 recognition
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
Tryptophan synthase beta chain-like PALP
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Gfo/Idh/MocA-like oxidoreductase C-terminal
D-galactonate dehydratase family member Achl_0790
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
NADH:flavin oxidoreductase/NADH oxidase N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Periplasmic copper-binding protein NosD beta helix
ATP synthase F1 complex delta/epsilon subunit N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Resolvase/invertase-type recombinase catalytic
NIF system FeS cluster assembly NifU N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
DnaJ homologue subfamily C member 28 conserved
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
DNA-directed RNA polymerase subunit beta'
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
D-inositol 3-phosphate glycosyltransferase
Bacterial type II secretion system protein E
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Pyruvate dehydrogenase E1 component middle
Shikimate dehydrogenase substrate binding N-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Phenol hydroxylase C-terminal dimerisation
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Thymidylate synthase/dCMP hydroxymethylase
ABC transporter substrate-binding protein PnrA-like
TRAP-T family transporter, periplasmic binding protein
Schiff-base intermediate with acetaldehyde
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Imidazole glycerol phosphate synthase subunit HisF
Acyltransferase MbtK/IucB-like conserved
Removed in mature form; by autocatalysis
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
TRAP C4-dicarboxylate transport system permease DctM subunit
Peptidase C39-like domain-containing protein
Pyridoxal 5'-phosphate synthase subunit PdxT
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Cell envelope-related transcriptional attenuator
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Type I restriction enzyme R protein N-terminal
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-135)
3-isopropylmalate dehydratase large subunit
Chromosomal replication initiator DnaA C-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Glutamate-1-semialdehyde 2,1-aminomutase
Succinate--CoA ligase [ADP-forming] subunit beta
Polyribonucleotide nucleotidyltransferase
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Cell division protein FtsQ/DivIB C-terminal
Flagellar basal body rod protein N-terminal
Ionotropic glutamate receptor C-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Electron transfer flavoprotein alpha/beta-subunit N-terminal
ABC3 transporter permease protein domain-containing protein
Carbamoyl-phosphate synthase large chain
PhoD-like phosphatase metallophosphatase
Reversibly protonated during proton transport
Essential for prephenate dehydratase activity
DNA-directed RNA polymerase subunit alpha
Holliday junction branch migration complex subunit RuvA
N-acetyl-gamma-glutamyl-phosphate reductase
Interaction with polymerase core subunit RpoC
Cytochrome b/b6 N-terminal region profile
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Exonuclease VII large subunit C-terminal
Prepilin type IV endopeptidase peptidase
General stress protein FMN-binding split barrel
ATP-dependent Clp protease ATP-binding subunit ClpX
Actinobacteria/chloroflexi VLRF1 release factor
Glucosamine/galactosamine-6-phosphate isomerase
Phosphogluconate dehydrogenase NAD-binding putative C-terminal
Probable transcriptional regulatory protein Achl_2034
SUF system FeS cluster assembly SufBD N-terminal
Important for substrate specificity; cannot use PPi as phosphoryl donor
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B
Phosphatidic acid phosphatase type 2/haloperoxidase
Glycoside hydrolase family 42 N-terminal
Galactofuranosyltransferase GlfT2 N-terminal
Galactofuranosyltransferase-2 C-terminal
Putative regulatory protein FmdB Zinc ribbon
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Na+/H+ antiporter MnhB subunit-related protein
NAD(P) transhydrogenase alpha subunit C-terminal
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Holliday junction branch migration complex subunit RuvB
LPXTG-motif cell wall anchor domain protein
Positions MEP for the nucleophilic attack
Docks into pockets in the proteasome alpha-ring
Endoribonuclease L-PSP/chorismate mutase-like
ABC-type glycine betaine transport system substrate-binding
Plays an important role in substrate specificity
Myo-inositol-1-phosphate synthase GAPDH-like
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Glutamate synthase alpha subunit C-terminal
Putative oxidoreductase/dehydrogenase Rossmann-like
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Glycosyl transferase family 3 N-terminal
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)
Probable 5-dehydro-4-deoxyglucarate dehydratase
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Flp pilus assembly protein RcpC/CpaB domain-containing protein
3-isopropylmalate dehydratase small subunit
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Bacterial transcription activator effector binding
Phosphomannose isomerase type I catalytic
SMP-30/Gluconolactonase/LRE-like region domain-containing protein
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Transcription regulator AsnC/Lrp ligand binding
Molybdopterin cofactor biosynthesis C (MoaC)
Peptide methionine sulfoxide reductase MsrA
Carbohydrate-binding domain-containing protein
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
6-phosphogluconate dehydrogenase C-terminal
Large ribosomal subunit protein uL15/eL18
DNA topoisomerase I catalytic core eukaryotic-type
Phosphotransferase system enzyme I N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Anthranilate synthase component I N-terminal
DNA replication/recombination mediator RecO N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Phosphatidylglycerol lysyltransferase C-terminal
Transcription antitermination protein NusB
Phosphoribosylformylglycinamidine synthase linker
Heat-inducible transcription repressor HrcA
Alpha-glycerophosphate oxidase C-terminal
Crossover junction endodeoxyribonuclease RuvC
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C