Important for beta-aspartyl-AMP intermediate formation
Thiopeptide-type bacteriocin biosynthesis
Major facilitator superfamily (MFS) profile
Cytochrome C biogenesis protein transmembrane
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Metallo-beta-lactamase domain-containing protein
Glycosyltransferase subfamily 4-like N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Mycothiol-dependent maleylpyruvate isomerase metal-binding
NADH-rubredoxin oxidoreductase C-terminal
Methionyl-tRNA synthetase anticodon-binding
Aminoacyl-transfer RNA synthetases class-II family profile
Plays an important role in substrate specificity
RNA polymerase sigma factor 70 region 4 type 2
Alpha-D-phosphohexomutase alpha/beta/alpha
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
N,N-dimethylformamidase beta subunit-like C-terminal
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
DNA primase/polymerase bifunctional N-terminal
Anthranilate synthase component I N-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Gram-positive cocci surface proteins LPxTG
Gram-positive cocci surface proteins LPxTG domain-containing protein
Cytochrome oxidase subunit II copper A binding
Ribosomal RNA adenine methylase transferase N-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Transposase IS116/IS110/IS902 C-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Tryptophan synthase beta chain-like PALP
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Sporulation transcription regulator WhiA N-terminal
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Alpha galactosidase C-terminal beta sandwich
Phosphatidic acid phosphatase type 2/haloperoxidase
Peptidase S9 prolyl oligopeptidase catalytic
Peptidase C39-like domain-containing protein
Phospholipase D-like domain-containing protein
S-adenosyl-L-homocysteine hydrolase NAD binding
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Cell wall-active antibiotics response LiaF-like C-terminal
Phosphoribosylformylglycinamidine synthase linker
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Gfo/Idh/MocA-like oxidoreductase N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Helix-hairpin-helix DNA-binding motif class 1
Mandelate racemase/muconate lactonizing enzyme C-terminal
Pyridoxamine 5'-phosphate oxidase putative
Polymerase/histidinol phosphatase N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Glycosyl hydrolase family 98 putative carbohydrate-binding module
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Glycerophosphoryl diester phosphodiesterase membrane
Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase C-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Resuscitation-promoting factor core lysozyme-like
Resuscitation-promoting factor core lysozyme-like domain-containing protein
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Phosphatidylglycerol lysyltransferase C-terminal
Resolvase/invertase-type recombinase catalytic
Thiamine pyrophosphate enzyme TPP-binding
Integral membrane protein YccS N-terminal
Important for the cation stabilization at C-11
Loss of synthase activity at pH 7.0. Strongly reduced synthase activity at pH 8.5.
No effect on synthase activity at pH 7 and 8.5.
Peptide methionine sulphoxide reductase MsrA
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Sodium/calcium exchanger membrane region
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Glycosyl transferase family 3 N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Exonuclease VII large subunit C-terminal
Phosphotransferase system enzyme I N-terminal
Squalene cyclase C-terminal domain-containing protein
PhoD-like phosphatase metallophosphatase
Thymidylate synthase/dCMP hydroxymethylase
Pyrroline-5-carboxylate reductase catalytic N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Solute-binding protein family 3/N-terminal
NIF system FeS cluster assembly NifU N-terminal
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
BAAT/Acyl-CoA thioester hydrolase C-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Cucumopine synthase C-terminal helical bundle
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Transcription regulator AsnC/Lrp ligand binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Essential for prephenate dehydratase activity
Nitrite/Sulfite reductase ferredoxin-like
Serine aminopeptidase S33 domain-containing protein
RNA 2-O ribose methyltransferase substrate binding
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
DNA polymerase III delta subunit C-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Prokaryotic-type class I peptide chain release factors
Bacterial bifunctional deaminase-reductase C-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
PknH-like extracellular domain-containing protein
DNA replication/recombination mediator RecO N-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Phosphoadenosine phosphosulphate reductase
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
DnaJ homologue subfamily C member 28 conserved
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
CobB/CobQ-like glutamine amidotransferase
Nucleophile; cysteine thiosulfonate intermediate
Glucose-methanol-choline oxidoreductase N-terminal
Removed in mature form; by autocatalysis
Protein O-mannosyl-transferase C-terminal four TM
Involved in allosteric activation by GTP
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Polysaccharide biosynthesis protein CapD-like
Translation elongation factor P/YeiP central
Important for autoinhibition of adenylyltransferase activity
Thiol:disulfide interchange protein DsbA
Peptidase M1 membrane alanine aminopeptidase
Shikimate dehydrogenase substrate binding N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Ricin B lectin domain-containing protein
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Important for substrate specificity; cannot use PPi as phosphoryl donor
TIGR04222 domain-containing membrane protein
Phosphomannose isomerase type I catalytic
YbaK/aminoacyl-tRNA synthetase-associated
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Electron transfer via tryptophanyl radical
Beta-hexosaminidase bacterial type N-terminal
Penicillin-binding protein transpeptidase
Endonuclease/exonuclease/phosphatase domain-containing protein
NADH:ubiquinone oxidoreductase 30kDa subunit
Cytochrome bc1 complex Rieske iron-sulfur subunit
Pyrimidine nucleoside phosphorylase C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
ABC-type glycine betaine transport system substrate-binding
Membrane insertase YidC/Oxa/ALB C-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Schiff-base intermediate with substrate; via pyruvic acid
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Cell envelope-related transcriptional attenuator
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Lantibiotic biosynthesis protein dehydration
Glutathionylspermidine synthase pre-ATP-grasp-like
Microcin J25-processing protein McjB C-terminal
Large ribosomal subunit protein uL2 C-terminal
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-? in acceptor proteins)
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Capsule synthesis protein CapA domain-containing protein
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Transglycosylase SLT domain-containing protein
Histidine-specific methyltransferase SAM-dependent
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Glycine cleavage T-protein C-terminal barrel
Erythromycin biosynthesis protein CIII-like central
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Nicotinate phosphoribosyltransferase N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Release factor glutamine methyltransferase N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-112)
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
Alpha-glycerophosphate oxidase C-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Pyruvate dehydrogenase E1 component middle
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-109)
Haemophore haem-binding domain-containing protein
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Putative regulatory protein FmdB Zinc ribbon
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Cytochrome b/b6 N-terminal region profile
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Tat pathway signal sequence domain protein
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Glucosamine/galactosamine-6-phosphate isomerase
Carbamoyl-phosphate synthase small subunit N-terminal
Reversibly protonated during proton transport
Beta-xylosidase C-terminal Concanavalin A-like
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Small ribosomal subunit protein uS4 N-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Right handed beta helix domain-containing protein
Membrane fusion protein biotin-lipoyl like
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Chitin-binding type-3 domain-containing protein
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Alanyl-transfer RNA synthetases family profile
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Myo-inositol-1-phosphate synthase GAPDH-like
Proton acceptor; for glutaminase activity
Pyrroline-5-carboxylate reductase dimerisation
Schiff-base intermediate with D-ribose 5-phosphate
Lysyl-tRNA synthetase N-terminal transmembrane region
SUF system FeS cluster assembly SufBD N-terminal
Leucine-binding protein domain-containing protein
Cysteine sulfenic acid (-SOH) intermediate
Heat-inducible transcription repressor HrcA C-terminal
4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase-like C-terminal
Threonine/serine exporter-like N-terminal
Homogentisate 1,2-dioxygenase C-terminal
6-phosphogluconate dehydrogenase C-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
(+)-corvol ether B synthase/(+)-corvol ether A synthase ((2E,6E)-farnesyl diphosphate cyclizing)
Plays a critical role for substrate recognition
Plays a critical role in the stabilization of intermediate cation
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Cytochrome bc1 complex cytochrome c subunit
Transition state stabilizer; via amide nitrogen
Prepilin type IV endopeptidase peptidase
Interaction with polymerase core subunit RpoC
ABC transporter substrate-binding protein PnrA-like
Endoribonuclease L-PSP/chorismate mutase-like
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Signal recognition particle SRP54 helical bundle
SGNH hydrolase-type esterase domain-containing protein
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Adaptive response protein AidB N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
BetI-type transcriptional repressor C-terminal
Heme-copper oxidase subunit III family profile
Superoxide dismutase copper/zinc binding domain-containing protein