Major facilitator superfamily (MFS) profile
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
RNA polymerase sigma factor 70 region 4 type 2
Sporulation transcription regulator WhiA N-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Could be important to modulate the pK values of the two catalytic cysteine residues
Pyruvate phosphate dikinase AMP/ATP-binding
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
Ribose-phosphate pyrophosphokinase N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Extracellular solute-binding protein family 1
Schiff-base intermediate with acetaldehyde
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Peptidase S9 prolyl oligopeptidase catalytic
Pyridoxamine 5'-phosphate oxidase putative
Acyltransferase MbtK/IucB-like conserved
O-(3'-phospho-DNA)-tyrosine intermediate
ABC transporter substrate-binding protein PnrA-like
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Plays an important role in substrate specificity
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Glucose-methanol-choline oxidoreductase C-terminal
Cytochrome bc1 complex cytochrome c subunit
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Putative glycogen debranching enzyme N-terminal
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Mandelate racemase/muconate lactonizing enzyme C-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Ribosomal RNA small subunit methyltransferase E methyltransferase
Carbamoyl-phosphate synthase small subunit N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
ATP synthase F1 complex delta/epsilon subunit N-terminal
Pyrimidine nucleoside phosphorylase C-terminal
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
LPXTG-motif cell wall anchor domain protein
Glucosamine/galactosamine-6-phosphate isomerase
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Glycine cleavage T-protein C-terminal barrel
Large ribosomal subunit protein uL6 alpha-beta
Alpha-D-phosphohexomutase alpha/beta/alpha
phosphoenolpyruvate--glycerone phosphotransferase
Bacterial type II secretion system protein E
Positions MEP for the nucleophilic attack
Prokaryotic-type class I peptide chain release factors
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Helix-hairpin-helix DNA-binding motif class 1
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Galactofuranosyltransferase GlfT2 N-terminal
Galactofuranosyltransferase-2 C-terminal
DNA topoisomerase I catalytic core eukaryotic-type
Transcription regulator AsnC/Lrp ligand binding
Phosphotransferase system enzyme I N-terminal
Glycosyl transferase family 3 N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Membrane insertase YidC/Oxa/ALB C-terminal
Cation-transporting P-type ATPase N-terminal
Putative host cell surface-exposed lipoprotein Ltp-like HTH region
Putative host cell surface-exposed lipoprotein Ltp-like HTH region domain-containing protein
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Anthranilate synthase component I N-terminal
Cell division protein FtsQ/DivIB C-terminal
Removed in mature form; by autocatalysis
Glycosyltransferase subfamily 4-like N-terminal
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Mycothiol-dependent maleylpyruvate isomerase metal-binding domain-containing protein
O-(5'-phospho-DNA)-tyrosine intermediate
6-phosphogluconate dehydrogenase C-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Alpha-glycerophosphate oxidase C-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Proton acceptor; for glutaminase activity
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Microcin J25-processing protein McjB C-terminal
Translation elongation factor P/YeiP central
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase
Ribosomal RNA adenine methylase transferase N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Threonine/serine exporter-like N-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Butirosin biosynthesis protein H N-terminal
Thymidylate synthase/dCMP hydroxymethylase
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Phosphatidate phosphatase APP1 catalytic
Na+/H+ antiporter MnhB subunit-related protein
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Polysaccharide chain length determinant N-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
D-inositol 3-phosphate glycosyltransferase
Glucose-methanol-choline oxidoreductase N-terminal
Myo-inositol-1-phosphate synthase GAPDH-like
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Type I restriction enzyme R protein N-terminal
Shikimate dehydrogenase substrate binding N-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Schiff-base intermediate with substrate; via pyruvic acid
Pyridine nucleotide-disulphide oxidoreductase dimerisation
BMP family ABC transporter substrate-binding protein
Docks into pockets in the proteasome alpha-ring
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Cell envelope-related transcriptional attenuator
RNA 2-O ribose methyltransferase substrate binding
Glycoside hydrolase family 42 N-terminal
Essential for prephenate dehydratase activity
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Small ribosomal subunit protein uS4 N-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Terminase large subunit gp17-like C-terminal
Mannose-6-phosphate isomerase type II C-terminal
Alanyl-transfer RNA synthetases family profile
Pyruvate dehydrogenase E1 component middle
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Polymerase/histidinol phosphatase N-terminal
Survival protein SurE-like phosphatase/nucleotidase
Large ribosomal subunit protein uL2 C-terminal
Glycerophosphoryl diester phosphodiesterase membrane
NADH:ubiquinone oxidoreductase 30kDa subunit
Penicillin-binding protein transpeptidase
SUF system FeS cluster assembly SufBD N-terminal
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Pseudouridine synthase I TruA alpha/beta
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
ABC-type glycine betaine transport system substrate-binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Reversibly protonated during proton transport
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Trigger factor ribosome-binding bacterial
Prepilin type IV endopeptidase peptidase
Peptidoglycan recognition protein family
ATP-dependent DNA helicase RecG C-terminal
Tryptophan synthase beta chain-like PALP
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Beta-hexosaminidase bacterial type N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
DNA primase/polymerase bifunctional N-terminal
Cytochrome C biogenesis protein transmembrane
Ribosome maturation factor RimP N-terminal
Putative regulatory protein FmdB Zinc ribbon
Peptidase M1 membrane alanine aminopeptidase
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
NIF system FeS cluster assembly NifU N-terminal
Could play a key role in the communication between the regulatory and the substrate sites
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Beta-xylosidase C-terminal Concanavalin A-like
Aconitase A/isopropylmalate dehydratase small subunit swivel
Carbohydrate-binding domain-containing protein
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Endoribonuclease L-PSP/chorismate mutase-like
Molybdopterin cofactor biosynthesis C (MoaC)
Schiff-base intermediate with substrate; via topaquinone
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Release factor glutamine methyltransferase N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Phosphoadenosine phosphosulphate reductase
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Polysaccharide biosynthesis protein C-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Cell wall-active antibiotics response LiaF-like C-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Phosphatidic acid phosphatase type 2/haloperoxidase
Phosphomannose isomerase type I C-terminal
Phosphomannose isomerase type I catalytic
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Phosphocysteine intermediate; for EIIB activity