Heat-inducible transcription repressor HrcA C-terminal
Major facilitator superfamily (MFS) profile
Aminoacyl-transfer RNA synthetases class-II family profile
Large ribosomal subunit protein uL2 C-terminal
RNA polymerase sigma factor 70 region 4 type 2
Protein O-mannosyl-transferase C-terminal four TM
Lantibiotic biosynthesis protein dehydration
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Acyl-CoA dehydrogenase/oxidase C-terminal
Glycerophosphoryl diester phosphodiesterase
Acyl-CoA dehydrogenase/oxidase N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Carboxypeptidase regulatory-like domain-containing protein
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase
MucB/RseB N-terminal domain-containing protein
Insecticide toxin TcdB middle/C-terminal
Insecticide toxin TcdB middle/N-terminal
Plays an important role in substrate specificity
DNA-directed DNA polymerase family A palm
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Tryptophan synthase beta chain-like PALP
O-(3'-phospho-DNA)-tyrosine intermediate
DNA replication/recombination mediator RecO N-terminal
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Important for beta-aspartyl-AMP intermediate formation
Helix-hairpin-helix DNA-binding motif class 1
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Myo-inositol-1-phosphate synthase GAPDH-like
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
6-phosphogluconate dehydrogenase NADP-binding
Interaction with polymerase core subunit RpoC
Peptidase S9 prolyl oligopeptidase catalytic
Peptidase M1 membrane alanine aminopeptidase
Microcystin LR degradation protein MlrC C-terminal
Microcystin LR degradation protein MlrC N-terminal
Trigger factor ribosome-binding bacterial
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Tat pathway signal sequence domain protein
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Pyridoxamine 5'-phosphate oxidase putative
FAD-dependent oxidoreductase 2 FAD binding
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Pyruvate phosphate dikinase AMP/ATP-binding
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Ribose-phosphate pyrophosphokinase N-terminal
6-phosphogluconate dehydrogenase C-terminal
Thiamine pyrophosphate enzyme TPP-binding
Right handed beta helix domain-containing protein
Prokaryotic-type class I peptide chain release factors
Rv2525c-like glycoside hydrolase-like domain-containing protein
TRAP C4-dicarboxylate transport system permease DctM subunit
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Beta-hexosaminidase bacterial type N-terminal
Integrin alpha beta-propellor repeat protein
D-inositol 3-phosphate glycosyltransferase
Histidine-specific methyltransferase SAM-dependent
Alpha-glycerophosphate oxidase C-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Alpha-L-rhamnosidase six-hairpin glycosidase
Bacterial alpha-L-rhamnosidase N-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Glycoside hydrolase family 5 domain-containing protein
Gfo/Idh/MocA-like oxidoreductase N-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
PknH-like extracellular domain-containing protein
SGNH hydrolase-type esterase domain-containing protein
CASTOR/POLLUX/SYM8 ion channel conserved
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Glycine cleavage T-protein C-terminal barrel
Bacterial EndoU nuclease domain-containing protein
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Thiamine pyrophosphate enzyme N-terminal TPP-binding
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Gfo/Idh/MocA-like oxidoreductase C-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
PhoD-like phosphatase metallophosphatase
Polysaccharide chain length determinant N-terminal
Bacterial type II secretion system protein E
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Translation elongation factor P/YeiP central
Cytochrome b/b6 N-terminal region profile
Polymerase/histidinol phosphatase N-terminal
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Glycosyltransferase subfamily 4-like N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Mycothiol-dependent maleylpyruvate isomerase metal-binding
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Peptidase M43 pregnancy-associated plasma-A
Peptidase M43 pregnancy-associated plasma-A domain-containing protein
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Small ribosomal subunit protein uS4 N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
LPXTG-motif cell wall anchor domain protein
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Asl1-like glycosyl hydrolase catalytic domain-containing protein
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Electron transfer via tryptophanyl radical
Sporulation transcription regulator WhiA N-terminal
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Actinobacteria/chloroflexi VLRF1 release factor
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Glucose-methanol-choline oxidoreductase N-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Transcription regulator AsnC/Lrp ligand binding
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
Peptidoglycan recognition protein family
Penicillin-binding protein transpeptidase
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
S-adenosyl-L-homocysteine hydrolase NAD binding
Cell envelope-related transcriptional attenuator
Tc toxin complex TcA C-terminal TcB-binding
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Endoribonuclease L-PSP/chorismate mutase-like
Large ribosomal subunit protein uL6 alpha-beta
PLD phosphodiesterase domain-containing protein
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
LamG-like jellyroll fold domain-containing protein
ABC-type glycine betaine transport system substrate-binding
Positions MEP for the nucleophilic attack
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Phosphotransferase system enzyme I N-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
Proton acceptor; for glutaminase activity
Microcin J25-processing protein McjB C-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Glucosamine/galactosamine-6-phosphate isomerase
Cysteine sulfenic acid (-SOH) intermediate
Shikimate dehydrogenase substrate binding N-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Peptidase S8 and S53 subtilisin kexin sedolisin
Essential for prephenate dehydratase activity
NADH-rubredoxin oxidoreductase C-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Glycoside hydrolase family 42 N-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Ribosomal RNA adenine methylase transferase N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Glycosyl hydrolase family 30 beta sandwich
Cytochrome C biogenesis protein transmembrane
Gamma-glutamylcyclotransferase AIG2-like
Transition state stabilizer; via amide nitrogen
Cation-transporting P-type ATPase N-terminal
N(4)-bis(aminopropyl)spermidine synthase C-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Glycosyl transferase family 3 N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Transcription elongation factor GreA/GreB C-terminal
Schiff-base intermediate with substrate; via pyruvic acid
Glycoside-hydrolase family GH114 TIM-barrel
Glycoside-hydrolase family GH114 TIM-barrel domain-containing protein
Resolvase/invertase-type recombinase catalytic
Extracellular repeat protein, HAF family
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase
Membrane insertase YidC/Oxa/ALB C-terminal
Peptidase C39-like domain-containing protein
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Schiff-base intermediate with D-ribose 5-phosphate
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Glycine transporter domain-containing protein
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Probable transposase IS891/IS1136/IS1341
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
NADH:ubiquinone oxidoreductase 30kDa subunit
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
NAD(P) transhydrogenase alpha subunit C-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Putative regulatory protein FmdB Zinc ribbon
Alanyl-transfer RNA synthetases family profile
Adaptive response protein AidB N-terminal
Beta-lactamase class A catalytic domain-containing protein
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
DnaJ homologue subfamily C member 28 conserved
Prepilin type IV endopeptidase peptidase
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Involved in ionization of N3 of dUMP, leading to its activation
Nicotinate phosphoribosyltransferase N-terminal
DNA primase/polymerase bifunctional N-terminal
Cobalamin-independent methionine synthase MetE N-terminal
Nitrite/Sulfite reductase ferredoxin-like
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
Carbamoyl-phosphate synthase small subunit N-terminal
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Translation initiation factor beta propellor-like
Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
Inosine/uridine-preferring nucleoside hydrolase
Schiff-base intermediate with acetaldehyde
SUF system FeS cluster assembly SufBD N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Molybdopterin cofactor biosynthesis C (MoaC)
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Methionyl-tRNA synthetase anticodon-binding