Polymerase/histidinol phosphatase N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Right handed beta helix domain-containing protein
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Polysaccharide chain length determinant N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Peptide methionine sulphoxide reductase MsrA
Major facilitator superfamily (MFS) profile
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Glycosyl transferase family 3 N-terminal
Sodium/calcium exchanger membrane region
Methionyl-tRNA synthetase anticodon-binding
Sporulation transcription regulator WhiA N-terminal
Important for substrate specificity; cannot use PPi as phosphoryl donor
Aminoacyl-transfer RNA synthetases class-II family profile
HTH-type transcriptional regulator MT1864/Rv1816-like C-terminal
Gram-positive cocci surface proteins LPxTG
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Prokaryotic-type class I peptide chain release factors
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Tat pathway signal sequence domain protein
Superoxide dismutase copper/zinc binding
Could play a key role in the communication between the regulatory and the substrate sites
Glycoside hydrolase GH146 substrate-binding
Alpha-D-phosphohexomutase alpha/beta/alpha
Translation elongation factor P/YeiP central
Phosphoadenosine phosphosulphate reductase
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
Transposase IS204/IS1001/IS1096/IS1165 DDE
Proton acceptor; for glutaminase activity
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Pyridoxamine 5'-phosphate oxidase putative
RNA polymerase sigma factor 70 region 4 type 2
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
ATP-dependent DNA helicase RecG C-terminal
Electron transfer via tryptophanyl radical
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
DNA-3-methyladenine glycosylase AlkA N-terminal
RNA 2-O ribose methyltransferase substrate binding
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Protein O-mannosyl-transferase C-terminal four TM
Beta-hexosaminidase bacterial type N-terminal
Helix-hairpin-helix DNA-binding motif class 1
Beta-xylosidase C-terminal Concanavalin A-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Alpha galactosidase C-terminal beta sandwich
Activator of Hsp90 ATPase homologue 1-like C-terminal
Resolvase/invertase-type recombinase catalytic
Cytochrome oxidase subunit II copper A binding
Ribosomal RNA adenine methylase transferase N-terminal
Positions MEP for the nucleophilic attack
Threonine/serine exporter-like N-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
YbaK/aminoacyl-tRNA synthetase-associated
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Putative oxidoreductase/dehydrogenase Rossmann-like
O-(3'-phospho-DNA)-tyrosine intermediate
Phosphomannose isomerase type I catalytic
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Cytochrome C biogenesis protein transmembrane
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Acyl-CoA dehydrogenase/oxidase C-terminal
Schiff-base intermediate with acetaldehyde
Alpha-glycerophosphate oxidase C-terminal
Bacterial transcription activator effector binding
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Solute-binding protein family 3/N-terminal
Essential for prephenate dehydratase activity
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Glycosyl transferase family 28 C-terminal
Tryptophan synthase beta chain-like PALP
ABC transporter substrate-binding protein PnrA-like
Large ribosomal subunit protein uL6 alpha-beta
Bacterial bifunctional deaminase-reductase C-terminal
DNA replication/recombination mediator RecO N-terminal
Glycoside hydrolase family 42 N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Ribosome maturation factor RimP N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Large ribosomal subunit protein uL2 C-terminal
Pyruvate dehydrogenase E1 component middle
Large ribosomal subunit protein uL15/eL18
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Phosphatidic acid phosphatase type 2/haloperoxidase
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Na+/H+ antiporter MnhB subunit-related protein
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Gram-positive pilin subunit D1 N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Removed in mature form; by autocatalysis
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
ATP synthase F1 complex delta/epsilon subunit N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Cell envelope-related transcriptional attenuator
Chromosomal replication initiator DnaA C-terminal
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
SUF system FeS cluster assembly SufBD N-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
6-phosphogluconate dehydrogenase C-terminal
General stress protein FMN-binding split barrel
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Pyrimidine nucleoside phosphorylase C-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Alanyl-transfer RNA synthetases family profile
Exonuclease VII large subunit C-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Bacterial type II secretion system protein E
DNA-directed DNA polymerase family A palm
Phosphotransferase system enzyme I N-terminal
ABC-type glycine betaine transport system substrate-binding
Cell wall-active antibiotics response LiaF-like C-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Polysaccharide biosynthesis protein CapD-like
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Heat-inducible transcription repressor HrcA C-terminal
N(4)-bis(aminopropyl)spermidine synthase C-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Phosphatidate phosphatase APP1 catalytic
Transcription regulator AsnC/Lrp ligand binding
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Thiostrepton-resistance methylase N-terminal
Small ribosomal subunit protein uS4 N-terminal
Cytochrome bc1 complex cytochrome c subunit
Ribosomally synthesized peptide with SipW-like signal peptide
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Gp5/Type VI secretion system Vgr protein OB-fold
NIF system FeS cluster assembly NifU N-terminal
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Peptidase M1 membrane alanine aminopeptidase
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Sigma 54 modulation/S30EA ribosomal protein C-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Plays an important role in substrate specificity
NADH:ubiquinone oxidoreductase-like 20kDa subunit
LPXTG-motif cell wall anchor domain protein
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Septum formation-related domain-containing protein
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Myo-inositol-1-phosphate synthase GAPDH-like
Schiff-base intermediate with substrate; via pyruvic acid
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
Anthranilate synthase component I N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Thymidylate synthase/dCMP hydroxymethylase
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Ribosomal RNA small subunit methyltransferase E methyltransferase
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase
Mandelate racemase/muconate lactonizing enzyme C-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Endoribonuclease L-PSP/chorismate mutase-like
Nicotinate phosphoribosyltransferase N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Peptidoglycan recognition protein family
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Penicillin-binding protein transpeptidase
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
DNA topoisomerase I catalytic core eukaryotic-type
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Phosphocysteine intermediate; for EIIB activity
Tetracyclin repressor-like C-terminal group 31