Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Erythromycin biosynthesis protein CIII-like central
Pyridoxamine 5'-phosphate oxidase putative
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
RNA polymerase sigma factor 70 region 4 type 2
Tricarboxylic transport membrane protein
Aconitase A/isopropylmalate dehydratase small subunit swivel
SD-repeat containing protein B domain-containing protein
DNA primase/polymerase bifunctional N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Peptidase M1 membrane alanine aminopeptidase
Prokaryotic-type class I peptide chain release factors
Calcium/calmodulin-dependent protein kinase II association-domain
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Major facilitator superfamily (MFS) profile
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Streptomyces killer toxin-like beta/gamma crystallin
Streptomyces killer toxin-like beta/gamma crystallin domain-containing protein
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Large ribosomal subunit protein uL15/eL18
Glycosyl hydrolase family 98 putative carbohydrate-binding module
FAD-dependent oxidoreductase 2 FAD binding
Tryptophan synthase beta chain-like PALP
Activator of Hsp90 ATPase homologue 1-like C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
Gp5/Type VI secretion system Vgr protein OB-fold
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Polysaccharide lyase 8 N-terminal alpha-helical
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Glycine cleavage T-protein C-terminal barrel
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
SGNH hydrolase-type esterase domain-containing protein
Sporulation transcription regulator WhiA N-terminal
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Positions MEP for the nucleophilic attack
Glycoside hydrolase family 42 N-terminal
Phosphotransferase system enzyme I N-terminal
Glycosyltransferase subfamily 4-like N-terminal
N(4)-bis(aminopropyl)spermidine synthase C-terminal
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase
Inosine/uridine-preferring nucleoside hydrolase
Membrane insertase YidC/Oxa/ALB C-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Peptidase S9 prolyl oligopeptidase catalytic
YbaK/aminoacyl-tRNA synthetase-associated
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Phosphocysteine intermediate; for EIIB activity
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Transcription elongation factor GreA/GreB C-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
N6 adenine-specific DNA methyltransferase N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Survival protein SurE-like phosphatase/nucleotidase
Cell wall-active antibiotics response LiaF-like C-terminal
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Threonine/serine exporter-like N-terminal
Plays an important role in substrate specificity
Phosphoribosylformylglycinamidine synthase linker
Endoribonuclease L-PSP/chorismate mutase-like
UDP-glucose/GDP-mannose dehydrogenase C-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
PhoD-like phosphatase metallophosphatase
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Docks into pockets in the proteasome alpha-ring
Lipid/polyisoprenoid-binding YceI-like domain-containing protein
SUF system FeS cluster assembly SufBD N-terminal
Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase C-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Nitrite/Sulfite reductase ferredoxin-like
Transcription regulator AsnC/Lrp ligand binding
Formamidopyrimidine-DNA glycosylase catalytic
ABC-type glycine betaine transport system substrate-binding
Peptidoglycan recognition protein family
RNA 2-O ribose methyltransferase substrate binding
Thiopeptide-type bacteriocin biosynthesis
Pyrroline-5-carboxylate reductase catalytic N-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Penicillin-binding protein transpeptidase
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Removed in mature form; by autocatalysis
Important for beta-aspartyl-AMP intermediate formation
Bacterial bifunctional deaminase-reductase C-terminal
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Ribose-phosphate pyrophosphokinase N-terminal
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Cell envelope-related transcriptional attenuator
Peptidase M15C domain-containing protein
DNA-directed DNA polymerase family A palm
Alpha-L-arabinofuranosidase B arabinose-binding
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Sodium/calcium exchanger membrane region
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Involved in ionization of N3 of dUMP, leading to its activation
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Beta-xylosidase C-terminal Concanavalin A-like
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Helix-hairpin-helix DNA-binding motif class 1
Large ribosomal subunit protein uL2 C-terminal
Glutathionylspermidine synthase pre-ATP-grasp-like
Bacterial transcription activator effector binding
Carbamoyl-phosphate synthase small subunit N-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Metallo-beta-lactamase domain-containing protein
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
1,4-alpha-glucan branching enzyme C-terminal
Glycoside hydrolase family 57 N-terminal
HTH-type transcriptional regulator MT1864/Rv1816-like C-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Transglycosylase SLT domain-containing protein
NADH:ubiquinone oxidoreductase 30kDa subunit
Pyrimidine nucleoside phosphorylase C-terminal
Methionyl-tRNA synthetase anticodon-binding
D-inositol 3-phosphate glycosyltransferase
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Centromere-binding protein ParB C-terminal
Translation elongation factor P/YeiP central
Myo-inositol-1-phosphate synthase GAPDH-like
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Alpha-glycerophosphate oxidase C-terminal
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Lactate utilization protein B C-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Glycoside hydrolase family 31 N-terminal
Prepilin type IV endopeptidase peptidase
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein
Phthiocerol/phthiodiolone dimycocerosyl transferase C-terminal
Peptidase MA-like domain-containing protein
Phosphatidic acid phosphatase type 2/haloperoxidase
Anthranilate synthase component I N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Anti-sigma-D factor RsdA sigma factor binding region
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Superoxide dismutase copper/zinc binding
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Release factor glutamine methyltransferase N-terminal
RlpA-like protein double-psi beta-barrel
PpiC-type peptidyl-prolyl cis-trans isomerase
NADH-rubredoxin oxidoreductase C-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
NIF system FeS cluster assembly NifU N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-? in acceptor proteins)
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
TRAP-T family transporter, periplasmic binding protein
6-phosphogluconate dehydrogenase C-terminal
Peptide methionine sulphoxide reductase MsrA
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
S-adenosyl-L-homocysteine hydrolase NAD binding
Putative regulatory protein FmdB Zinc ribbon
CDP-alcohol phosphatidyltransferase C-terminal
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Alpha-D-phosphohexomutase alpha/beta/alpha
Flagellar motor switch protein FliN-like C-terminal
Subtilisin inhibitor domain-containing protein
Bacterial type II secretion system protein E
Peptidase C39-like domain-containing protein
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
DNA topoisomerase I catalytic core eukaryotic-type
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Exonuclease VII large subunit C-terminal
Flagellar hook-length control protein-like C-terminal
Phosphatidylglycerol lysyltransferase C-terminal
Proton acceptor; for glutaminase activity
Gram-positive cocci surface proteins LPxTG
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-108)
Putative Flp pilus-assembly TadG-like N-terminal
Adaptive response protein AidB N-terminal
Alanyl-transfer RNA synthetases family profile
Gly-cisPro motif, important for rejection of L-amino acids
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Large ribosomal subunit protein uL6 alpha-beta
Reversibly protonated during proton transport
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
ABC transporter-associated repeat protein
Glycoside-hydrolase family GH114 TIM-barrel
Heat-inducible transcription repressor HrcA C-terminal
Polymerase/histidinol phosphatase N-terminal
Small ribosomal subunit protein uS4 N-terminal
Putative oxidoreductase/dehydrogenase Rossmann-like
Terminase large subunit-like endonuclease
Large ribosomal subunit protein uL30-like ferredoxin-like fold
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Phosphogluconate dehydrogenase (decarboxylating) C-terminal
Glycosyl transferase family 3 N-terminal
Phosphomannose isomerase type I catalytic
Acetylserotonin O-methyltransferase dimerisation
Chromosomal replication initiator DnaA C-terminal
Transcriptional regulator LacI/GalR-like sensor
DNA replication/recombination mediator RecO N-terminal
Type I restriction enzyme R protein N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Beta-lactamase class A catalytic domain-containing protein
Glycoside-hydrolase family GH114 TIM-barrel domain-containing protein
Septum formation-related domain-containing protein
HNH/Endo VII superfamily nuclease toxins
Histidine-specific methyltransferase SAM-dependent