Required for zinc-mediated homotetramerization and catalytic activity
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Could play a key role in the communication between the regulatory and the substrate sites
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
RND efflux pump membrane fusion protein barrel-sandwich
Carbamoyl-phosphate synthase small subunit N-terminal
Ribulose bisphosphate carboxylase small subunit
Nitrite/Sulfite reductase ferredoxin-like
TonB-dependent receptor-like beta-barrel
Signal recognition particle SRP54 helical bundle
Acyl-CoA dehydrogenase C-terminal bacterial-type
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Chromosomal replication initiator DnaA C-terminal
Essential for prephenate dehydratase activity
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Transposase IS116/IS110/IS902 C-terminal
Ribonucleotide reductase large subunit C-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Important for interaction with partner proteins
Type III restriction enzyme C-terminal endonuclease
Beta-lactamase hydrolase-like protein phosphatase-like
N6 adenine-specific DNA methyltransferase N-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Translation elongation factor P/YeiP central
Tryptophan synthase beta chain-like PALP
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Major facilitator superfamily (MFS) profile
HicB-like antitoxin of toxin-antitoxin system
Saccharopine dehydrogenase-like C-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Aminoacyl-transfer RNA synthetases class-II family profile
Alpha-D-phosphohexomutase alpha/beta/alpha
RNA polymerase sigma factor 70 region 4 type 2
NADH:ubiquinone oxidoreductase 30kDa subunit
Phosphotransferase system enzyme I N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Organic solvent tolerance-like N-terminal
Large ribosomal subunit protein uL2 C-terminal
High potential iron-sulfur proteins family profile
DNA mismatch repair proteins mutS family
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Transposase IS204/IS1001/IS1096/IS1165 DDE
Alpha-amylase/4-alpha-glucanotransferase C-terminal
Alpha-amylase/4-alpha-glucanotransferase central
Glycoside hydrolase family 57 N-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Polymerase/histidinol phosphatase N-terminal
CobB/CobQ-like glutamine amidotransferase
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
ABC-type transport auxiliary lipoprotein component
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Glycosyl transferase family 3 N-terminal
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Acetylserotonin O-methyltransferase dimerisation
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Large ribosomal subunit protein uL15/eL18
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Outer membrane protein beta-barrel domain-containing protein
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Release factor glutamine methyltransferase N-terminal
Prokaryotic-type class I peptide chain release factors
Cytochrome C biogenesis protein transmembrane
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Interaction with polymerase core subunit RpoC
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Type I restriction modification DNA specificity
O-(5'-phospho-DNA)-tyrosine intermediate
Penicillin-binding protein transpeptidase
Ribulose bisphosphate carboxylase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Lysidine-tRNA(Ile) synthetase C-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Ribose-phosphate pyrophosphokinase N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
SUF system FeS cluster assembly SufBD N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Phosphatidic acid phosphatase type 2/haloperoxidase
Large ribosomal subunit protein uL6 alpha-beta
Heme-copper oxidase subunit III family profile
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Prepilin type IV endopeptidase peptidase
Bacterial type II secretion system protein E
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
RNA 3'-terminal phosphate cyclase insert
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
peptide-methionine (R)-S-oxide reductase
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Exonuclease VII large subunit C-terminal
NAD(P) transhydrogenase alpha subunit C-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
NADH:ubiquinone oxidoreductase chain 4 N-terminal
RNA binding; important for wobble base 34 recognition
Glycine-zipper-containing OmpA-like membrane
Aminoacyl-tRNA synthetase class I anticodon-binding
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Histidine-specific methyltransferase SAM-dependent
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Peptidase S9 prolyl oligopeptidase catalytic
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Glucose/Sorbosone dehydrogenase domain-containing protein
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
RNA 2-O ribose methyltransferase substrate binding
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
DNA-directed RNA polymerase RpoA/D/Rpb3-type
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
N-acetylneuraminic acid synthase N-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Cation-transporting P-type ATPase N-terminal
Glycine cleavage T-protein C-terminal barrel
Reversibly protonated during proton transport
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Helix-hairpin-helix DNA-binding motif class 1
Regulator of nucleoside diphosphate kinase N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
NIF system FeS cluster assembly NifU N-terminal
DNA-directed DNA polymerase family A palm
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Positions MEP for the nucleophilic attack
Type II secretion system protein GspG C-terminal
Survival protein SurE-like phosphatase/nucleotidase
Water stress and hypersensitive response
3-beta hydroxysteroid dehydrogenase/isomerase
Glucosamine/galactosamine-6-phosphate isomerase
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Pseudouridine synthase I TruA alpha/beta
LPXTG-motif cell wall anchor domain-containing protein
Small ribosomal subunit protein uS4 N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Alanyl-transfer RNA synthetases family profile
Polysaccharide biosynthesis protein CapD-like
Chromosomal replication initiator protein DnaA
Pyruvate phosphate dikinase AMP/ATP-binding
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Mechanosensitive ion channel inner membrane
S-adenosyl-L-homocysteine hydrolase NAD binding
Cytochrome c-type biogenesis protein CcmF C-terminal
Plays an important role in substrate specificity
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Tetrahydrodipicolinate-N-succinyltransferase chain A
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Membrane fusion protein biotin-lipoyl like
DNA polymerase III delta subunit C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Carboxypeptidase regulatory-like domain-containing protein
Pyridoxamine 5'-phosphate oxidase putative
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Resolvase/invertase-type recombinase catalytic
Mitochondrial apoptosis-inducing factor C-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Type 4 fimbrial biogenesis protein PilX N-terminal
ABC-type uncharacterised transport system
Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
Putative regulatory protein FmdB Zinc ribbon
Outer-membrane lipoprotein carrier protein
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Outer membrane protein assembly factor BamA
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Methylguanine DNA methyltransferase ribonuclease-like
Shikimate dehydrogenase substrate binding N-terminal
Anthranilate synthase component I N-terminal
Putative beta-lactamase-inhibitor-like PepSY-like
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Proline utilization A proline dehydrogenase N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Gamma-butyrobetaine hydroxylase-like N-terminal
Invasion associated locus B (IalB) protein
Glycoside-hydrolase family GH114 TIM-barrel
Thymidylate synthase/dCMP hydroxymethylase
Mannose-6-phosphate isomerase type II C-terminal
DNA polymerase III subunit delta C-terminal
Quercetin 2,3-dioxygenase C-terminal cupin
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Membrane insertase YidC/Oxa/ALB C-terminal
7 transmembrane helices usually fused to an inactive transglutaminase
Inactive transglutaminase fused to 7 transmembrane helices
6-phosphogluconate dehydrogenase C-terminal
N-end rule aminoacyl transferase C-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal