Major facilitator superfamily (MFS) profile
Cation-transporting P-type ATPase N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
Flagellar basal body rod protein N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Molybdenum ABC transporter substrate-binding protein
Proline utilization A proline dehydrogenase N-terminal
YMGG-like Gly-zipper domain-containing protein
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
RND efflux pump membrane fusion protein barrel-sandwich
Glycine zipper 2TM domain-containing protein
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Polymerase/histidinol phosphatase N-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Heme-copper oxidase subunit III family profile
Aminoacyl-transfer RNA synthetases class-II family profile
Carboxypeptidase regulatory-like domain-containing protein
Alanyl-transfer RNA synthetases family profile
ATP synthase F1 complex delta/epsilon subunit N-terminal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Outer membrane protein beta-barrel domain-containing protein
Membrane fusion protein biotin-lipoyl like
Prepilin type IV endopeptidase peptidase
Chromosomal replication initiator protein DnaA
RND efflux pump membrane fusion protein barrel-sandwich domain-containing protein
Type III secretion system flagellar brake protein YcgR PilZN
Pyruvate phosphate dikinase AMP/ATP-binding
Molybdopterin cofactor biosynthesis C (MoaC)
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Solute-binding protein family 3/N-terminal
Solute-binding protein family 3/N-terminal domain-containing protein
Positions MEP for the nucleophilic attack
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Tryptophan synthase beta chain-like PALP
Aconitase A/isopropylmalate dehydratase small subunit swivel
Glycosyl transferase family 3 N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Flagellar assembly protein FliH/Type III secretion system HrpE
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Polypeptide-transport-associated ShlB-type
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Quercetin 2,3-dioxygenase C-terminal cupin
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
TRAP C4-dicarboxylate transport system permease DctM subunit
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
TonB-dependent receptor-like beta-barrel
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Cytochrome b561 bacterial/Ni-hydrogenase
Phosphoadenosine phosphosulphate reductase
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
peptide-methionine (R)-S-oxide reductase
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Acyl-CoA dehydrogenase/oxidase C-terminal
Large ribosomal subunit protein uL15/eL18
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Important for beta-aspartyl-AMP intermediate formation
Penicillin-binding protein transpeptidase
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Schiff-base intermediate with substrate; via pyruvic acid
Cysteine sulfenic acid (-SOH) intermediate
YbaK/aminoacyl-tRNA synthetase-associated
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Plays an important role in substrate specificity
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Bacterial collagen-like protein middle domain-containing protein
Arsenosugar biosynthesis radical SAM protein ArsS-like C-terminal
PHA accumulation regulator DNA-binding N-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
O-(phosphoribosyl dephospho-coenzyme A)serine
Flagellar basal-body/hook protein C-terminal
Outer-membrane lipoprotein carrier protein
Transposase IS116/IS110/IS902 C-terminal
DNA polymerase III subunit delta C-terminal
Pyruvate dehydrogenase E1 component middle
Exonuclease VII large subunit C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Alpha-D-phosphohexomutase alpha/beta/alpha
Bacterial type II secretion system protein E
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Glucan biosynthesis periplasmic MdoG C-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Glycine cleavage T-protein C-terminal barrel
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
ABC transporter substrate-binding protein
ABC-type transport auxiliary lipoprotein component
ABC-type transport auxiliary lipoprotein component domain-containing protein
Lipopolysaccharide export system protein LptA
Organic solvent tolerance-like N-terminal
N-sulphoglucosamine sulphohydrolase C-terminal
Soluble ligand binding domain-containing protein
Polysaccharide biosynthesis protein CapD-like
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Mannose-6-phosphate isomerase type II C-terminal
Ionotropic glutamate receptor C-terminal
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Aspartate/homoserine dehydrogenase NAD-binding
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
SMP-30/Gluconolactonase/LRE-like region domain-containing protein
Large ribosomal subunit protein uL6 alpha-beta
2-oxoisovalerate dehydrogenase E1 alpha subunit N-terminal
DNA-directed DNA polymerase family A palm
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
DNA-directed RNA polymerase RpoA/D/Rpb3-type
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Essential for prephenate dehydratase activity
ABC-type glycine betaine transport system substrate-binding
Polysaccharide chain length determinant N-terminal
NAD(P) transhydrogenase alpha subunit C-terminal
Adaptive response protein AidB N-terminal
Histidine-specific methyltransferase SAM-dependent
Survival protein SurE-like phosphatase/nucleotidase
RNA binding; important for wobble base 34 recognition
NADH-rubredoxin oxidoreductase C-terminal
Reversibly protonated during proton transport
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
RNA polymerase sigma factor 70 region 4 type 2
Interaction with polymerase core subunit RpoC
Ribosomal RNA adenine methylase transferase N-terminal
Nitrile hydratase alpha /Thiocyanate hydrolase gamma
N-end rule aminoacyl transferase C-terminal
6-phosphogluconate dehydrogenase C-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Prokaryotic-type class I peptide chain release factors
Activator of Hsp90 ATPase homologue 1-like C-terminal
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
Flagellar hook-length control protein-like C-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Endolytic peptidoglycan transglycosylase RlpA
RlpA-like protein double-psi beta-barrel
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
O-(3'-phospho-DNA)-tyrosine intermediate
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Carbamoyl-phosphate synthase small subunit N-terminal
Outer membrane protein assembly factor BamD
Glucosamine/galactosamine-6-phosphate isomerase
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Antitoxin Xre/MbcA/ParS-like toxin-binding
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Putative regulatory protein FmdB Zinc ribbon
DnaJ homologue subfamily C member 28 conserved
Disulphide bond isomerase DsbC/G N-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Putative Flp pilus-assembly TadG-like N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Anthranilate synthase component I N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Endoribonuclease L-PSP/chorismate mutase-like
Acetylserotonin O-methyltransferase dimerisation
Gamma-glutamylcyclotransferase AIG2-like
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Sodium symporter small subunit predicted
Helix-hairpin-helix DNA-binding motif class 1
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Flagellar motor switch protein FliN-like C-terminal
NIF system FeS cluster assembly NifU N-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Saccharopine dehydrogenase-like C-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Type III restriction enzyme C-terminal endonuclease
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Surface antigen domain-containing protein
High potential iron-sulfur proteins family profile
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Chalcone isomerase domain-containing protein
Lytic transglycosylase superhelical linker
DNA mismatch repair proteins mutS family
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Translation elongation factor P/YeiP central
Ribulose bisphosphate carboxylase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
RNA 2-O ribose methyltransferase substrate binding
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Bacterial bifunctional deaminase-reductase C-terminal
Shikimate dehydrogenase substrate binding N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Thymidylate synthase/dCMP hydroxymethylase
Resolvase/invertase-type recombinase catalytic
Schiff-base intermediate with acetoacetate
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Release factor glutamine methyltransferase N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Lipoprotein SmpA/OmlA domain-containing protein
Inner membrane protein YgaP-like transmembrane
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Transposase IS204/IS1001/IS1096/IS1165 DDE
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Proton acceptor; for glutaminase activity
Pyruvate/ketoisovalerate oxidoreductase catalytic
Electron transfer via tryptophanyl radical
Extradiol ring-cleavage dioxygenase LigAB LigA subunit
Outer membrane protein assembly factor BamA
Involved in tetramerization or stability of the tetramer
Phosphotransferase system enzyme I N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-91)
Pseudouridine synthase I TruA alpha/beta
Large ribosomal subunit protein uL2 C-terminal
D-galactarate/Altronate dehydratase C-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
UDP N-acetylglucosamine O-acyltransferase C-terminal
Important for interaction with partner proteins
Influences the redox potential of the prosthetic heme and FAD groups
Involved in heme-bound ligand stabilization and O-O bond activation
Gamma-butyrobetaine hydroxylase-like N-terminal
Integral membrane protein YccS N-terminal
Microcystin LR degradation protein MlrC C-terminal
Microcystin LR degradation protein MlrC N-terminal
Bacterial OB-fold domain-containing protein
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Required for dimer formation and molybdate binding
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Tetrahydrodipicolinate-N-succinyltransferase chain A
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Moybdenum cofactor oxidoreductase dimerisation
Chromosomal replication initiator DnaA C-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Required for zinc-mediated homotetramerization and catalytic activity
Small ribosomal subunit protein uS4 N-terminal
Amidohydrolase-related domain-containing protein
SGNH hydrolase-type esterase domain-containing protein