Heparan-alpha-glucosaminide N-acetyltransferase catalytic
DNA-directed DNA polymerase family A palm
Major facilitator superfamily (MFS) profile
Shikimate dehydrogenase substrate binding N-terminal
RNA polymerase sigma factor 70 region 4 type 2
Pyruvate phosphate dikinase AMP/ATP-binding
SUF system FeS cluster assembly SufBD N-terminal
Cysteine sulfenic acid (-SOH) intermediate
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Inosine/uridine-preferring nucleoside hydrolase
Glycosyltransferase family 28 N-terminal
ABC transporter substrate-binding protein
Bacterial transcription activator effector binding
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Single-stranded-DNA-specific exonuclease RecJ C-terminal
Alanyl-transfer RNA synthetases family profile
Polynucleotide kinase-phosphatase ligase
Pyrroline-5-carboxylate reductase catalytic N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Urease accessory protein UreH-like transmembrane
SsuA/THI5-like domain-containing protein
NIF system FeS cluster assembly NifU C-terminal
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Thiamine pyrophosphate enzyme TPP-binding
Chromosomal replication initiator DnaA C-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Diacylglycerol glucosyltransferase N-terminal
Glycosyl transferase family 28 C-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Cytochrome b/b6 N-terminal region profile
Molybdopterin cofactor biosynthesis C (MoaC)
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Reversibly protonated during proton transport
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
ABC transporter substrate-binding protein PnrA-like
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Mandelate racemase/muconate lactonizing enzyme C-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
O-(5'-phospho-DNA)-tyrosine intermediate
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Large ribosomal subunit protein uL6 alpha-beta
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Schiff-base intermediate with substrate; via pyruvic acid
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups
ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Inhibitor of growth protein N-terminal histone-binding domain-containing protein
Bacterial type II secretion system protein E
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Resolvase/invertase-type recombinase catalytic
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Polysaccharide biosynthesis protein C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Transcriptional regulator SgrR N-terminal HTH
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Hydroxymethylglutaryl-coenzyme A synthase C-terminal
Hydroxymethylglutaryl-coenzyme A synthase N-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Saccharopine dehydrogenase-like C-terminal
Glycine cleavage T-protein C-terminal barrel
Magnesium transporter MgtE intracellular
Phosphocysteine intermediate; for EIIB activity
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Siroheme decarboxylase AsnC-like ligand binding
Copper amine oxidase-like N-terminal domain-containing protein
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Nitrite/Sulfite reductase ferredoxin-like
RNA 2-O ribose methyltransferase substrate binding
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Helix-turn-helix conjugative transposon-like
Penicillin-binding protein transpeptidase
Important for interaction with partner proteins
Helix-hairpin-helix DNA-binding motif class 1
Tryptophan synthase beta chain-like PALP
Glycosyl transferase family 3 N-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Na+/H+ antiporter MnhB subunit-related protein
Could be important to modulate the pK values of the two catalytic cysteine residues
Polysaccharide chain length determinant N-terminal
Lipocalin-like domain-containing protein
Dinitrogenase iron-molybdenum cofactor biosynthesis
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Probable transposase IS891/IS1136/IS1341
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Cation-transporting P-type ATPase N-terminal
Glycoside hydrolase family 31 N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
DnaJ homologue subfamily C member 28 conserved
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Polymerase/histidinol phosphatase N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Solute-binding protein family 3/N-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Cell envelope-related transcriptional attenuator
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Cytochrome b561 bacterial/Ni-hydrogenase
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Ionotropic glutamate receptor C-terminal
Fibronectin type-III domain-containing protein
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Pyrimidine nucleoside phosphorylase C-terminal
Zinc ABC transporter substrate-binding protein
ABC-type glycine betaine transport system substrate-binding
3-keto-disaccharide hydrolase domain-containing protein
Large ribosomal subunit protein uL15/eL18
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Glycosyltransferase subfamily 4-like N-terminal
Cytochrome oxidase subunit II copper A binding
Essential for prephenate dehydratase activity
Anthranilate synthase component I N-terminal
Peptide ABC transporter substrate-binding protein
DNA replication/recombination mediator RecO N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Nitrogenase molybdenum-iron protein beta chain N-terminal
Solute-binding protein family 5 domain-containing protein
6-phosphogluconate dehydrogenase C-terminal
Protein-PII uridylyltransferase N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
N6 adenine-specific DNA methyltransferase N-terminal
Type 2A encapsulin shell protein SrpI-like
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Microcin J25-processing protein McjB C-terminal
S-adenosylmethionine-dependent methyltransferase
Mannose-6-phosphate isomerase type II C-terminal
Gamma-glutamylcyclotransferase AIG2-like
Bacterial bifunctional deaminase-reductase C-terminal
Sporulation stage II protein D amidase enhancer LytB N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Cytochrome oxidase subunit II transmembrane region profile
O-(3'-phospho-DNA)-tyrosine intermediate
Ferrous iron transport protein B C-terminal
Schiff-base intermediate with substrate; via topaquinone
YbaK/aminoacyl-tRNA synthetase-associated
Exonuclease VII large subunit C-terminal
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
NIF system FeS cluster assembly NifU N-terminal
Schiff-base intermediate with acetaldehyde
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Flagellar Assembly Protein A N-terminal region
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Fe/B12 periplasmic-binding domain-containing protein
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Molybdenum cofactor biosynthesis protein F N-terminal
Threonine/serine exporter-like N-terminal
Major facilitator superfamily associated
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Phosphoribosylformylglycinamidine synthase linker
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Phosphotransferase system enzyme I N-terminal
Na+-translocating membrane potential-generating system MpsC
Sporulation transcription regulator WhiA N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Dipicolinate synthase subunit A N-terminal
Cytochrome C biogenesis protein transmembrane
Translation elongation factor P/YeiP central
Peptidase M1 membrane alanine aminopeptidase
Sodium/calcium exchanger membrane region
Pseudouridine synthase I TruA alpha/beta
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
NADH-rubredoxin oxidoreductase C-terminal
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Putative aromatic acid exporter C-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Flagellar assembly protein FliH/Type III secretion system HrpE
Thymidylate synthase/dCMP hydroxymethylase
Cell wall-active antibiotics response LiaF-like C-terminal
6-hydroxymethylpterin diphosphokinase MptE-like
Signal recognition particle SRP54 helical bundle
Transcription regulator AsnC/Lrp ligand binding
Sporulation stage IV protein A C-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Phosphomannose isomerase type I catalytic
Septum formation inhibitor MinC C-terminal
Large ribosomal subunit protein uL2 C-terminal
Important for beta-aspartyl-AMP intermediate formation
Cadherin-like beta sandwich domain-containing protein
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Plays an important role in substrate specificity
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Thiamin pyrophosphokinase thiamin-binding
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
RNA binding; important for wobble base 34 recognition
Glucosamine/galactosamine-6-phosphate isomerase
Transcriptional coactivator p15 (PC4) C-terminal
Lysidine-tRNA(Ile) synthetase C-terminal
Deacetylase PdaC domain-containing protein
Pyridoxamine 5'-phosphate oxidase putative
Quercetin 2,3-dioxygenase C-terminal cupin
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Flagellar motor switch protein FliN-like C-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Intein C-terminal splicing domain-containing protein
ATP synthase F1 complex delta/epsilon subunit N-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Ribonucleotide reductase large subunit C-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
DNA mismatch repair proteins mutS family
Could play a key role in the communication between the regulatory and the substrate sites
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Transcriptional regulator TetR C-terminal Firmicutes type
Schiff-base intermediate with D-ribose 5-phosphate
Polysaccharide biosynthesis protein CapD-like
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Involved in allosteric activation by GTP
Heme-copper oxidase subunit III family profile
Glycosyl hydrolase-like 10 domain-containing protein
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Peptidase M10 metallopeptidase domain-containing protein
Gly-cisPro motif, important for rejection of L-amino acids
Prepilin type IV endopeptidase peptidase
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Periplasmic copper-binding protein NosD beta helix
Interaction with polymerase core subunit RpoC
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
S-adenosyl-L-homocysteine hydrolase NAD binding
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Transposase IS204/IS1001/IS1096/IS1165 DDE
Transposase IS204/IS1001/IS1096/IS1165 zinc-finger
Positions MEP for the nucleophilic attack
Glutathionylspermidine synthase pre-ATP-grasp-like
Excalibur calcium-binding domain-containing protein
Small ribosomal subunit protein uS4 N-terminal