Major facilitator superfamily (MFS) profile
Cytochrome b561 bacterial/Ni-hydrogenase
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
RND efflux pump membrane fusion protein barrel-sandwich
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Shikimate dehydrogenase substrate binding N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Glyoxalase/fosfomycin resistance/dioxygenase
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
DNA mismatch repair proteins mutS family
Gp5/Type VI secretion system Vgr protein OB-fold
Putative type VI secretion system Rhs element associated Vgr
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Tryptophan synthase beta chain-like PALP
Disulphide bond isomerase DsbC/G N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
For 3-hydroxyacyl-CoA dehydrogenase activity
Alpha-D-phosphohexomutase alpha/beta/alpha
NADH:flavin oxidoreductase/NADH oxidase N-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Membrane fusion protein biotin-lipoyl like
Bacterial type II secretion system protein E
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Phosphatidic acid phosphatase type 2/haloperoxidase
Glucose-methanol-choline oxidoreductase N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Polysaccharide chain length determinant N-terminal
TonB-dependent receptor-like beta-barrel
Pyruvate/ketoisovalerate oxidoreductase catalytic
O-(3'-phospho-DNA)-tyrosine intermediate
DNA-directed DNA polymerase family A palm
Aminoacyl-transfer RNA synthetases class-II family profile
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Reversibly protonated during proton transport
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Solute-binding protein family 3/N-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Important for substrate binding and specificity
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Putative oxidoreductase/dehydrogenase Rossmann-like
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Penicillin-binding protein transpeptidase
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Membrane insertase YidC/Oxa/ALB C-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Aspartate/homoserine dehydrogenase NAD-binding
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Heme-copper oxidase subunit III family profile
YbaK/aminoacyl-tRNA synthetase-associated
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Proline utilization A proline dehydrogenase N-terminal
NAD(P) transhydrogenase alpha subunit C-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Integral membrane protein YccS N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
NIF system FeS cluster assembly NifU N-terminal
Required for zinc-mediated homotetramerization and catalytic activity
RNA polymerase sigma factor 70 region 4 type 2
Quercetin 2,3-dioxygenase C-terminal cupin
TtsA-like Glycoside hydrolase family 108
Chalcone isomerase domain-containing protein
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Type II secretion system protein GspI C-terminal
RNA 2-O ribose methyltransferase substrate binding
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
TRAP C4-dicarboxylate transport system permease DctM subunit
Large ribosomal subunit protein uL15/eL18
Prepilin type IV endopeptidase peptidase
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Polymerase/histidinol phosphatase N-terminal
Positions MEP for the nucleophilic attack
Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Beta-lactamase hydrolase-like protein phosphatase-like
Methylene-tetrahydrofolate reductase C-terminal
O-(phosphoribosyl dephospho-coenzyme A)serine
Lysozyme inhibitor LprI N-terminal domain-containing protein
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Large ribosomal subunit protein bL25 L25
Interacts with tRNA; defines subfamily-specific binding signature
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Gamma-butyrobetaine hydroxylase-like N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
FAD-dependent oxidoreductase 2 FAD binding
Translation elongation factor P/YeiP central
NIF system FeS cluster assembly NifU C-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Outer-membrane lipoprotein carrier protein
Organic solvent tolerance-like N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Acyl-CoA dehydrogenase C-terminal bacterial-type
Bacterial OB-fold domain-containing protein
Peptidase M17 leucyl aminopeptidase N-terminal
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Activator of Hsp90 ATPase homologue 1-like C-terminal
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Signal transduction histidine kinase internal region
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Endolytic peptidoglycan transglycosylase RlpA
RlpA-like protein double-psi beta-barrel
S-adenosyl-L-homocysteine hydrolase NAD binding
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Metallo-beta-lactamase domain-containing protein
Essential for prephenate dehydratase activity
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Lipopolysaccharide export system protein LptA
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Helix-hairpin-helix DNA-binding motif class 1
Defence against restriction A N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Erythronate-4-phosphate dehydrogenase dimerisation
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Glycosyl transferase family 3 N-terminal
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Outer membrane lipoprotein carrier protein LolA
Ribosomal RNA small subunit methyltransferase E methyltransferase
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Virulence factor membrane-bound polymerase C-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
O-(5'-phospho-DNA)-tyrosine intermediate
Chromosomal replication initiator DnaA C-terminal
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Outer membrane protein assembly factor BamD
Large ribosomal subunit protein uL6 alpha-beta
Bacterial bifunctional deaminase-reductase C-terminal
Chromosomal replication initiator protein DnaA
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Interaction with polymerase core subunit RpoC
4'-phosphopantetheinyl transferase N-terminal
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Important for interaction with partner proteins
Choloylglycine hydrolase/NAAA C-terminal
Tetrahydrodipicolinate-N-succinyltransferase chain A
Styrene monooxygenase StyA putative substrate binding
Terminase large subunit gp17-like C-terminal
Type VI secretion system IcmF C-terminal
DNA replication/recombination mediator RecO N-terminal
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with Met-245)
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-98)
Electron transfer via tryptophanyl radical
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Outer membrane protein assembly factor BamA
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Large ribosomal subunit protein uL2 C-terminal
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
RNA binding; important for wobble base 34 recognition
Cyclophilin-like domain-containing protein
PhoD-like phosphatase metallophosphatase
Type 2A encapsulin shell protein SrpI-like
Polypeptide-transport-associated ShlB-type
Involved in tetramerization or stability of the tetramer
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Pseudouridine synthase I TruA alpha/beta
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Ribose-phosphate pyrophosphokinase N-terminal
N-end rule aminoacyl transferase C-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Release factor glutamine methyltransferase N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
YbgF trimerisation domain-containing protein
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
Acyl-ester intermediate; for transpeptidase activity
Proton donor; for transglycosylase activity
Schiff-base intermediate with substrate; via pyruvic acid
Na+/H+ antiporter MnhB subunit-related protein
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Proton acceptor; for glutaminase activity
Anthranilate synthase component I N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Seems to be a necessary countercharge to the potassium cations
Survival protein SurE-like phosphatase/nucleotidase
Alpha-glycerophosphate oxidase C-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Gamma-glutamylcyclotransferase AIG2-like
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Flavoprotein pyridine nucleotide cytochrome reductase-like FAD-binding
Ribosomal RNA small subunit methyltransferase E PUA-like
Peptide methionine sulphoxide reductase MsrA
Aminoacyl-tRNA synthetase class I anticodon-binding
Mandelate racemase/muconate lactonizing enzyme C-terminal
Prokaryotic-type class I peptide chain release factors
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold
Thymidylate synthase/dCMP hydroxymethylase
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Plays an important role in substrate specificity
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Nicotinamide phosphoribosyltransferase N-terminal
Small ribosomal subunit protein uS4 N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
UDP N-acetylglucosamine O-acyltransferase C-terminal
Malonate/sodium symporter MadM subunit N-terminal
Exonuclease VII large subunit C-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Cellulose biosynthesis cyclic di-GMP-binding regulatory protein BcsB
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Gly-cisPro motif, important for rejection of L-amino acids
Phosphoethanolamine transferase N-terminal
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Polysaccharide biosynthesis protein C-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Transcription factor NikR nickel binding C-terminal
Lipid/polyisoprenoid-binding YceI-like domain-containing protein
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region