NADH:flavin oxidoreductase/NADH oxidase N-terminal
Tryptophan synthase beta chain-like PALP
Chromosomal replication initiator DnaA C-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Aminoacyl-transfer RNA synthetases class-II family profile
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Major facilitator superfamily (MFS) profile
BetI-type transcriptional repressor C-terminal
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Sigma 54 modulation/S30EA ribosomal protein C-terminal
ABC-type glycine betaine transport system substrate-binding
PhoD-like phosphatase metallophosphatase
Small ribosomal subunit protein uS4 N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Acyl-CoA dehydrogenase/oxidase N-terminal
Gram-positive cocci surface proteins LPxTG domain-containing protein
DNA replication/recombination mediator RecO N-terminal
4'-phosphopantetheinyl transferase N-terminal
Peptidoglycan recognition protein family
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Erythromycin biosynthesis protein CIII-like central
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
RNA polymerase sigma factor 70 region 4 type 2
Release factor glutamine methyltransferase N-terminal
SUF system FeS cluster assembly SufBD N-terminal
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Pyridoxamine 5'-phosphate oxidase putative
Proton acceptor; for glutaminase activity
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Phosphomannose isomerase type I catalytic
Pyridine nucleotide-disulphide oxidoreductase dimerisation
FAD-dependent oxidoreductase 2 FAD binding
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
6-phosphogluconate dehydrogenase C-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Conserved hypothetical protein CHP02679 N terminus
Important for beta-aspartyl-AMP intermediate formation
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Acyltransferase MbtK/IucB-like conserved
Thymidylate synthase/dCMP hydroxymethylase
Glycosyltransferase subfamily 4-like N-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Carbamoyl-phosphate synthase small subunit N-terminal
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Mandelate racemase/muconate lactonizing enzyme C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Ricin B lectin domain-containing protein
Cytochrome b/b6 N-terminal region profile
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Neutral/alkaline non-lysosomal ceramidase C-terminal
Neutral/alkaline non-lysosomal ceramidase N-terminal
Glycine cleavage T-protein C-terminal barrel
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Plays an important role in substrate specificity
Transglycosylase SLT domain-containing protein
N(4)-bis(aminopropyl)spermidine synthase C-terminal
Removed in mature form; by autocatalysis
Transcription regulator AsnC/Lrp ligand binding
O-(3'-phospho-DNA)-tyrosine intermediate
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Superoxide dismutase copper/zinc binding
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Integral membrane protein YccS N-terminal
Nitrite/Sulfite reductase ferredoxin-like
Prepilin type IV endopeptidase peptidase
Phosphatidic acid phosphatase type 2/haloperoxidase
Glycosyl transferase family 3 N-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Peptidase S9 prolyl oligopeptidase catalytic
DNA-directed DNA polymerase family A palm
Prokaryotic-type class I peptide chain release factors
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase
Phosphotransferase system enzyme I N-terminal
Alpha-glycerophosphate oxidase C-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Molybdopterin cofactor biosynthesis C (MoaC)
Schiff-base intermediate with dihydroxyacetone-P
Phosphoribosylformylglycinamidine synthase linker
Glucosamine/galactosamine-6-phosphate isomerase
Peptidase M1 membrane alanine aminopeptidase
Alpha-L-arabinofuranosidase B arabinose-binding
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Pyrimidine nucleoside phosphorylase C-terminal
Beta-hexosaminidase bacterial type N-terminal
Large ribosomal subunit protein uL2 C-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Ribosomal RNA adenine methylase transferase N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Involved in ionization of N3 of dUMP, leading to its activation
Methionyl-tRNA synthetase anticodon-binding
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
Solute-binding protein family 3/N-terminal domain-containing protein
Positions MEP for the nucleophilic attack
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Glycoside hydrolase family 31 N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Peptide methionine sulphoxide reductase MsrA
Shikimate dehydrogenase substrate binding N-terminal
N6 adenine-specific DNA methyltransferase N-terminal
Glycosyl hydrolase family 98 putative carbohydrate-binding module
Could be important to modulate the pK values of the two catalytic cysteine residues
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
CobB/CobQ-like glutamine amidotransferase
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Alanyl-transfer RNA synthetases family profile
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Outer membrane lipoprotein carrier protein LolA
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
PsrA tetracyclin repressor-like C-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Endoribonuclease L-PSP/chorismate mutase-like
Cytochrome oxidase subunit II copper A binding
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Inosine/uridine-preferring nucleoside hydrolase
Penicillin-binding protein transpeptidase
3-beta hydroxysteroid dehydrogenase/isomerase
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
DNA helicase Holliday junction RuvA type
Holliday junction DNA helicase RuvA C-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Diacylglycerol glucosyltransferase N-terminal
Glycosyl transferase family 28 C-terminal
Resuscitation-promoting factor core lysozyme-like
Resuscitation-promoting factor core lysozyme-like domain-containing protein
Threonine/serine exporter-like N-terminal
Myo-inositol-1-phosphate synthase GAPDH-like
Electron transfer flavoprotein alpha/beta-subunit N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Cytochrome C biogenesis protein transmembrane
Probable transposase IS891/IS1136/IS1341
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
NADH-rubredoxin oxidoreductase C-terminal
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Activator of Hsp90 ATPase homologue 1-like C-terminal
Lactate utilization protein B C-terminal
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Protein O-mannosyl-transferase C-terminal four TM
O-(5'-phospho-DNA)-tyrosine intermediate
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
RNA 2-O ribose methyltransferase substrate binding
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Na+/H+ antiporter MnhB subunit-related protein
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Sporulation transcription regulator WhiA N-terminal
Subtilisin inhibitor domain-containing protein
Styrene monooxygenase StyA putative substrate binding
Gly-cisPro motif, important for rejection of L-amino acids
NIF system FeS cluster assembly NifU N-terminal
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
DNA primase/polymerase bifunctional N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Phosphocysteine intermediate; for EIIB activity
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Translation elongation factor P/YeiP central
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
Essential for prephenate dehydratase activity
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal