Glycine cleavage T-protein C-terminal barrel
Survival protein SurE-like phosphatase/nucleotidase
Pyruvate phosphate dikinase AMP/ATP-binding
6-phosphogluconate dehydrogenase C-terminal
Solute-binding protein family 3/N-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
ABC transporter substrate-binding protein PnrA-like
Major facilitator superfamily (MFS) profile
Peptidase S9 prolyl oligopeptidase catalytic
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
NADH:flavin oxidoreductase/NADH oxidase N-terminal
NADH:ubiquinone oxidoreductase intermediate-associated protein 30
Essential for prephenate dehydratase activity
Thiol:disulfide interchange protein DsbD N-terminal
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Flagellar basal-body/hook protein C-terminal
NAD(P) transhydrogenase alpha subunit C-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Mandelate racemase/muconate lactonizing enzyme C-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Glycosyl transferase family 3 N-terminal
Membrane fusion protein biotin-lipoyl like
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Thiamin pyrophosphokinase thiamin-binding
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
TonB-dependent receptor-like beta-barrel
SGNH hydrolase-type esterase domain-containing protein
Endoribonuclease L-PSP/chorismate mutase-like
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Rap1a immunity protein domain-containing protein
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Chromosomal replication initiator protein DnaA
TRAP C4-dicarboxylate transport system permease DctM subunit
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
RND efflux pump membrane fusion protein barrel-sandwich
Interacts with tRNA; defines subfamily-specific binding signature
Gamma-butyrobetaine hydroxylase-like N-terminal
D-galactarate/Altronate dehydratase C-terminal
DNA replication/recombination mediator RecO N-terminal
SUF system FeS cluster assembly SufBD N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Polysaccharide chain length determinant N-terminal
Leucine-binding protein domain-containing protein
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Penicillin-binding protein transpeptidase
Sigma 54 modulation/S30EA ribosomal protein C-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
DNA-directed DNA polymerase family A palm
Probable periplasmic serine endoprotease DegP-like
Sodium/calcium exchanger membrane region
Tryptophan synthase beta chain-like PALP
Aminoacyl-transfer RNA synthetases class-II family profile
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Methionyl-tRNA synthetase anticodon-binding
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Glycosyl transferase family 28 C-terminal
This mutant forms a disulfide bridge stabilizing the octamer and preventing dissociation into dimers upon biotin binding.
Protocatechuate 3,4-dioxygenase beta subunit N-terminal
Resolvase/invertase-type recombinase catalytic
Saccharopine dehydrogenase-like C-terminal
Polysaccharide biosynthesis protein CapD-like
Methylene-tetrahydrofolate reductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Phosphoadenosine phosphosulphate reductase
Glutamate synthase alpha subunit C-terminal
ABC-type transport auxiliary lipoprotein component
Peptide methionine sulphoxide reductase MsrA
RNA polymerase sigma factor 70 region 4 type 2
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
DNA mismatch repair proteins mutS family
Ribulose bisphosphate carboxylase large subunit C-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
RNA 2-O ribose methyltransferase substrate binding
Pseudouridine synthase I TruA alpha/beta
Flagellar motor switch protein FliN-like C-terminal
Exonuclease VII large subunit C-terminal
BAAT/Acyl-CoA thioester hydrolase C-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Pyridoxamine 5'-phosphate oxidase putative
Vanillate O-demethylase oxygenase-like C-terminal catalytic
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
ABC-type glycine betaine transport system substrate-binding
Plays an important role in substrate specificity
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Shikimate dehydrogenase substrate binding N-terminal
Inner membrane protein YgaP-like transmembrane
Peptide methionine sulfoxide reductase MsrA
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Prokaryotic-type class I peptide chain release factors
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Histidine phosphotransferase ChpT C-terminal
Cytochrome C biogenesis protein transmembrane
Cysteine sulfenic acid (-SOH) intermediate
PHA accumulation regulator DNA-binding N-terminal
Polymerase/histidinol phosphatase N-terminal
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
Pilus formation protein N-terminal domain-containing protein
Anaphase-promoting complex subunit 4-like WD40
Could play a key role in the communication between the regulatory and the substrate sites
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Cob(I)alamin adenosyltransferase N-terminal
Type I restriction modification DNA specificity
RNA binding; important for wobble base 34 recognition
Magnesium-protoporphyrin IX methyltransferase C-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
N-end rule aminoacyl transferase C-terminal
Guanylate kinase/L-type calcium channel beta subunit
Cytochrome c-type biogenesis protein CcmF C-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
NADH:ubiquinone oxidoreductase chain 4 N-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Reversibly protonated during proton transport
Flagellar basal body rod protein N-terminal
Poly-beta-hydroxybutyrate polymerase N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Ribose-phosphate pyrophosphokinase N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
tRNA pseudouridylate synthase B C-terminal
Interaction with polymerase core subunit RpoC
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Transcription regulator AsnC/Lrp ligand binding
Na+/H+ antiporter MnhB subunit-related protein
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
L,D-transpeptidase catalytic domain-containing protein
Ribosomal RNA adenine methylase transferase N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Bacterial type II secretion system protein E
Cobaltochelatase subunit CobS N-terminal
Alpha-glycerophosphate oxidase C-terminal
Small ribosomal subunit protein uS4 N-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Nicotinamide phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Terminase large subunit gp17-like C-terminal
Thiamin/hydroxymethyl pyrimidine-binding YkoF putative
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Photosynthetic reaction centre H subunit N-terminal
Glycoside hydrolase family 42 N-terminal
Alanyl-transfer RNA synthetases family profile
Lysozyme inhibitor LprI N-terminal domain-containing protein
Flavocytochrome c sulphide dehydrogenase flavin-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Phosphogluconate dehydrogenase (decarboxylating) C-terminal
Phage terminase large subunit GpA ATPase
Terminase large subunit GpA endonuclease
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Large ribosomal subunit protein uL2 C-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Required for zinc-mediated homotetramerization and catalytic activity
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Glyoxalase/fosfomycin resistance/dioxygenase
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Heme-copper oxidase subunit III family profile
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Prepilin type IV endopeptidase peptidase
Electron transfer via tryptophanyl radical
Translation elongation factor P/YeiP central
Light-independent protochlorophyllide reductase subunit B-like C-terminal
Pyruvate/ketoisovalerate oxidoreductase catalytic
Glycine zipper domain-containing protein
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Tetrahydrodipicolinate-N-succinyltransferase chain A
High-affinity zinc uptake system protein ZnuA
Ionotropic glutamate receptor C-terminal
Helix-hairpin-helix DNA-binding motif class 1
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
HTH-type transcriptional regulator MT1864/Rv1816-like C-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
5-glutamyl coenzyme A thioester intermediate
Pyrimidine nucleoside phosphorylase C-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Involved in allosteric activation by GTP
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Adaptive response protein AidB N-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Organic solvent tolerance-like N-terminal
Organic solvent tolerance-like N-terminal domain-containing protein
Magnesium chelatase subunit H N-terminal
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
HicB-like antitoxin of toxin-antitoxin system
Beta-xylosidase C-terminal Concanavalin A-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Cytochrome c oxidase subunit IV bacterial aa3 type
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
N6 adenine-specific DNA methyltransferase N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
S-adenosyl-L-homocysteine hydrolase NAD binding
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Phosphoribosylformylglycinamidine synthase linker
Acetyl-CoA dehydrogenase-like C-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Endolytic peptidoglycan transglycosylase RlpA
RlpA-like protein double-psi beta-barrel
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
D-glutamate N-acetyltransferase-like C-terminal
D-glutamate N-acetyltransferase-like N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Acetylserotonin O-methyltransferase dimerisation
S-adenosylmethionine-dependent methyltransferase
Could be important to modulate the pK values of the two catalytic cysteine residues
Inosine/uridine-preferring nucleoside hydrolase
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
CDP-alcohol phosphatidyltransferase C-terminal
2-oxoacid dehydrogenase acyltransferase catalytic
Glycosyltransferase family 28 N-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Sugar fermentation stimulation protein C-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Moybdenum cofactor oxidoreductase dimerisation
Thymidylate synthase/dCMP hydroxymethylase
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
UDP N-acetylglucosamine O-acyltransferase C-terminal
Chromosomal replication initiator DnaA C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Large ribosomal subunit protein uL15/eL18
ATP synthase F1 complex delta/epsilon subunit N-terminal