ABC-type uncharacterised transport system
Aminoacyl-transfer RNA synthetases class-II family profile
Resolvase/invertase-type recombinase catalytic
Large ribosomal subunit protein uL2 C-terminal
SAM-dependent methyltransferase TRM5/TYW2-type
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Cell envelope-related transcriptional attenuator
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Release factor glutamine methyltransferase N-terminal
RNA polymerase sigma factor 70 region 4 type 2
DNA mismatch repair protein MutS-like N-terminal
Tryptophan synthase beta chain-like PALP
N6 adenine-specific DNA methyltransferase N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Mandelate racemase/muconate lactonizing enzyme C-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Pseudouridine synthase I TruA alpha/beta
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
S-adenosylmethionine-dependent methyltransferase
Major facilitator superfamily (MFS) profile
Alanyl-transfer RNA synthetases family profile
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Carbamoyl-phosphate synthase small subunit N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Aspartate/homoserine dehydrogenase NAD-binding
Electron transfer flavoprotein alpha/beta-subunit N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Phosphatidic acid phosphatase type 2/haloperoxidase
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Tail specific protease domain-containing protein
Reversibly protonated during proton transport
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Signal transduction histidine kinase dimerisation/phosphoacceptor
Proton acceptor; for glutaminase activity
Phosphocysteine intermediate; for EIIB activity
Could be important to modulate the pK values of the two catalytic cysteine residues
Defence against restriction A C-terminal
Exonuclease VII large subunit C-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Aconitase A/isopropylmalate dehydratase small subunit swivel
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Schiff-base intermediate with acetaldehyde
Could play a key role in the communication between the regulatory and the substrate sites
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Sporulation stage IV protein A C-terminal
Helix-turn-helix conjugative transposon-like
Inosine/uridine-preferring nucleoside hydrolase
BREX system Lon protease-like BrxL N-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
ATP synthase F1 complex delta/epsilon subunit N-terminal
NIF system FeS cluster assembly NifU N-terminal
Involved in allosteric activation by GTP
Ribose-phosphate pyrophosphokinase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
YbaK/aminoacyl-tRNA synthetase-associated
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
Important for substrate specificity; cannot use PPi as phosphoryl donor
Phage terminase large subunit GpA ATPase
Terminase large subunit GpA endonuclease
Alpha-D-phosphohexomutase alpha/beta/alpha
TRAP C4-dicarboxylate transport system permease DctM subunit
Transcriptional regulator, IclR family protein
Polymerase/histidinol phosphatase N-terminal
Aldehyde ferredoxin oxidoreductase N-terminal
Chromosomal replication initiator DnaA C-terminal
Polysaccharide biosynthesis protein CapD-like
Penicillin-binding protein transpeptidase
Large ribosomal subunit protein uL15/eL18
Type I restriction modification DNA specificity
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Solute-binding protein family 3/N-terminal
RND efflux pump membrane fusion protein barrel-sandwich
Saccharopine dehydrogenase-like C-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Molybdopterin cofactor biosynthesis C (MoaC)
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Polysaccharide biosynthesis protein C-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Involved in ionization of N3 of dUMP, leading to its activation
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Aromatic amino acid beta-eliminating lyase/threonine aldolase
CobB/CobQ-like glutamine amidotransferase
O-(5'-phospho-DNA)-tyrosine intermediate
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Glycoside hydrolase family 31 N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Dinitrogenase iron-molybdenum cofactor biosynthesis
Small ribosomal subunit protein uS4 N-terminal
Pyrimidine nucleoside phosphorylase C-terminal
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Fe/B12 periplasmic-binding domain-containing protein
Translation elongation factor P/YeiP central
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Phosphotransferase system enzyme I N-terminal
Transcriptional coactivator p15 (PC4) C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Lacto-N-biose phosphorylase-like N-terminal TIM barrel
Signal recognition particle SRP54 helical bundle
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Transposase IS116/IS110/IS902 C-terminal
Type II restriction enzyme and methyltransferase RM.Eco57I-like
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Interaction with polymerase core subunit RpoC
Membrane fusion protein biotin-lipoyl like
DNA mismatch repair proteins mutS family
Peptidase S9 prolyl oligopeptidase catalytic
Replicative helicase inhibitor G39P N-terminal
SGNH hydrolase-type esterase domain-containing protein
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
RNA 2-O ribose methyltransferase substrate binding
Prokaryotic-type class I peptide chain release factors
Helix-hairpin-helix DNA-binding motif class 1
Large ribosomal subunit protein uL6 alpha-beta
Sodium/calcium exchanger membrane region
Large ribosomal subunit protein bL9 C-terminal
Shikimate dehydrogenase substrate binding N-terminal
Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal