Aminoacyl-transfer RNA synthetases class-II family profile
Aromatic amino acid beta-eliminating lyase/threonine aldolase
ATP synthase F1 complex delta/epsilon subunit N-terminal
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Choloylglycine hydrolase/NAAA C-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Pesticidal crystal protein Cry22Aa Ig-like
RNA polymerase sigma factor 70 region 4 type 2
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
ATPsynthase alpha/beta subunit N-terminal extension
Cell envelope-related transcriptional attenuator
DNA polymerase III delta subunit C-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Helix-hairpin-helix DNA-binding motif class 1
CO dehydrogenase/acetyl-CoA synthase complex beta subunit C-terminal
Carbon monoxide dehydrogenase subunit alpha ,N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Resolvase/invertase-type recombinase catalytic
Helix-turn-helix conjugative transposon-like
Saccharopine dehydrogenase-like C-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
FAD-dependent oxidoreductase 2 FAD binding
RND efflux pump membrane fusion protein barrel-sandwich
Polymerase/histidinol phosphatase N-terminal
CO dehydrogenase/acetyl-CoA synthase delta subunit TIM barrel
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Thiamin pyrophosphokinase thiamin-binding
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
TRAP C4-dicarboxylate transport system permease DctM subunit
Important for substrate specificity; cannot use PPi as phosphoryl donor
HicB-like antitoxin of toxin-antitoxin system
Meso-diaminopimelate D-dehydrogenase C-terminal
NIF system FeS cluster assembly NifU N-terminal
Important for autoinhibition of adenylyltransferase activity
Gram-positive signal peptide protein, YSIRK family
Solute-binding protein family 3/N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Polysaccharide chain length determinant N-terminal
Iron dependent repressor metal binding and dimerisation
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Penicillin-binding protein transpeptidase
Anthranilate synthase component I N-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
DNA replication/recombination mediator RecO N-terminal
Phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease 4
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Polysaccharide biosynthesis protein C-terminal
Restriction system protein Mrr-like N-terminal
Phosphocysteine intermediate; for EIIB activity
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
YbaK/aminoacyl-tRNA synthetase-associated
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
N6 adenine-specific DNA methyltransferase N-terminal
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Glycoside hydrolase family 31 N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Glycosyltransferase subfamily 4-like N-terminal
Major facilitator superfamily (MFS) profile
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Type I restriction modification DNA specificity
Bacterial type II secretion system protein E
Phosphotransferase system enzyme I N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Threonine/serine exporter-like N-terminal
Periplasmic binding protein domain-containing protein
Global transcriptional regulator CodY C-terminal
Global transcriptional regulator CodY N-terminal
Leucine-rich repeat domain-containing protein
S-adenosylmethionine-dependent methyltransferase
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Polysaccharide biosynthesis protein CapD-like
LPXTG-motif cell wall anchor domain protein
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Chromosomal replication initiator DnaA C-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Large ribosomal subunit protein bL9 C-terminal
Shikimate dehydrogenase substrate binding N-terminal
Alanyl-transfer RNA synthetases family profile
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Could play a key role in the communication between the regulatory and the substrate sites
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Lacto-N-biose phosphorylase-like N-terminal TIM barrel
Alpha-L-rhamnosidase six-hairpin glycosidase
Ribose-phosphate pyrophosphokinase N-terminal
tRNA pseudouridylate synthase B C-terminal
Large ribosomal subunit protein uL15/eL18
Terminase large subunit-like endonuclease
Aspartate/homoserine dehydrogenase NAD-binding
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Prepilin type IV endopeptidase peptidase
Sporulation stage II protein D amidase enhancer LytB N-terminal
CobB/CobQ-like glutamine amidotransferase
Gram-positive cocci surface proteins LPxTG
Transcriptional coactivator p15 (PC4) C-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Tryptophan synthase beta chain-like PALP
Reversibly protonated during proton transport
Glycoside hydrolase family 42 N-terminal
Putative exodeoxyribonuclease 8 PDDEXK-like
Glucosamine/galactosamine-6-phosphate isomerase
Lysidine-tRNA(Ile) synthetase C-terminal
Glyoxalase/fosfomycin resistance/dioxygenase
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
O-(5'-phospho-DNA)-tyrosine intermediate
Prokaryotic-type class I peptide chain release factors
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Glycine cleavage T-protein C-terminal barrel
Large ribosomal subunit protein uL6 alpha-beta
Lantibiotic immunity protein Spa1 C-terminal
Lantibiotic immunity protein Spa1 C-terminal domain-containing protein
Methylene-tetrahydrofolate reductase C-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Sodium/calcium exchanger membrane region
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Phosphoadenosine phosphosulphate reductase
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
ABC-type uncharacterised transport system
Positions MEP for the nucleophilic attack
Beta-xylosidase C-terminal Concanavalin A-like
Cell division protein FtsQ/DivIB C-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Increases nucleophilicity of active site Cys
Pyridoxamine 5'-phosphate oxidase putative
Sporulation stage IV protein A C-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Thymidylate synthase/dCMP hydroxymethylase
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Isopeptide-forming domain-containing fimbrial protein
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Translation elongation factor P/YeiP central
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like domain-containing protein
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Glycosyl transferase family 3 N-terminal
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
RNA 2-O ribose methyltransferase substrate binding
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Small ribosomal subunit protein uS4 N-terminal
Cation-transporting P-type ATPase N-terminal