Geranyl diphosphate 2-C-methyltransferase
DNA-directed RNA polymerase RpoA/D/Rpb3-type
DNA-directed RNA polymerase subunit alpha
Major facilitator superfamily (MFS) profile
Pyridoxal 5'-phosphate synthase subunit PdxT
3-methyl-2-oxobutanoate hydroxymethyltransferase
Glycine cleavage T-protein C-terminal barrel
DNA-directed DNA polymerase family A palm
Pyridoxamine 5'-phosphate oxidase putative
Transcription regulator AsnC/Lrp ligand binding
Thiamine pyrophosphate enzyme TPP-binding
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Aminoacyl-transfer RNA synthetases class-II family profile
CobB/CobQ-like glutamine amidotransferase
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Glycosyltransferase subfamily 4-like N-terminal
Increases nucleophilicity of active site Cys
Phosphatidic acid phosphatase type 2/haloperoxidase
Mandelate racemase/muconate lactonizing enzyme C-terminal
Solute-binding protein family 3/N-terminal
Alpha-glycerophosphate oxidase C-terminal
Cytochrome b/b6 N-terminal region profile
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Gly-cisPro motif, important for rejection of L-amino acids
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
NIF system FeS cluster assembly NifU N-terminal
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase 1
Reversibly protonated during proton transport
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Phosphocysteine intermediate; for EIIB activity
Probable 5-dehydro-4-deoxyglucarate dehydratase
Alpha galactosidase C-terminal beta sandwich
Formamidopyrimidine-DNA glycosylase catalytic
L-seryl-tRNA selenium transferase N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Succinate--CoA ligase [ADP-forming] subunit beta
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Important for beta-aspartyl-AMP intermediate formation
Tryptophan synthase beta chain-like PALP
RNA polymerase sigma factor 70 region 4 type 2
Bacterial bifunctional deaminase-reductase C-terminal
Plays an important role in substrate specificity
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Putative regulatory protein FmdB Zinc ribbon
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Penicillin-binding protein transpeptidase
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
N6 adenine-specific DNA methyltransferase N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase 2
Mannosyl-oligosaccharide alpha-1,2-mannosidase
DNA replication/recombination mediator RecO N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
DNA-directed RNA polymerase subunit beta'
NAD(P) transhydrogenase alpha subunit C-terminal
Beta-hexosaminidase bacterial type N-terminal
Cobalamin-independent methionine synthase MetE N-terminal
Acetylserotonin O-methyltransferase dimerisation
Prokaryotic-type class I peptide chain release factors
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Pyridoxine/pyridoxamine 5'-phosphate oxidase
Phosphoribosylformylglycinamidine synthase linker
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Cell envelope-related transcriptional attenuator
FAD-dependent oxidoreductase 2 FAD binding
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Essential for prephenate dehydratase activity
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Peptidoglycan recognition protein family
Endoribonuclease L-PSP/chorismate mutase-like
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Nitrite/Sulfite reductase ferredoxin-like
UDP-glucose/GDP-mannose dehydrogenase C-terminal
DNA primase/polymerase bifunctional N-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Pyrimidine nucleoside phosphorylase C-terminal
3-isopropylmalate dehydratase large subunit
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Homogentisate 1,2-dioxygenase C-terminal
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
DNA-directed RNA polymerase subunit beta
Fatty acid synthase subunit PfaD N-terminal
Prealbumin-like fold domain-containing protein
Membrane insertase YidC/Oxa/ALB C-terminal
Anti-sigma-D factor RsdA sigma factor binding region
Ribosomal RNA adenine methylase transferase N-terminal
Glycosyl transferase family 3 N-terminal
Moybdenum cofactor oxidoreductase dimerisation
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Probable transcriptional regulatory protein SACE_2018
ATP synthase F1 complex delta/epsilon subunit N-terminal
SUF system FeS cluster assembly SufBD N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
PhoD-like phosphatase metallophosphatase
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Release factor glutamine methyltransferase N-terminal
Sec-independent protein translocase protein TatA
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
Acetyl-coenzyme A carboxylase carboxyl transferase subunits beta/alpha
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Butirosin biosynthesis protein H N-terminal
Involved in ionization of N3 of dUMP, leading to its activation
Cell wall-active antibiotics response LiaF-like C-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Ribosomal RNA small subunit methyltransferase H
Glycoside hydrolase family 42 N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Erythromycin biosynthesis sensory transduction protein EryC1
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Glycosyl-hydrolase 97 C-terminal oligomerisation
3-isopropylmalate dehydratase small subunit
Aconitase A/isopropylmalate dehydratase small subunit swivel
Probable nicotinate-nucleotide adenylyltransferase
N-sulphoglucosamine sulphohydrolase C-terminal
NIF system FeS cluster assembly NifU C-terminal
Inosine/uridine-preferring nucleoside hydrolase
Phosphotransferase system enzyme I N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
NADH-rubredoxin oxidoreductase C-terminal
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Helix-hairpin-helix DNA-binding motif class 1
Holliday junction branch migration complex subunit RuvA
Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase C-terminal
Polymerase/histidinol phosphatase N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Carbamoyl-phosphate synthase small subunit N-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Transposase IS116/IS110/IS902 C-terminal
Bacterial type II secretion system protein E
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
ATP-dependent dethiobiotin synthetase BioD
Shikimate dehydrogenase substrate binding N-terminal
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Glycosyltransferase family 28 N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Sodium/calcium exchanger membrane region
Sigma 54 modulation/S30EA ribosomal protein C-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
N-acetyl-gamma-glutamyl-phosphate reductase
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Histidine-specific methyltransferase SAM-dependent
Erythromycin biosynthesis protein CIII-like central
Myo-inositol-1-phosphate synthase GAPDH-like
Glutamate-1-semialdehyde 2,1-aminomutase
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
RNA 2-O ribose methyltransferase substrate binding
PsrA tetracyclin repressor-like C-terminal
Anthranilate synthase component I N-terminal
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase
Transcription elongation factor GreA/GreB C-terminal
Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-253)
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-101)
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-101)
Phosphomannose isomerase type I catalytic
Ribosomal protein uS12 methylthiotransferase RimO
Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase
Glucosamine/galactosamine-6-phosphate isomerase
Glycosyl hydrolase family 98 putative carbohydrate-binding module
Peptidase M1 membrane alanine aminopeptidase
Peptidase S9 prolyl oligopeptidase catalytic
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
S-adenosyl-L-homocysteine hydrolase NAD binding
Chromosomal replication initiator DnaA C-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Electron transfer via tryptophanyl radical
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
Prokaryotic ubiquitin-like protein Pup 1
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
TRAP C4-dicarboxylate transport system permease DctM subunit
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
EfeO-type cupredoxin-like domain-containing protein
O-(5'-phospho-DNA)-tyrosine intermediate
Polyribonucleotide nucleotidyltransferase
Glucose-methanol-choline oxidoreductase C-terminal
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Cytochrome C biogenesis protein transmembrane
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
Hydroxymethylglutaryl-coenzyme A synthase C-terminal
Hydroxymethylglutaryl-coenzyme A synthase N-terminal
Actinobacteria/chloroflexi VLRF1 release factor
Alpha-D-phosphohexomutase alpha/beta/alpha
Docks into pockets in the proteasome alpha-ring
Crossover junction endodeoxyribonuclease RuvC
Cation-transporting P-type ATPase N-terminal
Putative Flp pilus-assembly TadG-like N-terminal
Large ribosomal subunit protein uL15/eL18
Conserved hypothetical protein CHP02679 N terminus
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
Pyruvate phosphate dikinase AMP/ATP-binding
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Schiff-base intermediate with D-ribose 5-phosphate
N(4)-bis(aminopropyl)spermidine synthase C-terminal
Diacylglycerol glucosyltransferase N-terminal
Glycosyl transferase family 28 C-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Na+/H+ antiporter MnhB subunit-related protein
Probable transposase IS891/IS1136/IS1341
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Small ribosomal subunit protein uS4 N-terminal
Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
BAAT/Acyl-CoA thioester hydrolase C-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
ABC-type glycine betaine transport system substrate-binding
Superoxide dismutase copper/zinc binding
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Siderophore-interacting protein C-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Large ribosomal subunit protein uL2 C-terminal
Sporulation-specific cell division protein SsgB
Pseudouridine synthase I TruA alpha/beta
Styrene monooxygenase StyA putative substrate binding
Peptide methionine sulphoxide reductase MsrA
Transcription antitermination protein NusB
Sec-independent protein translocase protein TatB
DnaJ homologue subfamily C member 28 conserved
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Bacterial transcription activator effector binding
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Endonuclease/exonuclease/phosphatase family metal-dependent hydrolase
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Proton acceptor; for FBP phosphatase activity
Proton donor/acceptor; for FBP aldolase activity
Schiff-base intermediate with DHAP; for FBP aldolase activity
Sporulation transcription regulator WhiA N-terminal
Probable dual-specificity RNA methyltransferase RlmN
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Threonine/serine exporter-like N-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Positions MEP for the nucleophilic attack
Galactofuranosyltransferase GlfT2 N-terminal
Galactofuranosyltransferase-2 C-terminal
3-phosphoshikimate 1-carboxyvinyltransferase
6-phosphogluconate dehydrogenase C-terminal
Putative S-adenosyl-L-methionine-dependent methyltransferase SACE_1742
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
D-inositol 3-phosphate glycosyltransferase
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Glutathionylspermidine synthase pre-ATP-grasp-like
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Cytochrome oxidase subunit II copper A binding
FbpC C-terminal regulatory nucleotide binding
3-alpha-mycarosylerythronolide B desosaminyl transferase
Resuscitation-promoting factor core lysozyme-like
Phosphoribosylaminoimidazole-succinocarboxamide synthase
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Uncharacterized MFS-type transporter SACE_5813
Aromatic amino acid beta-eliminating lyase/threonine aldolase
UDP-N-acetylenolpyruvoylglucosamine reductase
Beta-xylosidase C-terminal Concanavalin A-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Adaptive response protein AidB N-terminal
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Glycosyl hydrolases family 2 sugar binding
Translation elongation factor P/YeiP central
Neutral/alkaline non-lysosomal ceramidase C-terminal
Neutral/alkaline non-lysosomal ceramidase N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Methionyl-tRNA synthetase anticodon-binding
Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-? in acceptor proteins)
Prokaryotic ubiquitin-like protein Pup 2
DNA-directed RNA polymerase subunit omega
Alanyl-transfer RNA synthetases family profile
4'-phosphopantetheinyl transferase N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal