Involved in allosteric activation by GTP
Important for autoinhibition of adenylyltransferase activity
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Gly-cisPro motif, important for rejection of L-amino acids
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Gram-positive cocci surface proteins LPxTG
O-(phosphoribosyl dephospho-coenzyme A)serine
Shikimate dehydrogenase substrate binding N-terminal
X-Prolyl dipeptidyl aminopeptidase PepX N-terminal
Threonine/serine exporter-like N-terminal
Large ribosomal subunit protein uL2 C-terminal
Solute-binding protein family 3/N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Alpha-L-rhamnosidase six-hairpin glycosidase
Bacterial alpha-L-rhamnosidase N-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
Tryptophan synthase beta chain-like PALP
Polysaccharide chain length determinant N-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Global transcriptional regulator CodY C-terminal
Global transcriptional regulator CodY N-terminal
Schiff-base intermediate with acetaldehyde
RNA binding; important for wobble base 34 recognition
Thiamin pyrophosphokinase thiamin-binding
Regulator of chromosome segregation-like C-terminal
Large ribosomal subunit protein uL15/eL18
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Release factor glutamine methyltransferase N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Exonuclease VII large subunit C-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Phosphocysteine intermediate; for EIIB activity
Phosphoribosylformylglycinamidine synthase linker
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
O-(3'-phospho-DNA)-tyrosine intermediate
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Penicillin-binding protein transpeptidase
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
O-(5'-phospho-DNA)-tyrosine intermediate
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
Resolvase/invertase-type recombinase catalytic
Pyridoxamine 5'-phosphate oxidase putative
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Large ribosomal subunit protein uL6 alpha-beta
Translation elongation factor P/YeiP central
Pyridine nucleotide-disulphide oxidoreductase dimerisation
DNA replication/recombination mediator RecO N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Glycosyltransferase subfamily 4-like N-terminal
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Carbamoyl-phosphate synthase small subunit N-terminal
6-phosphogluconate dehydrogenase C-terminal
Polymerase/histidinol phosphatase N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
NIF system FeS cluster assembly NifU N-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Alpha-D-phosphohexomutase alpha/beta/alpha
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Important for interaction with partner proteins
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Putative aromatic acid exporter C-terminal
Pyrimidine nucleoside phosphorylase C-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Polysaccharide lyase 8 N-terminal alpha-helical
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Helix-hairpin-helix DNA-binding motif class 1
Inosine/uridine-preferring nucleoside hydrolase
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
TRAP C4-dicarboxylate transport system permease DctM subunit
SMODS-associating 2TM beta-strand rich effector
DNA/pantothenate metabolism flavoprotein C-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
DNA processing protein A sterile alpha motif
Pseudouridine synthase I TruA alpha/beta
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Beta-xylosidase C-terminal Concanavalin A-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Thiopeptide-type bacteriocin biosynthesis
Polysaccharide biosynthesis protein C-terminal
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
CobB/CobQ-like glutamine amidotransferase
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
DNA mismatch repair proteins mutS family
Ribose-phosphate pyrophosphokinase N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Cell envelope-related transcriptional attenuator
Phosphotransferase system enzyme I N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Hydroxymethylglutaryl-coenzyme A synthase C-terminal
Hydroxymethylglutaryl-coenzyme A synthase N-terminal
Transcriptional coactivator p15 (PC4) C-terminal
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
YbaK/aminoacyl-tRNA synthetase-associated
Cell wall-active antibiotics response LiaF-like C-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Major facilitator superfamily (MFS) profile
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
ATPsynthase alpha/beta subunit N-terminal extension
Plays an important role in substrate specificity
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Peptidase M1 membrane alanine aminopeptidase
Interaction with polymerase core subunit RpoC
ABC transporter substrate-binding protein PnrA-like
Alanyl-transfer RNA synthetases family profile
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
RNA polymerase sigma factor 70 region 4 type 2
Bacterial transcription activator effector binding
Sporulation transcription regulator WhiA N-terminal
Bacterial type II secretion system protein E
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Small ribosomal subunit protein uS4 N-terminal
SUF system FeS cluster assembly SufBD N-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Prokaryotic-type class I peptide chain release factors
Reversibly protonated during proton transport
Gram-positive cocci surface proteins LPxTG domain-containing protein
Peptide methionine sulphoxide reductase MsrA
Increases nucleophilicity of active site Cys
Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
RND efflux pump membrane fusion protein barrel-sandwich
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cation-transporting P-type ATPase N-terminal
Thymidylate synthase/dCMP hydroxymethylase
RNA 2-O ribose methyltransferase substrate binding
ABC-type glycine betaine transport system substrate-binding
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
ATP synthase F1 complex delta/epsilon subunit N-terminal