Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
RND efflux pump membrane fusion protein barrel-sandwich
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Cation-transporting P-type ATPase N-terminal
Chromosomal replication initiator protein DnaA
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
DNA-directed RNA polymerase subunit beta
RNA binding; important for wobble base 34 recognition
Phosphoadenosine phosphosulphate reductase
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Plays an important role in substrate specificity
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Cytochrome c7-like domain-containing protein
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Prokaryotic-type class I peptide chain release factors
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Aminoacyl-transfer RNA synthetases class-II family profile
Tryptophan synthase beta chain-like PALP
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
RNA 2-O ribose methyltransferase substrate binding
Ribulose bisphosphate carboxylase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Ribonucleotide reductase large subunit C-terminal
DNA replication/recombination mediator RecO N-terminal
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Flagellar transcriptional regulator FlhC
Alanyl-transfer RNA synthetases family profile
N-end rule aminoacyl transferase C-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Tetrahydrodipicolinate-N-succinyltransferase chain A
Signal transduction histidine kinase internal region
Bacterial type II secretion system protein E
Positions MEP for the nucleophilic attack
BREX system Lon protease-like BrxL N-terminal
Glycine zipper 2TM domain-containing protein
Large ribosomal subunit protein uL15/eL18
Could play a key role in the communication between the regulatory and the substrate sites
Penicillin-binding protein transpeptidase
Flagellar hook-length control protein-like C-terminal
Type II restriction enzyme and methyltransferase RM.Eco57I-like
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Flagellar motor switch protein FliN-like C-terminal
Solute-binding protein family 3/N-terminal domain-containing protein
N6 adenine-specific DNA methyltransferase N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
DNA polymerase III subunit delta C-terminal
Transposon Tn7 transposition protein TnsD C-terminal
Essential for prephenate dehydratase activity
RNA polymerase sigma factor 70 region 4 type 2
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Polysaccharide biosynthesis protein CapD-like
DNA mismatch repair proteins mutS family
Resolvase/invertase-type recombinase catalytic
ABC transporter substrate binding protein
Sodium/calcium exchanger membrane region
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
TonB-dependent receptor-like beta-barrel
Type III secretion system flagellar brake protein YcgR PilZN
Membrane fusion protein biotin-lipoyl like
Type I restriction modification DNA specificity
Protein kinase G tetratricopeptide repeat containing
Bacteriophage T7 Gp4 DNA primase/helicase N-terminal
TRAP C4-dicarboxylate transport system permease DctM subunit
Putative exodeoxyribonuclease 8 PDDEXK-like
Outer membrane protein assembly factor BamE
Solute-binding protein family 3/N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Inner membrane protein YgaP-like transmembrane
Small ribosomal subunit protein uS4 N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
EfeO-type cupredoxin-like domain-containing protein
Major facilitator superfamily (MFS) profile
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Cytochrome b561 bacterial/Ni-hydrogenase
Large ribosomal subunit protein uL6 alpha-beta
Four-helix bundle copper-binding protein
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Flagella basal body P-ring formation protein FlgA
Glycogen debranching enzyme bacterial and archaeal type N-terminal
Urease accessory protein UreH-like transmembrane
NADH:ubiquinone oxidoreductase 30kDa subunit
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-90)
Thiamine pyrophosphate enzyme TPP-binding
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Interaction with polymerase core subunit RpoC
Cysteine sulfenic acid (-SOH) intermediate
Mannose-6-phosphate isomerase type II C-terminal
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Cytochrome oxidase subunit II copper A binding
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Schiff-base intermediate with substrate; via pyruvic acid
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Type IV methyl-directed restriction enzyme EcoKMcrB subunit DNA-binding
Outer-membrane lipoprotein carrier protein
Membrane insertase YidC/Oxa/ALB C-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Outer membrane lipoprotein-sorting protein
Ribosomal RNA adenine methylase transferase N-terminal
ABC-type uncharacterised transport system
Exonuclease VII large subunit C-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Polymerase/histidinol phosphatase N-terminal
Glycine cleavage T-protein C-terminal barrel
Glycoside hydrolase family 57 N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Shikimate dehydrogenase substrate binding N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Cytochrome c-type biogenesis protein CcmF C-terminal
Transposase IS116/IS110/IS902 C-terminal
Malonyl-[acyl-carrier protein] O-methyltransferase
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Major facilitator superfamily associated
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Pseudouridine synthase I TruA alpha/beta
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Outer membrane protein assembly factor BamD
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Proton acceptor; for glutaminase activity
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Nucleophile; cysteine thiosulfonate intermediate
Pyrroline-5-carboxylate reductase catalytic N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Could be important to modulate the pK values of the two catalytic cysteine residues
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Histidine-specific methyltransferase SAM-dependent
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Glycosyl transferase family 3 N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Translation elongation factor P/YeiP central
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Interacts with tRNA; defines subfamily-specific binding signature
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Anthranilate synthase component I N-terminal
Pyruvate/ketoisovalerate oxidoreductase catalytic
6-phosphogluconate dehydrogenase C-terminal
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Lipopolysaccharide export system protein LptA
Organic solvent tolerance-like N-terminal
Phosphotransferase system enzyme I N-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Cytochrome C biogenesis protein transmembrane
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Flagellar Assembly Protein A N-terminal region
Large ribosomal subunit protein uL2 C-terminal
Prepilin type IV endopeptidase peptidase
Abortive infection protein-like C-terminal
UDP N-acetylglucosamine O-acyltransferase C-terminal
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Lysidine-tRNA(Ile) synthetase C-terminal
Chromosomal replication initiator DnaA C-terminal
DNA-directed DNA polymerase family A palm
Putative regulatory protein FmdB Zinc ribbon
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Lipoprotein SmpA/OmlA domain-containing protein
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Type IV secretion system coupling protein TraD DNA-binding
ATP synthase F1 complex delta/epsilon subunit N-terminal
Helix-hairpin-helix DNA-binding motif class 1
NIF system FeS cluster assembly NifU N-terminal
Important for interaction with partner proteins
Thymidylate synthase/dCMP hydroxymethylase
Nitrite/Sulfite reductase ferredoxin-like
Gamma-butyrobetaine hydroxylase-like N-terminal
ParB-related ThiF-related cassette protein E
Survival protein SurE-like phosphatase/nucleotidase
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Outer membrane protein assembly factor BamA
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Required for zinc-mediated homotetramerization and catalytic activity
Arsenosugar biosynthesis radical SAM protein ArsS-like C-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Pyrroline-5-carboxylate reductase dimerisation
NADH:ubiquinone oxidoreductase intermediate-associated protein 30