Aminoacyl-transfer RNA synthetases class-II family profile
DnaJ homologue subfamily C member 28 conserved
Cation-transporting P-type ATPase N-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Putative glycogen debranching enzyme N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Acid phosphatase of HAD superfamily subfamily IIIB
Major facilitator superfamily (MFS) profile
Sodium/calcium exchanger membrane region
FAD-dependent oxidoreductase 2 FAD binding
Proton acceptor; for glutaminase activity
Heat-inducible transcription repressor HrcA C-terminal
Pyridoxamine 5'-phosphate oxidase putative
Peptidase S9 prolyl oligopeptidase catalytic
RNA polymerase sigma factor 70 region 4 type 2
Glycoside hydrolase family 3 N-terminal domain-containing protein
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
6-phosphogluconate dehydrogenase NADP-binding
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
6-phosphogluconate dehydrogenase C-terminal
Phosphodiester glycosidase domain-containing protein
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Peptidoglycan recognition protein family
Gfo/Idh/MocA-like oxidoreductase N-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
ABC-type glycine betaine transport system substrate-binding
ABC-type glycine betaine transport system substrate-binding domain-containing protein
Alpha-L-rhamnosidase six-hairpin glycosidase
Bacterial alpha-L-rhamnosidase N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
6-phosphogluconolactonase (Cycloisomerase 2 family)
Mandelate racemase/muconate lactonizing enzyme C-terminal
Glycosyl hydrolase family 98 putative carbohydrate-binding module
Styrene monooxygenase StyA putative substrate binding
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Tryptophan synthase beta chain-like PALP
Na+/H+ antiporter MnhB subunit-related protein
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Transcription regulator AsnC/Lrp ligand binding
Pyrimidine nucleoside phosphorylase C-terminal
Bacterial transcription activator effector binding
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Polysaccharide chain length determinant N-terminal
Important for beta-aspartyl-AMP intermediate formation
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Gram-positive cocci surface proteins LPxTG
Cell wall-active antibiotics response LiaF-like C-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Putative oxidoreductase/dehydrogenase Rossmann-like
Beta-hexosaminidase bacterial type N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Large ribosomal subunit protein uL15/eL18
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Could be important to modulate the pK values of the two catalytic cysteine residues
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Helix-hairpin-helix DNA-binding motif class 1
Cell envelope-related transcriptional attenuator
Carbamoyl-phosphate synthase small subunit N-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
Polymerase/histidinol phosphatase N-terminal
Schiff-base intermediate with substrate; via pyruvic acid
Gram-positive cocci surface proteins LPxTG domain-containing protein
S-adenosyl-L-homocysteine hydrolase NAD binding
RNA 2-O ribose methyltransferase substrate binding
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Glycoside hydrolase family 38 N-terminal
Lantibiotic biosynthesis protein dehydration
Essential for prephenate dehydratase activity
Exonuclease VII large subunit C-terminal
Glycosyltransferase subfamily 4-like N-terminal
Acyl-CoA dehydrogenase C-terminal bacterial-type
Centromere-binding protein ParB C-terminal
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Myo-inositol-1-phosphate synthase GAPDH-like
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
Pseudouridine synthase I TruA alpha/beta
CobB/CobQ-like glutamine amidotransferase
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Penicillin-binding protein transpeptidase
NIF system FeS cluster assembly NifU N-terminal
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
3-beta hydroxysteroid dehydrogenase/isomerase
Alpha-N-acetylglucosaminidase C-terminal
Alpha-N-acetylglucosaminidase N-terminal
Alpha-N-acetylglucosaminidase tim-barrel
Alpha-glycerophosphate oxidase C-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Mannose-6-phosphate isomerase type II C-terminal
DNA primase/polymerase bifunctional N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Phosphomannose isomerase type I catalytic
Methionyl-tRNA synthetase anticodon-binding
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Actinobacteria/chloroflexi VLRF1 release factor
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Endonuclease/exonuclease/phosphatase domain-containing protein
Ribose-phosphate pyrophosphokinase N-terminal
Cytochrome bc1 complex Rieske iron-sulfur subunit
GxGYxYP putative glycoside hydrolase C-terminal
GxGYxYP putative glycoside hydrolase N-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
O-(5'-phospho-DNA)-tyrosine intermediate
Glycosyl transferase family 3 N-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
N-acetylmuramoyl-L-alanine amidase domain-containing protein
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Nitrite/Sulfite reductase ferredoxin-like
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Large ribosomal subunit protein uL2 C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Phage tail lysozyme domain-containing protein
Peptidase M1 membrane alanine aminopeptidase
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
L,D-transpeptidase catalytic domain-containing protein
Alpha-galactosidase NEW3 domain-containing protein
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Alpha-D-phosphohexomutase alpha/beta/alpha
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Phosphotransferase system enzyme I N-terminal
Integral membrane protein YccS N-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Schiff-base intermediate with D-ribose 5-phosphate
Reversibly protonated during proton transport
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Gfo/Idh/MocA-like oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-108)
Plays an important role in substrate specificity
O-(3'-phospho-DNA)-tyrosine intermediate
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
NAD(P) transhydrogenase alpha subunit C-terminal
Phospholipase D-like domain-containing protein
Inosine/uridine-preferring nucleoside hydrolase
D-glutamate N-acetyltransferase-like C-terminal
D-glutamate N-acetyltransferase-like N-terminal
Microcystin LR degradation protein MlrC C-terminal
Microcystin LR degradation protein MlrC N-terminal
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Glycosyl-hydrolase family 116 N-terminal
Glycosyl-hydrolase family 116 catalytic region
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Adaptive response protein AidB N-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Dienelactone hydrolase domain-containing protein
Pyrroloquinoline-quinone binding quinoprotein
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Interaction with polymerase core subunit RpoC
Alanyl-transfer RNA synthetases family profile
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Carbohydrate ABC transporter substrate-binding protein (CUT1 family)
Cytochrome C biogenesis protein transmembrane
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Glycoside hydrolase family 42 N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Outer membrane protein assembly factor BamB
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Gly-cisPro motif, important for rejection of L-amino acids
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Putative regulatory protein FmdB Zinc ribbon
Erythromycin biosynthesis protein CIII-like central
Prokaryotic-type class I peptide chain release factors
Large ribosomal subunit protein uL6 alpha-beta
ATP synthase F1 complex delta/epsilon subunit N-terminal
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Small ribosomal subunit protein uS4 N-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Glycine cleavage T-protein C-terminal barrel
Anthranilate synthase component I N-terminal