Tryptophan synthase beta chain-like PALP
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
RNA polymerase sigma factor 70 region 4 type 2
Glycine cleavage T-protein C-terminal barrel
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Threonine/serine exporter-like N-terminal
CobB/CobQ-like glutamine amidotransferase
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
TetR transcriptional regulator CgmR-like C-terminal
Major facilitator superfamily (MFS) profile
Schiff-base intermediate with acetaldehyde
Penicillin-binding protein transpeptidase
Involved in ionization of N3 of dUMP, leading to its activation
Aminoacyl-transfer RNA synthetases class-II family profile
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Reversibly protonated during proton transport
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
L-seryl-tRNA selenium transferase N-terminal
Phosphomannose isomerase type I catalytic
Cysteine sulfenic acid (-SOH) intermediate
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Phosphotransferase system enzyme I N-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
Anthranilate synthase component I N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Thymidylate synthase/dCMP hydroxymethylase
Helix-hairpin-helix DNA-binding motif class 1
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Ribosome maturation factor RimP N-terminal
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Alpha-glycerophosphate oxidase C-terminal
Transposase IS204/IS1001/IS1096/IS1165 DDE
Transposase IS204/IS1001/IS1096/IS1165 zinc-finger
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Glycosyltransferase subfamily 4-like N-terminal
Cytochrome C biogenesis protein transmembrane
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Positions MEP for the nucleophilic attack
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Phosphocysteine intermediate; for EIIB activity
ATP synthase F1 complex delta/epsilon subunit N-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-? in acceptor proteins)
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Ribose-phosphate pyrophosphokinase N-terminal
Release factor glutamine methyltransferase N-terminal
Polymerase/histidinol phosphatase N-terminal
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Glucosamine/galactosamine-6-phosphate isomerase
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Aconitase A/isopropylmalate dehydratase small subunit swivel
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Peptidase M1 membrane alanine aminopeptidase
Large ribosomal subunit protein uL6 alpha-beta
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Peptidoglycan recognition protein family
ATP-dependent DNA helicase RecG C-terminal
Plays an important role in substrate specificity
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
HTH-type transcriptional regulator MT1864/Rv1816-like C-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
RNA binding; important for wobble base 34 recognition
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Cell wall-active antibiotics response LiaF-like C-terminal
Large ribosomal subunit protein uL15/eL18
Solute-binding protein family 3/N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Arabinofuranosyltransferase AftA C-terminal
Arabinofuranosyltransferase AftA N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Heat-inducible transcription repressor HrcA C-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Essential for prephenate dehydratase activity
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Schiff-base intermediate with D-ribose 5-phosphate
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Phosphatidate phosphatase APP1 catalytic
Formamidopyrimidine-DNA glycosylase catalytic
Interaction with polymerase core subunit RpoC
Cobalamin-independent methionine synthase MetE N-terminal
Translation elongation factor P/YeiP central
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Na+/H+ antiporter MnhB subunit-related protein
Important for beta-aspartyl-AMP intermediate formation
NIF system FeS cluster assembly NifU N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
ABC-type glycine betaine transport system substrate-binding
Important for substrate specificity; cannot use PPi as phosphoryl donor
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
O-(5'-phospho-DNA)-tyrosine intermediate
Peptidase S9 prolyl oligopeptidase catalytic
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Peptide methionine sulphoxide reductase MsrA
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Bacterial type II secretion system protein E
Prokaryotic-type class I peptide chain release factors
Ribosomal RNA adenine methylase transferase N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Pyrimidine nucleoside phosphorylase C-terminal
DNA replication/recombination mediator RecO N-terminal
Transposase IS116/IS110/IS902 C-terminal
Small ribosomal subunit protein uS4 N-terminal
Glycosyl transferase family 3 N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Phenol hydroxylase C-terminal dimerisation
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Cytochrome b/b6 N-terminal region profile
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
RNA 2-O ribose methyltransferase substrate binding
Pseudouridine synthase I TruA alpha/beta
Exonuclease VII large subunit C-terminal
Endoribonuclease L-PSP/chorismate mutase-like
Phosphoribosylformylglycinamidine synthase linker
Membrane insertase YidC/Oxa/ALB C-terminal
4'-phosphopantetheinyl transferase N-terminal
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Sporulation transcription regulator WhiA N-terminal
Alanyl-transfer RNA synthetases family profile
Could be important to modulate the pK values of the two catalytic cysteine residues
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Large ribosomal subunit protein uL2 C-terminal
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Inosine/uridine-preferring nucleoside hydrolase
Molybdopterin cofactor biosynthesis C (MoaC)
Resuscitation-promoting factor Rpf1 C-terminal
Resuscitation-promoting factor core lysozyme-like
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation