Major facilitator superfamily (MFS) profile
Glycine cleavage T-protein C-terminal barrel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Phosphatidate phosphatase APP1 catalytic
Inosine/uridine-preferring nucleoside hydrolase
NADH:flavin oxidoreductase/NADH oxidase N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Resolvase/invertase-type recombinase catalytic
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Solute-binding protein family 3/N-terminal
Glucosamine/galactosamine-6-phosphate isomerase
TRAP C4-dicarboxylate transport system permease DctM subunit
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Transposase IS204/IS1001/IS1096/IS1165 zinc-finger
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Mycothiol-dependent maleylpyruvate isomerase metal-binding
FAD-dependent oxidoreductase 2 FAD binding
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
TRAP transporter solute receptor, TAXI family
Acyl-CoA dehydrogenase/oxidase N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Translation elongation factor P/YeiP central
Glycosyl transferase family 3 N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Gram-positive cocci surface proteins LPxTG
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Polymerase/histidinol phosphatase N-terminal
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
RNA polymerase sigma factor 70 region 4 type 2
ABC-type glycine betaine transport system substrate-binding
Survival protein SurE-like phosphatase/nucleotidase
Putative oxidoreductase/dehydrogenase Rossmann-like
Prokaryotic-type class I peptide chain release factors
Essential for prephenate dehydratase activity
Mandelate racemase/muconate lactonizing enzyme C-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Aminoacyl-transfer RNA synthetases class-II family profile
Cell envelope-related transcriptional attenuator
DNA replication/recombination mediator RecO N-terminal
Meso-diaminopimelate D-dehydrogenase C-terminal
Actinobacteria/chloroflexi VLRF1 release factor
Pseudouridine synthase I TruA alpha/beta
Plays an important role in substrate specificity
Membrane insertase YidC/Oxa/ALB C-terminal
Pyruvate dehydrogenase E1 component middle
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Acyl-CoA dehydrogenase/oxidase C-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Bacterial bifunctional deaminase-reductase C-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
YbaK/aminoacyl-tRNA synthetase-associated
Gram-positive cocci surface proteins LPxTG domain-containing protein
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Formamidopyrimidine-DNA glycosylase catalytic
Type VII secretion system protein EssD-like
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
RNA binding; important for wobble base 34 recognition
Phosphotransferase system enzyme I N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
Tryptophan synthase beta chain-like PALP
Gly-cisPro motif, important for rejection of L-amino acids
General stress protein FMN-binding split barrel
Bacterial type II secretion system protein E
TetR transcriptional regulator CgmR-like C-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Oligopeptide transport permease C-like N-terminal
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Transposase IS116/IS110/IS902 C-terminal
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Trigger factor ribosome-binding bacterial
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Peptide methionine sulphoxide reductase MsrA
Glycosyltransferase subfamily 4-like N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Heme-copper oxidase subunit III family profile
Ionotropic glutamate receptor C-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Mannose-6-phosphate isomerase type II C-terminal
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
Polysaccharide biosynthesis protein C-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Carbamoyl-phosphate synthase small subunit N-terminal
Cytochrome C biogenesis protein transmembrane
Sporulation transcription regulator WhiA N-terminal
Anthranilate synthase component I N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
6-phosphogluconate dehydrogenase C-terminal
Putative glycogen debranching enzyme N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Transition state stabilizer; via amide nitrogen
Alternate signal-mediated exported protein, RER_14450 family
Penicillin-binding protein transpeptidase
Centromere-binding protein ParB C-terminal
Subtilisin-like protease fibronectin type-III
Pyrimidine nucleoside phosphorylase C-terminal
Cell division protein FtsQ/DivIB C-terminal
Heavy-metal-associated domain-containing protein
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
O-(3'-phospho-DNA)-tyrosine intermediate
Ribosomal RNA adenine methylase transferase N-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Protein O-mannosyl-transferase C-terminal four TM
Alanyl-transfer RNA synthetases family profile
Putative Flp pilus-assembly TadG-like N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Type I restriction enzyme R protein N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
RNA 2-O ribose methyltransferase substrate binding
Exonuclease VII large subunit C-terminal
Reversibly protonated during proton transport
PhoD-like phosphatase metallophosphatase
Pyruvate phosphate dikinase AMP/ATP-binding
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Polysaccharide biosynthesis protein CapD-like
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Myo-inositol-1-phosphate synthase GAPDH-like
Schiff-base intermediate with substrate; via topaquinone
Transcription regulator AsnC/Lrp ligand binding
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
NIF system FeS cluster assembly NifU N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Heat-inducible transcription repressor HrcA C-terminal
Large ribosomal subunit protein uL2 C-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Methionyl-tRNA synthetase anticodon-binding
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Cell wall-active antibiotics response LiaF-like C-terminal
Schiff-base intermediate with D-ribose 5-phosphate
Large ribosomal subunit protein uL15/eL18
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Ribose-phosphate pyrophosphokinase N-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
N-acetylneuraminic acid synthase N-terminal
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Could be important to modulate the pK values of the two catalytic cysteine residues
Phenol hydroxylase C-terminal dimerisation
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-131)
Thiopeptide-type bacteriocin biosynthesis
Helix-hairpin-helix DNA-binding motif class 1
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Prepilin type IV endopeptidase peptidase
Putative regulatory protein FmdB Zinc ribbon
Phosphomannose isomerase type I catalytic
Nicotinamide phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Large ribosomal subunit protein uL6 alpha-beta
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Butirosin biosynthesis protein H N-terminal
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
ATP synthase F1 complex delta/epsilon subunit N-terminal
CobB/CobQ-like glutamine amidotransferase
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Endoribonuclease L-PSP/chorismate mutase-like
Removed in mature form; by autocatalysis
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
SUF system FeS cluster assembly SufBD N-terminal
Release factor glutamine methyltransferase N-terminal
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Cytochrome oxidase subunit II copper A binding
Alpha-glycerophosphate oxidase C-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
DNA-3-methyladenine glycosylase AlkA N-terminal