FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Major facilitator superfamily (MFS) profile
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Gram-positive cocci surface proteins LPxTG
Gram-positive cocci surface proteins LPxTG domain-containing protein
Alpha-D-phosphohexomutase alpha/beta/alpha
SUF system FeS cluster assembly SufBD N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Heat-inducible transcription repressor HrcA C-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Glycosyltransferase subfamily 4-like N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
N6 adenine-specific DNA methyltransferase N-terminal
ABC transporter substrate-binding protein PnrA-like
Gfo/Idh/MocA-like oxidoreductase N-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Na+/H+ antiporter MnhB subunit-related protein
Alpha-glycerophosphate oxidase C-terminal
Ricin B lectin domain-containing protein
Moves into active site upon enzyme activation, plays a role in electron transfer
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Tryptophan synthase beta chain-like PALP
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Transposase IS204/IS1001/IS1096/IS1165 DDE
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Glycoside hydrolase family 42 N-terminal
Helix-hairpin-helix DNA-binding motif class 1
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
TrbL/VirB6 plasmid conjugal transfer protein
Bacterial bifunctional deaminase-reductase C-terminal
Chromosomal replication initiator DnaA C-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Endoribonuclease L-PSP/chorismate mutase-like
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Important for substrate specificity; cannot use PPi as phosphoryl donor
Cytochrome b561 bacterial/Ni-hydrogenase
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Activator of Hsp90 ATPase homologue 1-like C-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Phosphotransferase system enzyme I N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Thymidylate synthase/dCMP hydroxymethylase
Inner membrane protein YgaP-like transmembrane
Peptide methionine sulphoxide reductase MsrA
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Formamidopyrimidine-DNA glycosylase catalytic
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Polymerase/histidinol phosphatase N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Glycosyl transferase family 3 N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Acyl-CoA dehydrogenase/oxidase N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
RNA polymerase sigma factor 70 region 4 type 2
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Could be important to modulate the pK values of the two catalytic cysteine residues
Prokaryotic-type class I peptide chain release factors
Peptidase M1 membrane alanine aminopeptidase
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Cytochrome C biogenesis protein transmembrane
Reversibly protonated during proton transport
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Essential for prephenate dehydratase activity
Cation-transporting P-type ATPase N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Transposase IS116/IS110/IS902 C-terminal
Penicillin-binding protein transpeptidase
Schiff-base intermediate with D-ribose 5-phosphate
Gfo/Idh/MocA-like oxidoreductase C-terminal
Shikimate dehydrogenase substrate binding N-terminal
DNA-directed DNA polymerase family A palm
Aromatic amino acid beta-eliminating lyase/threonine aldolase
YbaK/aminoacyl-tRNA synthetase-associated
Schiff-base intermediate with acetaldehyde
Acyl-CoA dehydrogenase/oxidase C-terminal
General stress protein FMN-binding split barrel
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
ABC-type glycine betaine transport system substrate-binding
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Interaction with polymerase core subunit RpoC
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Phosphatidic acid phosphatase type 2/haloperoxidase
Periplasmic binding protein domain-containing protein
ATP synthase F1 complex delta/epsilon subunit N-terminal
Nitrite/Sulfite reductase ferredoxin-like
SsuA/THI5-like domain-containing protein
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Cytochrome b/b6 N-terminal region profile
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Sporulation transcription regulator WhiA N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Phosphomannose isomerase type I catalytic
Release factor glutamine methyltransferase N-terminal
DNA primase/polymerase bifunctional N-terminal
Glucose-6-phosphate isomerase prokaryote
Protein O-mannosyl-transferase C-terminal four TM
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Type I restriction modification DNA specificity
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Gamma-glutamylcyclotransferase AIG2-like
NADH-rubredoxin oxidoreductase C-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Phosphocysteine intermediate; for EIIB activity
Extradiol ring-cleavage dioxygenase LigAB LigA subunit
Transcriptional regulator LacI/GalR-like sensor
Putative oxidoreductase/dehydrogenase Rossmann-like
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Siderophore-interacting protein C-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-138)
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Mandelate racemase/muconate lactonizing enzyme C-terminal
Solute-binding protein family 3/N-terminal domain-containing protein
Solute-binding protein family 5 domain-containing protein
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Alanyl-transfer RNA synthetases family profile
Translation elongation factor P/YeiP central
Exonuclease VII large subunit C-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Solute-binding protein family 3/N-terminal
Mannose-6-phosphate isomerase type II C-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Heme-copper oxidase subunit III family profile
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Positions MEP for the nucleophilic attack
Resolvase/invertase-type recombinase catalytic
Methylene-tetrahydrofolate reductase C-terminal
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Septum formation-related domain-containing protein
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Polysaccharide chain length determinant N-terminal
Glycine cleavage T-protein C-terminal barrel
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Cell envelope-related transcriptional attenuator
4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase-like C-terminal
Plays an important role in substrate specificity
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Putative regulatory protein FmdB Zinc ribbon
Large ribosomal subunit protein uL6 alpha-beta
RNA 2-O ribose methyltransferase substrate binding
Large ribosomal subunit protein uL2 C-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Lipoprotein LpqB beta-propeller domain-containing protein
Pyrroline-5-carboxylate reductase dimerisation
CagE TrbE VirB component of type IV transporter system central
Threonine/serine exporter-like N-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Phosphatidate phosphatase APP1 catalytic
Phenol hydroxylase C-terminal dimerisation
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
DNA replication/recombination mediator RecO N-terminal
Phosphoribosylformylglycinamidine synthase linker
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Methylguanine DNA methyltransferase ribonuclease-like
Ribose-phosphate pyrophosphokinase N-terminal
Sugar ABC transporter substrate-binding protein
Alpha-L-glutamate ligase-related protein ATP-grasp
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
S-adenosyl-L-homocysteine hydrolase NAD binding
O-(5'-phospho-DNA)-tyrosine intermediate
Nitrate ABC transporter substrate-binding protein
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Pseudouridine synthase I TruA alpha/beta
Prepilin type IV endopeptidase peptidase
Proton acceptor; for glutaminase activity
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Signal recognition particle SRP54 helical bundle
Pyrimidine nucleoside phosphorylase C-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA dehydrogenase-like C-terminal
NIF system FeS cluster assembly NifU N-terminal
Large ribosomal subunit protein uL15/eL18
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Small ribosomal subunit protein uS4 N-terminal
Gram-positive pilin subunit D1 N-terminal
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Adaptive response protein AidB N-terminal
Bacterial type II secretion system protein E
Pyruvate dehydrogenase E1 component middle
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Cytochrome oxidase subunit II copper A binding
Electron transfer via tryptophanyl radical
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding