Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Aminoacyl-transfer RNA synthetases class-II family profile
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Flagellar motor switch protein FliN-like C-terminal
Penicillin-binding protein transpeptidase
Mandelate racemase/muconate lactonizing enzyme C-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
DNA polymerase III delta subunit C-terminal
Threonine/serine exporter-like N-terminal
Acyltransferase MbtK/IucB-like conserved
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Electron transfer via tryptophanyl radical
Schiff-base intermediate with substrate; via pyruvic acid
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Cation-transporting P-type ATPase N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Flagellar assembly protein FliH/Type III secretion system HrpE
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Proton acceptor; for glutaminase activity
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Tellurite resistance methyltransferase TehB-like
O-(3'-phospho-DNA)-tyrosine intermediate
Solute-binding protein family 3/N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Polysaccharide chain length determinant N-terminal
Major facilitator superfamily (MFS) profile
Gamma-glutamylcyclotransferase AIG2-like
Survival protein SurE-like phosphatase/nucleotidase
Arginine decarboxylase C-terminal helical
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Essential for prephenate dehydratase activity
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
RND efflux pump membrane fusion protein barrel-sandwich
Pyruvate dehydrogenase E1 component middle
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Prepilin type IV endopeptidase peptidase
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Acyl-ester intermediate; for transpeptidase activity
Proton donor; for transglycosylase activity
Transglycosylase PBP1b N-terminal transmembrane
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Hydroxymethylglutaryl-coenzyme A synthase C-terminal
Hydroxymethylglutaryl-coenzyme A synthase N-terminal
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
RNA 2-O ribose methyltransferase substrate binding
Gp5/Type VI secretion system Vgr protein OB-fold
Ion-translocating oxidoreductase complex subunit G
Carbamoyl-phosphate synthase small subunit N-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Tryptophan synthase beta chain-like PALP
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Molybdopterin cofactor biosynthesis C (MoaC)
Phosphoadenosine phosphosulphate reductase
DNA mismatch repair proteins mutS family
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
TonB-dependent receptor-like beta-barrel
4'-phosphopantetheinyl transferase N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Translation elongation factor P/YeiP central
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
DNA polymerase III subunit delta C-terminal
Bacterial type II secretion system protein E
Phosphoethanolamine transferase N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Cytochrome b561 bacterial/Ni-hydrogenase
Nucleophile; cysteine thiosulfonate intermediate
Regulator of nucleoside diphosphate kinase N-terminal
Periplasmic binding protein/LacI sugar binding
The binding site for the sugar molecule has not yet been established, but C-87 may be involved
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Quercetin 2,3-dioxygenase C-terminal cupin
Shikimate dehydrogenase substrate binding N-terminal
Antitoxin Xre/MbcA/ParS-like toxin-binding
Signal transduction histidine kinase 5TM receptor LytS transmembrane region
Signal transduction histidine kinase internal region
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
Tetrahydrodipicolinate-N-succinyltransferase chain A
Gfo/Idh/MocA-like oxidoreductase N-terminal
Glycine cleavage T-protein C-terminal barrel
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Peptide methionine sulphoxide reductase MsrA
Plays an important role in discriminating NADH against NADPH
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Thiol:disulfide interchange protein DsbD
High-affinity zinc uptake system protein ZnuA
Lysidine-tRNA(Ile) synthetase C-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Large ribosomal subunit protein uL6 alpha-beta
Reversibly protonated during proton transport
Phosphotransferase system enzyme I N-terminal
DNA replication/recombination mediator RecO N-terminal
Translocation and assembly module subunit TamA
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Heme-copper oxidase subunit III family profile
Small ribosomal subunit protein uS4 N-terminal
Large ribosomal subunit protein bL25 L25
Chromosomal replication initiator DnaA C-terminal
Erythronate-4-phosphate dehydrogenase dimerisation
DNA-directed DNA polymerase family A palm
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
HicB-like antitoxin of toxin-antitoxin system
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Aminoacyl-tRNA synthetase class I anticodon-binding
Penicillin-binding protein activator LpoB
Aspartate/homoserine dehydrogenase NAD-binding
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Appears to be important in orienting the phosphate for catalysis
Phosphocysteine intermediate; for EIIB activity
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
RNA polymerase sigma factor 70 region 4 type 2
Glycosyl transferase family 3 N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Chromosomal replication initiator protein DnaA
Could play a key role in the communication between the regulatory and the substrate sites
Lipopolysaccharide export system protein LptA
Organic solvent tolerance-like N-terminal
Sugar fermentation stimulation protein C-terminal
Disulphide bond isomerase DsbC/G N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Large ribosomal subunit protein uL15/eL18
Peptidase S9 prolyl oligopeptidase catalytic
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Involved in allosteric activation by GTP
Alanyl-transfer RNA synthetases family profile
DNA-directed DNA polymerase family B exonuclease
DNA-directed DNA polymerase family B multifunctional
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Sodium/calcium exchanger membrane region
O-(5'-phospho-DNA)-tyrosine intermediate
Integral membrane protein YccS N-terminal
Large ribosomal subunit protein uL2 C-terminal
Transcriptional regulator AbiEi antitoxin N-terminal
Mechanosensitive ion channel inner membrane
Glucose-methanol-choline oxidoreductase N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Non-canonical purine NTP phosphatase/PRRC1
Ionotropic glutamate receptor C-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Phosphomannose isomerase type I C-terminal
Phosphomannose isomerase type I catalytic
Phosphomannose isomerase type I helical insertion
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
ABC-type glycine betaine transport system substrate-binding
Alpha-glycerophosphate oxidase C-terminal
D-galactose/methyl-galactoside binding periplasmic protein MglB
Flagellar motor switch protein FliN N-terminal
SUF system FeS cluster assembly SufBD N-terminal
Essential for degradation by Lon protease
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Gfo/Idh/MocA-like oxidoreductase C-terminal
NIF system FeS cluster assembly NifU C-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Ribosomal RNA adenine methylase transferase N-terminal
Greasy slide, important in sugar transport
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
Could be important to modulate the pK values of the two catalytic cysteine residues
Cysteine sulfenic acid (-SOH) intermediate
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Interaction with polymerase core subunit RpoC
Outer membrane protein assembly factor BamE
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Phosphatidic acid phosphatase type 2/haloperoxidase
Outer-membrane lipoprotein carrier protein
Alpha-D-phosphohexomutase alpha/beta/alpha
Type II secretion system protein GspG C-terminal
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Membrane fusion protein biotin-lipoyl like
Glutathionylspermidine synthase pre-ATP-grasp-like
Lytic transglycosylase superhelical linker
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
For 3-hydroxyacyl-CoA dehydrogenase activity
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Chromosome partition protein MukF C-terminal
Chromosome partition protein MukF middle
Chromosome partition protein MukF winged-helix
Transcriptional regulator SgrR N-terminal HTH
Plays an important role in substrate specificity
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Major facilitator superfamily associated
NIF system FeS cluster assembly NifU N-terminal
Gly-cisPro motif, important for rejection of L-amino acids
ABC-type transport auxiliary lipoprotein component
Proline utilization A proline dehydrogenase N-terminal