Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Glycosyl transferase family 3 N-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
UDP N-acetylglucosamine O-acyltransferase C-terminal
Twin-arginine translocation pathway signal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Cytochrome b561 bacterial/Ni-hydrogenase
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Tryptophan synthase beta chain-like PALP
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Interaction with polymerase core subunit RpoC
Polysaccharide biosynthesis protein CapD-like
Phosphoadenosine phosphosulphate reductase
RND efflux pump membrane fusion protein barrel-sandwich
NAD(P) transhydrogenase alpha subunit C-terminal
Aldehyde ferredoxin oxidoreductase N-terminal
Polysaccharide chain length determinant N-terminal
Ribosomal RNA small subunit methyltransferase A
Major facilitator superfamily (MFS) profile
Polyribonucleotide nucleotidyltransferase
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Transposase IS116/IS110/IS902 C-terminal
FAD-dependent oxidoreductase 2 FAD binding
Glycosyltransferase subfamily 4-like N-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Important for interaction with partner proteins
Cation-transporting P-type ATPase N-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Putative iron-sulfur cluster insertion protein ErpA 1
Heat-inducible transcription repressor HrcA
Imidazole glycerol phosphate synthase subunit HisF
ABC transporter substrate-binding protein PnrA-like
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Prokaryotic-type class I peptide chain release factors
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Peptide methionine sulfoxide reductase MsrB
Bacterial type II secretion system protein E
Large-conductance mechanosensitive channel
Poly-beta-hydroxybutyrate polymerase N-terminal
Extradiol ring-cleavage dioxygenase LigAB LigA subunit
Electron transfer flavoprotein alpha/beta-subunit N-terminal
NADPH-dependent 7-cyano-7-deazaguanine reductase
YbaK/aminoacyl-tRNA synthetase-associated
Schiff-base intermediate with substrate; via pyruvic acid
Cytochrome C biogenesis protein transmembrane
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Proton acceptor; for glutaminase activity
TRAP C4-dicarboxylate transport system permease DctM subunit
RNA 2-O ribose methyltransferase substrate binding
Solute-binding protein family 3/N-terminal
Probable transposase IS891/IS1136/IS1341
N6 adenine-specific DNA methyltransferase N-terminal
Succinate--CoA ligase [ADP-forming] subunit beta
Pyridoxine/pyridoxamine 5'-phosphate oxidase
Malonate/sodium symporter MadM subunit N-terminal
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Penicillin-binding protein transpeptidase
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
FMN-dependent NADH:quinone oxidoreductase
Mannose-6-phosphate isomerase type II C-terminal
Virulence factor membrane-bound polymerase C-terminal
Glycerol-3-phosphate dehydrogenase [NAD(P)+]
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
Interacts with tRNA; defines subfamily-specific binding signature
Ribosomal protein uS12 methylthiotransferase RimO
Could play a key role in the communication between the regulatory and the substrate sites
Transposase DDE domain-containing protein
3-deoxy-manno-octulosonate cytidylyltransferase
Quinoprotein dehydrogenase-associated SoxYZ-like carrier
Pyridoxamine 5'-phosphate oxidase putative
Release factor glutamine methyltransferase N-terminal
Polypeptide-transport-associated ShlB-type
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Putative regulatory protein FmdB Zinc ribbon
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC
Resolvase/invertase-type recombinase catalytic
Polymerase/histidinol phosphatase N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Calcium/calmodulin-dependent protein kinase II association-domain
Formate-dependent phosphoribosylglycinamide formyltransferase
RNA polymerase sigma factor 70 region 4 type 2
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Diacylglycerol glucosyltransferase N-terminal
Glycosyl transferase family 28 C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Essential for prephenate dehydratase activity
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Dinitrogenase iron-molybdenum cofactor biosynthesis
S-adenosyl-L-homocysteine hydrolase NAD binding
UDP-3-O-acyl-N-acetylglucosamine deacetylase
Quercetin 2,3-dioxygenase C-terminal cupin
Abortive infection protein-like C-terminal
Urease accessory protein UreH-like transmembrane
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
NIF system FeS cluster assembly NifU N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Outer membrane protein assembly factor BamA
Putative iron-sulfur cluster insertion protein ErpA 2
DNA-directed RNA polymerase subunit beta
Reversibly protonated during proton transport
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
DNA-directed RNA polymerase subunit omega
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Na+/H+ antiporter MnhB subunit-related protein
Positions MEP for the nucleophilic attack
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Helix-hairpin-helix DNA-binding motif class 1
Calcineurin-like phosphoesterase domain-containing protein
Serine aminopeptidase S33 domain-containing protein
Potassium-transporting ATPase potassium-binding subunit
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
RND efflux pump membrane fusion protein barrel-sandwich domain-containing protein
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
Nitrogenase molybdenum-iron protein beta chain N-terminal
Phosphogluconate dehydrogenase NAD-binding putative C-terminal
3-isopropylmalate dehydratase small subunit
2-dehydro-3-deoxyphosphooctonate aldolase
Gp5/Type VI secretion system Vgr protein OB-fold
Holliday junction branch migration complex subunit RuvB
Cobalt-precorrin-5B C(1)-methyltransferase
Probable 5-dehydro-4-deoxyglucarate dehydratase
Ribose-phosphate pyrophosphokinase N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
EfeO-type cupredoxin-like domain-containing protein
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Nitrogenase-stabilizing/protective protein NifW
Adaptive response protein AidB N-terminal
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Protein-methionine-sulfoxide reductase heme-binding subunit MsrQ
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Nitrite/Sulfite reductase ferredoxin-like
Lipopolysaccharide export system protein LptA
Organic solvent tolerance-like N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Chromosomal replication initiator DnaA C-terminal
Transcription elongation factor GreA/GreB C-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Ribosomal RNA small subunit methyltransferase H
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Endolytic peptidoglycan transglycosylase RlpA
RlpA-like protein double-psi beta-barrel
O-(5'-phospho-DNA)-tyrosine intermediate
Phosphatidic acid phosphatase type 2/haloperoxidase
5-glutamyl coenzyme A thioester intermediate
CNP1-like uncharacterized domain-containing protein
Mandelate racemase/muconate lactonizing enzyme C-terminal
4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase-like C-terminal
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Important for autoinhibition of adenylyltransferase activity
Heme-copper oxidase subunit III family profile
Phosphoethanolamine transferase N-terminal
Required for dimer formation and molybdate binding
DNA polymerase III beta sliding clamp central
Dual-specificity RNA methyltransferase RlmN
Tetrahydrodipicolinate-N-succinyltransferase chain A
Inner membrane protein YgaP-like transmembrane
SD-repeat containing protein B domain-containing protein
Meta-pathway phenol degradation-like protein
Phage terminase large subunit GpA ATPase
Terminase large subunit GpA endonuclease
Sec-independent protein translocase protein TatB
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Putative phosphoenolpyruvate synthase regulatory protein
DNA-directed DNA polymerase family A palm
Molybdopterin cofactor biosynthesis C (MoaC)
Alpha-D-phosphohexomutase alpha/beta/alpha
Ionotropic glutamate receptor C-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Signal recognition particle SRP54 helical bundle
Glucose-methanol-choline oxidoreductase N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
DNA-directed RNA polymerase subunit alpha
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
Cell division topological specificity factor
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Beta-ketoacyl-[acyl-carrier-protein] synthase III
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
HicB-like antitoxin of toxin-antitoxin system
3-isopropylmalate dehydratase large subunit
Outer-membrane lipoprotein carrier protein
Aminoacyl-transfer RNA synthetases class-II family profile
Pili assembly chaperone N-terminal domain-containing protein
Crossover junction endodeoxyribonuclease RuvC
Cysteine sulfenic acid (-SOH) intermediate
Type II secretion system protein GspI C-terminal
Ribosomal RNA small subunit methyltransferase G
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Toxin co-regulated pilus biosynthesis protein Q C-terminal
Adenosylcobinamide-GDP ribazoletransferase
Exonuclease VII large subunit C-terminal
NADH-rubredoxin oxidoreductase C-terminal
DNA-directed RNA polymerase subunit beta'
6-phosphogluconate dehydrogenase C-terminal
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Plays an important role in substrate specificity
Potassium-transporting ATPase KdpC subunit
Transcription elongation factor GreA/GreB N-terminal
Glucose-methanol-choline oxidoreductase C-terminal
Glycine cleavage T-protein C-terminal barrel
Glyoxalase/fosfomycin resistance/dioxygenase
High potential iron-sulfur proteins family profile
Membrane fusion protein biotin-lipoyl like
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Gly-cisPro motif, important for rejection of L-amino acids
CagE TrbE VirB component of type IV transporter system central
Terminase large subunit gp17-like C-terminal
Required for zinc-mediated homotetramerization and catalytic activity
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Peptidase S9 prolyl oligopeptidase catalytic
Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein
tRNA N6-adenosine threonylcarbamoyltransferase
NADH:flavin oxidoreductase/NADH oxidase N-terminal
CobB/CobQ-like glutamine amidotransferase
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase
Phosphoribosyltransferase domain-containing protein
Sodium/calcium exchanger membrane region
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
ATP-dependent Clp protease ATP-binding subunit ClpX
Endoribonuclease L-PSP/chorismate mutase-like
ABC-type transport auxiliary lipoprotein component
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Anthranilate synthase component I N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Sec-independent protein translocase protein TatA
ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Biopterin-dependent aromatic amino acid hydroxylase family profile
NarX-like N-terminal domain-containing protein
Phosphoribosylaminoimidazole-succinocarboxamide synthase
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase
Pyrimidine/purine nucleoside phosphorylase
TrbL/VirB6 plasmid conjugal transfer protein
Nucleophile; cysteine thiosulfonate intermediate
Cytochrome c-type biogenesis protein CcmE
Helical; Signal-anchor for type II membrane protein
Gamma-butyrobetaine hydroxylase-like N-terminal
RNA binding; important for wobble base 34 recognition
Outer membrane protein assembly factor BamD
Glutamate-1-semialdehyde 2,1-aminomutase
Probable potassium transport system protein Kup
Oxygen-dependent coproporphyrinogen-III oxidase
Lipopolysaccharide assembly protein A domain-containing protein
Transposase IS204/IS1001/IS1096/IS1165 DDE
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Type I restriction modification DNA specificity
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
D-(-)-3-hydroxybutyrate oligomer hydrolase
Peptide methionine sulphoxide reductase MsrA
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
O-(phosphoribosyl dephospho-coenzyme A)serine
Anti-bacteriophage protein A/HamA C-terminal
Ribosomal RNA large subunit methyltransferase H
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Cytochrome c-type biogenesis protein CcmF C-terminal
Prepilin type IV endopeptidase peptidase
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG
SGNH hydrolase-type esterase domain-containing protein
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
HupH hydrogenase expression protein C-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
UDP-3-O-acylglucosamine N-acyltransferase
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Moybdenum cofactor oxidoreductase dimerisation
Isocitrate dehydrogenase kinase/phosphatase
Phosphotransferase system enzyme I N-terminal
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Pyruvate dehydrogenase E1 component middle
PhoD-like phosphatase metallophosphatase