Cysteine-rich interdomain region 1 gamma
Plasmodium falciparum erythrocyte membrane protein 1 acidic terminal segment
Plasmodium falciparum erythrocyte membrane protein-1 N-terminal segment
Proteasome activator complex subunit 4 C-terminal
Large ribosomal subunit protein uL18 C-terminal eukaryotes
Cation-transporting P-type ATPase N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Ancestral coatomer element 1 Sec16/Sec31
ATP-dependent Clp protease proteolytic subunit
DNA polymerase epsilon catalytic subunit A C-terminal
Trafficking protein particle complex subunit 5
Prokaryotic-type class I peptide chain release factors
Homologous-pairing protein 2 winged helix
Ubiquitin-activating enzyme E1 C-terminal
Phosphatidylserine amidated glycine; alternate
Helical; Signal-anchor for type II membrane protein
Slight reduction in catalytic efficiency towards a synthetic peptide.
No effect on lipoylation of BCKDH-E2/BCDH and KDH in the presence of LipL1.
GRIP and coiled-coil domain-containing protein
Important for the stable binding to the membranes
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Impairs homodimerization. 30-fold decrease in catalytic activity without affecting affinity for substrate 2-phosphoglyceric acid. Decreases affinity for Mg(2+).
No effect on homodimerization. Decreases catalytic activity without affecting affinity for substrate 2-phosphoglyceric acid. Loss of Mg(2+) binding.
Reduces homodimerization efficiency. Decreases catalytic activity without affecting affinity for substrate 2-phosphoglyceric acid. Loss of Mg(2+) binding.
Large ribosomal subunit protein uL15/eL18
May act as a substrate filter by repelling compounds with a negatively charged alpha-carboxylate
Activator of Hsp90 ATPase AHSA1-like N-terminal
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
DNA-directed DNA polymerase family A palm
Critical for specifying symmetric addition of methyl groups
2.5-fold reduction in affinity for dTMP. 2.6-fold reduction in affinity for dGMP.
4 to 5-fold decrease in affinity for dTMP and dGMP. 6-fold decrease in catalytic efficiency with dTMP as substrate. 65-fold decrease in catalytic efficiency with dGMP as substrate.
8-fold decrease in affinity for dTMP. 4-fold decrease in affinity for dGMP. 439-fold decrease in catalytic efficiency with dGMP as substrate.2000-fold decrease in catalytic efficiency with dGMP as substrate.
Loss of thymidylate and guanylate kinase activities.
No defect in thymidylate kinase activity. 1.3-fold reduction in affinity for dGMP.
No defect in thymidylate kinase activity. 2.1-fold reduction in affinity for dGMP.
Serine/threonine specific protein phosphatases
cGMP-specific 3',5'-cyclic phosphodiesterase delta
GPI-GlcNAc transferase complex PIG-H component conserved
Interaction with phosphoserine on interacting protein
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial
Probable DNA-directed RNA polymerase II subunit RPB11
No effect on nuclease activity; when associated with A-32, A-41, A-76 and A-100.
No effect on nuclease activity; when associated with A-32, A-41, A-76 and A-99.
No effect on nuclease activity; when associated with A-32, A-41, A-99 and A-100.
No effect on nuclease activity; when associated with A-32, A-76, A-99 and A-100.
No effect on nuclease activity; when associated with A-41, A-76, A-99 and A-100.
No effect on nuclease activity; when associated with A-57 and A-68.
No effect on nuclease activity; when associated with A-57 and A-93.
No effect on nuclease activity; when associated with A-68 and A-93.
Results in a significant loss of nuclease activity.
Results in a significant loss of the binding with DNA, loss of cooperativity and nuclease activity.
12-fold reduction in affinity for TRX1 and 25-fold decrease in catalytic efficiency.
7-fold reduction in affinity for TRX1 and 16-fold decrease in catalytic efficiency.
Loop important for the interaction with TRX1
No effect on affinity for TRX1 and 2-fold decrease in catalytic efficiency.
11-fold reduction in affinity for L-arginine. Loss of oligomerization.
2.5-fold decrease in affinity for L-arginine.
3.4-fold reduction in affinity for L-arginine. Loss of oligomerization.
Loss of catalytic activity and loss of oligomerization; when associated with A-323.
Loss of catalytic activity and loss of oligomerization; when associated with A-325.
Loss of catalytic activity. Loss of oligomerization.
Loss of catalytic activity. No defect in oligomerization.
Severe loss of catalytic activity. Loss of oligomerization.
Severe loss of catalytic activity. Oligomerization is partially reduced.
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Reticulocyte-binding protein homolog 1 120 kDa form
Reticulocyte-binding protein homolog 1 240 kDa form
Tyrosine-protein kinase ephrin type A/B receptor-like
CBF1-interacting co-repressor CIR N-terminal
ATP-grasp fold succinyl-CoA synthetase-type
Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate
Schiff-base intermediate with dihydroxyacetone-P
Vacuolar protein sorting-associated protein 26
Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange
Spindle assembly abnormal protein 6 N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Complete loss of deubiquitinating and deneddylating activities.
Crossover loop which restricts access of large ubiquitin adducts to the active site
Small increase in deubiquitinating and deneddylating activities. Small reduction in deubiquitinating and deneddylating activities; when associated with E-33.
Small reduction in deubiquitinating and deneddylating activities. Small reduction in deubiquitinating and deneddylating activities; when associated with D-13.
Ubiquitin carboxyl-terminal hydrolase UCHL3
Clathrin/coatomer adaptor adaptin-like N-terminal
Coatomer beta subunit appendage platform
Erythrocyte binding antigen 175 C-terminal
cGMP-specific 3',5'-cyclic phosphodiesterase alpha
Large ribosomal subunit protein uL6 alpha-beta
RNA polymerase II-associated protein 1 C-terminal
Inhibitor of growth protein N-terminal histone-binding
Anaphase-promoting complex subunit 4-like WD40
Structural maintenance of chromosomes protein 3 homolog
Conserved oligomeric Golgi complex subunit 2 N-terminal
SAM-dependent methyltransferase TRM5/TYW2-type
DNA-directed RNA polymerase subunit 2 hybrid-binding
Ribose-phosphate pyrophosphokinase N-terminal
Loss of N-glycosylation; when associated with D-145 and D-322.
Loss of N-glycosylation; when associated with D-145 and D-338.
Loss of N-glycosylation; when associated with D-322 and D-338.
Prevents the interaction with c2 neutralizing antibodies.
Iron hydrogenase large subunit C-terminal
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
PhoD-like phosphatase metallophosphatase
Cleavage/polyadenylation specificity factor A subunit C-terminal
Coiled-coil domain-containing protein PF3D7_1144200
Translation elongation factor P/YeiP central
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Histone-binding protein RBBP4 N-terminal
Eukaryotic translation initiation factor 2-alpha kinase 1
Tryptophan/threonine-rich plasmodium antigen C-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Plasmodium RESA N-terminal domain-containing protein
RNA 2-O ribose methyltransferase substrate binding
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Merozoite surface protein P12, processed form
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Putative chloroquine resistance transporter
Large ribosomal subunit protein uL10-like insertion
Plasmodium-specific profilin mini-domain
Dihydroorotate dehydrogenase (quinone), mitochondrial
Fewer and larger knobs. No EMP1 at the erythrocyte cell surface. Increase in the number of vesicles at the Maurer's clefts. PTP7 appears to be mislocalized.
No significant effect on knob density and knob diameter. 32-percent reduction in EMP1 at the erythrocyte cell surface.
Slight decrease in knob density and slight increase in knob diameter. 65-percent reduction in EMP1 at the erythrocyte cell surface. PTP7 appears to be mislocalized.
Condensin II complex subunit H2 N-terminal
Aspartyl/Glutamyl-tRNA(Gln) amidotransferase subunit B/E catalytic
Loss of myristoylation. Loss of myristoylation; when associated with A-3.
Loss of myristoylation; when associated with A-2.
Glycerol-3-phosphate dehydrogenase [NAD(+)]
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase beta
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
10-fold decrease in substrate affinity and 20-fold decrease in activity.
3-fold decrease in substrate affinity and 2-fold decrease in activity.
Greater than 10-fold decrease in activity.
Bifunctional glucose-6-phosphate 1-dehydrogenase/6-phosphogluconolactonase
Schiff-base intermediate with acetaldehyde
A-kinase anchor protein 7-like phosphoesterase
Dynein heavy chain hydrolytic ATP-binding dynein motor region
Beta-adaptin appendage C-terminal subdomain
3-hydroxyacyl-[acyl-carrier-protein] dehydratase
Basic cluster involved in membrane binding
Does not affect myristoylation. Severe reduction in membrane binding. Loss of membrane binding; when associated with V-2.
J domain interacts with the EF-hand domains
Loss of myristoylation. Severe reduction in membrane binding. Loss of membrane binding; when associated with 10-K--T-20 DEL.
Loss of phosphorylation. Loss of catalytic activity.
Loss of phosphorylation. No effect on catalytic activity.
Phospho-mimetic mutant.No effect on catalytic activity.
Phosphothreonine; by PKG; by autocatalysis
Severe loss of ATP binding. Partial loss of catalytic activity.
Vacuolar protein 14 C-terminal Fig4-binding
No effect on GAP45 phosphorylation by CDPK1.
No effect on GAP45 phosphorylation levels.
No effect on GAP45 phosphorylation levels. Severe reduction in GAP45 phosphorylation levels; when associated with A-103. Reduces phosphorylation by CDPK1.
Severe reduction in GAP45 phosphorylation levels. Further reduction in GAP45 phosphorylation levels; when associated with A-103. Loss of phosphorylation by PKB. Reduces phosphorylation by CDPK1.
Targets GAP45 to the cell membrane; however, dispensable for the formation of the glideosome complex and the association with the inner membrane complex
Cleavage/polyadenylation specificity factor A subunit N-terminal
Pre-mRNA-processing-splicing factor 8 U5-snRNA-binding
Pre-mRNA-processing-splicing factor 8 U6-snRNA-binding
TATA box binding protein associated factor (TAF) histone-like fold
16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal
Translationally-controlled tumor protein homolog
Increases catalytic activity and chitin binding. Loss of catalytic activity and chitin binding; when associated with S-220 and S-230.
Loss of catalytic activity. Loss of chitin binding. Loss of catalytic activity and chitin binding; when associated with S-203 and S-220.
Loss of catalytic activity. Loss of chitin binding. Loss of catalytic activity and chitin binding; when associated with S-203 and S-230.
Normal ookinete formation but the formation of oocysts in A.freeborni midguts is impaired. Loss of apical localization in the ookinete. Normal gametocytogenesis and exflagellation.
Apoptosis-antagonizing transcription factor C-terminal
Small nuclear ribonucleoprotein Prp3 C-terminal
Tyrosine-protein kinase ephrin type A/B receptor-like domain-containing protein
Polyribonucleotide 5'-hydroxyl-kinase Clp1 P-loop
Vacuolar protein sorting-associated protein 13 DH-like
Pre-mRNA processing factor 4 (PRP4)-like
Major facilitator superfamily (MFS) profile
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
proton-translocating NAD(P)(+) transhydrogenase
FACT complex subunit Spt16 N-terminal lobe
Histone chaperone RTT106/FACT complex subunit SPT16-like middle
Small ribosomal subunit protein mS35 mitochondrial conserved
Small ribosomal subunit protein uS15 N-terminal
Translation initiation factor beta propellor-like
NIF system FeS cluster assembly NifU N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Glycoside hydrolase 35 catalytic domain-containing protein
Helix-hairpin-helix DNA-binding motif class 1
Required for peripherial nuclear localization
U2A'/phosphoprotein 32 family A C-terminal
172-fold decrease in affinity for glutamine. Severe loss of glutaminase activity.
2.7-fold decrease in affinity for glutamine. No defect in glutaminase activity.
2.9-fold decrease in affinity for ATP and 1.9-fold decrease in affinity for XMP; when associated with A-89.
20 percent decrease in glutaminase activity. 4.4-fold decrease in affinity for glutamine. 1.8-fold decrease in affinity for XMP.
20 percent decrease in glutaminase activity. No effect on GMP formation.
30 percent decrease in glutaminase activity. 7.9-fold decrease in affinity for glutamine.
35 percent decrease in glutaminase activity. 3.6-fold decrease in affinity for glutamine.
40 percent decrease in glutaminase activity. 1.4-fold decrease in affinity for glutamine. 1.3-fold decrease in affinity for ATP. 1.8-fold decrease in affinity for XMP.
50 percent decrease in glutaminase activity. 5.3-fold decrease in affinity for glutamine. 1.7-fold increase in affinity for ATP. 2.8-fold decrease in affinity for XMP.
70 percent decrease in glutaminase activity. Loss of GMP formation.
8.9-fold decrease in affinity for ammonia. Severe loss of glutaminase activity.
85 percent decrease in glutaminase activity.
Impaired formation of adenyl-XMP intermediate. Slight increase in glutaminase activity.
Increases glutaminase activity. 4.2-fold decrease in affinity for ATP.
Loss of ATP pyrophosphatase (ATPPase) activity. 67 percent decrease in glutaminase activity. Impaired GMP formation.
Loss of glutaminase activity, however, glutamine binding is not affected. In presence of exogenous ammonia, the amination of XMP to produce GMP is normal. 2.3-fold decrease in affinity for ATP and 1.8-fold decrease in affinity for XMP. 2.9-fold decrease in affinity for ATP and 1.9-fold decrease in affinity for XMP; when associated with A-113.
Moderate decrease in ATP pyrophosphatase (ATPPase) activity. Reduces 49 percent decrease in glutaminase activity. Impaired GMP formation.
No effect on ATP pyrophosphatase (ATPPase) activity. 20 percent decrease in glutaminase activity. No effect on GMP formation.
No effect on ATP pyrophosphatase (ATPPase) activity. Increases glutaminase activity. Loss of GMP formation.
No effect on glutaminase activity. 1.2-fold decrease in affinity for ATP. 1.8-fold decrease in affinity for XMP.
No effect on glutaminase activity. 1.4-fold decrease in affinity for glutamine.
Severe loss of ATP pyrophosphatase (ATPPase) activity. 80 percent decrease in glutaminase activity. Impaired GMP formation.
Slight decrease in affinity for glutamine. 1.8-fold increase in affinity for ATP. Slight increase in affinity for XMP. Moderate reduction in glutaminase activity.
Slight decrease in affinity for glutamine. Slight increase in glutaminase activity.
Slight increase in affinity for glutamine. No defect in glutaminase activity.
Decreases sensitivity towards inhibitors.
Important for nucleoside inhibitor binding
Ribosome maturation protein SDO1/SBDS N-terminal
NIF system FeS cluster assembly NifU C-terminal
DNA polymerase alpha/delta/epsilon subunit B
LamG-like jellyroll fold domain-containing protein
Methionyl-tRNA synthetase anticodon-binding
Peptidase S9 prolyl oligopeptidase catalytic
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Transcription factor IIIC subunit Tfc1/Sfc1 triple barrel
Leucine-rich repeat and coiled-coil domain-containing protein PF3D7_0703800
Pseudouridine synthase I TruA alpha/beta
6-phosphogluconate dehydrogenase C-terminal
Small ribosomal subunit protein uS17 N-terminal
Gly-cisPro motif, allows the protein to recognize chirality of D-amino acids
Loss of deacylation of D-tyrosyl-tRNA(Tyr), loss of deacylation of glycyl-tRNA(Gly), not toxic upon overexpression.
Loss of deacylation of D-tyrosyl-tRNA(Tyr), loss of deacylation of glycyl-tRNA(Gly).
Loss of deacylation of D-tyrosyl-tRNA(Tyr).
Partial loss of deacylation of D-tyrosyl-tRNA(Tyr).
Wild-type deacylation of D-tyrosyl-tRNA(Tyr).
Nucleolar GTP-binding protein 2 N-terminal
Dynein heavy chain ATP-binding dynein motor region
Structural maintenance of chromosomes protein 2
Acidic leucine-rich nuclear phosphoprotein 32-related protein
May be important for nuclear localization
No effect on homotrimerization and stability. Slight reduction in protein stability; when associated with A-191.
No effect on homotrimerization and stability. Slight reduction in protein stability; when associated with F-213.
Large ribosomal subunit protein bL12 C-terminal
Heptatricopeptide repeat-containing protein
Transcription elongation factor Spt6 helix-hairpin-helix motif
Glycosyl transferase family 28 C-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Programmed cell death protein 2 C-terminal
Gamma tubulin complex component C-terminal
Gamma tubulin complex component protein N-terminal
General stress protein FMN-binding split barrel
BC loop; binds and inhibits the active site cavity of cysteine proteases
No effect on the inhibition of FP3 protease activity.
Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)
Loss of catalytic activity. Blood stage parasites are not viable.
Probable U3 small nucleolar RNA-associated protein 11
Peptidase M1 membrane alanine aminopeptidase
Ribosomal RNA adenine methylase transferase N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Dipeptidyl aminopeptidase 1 exclusion domain chain
100-fold decrease in catalytic efficiency. 2-fold decrease in substrate affinity. Loss of hexamer formation with formation of dimers and trimers.
13-fold decrease in catalytic efficiency. 1.5-fold decrease in substrate affinity. No effect on hexamer formation.
16-fold decrease in catalytic efficiency. No effect on hexamer formation.
6.5-fold reduction in catalytic efficiency in the presence of Co(2+); 854-fold reduction in catalytic efficiency in the presence of Mn(2+); substrate affinity is slightly reduced; impairs formation of stable homohexamer; when associated with A-379.
6.5-fold reduction in catalytic efficiency in the presence of Co(2+); 854-fold reduction in catalytic efficiency in the presence of Mn(2+); substrate affinity is slightly reduced; impairs formation of stable homohexamer; when associated with L-461.
7.5-fold increase in catalytic efficiency. No effect on hexamer formation. 1.7-fold increase in substrate affinity.
8-fold decrease in catalytic efficiency. 3-fold decrease in substrate affinity. No effect on hexamer formation.
Loss of catalytic activity and impairs oligomerization; when associated with A-525.
Loss of catalytic activity and impairs oligomerization; when associated with A-533.
Activator of Hsp90 ATPase homologue 1-like C-terminal
Ubiquitin-like modifier-activating enzyme Atg7 N-terminal
Glycylpeptide N-tetradecanoyltransferase
Loss of apurinic/apyrimidinic (AP) endonuclease activity.
Loss of apurinic/apyrimidinic (AP) endonuclease activity. Loss of Mn(2+) binding. Impairs DNA binding.
MATH and LRR domain-containing protein PFE0570w
Schizont-infected cell agglutination C-terminal
Histone acetyl transferase HAT1 N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Cysteine sulfenic acid (-SOH) intermediate
Variant-silencing SET domain-containing protein
AP2/ERF domain-containing protein PFD0985w
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
Alpha-glycerophosphate oxidase C-terminal
Calcium-activated potassium channel BK alpha subunit
Does not stably interact with OAT and fails to increase OAT catalytic activity; when associated with S-33 or S-30 and S-33.
Does not stably interact with OAT and fails to increase OAT catalytic activity; when associated with S-33 or S-33 and S-43. Does not stably interact with SAHH; when associated with S-33.
Forms a stable disulfide intermediate with OAT. Fails to increase OAT catalytic activity. Does not stably interact with OAT and fails to increase OAT catalytic activity; when associated with S-30 and/or S-43. Forms a stable disulfide intermediate with SAHH. Does not stably interact with SAHH; when associated with S-30.
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Uncharacterized J domain-containing protein PF3D7_1401100
Queuine tRNA-ribosyltransferase-like protein
Alpha-D-phosphohexomutase alpha/beta/alpha
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
Glycine cleavage T-protein C-terminal barrel
CCR4-NOT transcription complex subunit 1
CCR4-NOT transcription complex subunit 1 TTP binding
CCR4-Not complex component Not1 C-terminal
Damage-control phosphatase ARMT1-like metal-binding
12% reduction in cGMP-mediated catalytic activity. Slight reduction in cGMP-mediated catalytic activity; when associated with A-133. Severe loss of cGMP-mediated catalytic activity; when associated with A-493 or A-133 and A-493.
4.5-fold reduction in affinity for ATP. No defect in schizogony during host erythrocyte invasion. However, Ca(2+) increase in response to cGMP is reduced in schizonts. Does not affect merozoite egress from host erythrocytes. Resistant to trisubstituted pyrrole compound 1 (C1) and imidazopyridine-based compound 2 (C2) inhibitors.
42% reduction in cGMP-mediated catalytic activity. Severe loss of cGMP-mediated catalytic activity; when associated with A-133, A-251 or A-133 and A-251.
55% loss in cGMP-mediated catalytic activity.
Has low catalytic activity in absence of cGMP.
Has low catalytic activity in absence of cGMP. Normal increase in catalytic activity in presence of cGMP.
Has low catalytic activity in absence of cGMP. cGMP binding is still required for full activation.
Loss of catalytic activity and irresponsive to cGMP, with peptides as substrates.
Low basal catalytic activity. Normal increase in catalytic activity in presence of cGMP.
No effect on cGMP-mediated catalytic activity. Slight reduction in cGMP-mediated catalytic activity; when associated with A-251. Severe loss of cGMP-mediated catalytic activity; when associated with A-493 or A-251 and A-493.
Part of a catalytic triad required for cGMP binding and cGMP-dependent kinase activity
Reduces affinity for cGMP and severe loss of kinase activity.
Transcription factor CBF/NF-Y/archaeal histone
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
12 X 10 AA tandem repeat of Q-T-E-I-[K/N]-N-D-[H/N/I][I/N]
V-type proton ATPase catalytic subunit A
Important for substrate specificity; cannot use PPi as phosphoryl donor
Parasitophorous vacuole membrane protein S16
JAB1/MPN/MOV34 metalloenzyme domain-containing protein
1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic
10 X 7 AA tandem repeat of D-K-N-[GE]-L-D-[GD]
Eukaryotic translation initiation factor 2-alpha kinase PK4
Histone RNA hairpin-binding protein RNA-binding
Ribosome biogenesis protein BMS1/TSR1 C-terminal
Lacks protease activity. No cellular location and growth defects in host red blood cells.
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
7-fold reduction in affinity for adenosine and 9-fold reduction in affinity for 5'-methylthioadenosine. Reduces further catalytic efficiency with adenosine or 5'-methylthioadenosine as substrates; when associated H-179.
Gating helix loop; regulates binding affinity for substrates and thus substrate selectivity
Important for substrate specificity for S-methyl-5'-thioadenosine
No effect on catalytic activity towards adenosine or 5'-methylthioadenosine; when associated with I-227.
No effect on catalytic activity towards adenosine or 5'-methylthioadenosine; when associated with Q-27.
No effect on catalytic activity. Reduces further catalytic efficiency with adenosine or 5'-methylthioadenosine as substrates; when associated A-176.
Severe decrease in catalytic activity towards adenosine or 5'-methylthioadenosine.
Severe reduction in catalytic efficiency with adenosine or 5'-methylthioadenosine as substrates.
Slight decrease in affinity for adenosine and severe reduction in affinity for 5'-methylthioadenosine.
Slight increase in affinity for adenosine and severe reduction in affinity for 5'-methylthioadenosine.
Spo11/DNA topoisomerase VI subunit A N-terminal
Loss of the first autocatalytic maturation cleavage. Impaired microneme localization and accumulation in a ER-like secretory compartment.
Merozoite surface protein P41, processed form
Cytochrome oxidase subunit II copper A binding
Chromosome segregation protein Spc25 C-terminal
43 X 4 AA tandem repeats of N-[PVA]-[DN]-P
Region I; contains the proteolytic cleavage site
Required for the binding to heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes
Loss of catalytic activity and auto-phosphorylation.
Loss of catalytic activity in absence or in presence of calcium.
No effect on catalytic activity and auto-phosphorylation.
No effect on catalytic activity. Is active in absence of calcium.
Partial loss of catalytic activity in presence of calcium.
Partial loss of catalytic activity. Is active in absence of calcium.
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
25S rRNA (uridine-N(3))-methyltransferase BMT5-like
DNA mismatch repair proteins mutS family
Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term
Chromatin target of PRMT1 protein C-terminal
30% reduction in catalytic activity. Slight decrease in heme binding.
50% reduction in catalytic activity. 50% reduction in catalytic activity; when associated with A-44, A-58, A-70, A-79, A-122, A-172, A-175 and A-192.
50% reduction in catalytic activity. 50% reduction in catalytic activity; when associated with A-44, A-58, A-70, A-79, A-122, A-172, A-192 and A-197.
50% reduction in catalytic activity. 50% reduction in catalytic activity; when associated with A-44, A-58, A-70, A-79, A-122, A-175, A-192 and A-197.
50% reduction in catalytic activity. 50% reduction in catalytic activity; when associated with A-44, A-58, A-70, A-79, A-172, A-175, A-192 and A-197.
60% reduction in catalytic activity. Decreases heme binding.
No effect on catalytic activity. 50% reduction in catalytic activity; when associated with A-44, A-58, A-70, A-122, A-172, A-175, A-192 and A-197.
No effect on catalytic activity. 50% reduction in catalytic activity; when associated with A-44, A-58, A-70, A-79, A-122, A-172, A-175 and A-197.
No effect on catalytic activity. 50% reduction in catalytic activity; when associated with A-44, A-58, A-79, A-122, A-172, A-175, A-192 and A-197.
No effect on catalytic activity. 50% reduction in catalytic activity; when associated with A-44, A-70, A-79, A-122, A-172, A-175, A-192 and A-197.
No effect on catalytic activity. 50% reduction in catalytic activity; when associated with A-58, A-70, A-79, A-122, A-172, A-175, A-192 and A-197.
Required to bring heme into proper alignment for the reaction
DNA-(apurinic or apyrimidinic site) endonuclease
Cell division control protein 73 C-terminal
RecQ mediated genome instability protein 1 N-terminal
Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding
Sodium/calcium exchanger membrane region
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Cofilin/actin-depolymerizing factor homolog 2
Cofilin/actin-depolymerizing factor homolog 1
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Required for ER targeting and membrane association; not cleaved
Severely affects substrate specificity. No effect on Zn(2+) binding.
Sufficient for targeting to the food vacuole
Nitric oxide synthase-interacting protein zinc-finger
Origin recognition complex subunit 3 N-terminal
Putative vacuolar protein sorting-associated protein 60
Peptidyl-prolyl cis-trans isomerase FKBP35
Severe loss of binding to a HSP90 C-terminus peptide (MEEVD).
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, apicoplast
DNA endonuclease activator Ctp1 C-terminal
Small ribosomal subunit protein uS4 N-terminal
56 X 8 AA tandem repeats of E-D-[EK]-V-S-N-G-[RG]
Alanyl-transfer RNA synthetases family profile
Important for beta-aspartyl-AMP intermediate formation
Thiamin pyrophosphokinase thiamin-binding
Post-transcriptional regulator MKT1 C-terminal
Post-transcriptional regulator MKT1 N-terminal
RNA polymerase subunit H/Rpb5 C-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
U3 small nucleolar RNA-associated protein 13 C-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Plasmodium falciparum erythrocyte membrane protein 1 N-terminal
Phosphatidylinositol 4-phosphate 5-kinase
Dolichol-phosphate mannosyltransferase subunit 1
50% reduction in activity with Zn(2+) as cofactor. Increases activity with Co(2+) as cofactor and acquires new substrate specificity to leucine, tryptophan and phenylalanine.
Important for substrate specificity to methionine
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Dispensable for parasite growth in host erythrocytes
ER membrane protein complex subunit 1 C-terminal
U3 small nucleolar RNA-associated protein 20 C-terminal
Required for editing of incorrectly charged tRNA
Large ribosomal subunit protein uL30 N-terminal eukaryotes
Large ribosomal subunit protein uL30-like ferredoxin-like fold
tRNA(Met) cytidine acetyltransferase TmcA N-terminal
Pentatricopeptide repeat-containing protein 2
Coatomer gamma subunit appendage Ig-like subdomain
Intron-binding protein aquarius N-terminal
Signal peptidase complex catalytic subunit SEC11
5-fold increase in inorganic phosphate (Pi) release in presence of Mg(2+).
DNAseI-binding D loop; regulates polymerization and stability of the actin filament
Fail to form long filaments. No inorganic phosphate (Pi) release in presence of Ca(2+). Increases Pi release in presence of Mg(2+). No effect of K(+) on Pi release.
Failure to form long filaments. Inorganic phosphate (Pi) release is slightly better in presence of Ca(2+) than Mg(2+). Slight decrease in inorganic phosphate (Pi) release rates in presence of Mg(2+) or Mg(2+) and K(+).
Forms longer filaments. 18.9-fold increase in inorganic phosphate (Pi) release in presence of Mg(2+). Filament elongation rate is normal.
Forms longer filaments. Increased inorganic phosphate (Pi) release in presence of Mg(2+) which is further increased in presence of K(+). Filament elongation rate is normal.
Increases inorganic phosphate (Pi) release in presence of Mg(2+). No effect of K(+) on Pi release. No effect on Pi release in absence or in presence of K(+); when associated with Q-42.
No formation of long filaments. Reduces inorganic phosphate (Pi) release. No effect of Mg(2+) or K(+) on Pi release. Filament elongation rate appears normal.
Reduces inorganic phosphate (Pi) release in presence of Mg(2+). No effect of K(+) on Pi release. No effect on Pi release in absence or in presence of K(+); when associated with G-49.
Phosphorylated adapter RNA export protein RNA-binding
8 X 6 AA tandem repeats of [VT]-N-D-[ED]-[ED]-D
Interaction with MSP1 and host SLC4A1/Band 3
About 70% reduction in catalytic activity. Does not affect TRX1-mediated activation.
No effect on catalytic activity. Requires higher concentrations of TRX1 for activation. Severe reduction in catalytic activity and loss of TRX1-mediated activation; when associated with S-154.
Severe reduction in catalytic activity. Does not affect TRX1-mediated activation. Severe reduction in catalytic activity and loss of TRX1-mediated activation; when associated with S-163.
No defect in parasite growth in host erythrocytes. Severe loss of deneddylating activity with no effect on deubiquitinating activity; when associated with 251-K--M-295 DEL.
No effect on deubiquitinating activity. Slight increase in deneddylating activity. Severe loss of deneddylating activity with no effect on deubiquitinating activity; when associated with E-38. No effect on deubiquitinating and deneddylating activities; when associated with D-18.
No effect on deubiquitinating and deneddylating activities; when associated with 251-K--M-295 DEL.
Ubiquitin carboxyl-terminal hydrolase UCH54
Translation initiation factor 3 C-terminal
Eukaryotic translation initiation factor 2 subunit 1
Loss of phosphorylation by eIK1. Loss of interaction with phosphatase IUS2.
Phosphomimetic mutant. No effect on the interaction with phosphatase IUS2.
NF-kappa-B-activating protein C-terminal
No effect on catalytic activity. Active in both reducing and non-reducing conditions.
Severe loss of catalytic activity characterized by a severe loss in substrate affinity.
18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Large ribosomal subunit protein bL12 oligomerization
Large ribosomal subunit protein uL4 C-terminal
Increases catalytic activity. Slightly decreases affinity for NADPH.
Strongly decreases catalytic activity. Abolishes NADPH binding.
DNA-directed RNA polymerase RBP11-like dimerisation
Guanine nucleotide-binding protein-like 3 N-terminal
Putative E3 ubiquitin-protein ligase protein PFF1365c
ER membrane protein complex subunit 7 beta-sandwich
Pyridoxal 5'-phosphate synthase subunit PDX2
DNA (cytosine-5)-methyltransferase 1 replication foci
1300-fold decrease in catalytic efficiency for inosine as substrate. Loss of catalytic activity towards 5'-methylthioinosine.
17300-fold decrease in catalytic efficiency with inosine as substrate. Reduced affinity for DADMe-ImmG inhibitor.
20-fold decrease in affinity for inosine. Loss of catalytic activity towards 5'-methylthioinosine.
200-fold decrease in catalytic efficiency with inosine as substrate. Loss of catalytic activity towards 5'-methylthioinosine.
23-fold decrease in catalytic efficiency for inosine as substrate. Slight decrease in catalytic efficiency for 5'-methylthioinosine as substrate.
4-fold decrease in catalytic efficiency with inosine as substrate. Reduced affinity for DADMe-ImmG inhibitor.
40-fold decrease in catalytic efficiency with inosine as substrate. Loss of catalytic activity towards 5'-methylthioinosine.
680-fold decrease in catalytic efficiency with inosine as substrate. 200-fold decrease in catalytic efficiency with 5'-methylthioinosine as substrate.
790-fold decrease in catalytic efficiency for inosine as substrate. 4000-fold decrease in catalytic efficiency for 5'-methylthioinosine as substrate.
8-fold decrease in catalytic efficiency with inosine as substrate. Slight increase in catalytic efficiency with 5'-methylthioinosine as substrate.
Loss of catalytic activity towards inosine and 5'-methylthioinosine.
No effect on catalytic activity towards inosine or 5'-methylthioinosine; when associated with I-66. 20-fold decrease in catalytic efficiency with 5'-methylthioinosine as substrate and no effect on catalytic activity towards inosine; when associated with F-160. 170-fold decrease in catalytic efficiency with 5'-methylthioinosine as substrate and no effect on catalytic activity towards inosine; when associated with I-66 and F-160.
No effect on catalytic activity towards inosine or 5'-methylthioinosine; when associated with I-73. 20-fold decrease in catalytic efficiency with 5'-methylthioinosine as substrate and no effect on catalytic activity towards inosine; when associated with F-160. 170-fold decrease in catalytic efficiency with 5'-methylthioinosine as substrate and no effect on catalytic activity towards inosine; when associated with I-73 and F-160.
No effect on catalytic activity towards inosine. 14-fold decrease in catalytic efficiency with 5'-methylthioinosine as substrate. 20-fold decrease in catalytic efficiency with 5'-methylthioinosine as substrate; when associated with I-66 or I-73. 170-fold decrease in catalytic efficiency with 5'-methylthioinosine as substrate and no effect on catalytic activity towards inosine; when associated with I-66 and I-73.
No effect on catalytic activity towards inosine. Slight increase in catalytic efficiency with 5'-methylthioinosine as substrate.
Slight decrease in catalytic activity towards inosine and 5'-methylthioinosine.
Slight decrease in catalytic activity towards inosine. Slight increase in catalytic activity towards 5'-methylthioinosine.
Slight decrease in catalytic efficiency with inosine as substrate. 8500-fold decrease in catalytic efficiency with 5'-methylthioinosine as substrate.
Slight decrease in catalytic efficiency with inosine or 5'-methylthioinosine as substrates.
Putative histone-lysine N-methyltransferase 1
Mislocalizes to the cytoplasm. Mislocalizes to the cytoplasm; when associated with A-4.
Partial mislocalization to the cytoplasm with some localization to the cell membrane. Mislocalizes to the cytoplasm; when associated with A-2.
Remains associated with the cytoplasmic side of the cell membrane with no translocation across the cell membrane.
Required for cell membrane translocation but dispensable for cell membrane localization
Mitochondrial inner membrane magnesium transporter MIT1
Gamma-butyrobetaine hydroxylase-like N-terminal
26S proteasome non-ATPase regulatory subunit RPN1 C-terminal
U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein
Dual specificity protein phosphatase YVH1
Translation factor GUF1 homolog, mitochondrial
Conditional deletion at the beginning of the first erythrocyte infection cycle results in no defect in egress and subsequent invasion. However, in the next invasion cycle, causes a severe growth defect and developmental arrest between the ring and trophozoite stages. Export of HRP2 into the host erythrocyte is also partially impaired.
Loss of catalytic activity. Loss of catalytic activity; when associated with A-365 or A-365 and A-370.
Loss of catalytic activity; when associated with A-118 and A-365.
Loss of catalytic activity; when associated with A-118 or A-118 and A-370.
Loses the ability to form the reaction intermediate lipoyl-AMP resulting in a loss of catalytic activity. Abolishes lipoylation of GCVH/H-protein. Abolishes lipoylation of BCKDH-E2/BCDH and KDH in the presence of LipL2.
Abscisic acid G-protein coupled receptor-like
Minichromosome loss protein Mcl1 middle region
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Probable ATP-dependent helicase PF08_0048
Cell-traversal protein for ookinetes and sporozoites
Large ribosomal subunit protein uL2 C-terminal
SUEL-type lectin domain-containing protein
Reticulocyte-binding protein homolog 2a 285 kDa form
Reticulocyte-binding protein homolog 2a 85 kDa form
Phosphoadenosine phosphosulphate reductase
Ribosomal RNA methyltransferase SPB1-like C-terminal
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, apicoplast
Micro-fibrillar-associated protein 1 C-terminal
Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
DNA-directed DNA polymerase family B multifunctional
Prevalent in Kenyan and Tanzanian populations.
3'-phosphate/5'-hydroxy nucleic acid ligase
C4-type zinc-finger of DNA polymerase delta
DNA-directed DNA polymerase family B exonuclease
Ubiquitin/SUMO-activating enzyme ubiquitin-like
Large ribosomal subunit protein uL23 N-terminal
Pentatricopeptide repeat-containing protein 1, apicoplast
Cysteine-rich protective antigen 6 bladed
No activity. The mutant forms hexamers instead of dodecamers.
No activity; when associated with A-136 and A-139.
No activity; when associated with A-136 and A-140.
No effect on dodecamer assembly. No activity; when associated with A-139 and A-140.
Pyridoxal 5'-phosphate synthase subunit Pdx1
Schiff-base intermediate with D-ribose 5-phosphate
26S proteasome regulatory subunit RPN2 C-terminal
Ribosomal RNA-processing protein 7 C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Translation elongation factor IF5A C-terminal
Phosphomannose isomerase type I catalytic
Abolishes inosine binding and transport activity.
Abolishes inosine binding and transport activity. Reduces the binding affinity of GSK4 inhibitor.
Abolishes transport activity while maintaining inosine binding.
Reduces inosine binding and abolishes transport activity. Abolishes the GSK4 inhibitor binding.
Reduces the binding affinity of GSK4 inhibitor.
Mei2-like C-terminal RNA recognition motif
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha