Mycothiol-dependent maleylpyruvate isomerase metal-binding
4'-phosphopantetheinyl transferase N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Bacterial type II secretion system protein E
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Major facilitator superfamily (MFS) profile
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Nitrite/Sulfite reductase ferredoxin-like
Thiopeptide-type bacteriocin biosynthesis
Cysteine sulfenic acid (-SOH) intermediate
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
6-phosphogluconate dehydrogenase NADP-binding
Gram-positive cocci surface proteins LPxTG
N-acetylneuraminic acid synthase N-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-? in acceptor proteins)
Erythromycin biosynthesis protein CIII-like central
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Pyridoxamine 5'-phosphate oxidase putative
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Beta-xylosidase C-terminal Concanavalin A-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
RNA polymerase sigma factor 70 region 4 type 2
Membrane insertase YidC/Oxa/ALB C-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Penicillin-binding protein transpeptidase
Anthranilate synthase component I N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Peptidase M1 membrane alanine aminopeptidase
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Ricin B lectin domain-containing protein
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Thiamine pyrophosphate enzyme TPP-binding
Sodium/calcium exchanger membrane region
Cell envelope-related transcriptional attenuator
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Gram-positive cocci surface proteins LPxTG domain-containing protein
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
ABC-type glycine betaine transport system substrate-binding
Glycine cleavage T-protein C-terminal barrel
ATP synthase F1 complex delta/epsilon subunit N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Peptidase C39-like domain-containing protein
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Solute-binding protein family 3/N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
S-adenosyl-L-homocysteine hydrolase NAD binding
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Small ribosomal subunit protein uS4 N-terminal
UDP-glucose/GDP-mannose dehydrogenase dimerisation
6-phosphogluconate dehydrogenase C-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Inosine/uridine-preferring nucleoside hydrolase
Polymerase/histidinol phosphatase N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Probable transposase IS891/IS1136/IS1341
6-phosphogluconate dehydrogenase NADP-binding domain-containing protein
Aconitase A/isopropylmalate dehydratase small subunit swivel
Moybdenum cofactor oxidoreductase dimerisation
Plays an important role in substrate specificity
Translation elongation factor P/YeiP central
YbaK/aminoacyl-tRNA synthetase-associated
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Methylguanine DNA methyltransferase ribonuclease-like
DNA primase/polymerase bifunctional N-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
Phosphocysteine intermediate; for EIIB activity
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Lactate utilization protein B C-terminal
Alpha-glycerophosphate oxidase C-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Heme-copper oxidase subunit III family profile
Reversibly protonated during proton transport
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Glycosyl hydrolase family 98 putative carbohydrate-binding module
Glutathionylspermidine synthase pre-ATP-grasp-like
Pyruvate dehydrogenase E1 component middle
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Electron transfer via tryptophanyl radical
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Protein O-mannosyl-transferase C-terminal four TM
Aminoacyl-transfer RNA synthetases class-II family profile
PsrA tetracyclin repressor-like C-terminal
PknH-like extracellular domain-containing protein
Phosphotransferase system enzyme I N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Tryptophan synthase beta chain-like PALP
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
HNH/Endo VII superfamily nuclease toxins
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Alanyl-transfer RNA synthetases family profile
NADH-rubredoxin oxidoreductase C-terminal
Exonuclease VII large subunit C-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Sporulation transcription regulator WhiA N-terminal
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Glucosamine/galactosamine-6-phosphate isomerase
Cytochrome C biogenesis protein transmembrane
Gamma-glutamylcyclotransferase AIG2-like
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Cytochrome bc1 complex Rieske iron-sulfur subunit
Activator of Hsp90 ATPase homologue 1-like C-terminal
DNA-directed DNA polymerase family A palm
Transposase IS116/IS110/IS902 C-terminal
Transcription regulator AsnC/Lrp ligand binding
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Shikimate dehydrogenase substrate binding N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Helix-hairpin-helix DNA-binding motif class 1
Molybdopterin cofactor biosynthesis C (MoaC)
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Large ribosomal subunit protein uL15/eL18
Release factor glutamine methyltransferase N-terminal
Peptidoglycan recognition protein family
RNA 2-O ribose methyltransferase substrate binding
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
SUF system FeS cluster assembly SufBD N-terminal
PhoD-like phosphatase metallophosphatase
Saccharopine dehydrogenase-like C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Styrene monooxygenase StyA putative substrate binding
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
Large ribosomal subunit protein uL6 alpha-beta
Peptidase S9 prolyl oligopeptidase catalytic
Sugar ABC transporter substrate-binding protein
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
LPXTG-motif cell wall anchor domain protein
Positions MEP for the nucleophilic attack
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Ribose-phosphate pyrophosphokinase N-terminal
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Polysaccharide chain length determinant N-terminal
DNA topoisomerase I catalytic core eukaryotic-type
Important for substrate specificity; cannot use PPi as phosphoryl donor
Peptide methionine sulphoxide reductase MsrA
non-reducing end alpha-L-arabinofuranosidase
Phosphatidic acid phosphatase type 2/haloperoxidase
Removed in mature form; by autocatalysis
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Mandelate racemase/muconate lactonizing enzyme C-terminal
Cytochrome bc1 complex cytochrome c subunit
Cellulose 1,4-beta-cellobiosidase family protein
Choice-of-anchor A domain-containing protein
Myo-inositol-1-phosphate synthase GAPDH-like
Could be important to modulate the pK values of the two catalytic cysteine residues
Methionyl-tRNA synthetase anticodon-binding
O-(5'-phospho-DNA)-tyrosine intermediate
Solute-binding protein family 5 domain-containing protein
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Putative glycogen debranching enzyme N-terminal
Alpha-L-arabinofuranosidase B arabinose-binding
NADH:ubiquinone oxidoreductase 30kDa subunit
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Glycosyl transferase family 3 N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Pyrimidine nucleoside phosphorylase C-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Ionotropic glutamate receptor C-terminal
Type ISP restriction-modification enzyme LLaBIII C-terminal specificity
SMP-30/Gluconolactonase/LRE-like region domain-containing protein
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Endoribonuclease L-PSP/chorismate mutase-like
Heat-inducible transcription repressor HrcA C-terminal
Glycoside hydrolase family 31 N-terminal
Lantibiotic biosynthesis protein dehydration
Calcium/calmodulin-dependent protein kinase II association-domain
Calcium/calmodulin-dependent protein kinase II association-domain domain-containing protein
Diiron non-heme beta-hydroxylase N-terminal
Essential for prephenate dehydratase activity
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Transglycosylase SLT domain-containing protein
Right handed beta helix domain-containing protein
Acyltransferase MbtK/IucB-like conserved
Glycoside-hydrolase family GH114 TIM-barrel
Cell wall-active antibiotics response LiaF-like C-terminal
Large ribosomal subunit protein uL2 C-terminal
NIF system FeS cluster assembly NifU N-terminal
Thymidylate synthase/dCMP hydroxymethylase
1-phosphatidylinositol phosphodiesterase
Phosphatidylinositol-specific phospholipase C X
Damage-control phosphatase ARMT1-like metal-binding
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Transition state stabilizer; via amide nitrogen
Threonine/serine exporter-like N-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase C-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Prokaryotic-type class I peptide chain release factors
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Glycoside hydrolase family 42 N-terminal
Adaptive response protein AidB N-terminal
Phosphoribosylformylglycinamidine synthase linker
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
Histidine-specific methyltransferase SAM-dependent
Signal recognition particle SRP54 helical bundle
Carboxypeptidase regulatory-like domain-containing protein
Blue (type 1) copper domain-containing protein
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Subtilisin inhibitor domain-containing protein
Cytochrome oxidase subunit II copper A binding
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Proton acceptor; for glutaminase activity
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
N,N-dimethylformamidase beta subunit-like C-terminal
Pseudouridine synthase I TruA alpha/beta
Cytochrome b/b6 N-terminal region profile
L,D-transpeptidase catalytic domain-containing protein
2,4-diaminopentanoate dehydrogenase C-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Gp5/Type VI secretion system Vgr protein OB-fold
Prepilin type IV endopeptidase peptidase
7 transmembrane helices usually fused to an inactive transglutaminase
Involved in allosteric activation by GTP
Carbamoyl-phosphate synthase small subunit N-terminal
Phospholipase D-like domain-containing protein
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
DNA polymerase III delta subunit C-terminal
DnaJ homologue subfamily C member 28 conserved
Integral membrane protein YccS N-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Phosphomannose isomerase type I catalytic
Important for beta-aspartyl-AMP intermediate formation
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Squalene cyclase C-terminal domain-containing protein
DNA replication/recombination mediator RecO N-terminal
SGNH hydrolase-type esterase domain-containing protein
Quercetin 2,3-dioxygenase C-terminal cupin
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-108)
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
ABC transporter substrate-binding protein PnrA-like
vWA-MoxR associated protein middle region 2
Gly-cisPro motif, important for rejection of L-amino acids
Lysyl-tRNA synthetase N-terminal transmembrane region
Phosphatidylglycerol lysyltransferase C-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
ABC transporter substrate-binding protein
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Leucine-binding protein domain-containing protein
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding