Saccharopine dehydrogenase-like C-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Beta-lactamase hydrolase-like protein phosphatase-like
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Large ribosomal subunit protein uL2 C-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
ATP synthase F1 complex delta/epsilon subunit N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Prepilin type IV endopeptidase peptidase
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
DNA-directed DNA polymerase family A palm
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Protein O-mannosyl-transferase C-terminal four TM
General stress protein FMN-binding split barrel
Outer membrane protein beta-barrel domain-containing protein
Nitrite/Sulfite reductase ferredoxin-like
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Glycosyltransferase subfamily 4-like N-terminal
Inositolphosphotransferase Aur1/Ipt1 domain-containing protein
PhoD-like phosphatase metallophosphatase
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Required for zinc-mediated homotetramerization and catalytic activity
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
SUF system FeS cluster assembly SufBD N-terminal
Restriction endonuclease type II EcoRII N-terminal
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Positions MEP for the nucleophilic attack
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
TonB-dependent receptor-like beta-barrel
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Electron transfer via tryptophanyl radical
Major facilitator superfamily (MFS) profile
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
RNA polymerase sigma factor 70 region 4 type 2
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Amidohydrolase 3 domain-containing protein
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Putative Flp pilus-assembly TadG-like N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Translation elongation factor P/YeiP central
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
Phosphoadenosine phosphosulphate reductase
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Pseudouridine synthase I TruA alpha/beta
Peptide methionine sulphoxide reductase MsrA
Cytochrome c-type biogenesis protein CcmF C-terminal
Reversibly protonated during proton transport
Tryptophan synthase beta chain-like PALP
tRNA pseudouridylate synthase B C-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Important for interaction with partner proteins
Alanyl-transfer RNA synthetases family profile
Putative auto-transporter adhesin head GIN
Putative auto-transporter adhesin head GIN domain-containing protein
Signal transduction histidine kinase dimerisation/phosphoacceptor
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
RND efflux pump membrane fusion protein barrel-sandwich
Type II secretion system protein TadB-like N-terminal
Endoribonuclease L-PSP/chorismate mutase-like
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Proline utilization A proline dehydrogenase N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Prokaryotic-type class I peptide chain release factors
Phosphatidate phosphatase APP1 catalytic
Phosphoribosylformylglycinamidine synthase linker
Membrane fusion protein biotin-lipoyl like
Polymerase/histidinol phosphatase N-terminal
Methionyl-tRNA synthetase anticodon-binding
Pyridoxamine 5'-phosphate oxidase putative
Glycosyl transferase family 3 N-terminal
Penicillin-binding protein transpeptidase
Aminoacyl-transfer RNA synthetases class-II family profile
N-end rule aminoacyl transferase C-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Nucleophile; cysteine thiosulfonate intermediate
Release factor glutamine methyltransferase N-terminal
Ribonucleotide reductase large subunit C-terminal
Ribonucleotide reductase large subunit N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Aconitase A/isopropylmalate dehydratase small subunit swivel
Sodium/calcium exchanger membrane region
Lipid/polyisoprenoid-binding YceI-like domain-containing protein
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Twin-arginine translocation pathway signal
Helix-hairpin-helix DNA-binding motif class 1
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
NAD(P) transhydrogenase alpha subunit C-terminal
Inner membrane protein YgaP-like transmembrane
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
RNA 2-O ribose methyltransferase substrate binding
Pyrroline-5-carboxylate reductase dimerisation
O-(3'-phospho-DNA)-tyrosine intermediate
Tetrahydrodipicolinate-N-succinyltransferase chain A
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
TonB-dependent receptor-like beta-barrel domain-containing protein
S-adenosylmethionine-dependent methyltransferase
RNA binding; important for wobble base 34 recognition
Essential for prephenate dehydratase activity
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Outer membrane protein assembly factor BamA
Interaction with polymerase core subunit RpoC
Survival protein SurE-like phosphatase/nucleotidase
Membrane insertase YidC/Oxa/ALB C-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Histidine-specific methyltransferase SAM-dependent
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Carbamoyl-phosphate synthase small subunit N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Peptide methionine sulfoxide reductase MsrA
Polysaccharide chain length determinant N-terminal
Peptidase M20 dimerisation domain-containing protein
Pyruvate phosphate dikinase AMP/ATP-binding
Heat-inducible transcription repressor HrcA C-terminal
Heme-copper oxidase subunit III family profile
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Organic solvent tolerance-like N-terminal
Right handed beta helix domain-containing protein
Deacetylase PdaC domain-containing protein
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
2-oxoisovalerate dehydrogenase E1 alpha subunit N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Important for beta-aspartyl-AMP intermediate formation
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
TRAP C4-dicarboxylate transport system permease DctM subunit
Large ribosomal subunit protein uL15/eL18
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Alpha-glycerophosphate oxidase C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
DNA replication/recombination mediator RecO N-terminal
Exonuclease VII large subunit C-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Endolytic peptidoglycan transglycosylase RlpA
RlpA-like protein double-psi beta-barrel
TonB-dependent receptor plug domain-containing protein
Could be important to modulate the pK values of the two catalytic cysteine residues
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Small ribosomal subunit protein uS4 N-terminal
Signal recognition particle SRP54 helical bundle
Nuclear transport factor 2 family protein
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Carboxypeptidase regulatory-like domain-containing protein
Cysteine sulfenic acid (-SOH) intermediate
Disulphide bond isomerase DsbC/G N-terminal
Quercetin 2,3-dioxygenase C-terminal cupin
Polyketide cyclase / dehydrase and lipid transport
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Poly-beta-hydroxybutyrate polymerase N-terminal
Small-conductance mechanosensitive channel
Large ribosomal subunit protein uL6 alpha-beta
Amidohydrolase-related domain-containing protein
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Glucose-methanol-choline oxidoreductase N-terminal
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Shikimate dehydrogenase substrate binding N-terminal
Plays an important role in substrate specificity