Aromatic amino acid beta-eliminating lyase/threonine aldolase
Biopterin-dependent aromatic amino acid hydroxylase family profile
Activator of Hsp90 ATPase homologue 1-like C-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
S-adenosylmethionine-dependent methyltransferase
Gp5/Type VI secretion system Vgr protein OB-fold
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Phosphatidic acid phosphatase type 2/haloperoxidase
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
L,D-transpeptidase catalytic domain-containing protein
Plays an important role in substrate specificity
Solute-binding protein family 3/N-terminal
Heme-copper oxidase subunit III family profile
Membrane fusion protein biotin-lipoyl like
Glycine cleavage T-protein C-terminal barrel
Quercetin 2,3-dioxygenase C-terminal cupin
Interaction with polymerase core subunit RpoC
TonB-dependent receptor-like beta-barrel
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Moves into active site upon enzyme activation, plays a role in electron transfer
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Chalcone isomerase domain-containing protein
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Type I restriction modification DNA specificity
Chromosomal replication initiator DnaA C-terminal
Shikimate dehydrogenase substrate binding N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Anthranilate synthase component I N-terminal
Major facilitator superfamily (MFS) profile
RND efflux pump membrane fusion protein barrel-sandwich
Transposase IS116/IS110/IS902 C-terminal
Interacts with tRNA; defines subfamily-specific binding signature
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Gamma-butyrobetaine hydroxylase-like N-terminal
Reversibly protonated during proton transport
Proline utilization A proline dehydrogenase N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Tryptophan synthase beta chain-like PALP
Nitrite/Sulfite reductase ferredoxin-like
Cytochrome b561 bacterial/Ni-hydrogenase
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
High-affinity branched-chain amino acid transport system permease LivHM N-terminal
Bacterial type II secretion system protein E
Type VI secretion system IcmF C-terminal
4'-phosphopantetheinyl transferase N-terminal
NIF system FeS cluster assembly NifU N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Cysteine sulfenic acid (-SOH) intermediate
Flagellar motor switch protein FliN-like C-terminal
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Flagellar hook-length control protein-like C-terminal
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
RNA polymerase sigma factor 70 region 4 type 2
Flagellar assembly protein FliH/Type III secretion system HrpE
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
ABC-type glycine betaine transport system substrate-binding
Glycosyltransferase subfamily 4-like N-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Pyruvate dehydrogenase E1 component middle
Alpha-glycerophosphate oxidase C-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
DNA-directed DNA polymerase family A palm
Adaptive response protein AidB N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Putative regulatory protein FmdB Zinc ribbon
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Mandelate racemase/muconate lactonizing enzyme C-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Glucan biosynthesis periplasmic MdoG C-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Penicillin-binding protein transpeptidase
Peptidase S9 prolyl oligopeptidase catalytic
Glucose-methanol-choline oxidoreductase N-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
DNA-directed DNA polymerase family B exonuclease
DNA-directed DNA polymerase family B multifunctional
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Seems to be a necessary countercharge to the potassium cations
Flagellar basal-body/hook protein C-terminal
Water stress and hypersensitive response
Water stress and hypersensitive response domain-containing protein
Saccharopine dehydrogenase-like C-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
ABC-type transport auxiliary lipoprotein component
Thiol:disulfide interchange protein DsbD
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Glutamate synthase alpha subunit C-terminal
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Alginate biosynthesis protein AlgX C-terminal carbohydrate-binding module
ssDNA thymidine ADP-ribosyltransferase DarT
Terminase large subunit-like endonuclease
Alpha-D-phosphohexomutase alpha/beta/alpha
Sodium/calcium exchanger membrane region
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Ionotropic glutamate receptor C-terminal
6-phosphogluconate dehydrogenase C-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Type 4 fimbrial biogenesis protein PilX N-terminal
Prokaryotic-type class I peptide chain release factors
Flagellar basal body rod protein N-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Glycoside hydrolase family 42 N-terminal
2-oxoisovalerate dehydrogenase E1 alpha subunit N-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Exonuclease VII large subunit C-terminal
Phosphocysteine intermediate; for EIIB activity
Polypeptide-transport-associated ShlB-type
Transposase IS204/IS1001/IS1096/IS1165 DDE
Lysidine-tRNA(Ile) synthetase C-terminal
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
ABC-type uncharacterised transport system
Type II secretion system protein GspC N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
DNA mismatch repair proteins mutS family
Endolytic peptidoglycan transglycosylase RlpA
Regulator of nucleoside diphosphate kinase N-terminal
Outer membrane protein assembly factor BamB
ATP synthase F1 complex delta/epsilon subunit N-terminal
Important for substrate binding and specificity
Glucose-methanol-choline oxidoreductase C-terminal
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
NADH-rubredoxin oxidoreductase C-terminal
Mechanosensitive ion channel inner membrane
N6 adenine-specific DNA methyltransferase N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Polymerase/histidinol phosphatase N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Glycoside-hydrolase family GH114 TIM-barrel
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Outer membrane protein assembly factor BamD
Outer-membrane lipoprotein carrier protein
Outer membrane protein assembly factor BamA
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Inner membrane protein YgaP-like transmembrane
Disulphide bond isomerase DsbC/G N-terminal
Polysaccharide chain length determinant N-terminal
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Helix-hairpin-helix DNA-binding motif class 1
Malonate/sodium symporter MadM subunit N-terminal
Phosphoadenosine phosphosulphate reductase
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Hypersensitivity response secretion-like HrpJ
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
NAD(P) transhydrogenase alpha subunit C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
YbaK/aminoacyl-tRNA synthetase-associated
Flagella basal body P-ring formation protein FlgA
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Essential for prephenate dehydratase activity
DNA polymerase III subunit delta C-terminal
Poly-beta-hydroxybutyrate polymerase N-terminal
Catalytic role in ketonization of the dienol substrate (substrate destabilization)
N-end rule aminoacyl transferase C-terminal
DNA polymerase III delta subunit C-terminal
Bacteriophage tail tape measure C-terminal
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
Large ribosomal subunit protein uL15/eL18
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
PHA accumulation regulator DNA-binding N-terminal
Erythronate-4-phosphate dehydrogenase dimerisation
Periplasmic binding protein/LacI sugar binding
The binding site for the sugar molecule has not yet been established, but C-87 may be involved
TRAP C4-dicarboxylate transport system permease DctM subunit
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
PhoD-like phosphatase metallophosphatase
Small ribosomal subunit protein uS4 N-terminal
Integral membrane protein YccS N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Glucosamine/galactosamine-6-phosphate isomerase
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
O-(3'-phospho-DNA)-tyrosine intermediate
RlpA-like protein double-psi beta-barrel
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
HupH hydrogenase expression protein C-terminal
Large ribosomal subunit protein uL2 C-terminal
Polyribonucleotide nucleotidyltransferase (Polynucleotide phosphorylase)
ATP-dependent DNA helicase RecG C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Transcription factor NikR nickel binding C-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
O-(phosphoribosyl dephospho-coenzyme A)serine
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Type II secretion system protein GspI C-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Acyl-ester intermediate; for transpeptidase activity
Proton donor; for transglycosylase activity
S-adenosyl-L-homocysteine hydrolase NAD binding
Nucleoside-specific outer membrane channel protein Tsx
Prepilin type IV endopeptidase peptidase
Sugar fermentation stimulation protein C-terminal
Lytic transglycosylase superhelical linker
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Translation elongation factor P/YeiP central
Antitoxin Xre/MbcA/ParS-like toxin-binding
Positions MEP for the nucleophilic attack
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Putative conjugal transfer nickase/helicase TraI C-terminal
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
NIF system FeS cluster assembly NifU C-terminal
Survival protein SurE-like phosphatase/nucleotidase
Could be important to modulate the pK values of the two catalytic cysteine residues
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Resolvase/invertase-type recombinase catalytic
Molybdopterin cofactor biosynthesis C (MoaC)
Required for dimer formation and molybdate binding
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Mannose-6-phosphate isomerase type II C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Arginine decarboxylase C-terminal helical
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Type III secretion system flagellar brake protein YcgR PilZN
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Terminase large subunit gp17-like C-terminal
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Type II secretion system protein GspG C-terminal
SMODS-associated and fused to various effectors
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Schiff-base intermediate with acetaldehyde
Extradiol ring-cleavage dioxygenase LigAB LigA subunit
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease 2
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Acyl-CoA dehydrogenase C-terminal bacterial-type
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Electron transfer via tryptophanyl radical
7 transmembrane helices usually fused to an inactive transglutaminase
Inactive transglutaminase fused to 7 transmembrane helices
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Alanyl-transfer RNA synthetases family profile
Important for beta-aspartyl-AMP intermediate formation
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Involved in tetramerization or stability of the tetramer
Quorum-sensing-regulated virulence factor
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Translocation and assembly module subunit TamA
Pseudouridine synthase I TruA alpha/beta
DNA replication/recombination mediator RecO N-terminal
Organic solvent tolerance-like N-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
Glycosyl transferase family 3 N-terminal
Peptidase C-terminal archaeal/bacterial domain-containing protein
Carbamoyl-phosphate synthase small subunit N-terminal
For 3-hydroxyacyl-CoA dehydrogenase activity
Ribosomal RNA adenine methylase transferase N-terminal
Urease accessory protein UreH-like transmembrane
Guanylate kinase/L-type calcium channel beta subunit
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Gly-cisPro motif, important for rejection of L-amino acids
Important for interaction with partner proteins
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Cation-transporting P-type ATPase N-terminal
Cytochrome c-type biogenesis protein CcmF C-terminal
Chitin-binding type-3 domain-containing protein
RNA 2-O ribose methyltransferase substrate binding
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Lipopolysaccharide export system protein LptA
Proton acceptor; for decarboxylase activity
Proton donor; for decarboxylase activity
Proton donor; for formyltransferase activity
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
HicB-like antitoxin of toxin-antitoxin system
Peptide methionine sulphoxide reductase MsrA
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Bacterial transcription activator effector binding
YMGG-like Gly-zipper domain-containing protein
Thymidylate synthase/dCMP hydroxymethylase
Chromosomal replication initiator protein DnaA
Aminoacyl-tRNA synthetase class I anticodon-binding
Na+/H+ antiporter MnhB subunit-related protein
Bacterial bifunctional deaminase-reductase C-terminal
UDP N-acetylglucosamine O-acyltransferase C-terminal
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Release factor glutamine methyltransferase N-terminal
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Cob(I)alamin adenosyltransferase N-terminal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Bacteriophage tail tape measure N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Nucleophile; cysteine thiosulfonate intermediate
Plays an important role in discriminating NADH against NADPH
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Probable periplasmic serine endoprotease DegP-like
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal