YbaK/aminoacyl-tRNA synthetase-associated
Major facilitator superfamily (MFS) profile
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Pyrroline-5-carboxylate reductase catalytic N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
RNA polymerase sigma factor 70 region 4 type 2
Aconitase A/isopropylmalate dehydratase small subunit swivel
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Prokaryotic-type class I peptide chain release factors
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Cysteine sulfenic acid (-SOH) intermediate
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Bacterial bifunctional deaminase-reductase C-terminal
HTH-type transcriptional regulator MT1864/Rv1816-like C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Peptidase M1 membrane alanine aminopeptidase
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Cell envelope-related transcriptional attenuator
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
DNA primase/polymerase bifunctional N-terminal
MucB/RseB N-terminal domain-containing protein
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Lactate utilization protein B C-terminal
Peptidoglycan recognition protein family
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Polysaccharide biosynthesis protein CapD-like
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Glycosyltransferase subfamily 4-like N-terminal
Actinobacteria/chloroflexi VLRF1 release factor
Alpha-L-rhamnosidase six-hairpin glycosidase
Bacterial alpha-L-rhamnosidase N-terminal
Alpha-L-arabinofuranosidase B arabinose-binding
Solute-binding protein family 5 domain-containing protein
Activator of Hsp90 ATPase homologue 1-like C-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Alpha-D-phosphohexomutase alpha/beta/alpha
Methionyl-tRNA synthetase anticodon-binding
Ribose-phosphate pyrophosphokinase N-terminal
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
RNA 2-O ribose methyltransferase substrate binding
Aminoacyl-transfer RNA synthetases class-II family profile
Plays an important role in substrate specificity
Glycosyl transferase family 28 C-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Putative glycogen debranching enzyme N-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Alanyl-transfer RNA synthetases family profile
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Peptidase M43 pregnancy-associated plasma-A
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Phosphatidic acid phosphatase type 2/haloperoxidase
Mandelate racemase/muconate lactonizing enzyme C-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Gfo/Idh/MocA-like oxidoreductase N-terminal
Polymerase/histidinol phosphatase N-terminal
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase
Prepilin type IV endopeptidase peptidase
Large ribosomal subunit protein uL6 alpha-beta
Sporulation transcription regulator WhiA N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Glycoside hydrolase family 42 N-terminal
GDSL-like Lipase/Acylhydrolase family protein
Ribosome maturation factor RimP N-terminal
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Transcription regulator AsnC/Lrp ligand binding
Gfo/Idh/MocA-like oxidoreductase C-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Acetylserotonin O-methyltransferase dimerisation
6-phosphogluconate dehydrogenase C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Solute-binding protein family 3/N-terminal
Schiff-base intermediate with substrate; via pyruvic acid
Copper type II ascorbate-dependent monooxygenase C-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Tryptophan synthase beta chain-like PALP
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Formylmethanofuran dehydrogenase subunit E
Peptidase S9 prolyl oligopeptidase catalytic
Large ribosomal subunit protein uL30-like ferredoxin-like fold
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Erythromycin biosynthesis protein CIII-like central
Penicillin-binding protein transpeptidase
Alpha-glycerophosphate oxidase C-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Cytochrome b/b6 N-terminal region profile
Glycoside-hydrolase family GH114 TIM-barrel
Glycoside hydrolase family 31 N-terminal
Glycine cleavage T-protein C-terminal barrel
Glycosyl transferase family 3 N-terminal
4'-phosphopantetheinyl transferase N-terminal
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Phosphatidylglycerol lysyltransferase C-terminal
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Phosphotransferase system enzyme I N-terminal
Type IV secretion system coupling protein TraD DNA-binding
Glycosyltransferase family 28 N-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Polymerase/histidinol phosphatase N-terminal domain-containing protein
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Pyruvate/ketoisovalerate oxidoreductase catalytic
Quinolinate phosphoribosyl transferase N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
MmyB-like transcription regulator ligand binding
Subtilisin-like protease fibronectin type-III
Gly-cisPro motif, important for rejection of L-amino acids
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Small ribosomal subunit protein uS4 N-terminal
Sodium/calcium exchanger membrane region
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
SD-repeat containing protein B domain-containing protein
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Mannose-6-phosphate isomerase type II C-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Thymidylate synthase/dCMP hydroxymethylase
Aromatic amino acid beta-eliminating lyase/threonine aldolase
DNA replication/recombination mediator RecO N-terminal
Cytochrome C biogenesis protein transmembrane
Nicotinate/nicotinamide phosphoribosyltransferase
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Myo-inositol-1-phosphate synthase GAPDH-like
Haemophore haem-binding domain-containing protein
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-128)
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Cytochrome oxidase subunit II copper A binding
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Transcriptional regulator LacI/GalR-like sensor
Ribosomal RNA adenine methylase transferase N-terminal
PhoD-like phosphatase metallophosphatase
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Right handed beta helix domain-containing protein
Moybdenum cofactor oxidoreductase dimerisation
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Resolvase/invertase-type recombinase catalytic
Cytochrome bc1 complex Rieske iron-sulfur subunit
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
DnaJ homologue subfamily C member 28 conserved
Gram-positive cocci surface proteins LPxTG
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Flagellar motor switch protein FliN-like C-terminal
Translation elongation factor P/YeiP central
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Important for substrate specificity; cannot use PPi as phosphoryl donor
Molybdopterin cofactor biosynthesis C (MoaC)
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Helix-hairpin-helix DNA-binding motif class 1
O-(3'-phospho-DNA)-tyrosine intermediate
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Gram-positive cocci surface proteins LPxTG domain-containing protein
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Schiff-base intermediate with acetaldehyde
O-(5'-phospho-DNA)-tyrosine intermediate
EfeO-type cupredoxin-like domain-containing protein
Beta-xylosidase C-terminal Concanavalin A-like
Tat pathway signal sequence domain protein
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Transposase IS116/IS110/IS902 C-terminal
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Large ribosomal subunit protein uL2 C-terminal
Ionotropic glutamate receptor C-terminal
Butirosin biosynthesis protein H N-terminal
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Large ribosomal subunit protein uL15/eL18
DNA-directed DNA polymerase family A palm
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Anthranilate synthase component I N-terminal
Polysaccharide biosynthesis protein C-terminal
Heat-inducible transcription repressor HrcA C-terminal
Glycogen debranching enzyme bacterial and archaeal type N-terminal
Flagellar basal-body/hook protein C-terminal
Signal transduction histidine kinase dimerisation/phosphoacceptor
Pyrimidine nucleoside phosphorylase C-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Ricin B lectin domain-containing protein
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
RND efflux pump membrane fusion protein barrel-sandwich
ABC transporter substrate-binding protein PnrA-like
Nitrite/Sulfite reductase ferredoxin-like
Proton acceptor; for glutaminase activity
Could play a key role in the communication between the regulatory and the substrate sites
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Flagellar basal body rod protein N-terminal
Adaptive response protein AidB N-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Membrane insertase YidC/Oxa/ALB C-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
SUF system FeS cluster assembly SufBD N-terminal
Involved in ionization of N3 of dUMP, leading to its activation
Histidine-specific methyltransferase SAM-dependent
Acetyl-CoA hydrolase/transferase C-terminal
Cation-transporting P-type ATPase N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Polysaccharide chain length determinant N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Flagellar assembly protein FliH/Type III secretion system HrpE
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
DNA topoisomerase I catalytic core eukaryotic-type
N-terminal domain of peptidoglycan hydrolase CwlO-containing protein
Membrane fusion protein biotin-lipoyl like
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase
Endoribonuclease L-PSP/chorismate mutase-like
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Could be important to modulate the pK values of the two catalytic cysteine residues
Saccharopine dehydrogenase-like C-terminal
NIF system FeS cluster assembly NifU N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Reversibly protonated during proton transport
Cytochrome c-type biogenesis protein CcmF C-terminal
Phosphomannose isomerase type I catalytic
Flagellar hook-length control protein-like C-terminal
2-oxoacid dehydrogenase acyltransferase catalytic