Large ribosomal subunit protein uL30-like ferredoxin-like fold
Flagellar assembly protein FliH/Type III secretion system HrpE
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
For 3-hydroxyacyl-CoA dehydrogenase activity
NIF system FeS cluster assembly NifU C-terminal
RNA methyltransferase SpoU/TrmH type C-terminal
Resolvase/invertase-type recombinase catalytic
Cytochrome c-type biogenesis protein CcmF C-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Penicillin-binding protein transpeptidase
ABC-type transport auxiliary lipoprotein component
Major facilitator superfamily (MFS) profile
Heme-copper oxidase subunit III family profile
Bacterial transcription activator effector binding
Regulator of nucleoside diphosphate kinase N-terminal
Transcription elongation factor GreA/GreB C-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Toxin co-regulated pilus biosynthesis protein Q C-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Phosphocysteine intermediate; for EIIB activity
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Could play a key role in the communication between the regulatory and the substrate sites
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Acyl-CoA dehydrogenase/oxidase C-terminal
Adaptive response protein AidB N-terminal
RND efflux pump membrane fusion protein barrel-sandwich
Gp5/Type VI secretion system Vgr protein OB-fold
Tellurite resistance methyltransferase TehB-like
Schiff-base intermediate with substrate; via pyruvic acid
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Negative modulator of initiation of replication SeqA N-terminal
Replication modulator SeqA C-terminal DNA-binding
Solute-binding protein family 3/N-terminal
Flagellar motor switch protein FliN N-terminal
Flagellar motor switch protein FliN-like C-terminal
Chromosomal replication initiator DnaA C-terminal
Membrane fusion protein biotin-lipoyl like
Organic solvent tolerance-like N-terminal
sn-glycerol-3-phosphate-binding periplasmic protein UgpB
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Polysaccharide chain length determinant N-terminal
Tryptophan synthase beta chain-like PALP
Electron transfer via tryptophanyl radical
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Sodium/calcium exchanger membrane region
TonB-dependent receptor-like beta-barrel
Alpha-D-phosphohexomutase alpha/beta/alpha
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Tc toxin complex TcA C-terminal TcB-binding
Positions MEP for the nucleophilic attack
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Menaquinone biosynthesis protein MenD middle
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Inosine/uridine-preferring nucleoside hydrolase
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Ionotropic glutamate receptor C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Acetylserotonin O-methyltransferase dimerisation
O-(3'-phospho-DNA)-tyrosine intermediate
6-phosphogluconate dehydrogenase C-terminal
Superoxide dismutase copper/zinc binding
DNA polymerase III delta subunit C-terminal
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
4'-phosphopantetheinyl transferase N-terminal
Type II secretion system protein GspG C-terminal
Prepilin type IV endopeptidase peptidase
Periplasmic nitrate reductase, electron transfer subunit
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
Two-partner system transport domain (TPS)
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Putative type VI secretion system Rhs element associated Vgr
Thiol:disulfide interchange protein DsbD
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
Flagella basal body P-ring formation protein FlgA
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Lipopolysaccharide export system protein LptA
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Bacterial type II secretion system protein E
Hypersensitivity response secretion-like HrpJ
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Lysidine-tRNA(Ile) synthetase C-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Cytochrome C biogenesis protein transmembrane
Thiol:disulfide interchange protein DsbD N-terminal
Integral membrane protein YccS N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Tetrahydrodipicolinate-N-succinyltransferase chain A
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Acyltransferase MbtK/IucB-like conserved
CASTOR/POLLUX/SYM8 ion channel conserved
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Na(+)-translocating NADH-quinone reductase subunit A C-terminal
Cation-transporting P-type ATPase N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Proton acceptor; for glutaminase activity
Type III secretion system flagellar brake protein YcgR PilZN
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Serine/threonine specific protein phosphatases
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Pyrimidine nucleoside phosphorylase C-terminal
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
UDP N-acetylglucosamine O-acyltransferase C-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Translation elongation factor P/YeiP central
YbaK/aminoacyl-tRNA synthetase-associated
Outer membrane protein assembly factor BamE
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Phosphatidylinositol-specific phospholipase C X
Phosphomannose isomerase type I C-terminal
Phosphomannose isomerase type I catalytic
Phosphomannose isomerase type I helical insertion
Glucosamine/galactosamine-6-phosphate isomerase
Plays an important role in discriminating NADH against NADPH
Acyl-CoA dehydrogenase C-terminal bacterial-type
Acyl-CoA dehydrogenase/oxidase N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Major facilitator superfamily associated
DNA polymerase III subunit delta C-terminal
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
High-affinity branched-chain amino acid transport system permease LivHM N-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
DNA mismatch repair MutH/Type II restriction enzyme Sau3AI
Pyruvate dehydrogenase E1 component middle
Peptidase S9 prolyl oligopeptidase catalytic
Flagellar hook-length control protein-like C-terminal
Glycoside hydrolase family 31 N-terminal
Pyridoxamine 5'-phosphate oxidase putative
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Schiff-base intermediate with acetaldehyde
Release factor glutamine methyltransferase N-terminal
Glucose-methanol-choline oxidoreductase C-terminal
Quercetin 2,3-dioxygenase C-terminal cupin
Nucleoside-specific channel-forming protein, Tsx
Type II secretion system protein GspI C-terminal
RNA 2-O ribose methyltransferase substrate binding
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Chitobiase/beta-hexosaminidases N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
DNA-directed DNA polymerase family A palm
Prokaryotic-type class I peptide chain release factors
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Glycosyltransferase 2-like prokaryotic type
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
Influences the redox potential of the prosthetic heme and FAD groups
Involved in heme-bound ligand stabilization and O-O bond activation
Thymidylate synthase/dCMP hydroxymethylase
Penicillin-binding protein activator LpoB
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Reversibly protonated during proton transport
Required for zinc-mediated homotetramerization and catalytic activity
Transcriptional regulator SgrR N-terminal HTH
Large ribosomal subunit protein bL25 L25
Carbamoyl-phosphate synthase small subunit N-terminal
Phosphoadenosine phosphosulphate reductase
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Large ribosomal subunit protein uL15/eL18
Transcription elongation factor GreA/GreB N-terminal
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Shikimate dehydrogenase substrate binding N-terminal
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
DNA replication/recombination mediator RecO N-terminal
ABC-type glycine betaine transport system substrate-binding
Membrane iron-sulfur containing protein FtrD-like
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
HicB-like antitoxin of toxin-antitoxin system
L-seryl-tRNA selenium transferase N-terminal
Outer membrane protein assembly factor BamB
Moves into active site upon enzyme activation, plays a role in electron transfer
Nucleophile; cysteine thiosulfonate intermediate
Anthranilate synthase component I N-terminal
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Aspartate/homoserine dehydrogenase NAD-binding
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
Gamma-glutamylcyclotransferase AIG2-like
Interaction with polymerase core subunit RpoC
Exonuclease VII large subunit C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Erythronate-4-phosphate dehydrogenase dimerisation
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Penicillin-binding protein activator LpoA
O-(phosphoribosyl dephospho-coenzyme A)serine
Molybdopterin cofactor biosynthesis C (MoaC)
Phosphoethanolamine transferase N-terminal
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
Greasy slide, important in sugar transport
Common pilus major fimbrillin subunit EcpA
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Alanyl-transfer RNA synthetases family profile
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Outer membrane protein assembly factor BamD
Chromosome partition protein MukF C-terminal
Chromosome partition protein MukF middle
Chromosome partition protein MukF winged-helix
Glycosyl transferase family 3 N-terminal
RNA polymerase sigma factor 70 region 4 type 2
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Periplasmic binding protein/LacI sugar binding
The binding site for the sugar molecule has not yet been established, but C-87 may be involved
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
RNA binding; important for wobble base 34 recognition
Polymerase/histidinol phosphatase N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Lytic transglycosylase superhelical linker
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Methylguanine DNA methyltransferase ribonuclease-like
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Ion-translocating oxidoreductase complex subunit G
SUF system FeS cluster assembly SufBD N-terminal
Bacteriophage T7 Gp4 DNA primase/helicase N-terminal
Membrane-bound lytic murein transglycosylase C
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Appears to be important in orienting the phosphate for catalysis
Outer membrane protein assembly factor BamA
Helix-hairpin-helix DNA-binding motif class 1
Pyruvate phosphate dikinase AMP/ATP-binding
Outer-membrane lipoprotein carrier protein
Peptide methionine sulphoxide reductase MsrA
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
Required for dimer formation and molybdate binding
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
DNA-directed DNA polymerase family B exonuclease
DNA-directed DNA polymerase family B multifunctional
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Large ribosomal subunit protein uL6 alpha-beta
D-galactose/methyl-galactoside binding periplasmic protein MglB
Insecticide toxin TcdB middle/C-terminal
Insecticide toxin TcdB middle/N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
NADH:ubiquinone oxidoreductase 30kDa subunit
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Chromosomal replication initiator protein DnaA
Proton acceptor; for decarboxylase activity
Proton donor; for decarboxylase activity
Proton donor; for formyltransferase activity
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Glycine cleavage T-protein C-terminal barrel
NIF system FeS cluster assembly NifU N-terminal
Proline utilization A proline dehydrogenase N-terminal
Glutathionylspermidine synthase pre-ATP-grasp-like
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Acyl-ester intermediate; for transpeptidase activity
Proton donor; for transglycosylase activity
Transglycosylase PBP1b N-terminal transmembrane
ATP synthase F1 complex delta/epsilon subunit N-terminal
Mannose-6-phosphate isomerase type II C-terminal
Involved in allosteric activation by GTP
Sugar fermentation stimulation protein C-terminal
Large ribosomal subunit protein uL2 C-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Cysteine sulfenic acid (-SOH) intermediate
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Essential for degradation by Lon protease
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Important for interaction with partner proteins
Small ribosomal subunit protein uS4 N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Arginine decarboxylase C-terminal helical
Interacts with tRNA; defines subfamily-specific binding signature
Translocation and assembly module subunit TamA
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Threonine/serine exporter-like N-terminal
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Important for substrate binding and specificity
Type VI secretion system IcmF C-terminal
Non-canonical purine NTP phosphatase/PRRC1
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Alpha-glycerophosphate oxidase C-terminal
Survival protein SurE-like phosphatase/nucleotidase
Curli production assembly/transport component CsgG
High-affinity zinc uptake system protein ZnuA
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Plays an important role in substrate specificity
Methylamine/Aralkylamine dehydrogenase light chain C-terminal
Tryptophylquinone 6'-substrate hemiaminal intermediate
Mechanosensitive ion channel inner membrane
Involved in tetramerization or stability of the tetramer
Pseudouridine synthase I TruA alpha/beta
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Antitoxin Xre/MbcA/ParS-like toxin-binding
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Important for beta-aspartyl-AMP intermediate formation
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Essential for prephenate dehydratase activity
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Signal transduction histidine kinase 5TM receptor LytS transmembrane region
Signal transduction histidine kinase internal region