UDP-glucose/GDP-mannose dehydrogenase C-terminal
Interaction with polymerase core subunit RpoC
Solute-binding protein family 3/N-terminal
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Major facilitator superfamily (MFS) profile
RNA polymerase sigma factor 70 region 4 type 2
Bacterial DNA polymerase III alpha subunit NTPase
DNA polymerase helix-hairpin-helix motif
DNA-directed DNA polymerase family A palm
Probable periplasmic serine endoprotease DegP-like
YbaK/aminoacyl-tRNA synthetase-associated
Aminoacyl-transfer RNA synthetases class-II family profile
RND efflux pump membrane fusion protein barrel-sandwich
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Membrane fusion protein biotin-lipoyl like
Signal transduction histidine kinase HWE region
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Polysaccharide biosynthesis protein C-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Bacterial bifunctional deaminase-reductase C-terminal
6-phosphogluconate dehydrogenase C-terminal
Sodium/calcium exchanger membrane region
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Glycoside hydrolase family 42 N-terminal
Polysaccharide biosynthesis protein CapD-like
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Inosine/uridine-preferring nucleoside hydrolase
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
RNA 2-O ribose methyltransferase substrate binding
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Superoxide dismutase copper/zinc binding
Influences the redox potential of the prosthetic heme and FAD groups
Involved in heme-bound ligand stabilization and O-O bond activation
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Glucosamine/galactosamine-6-phosphate isomerase
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
L,D-transpeptidase catalytic domain-containing protein
Transposase IS116/IS110/IS902 C-terminal
UDP N-acetylglucosamine O-acyltransferase C-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Mandelate racemase/muconate lactonizing enzyme C-terminal
Outer membrane protein beta-barrel domain-containing protein
Antitoxin Xre/MbcA/ParS-like toxin-binding
Activator of Hsp90 ATPase homologue 1-like C-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
Cysteine sulfenic acid (-SOH) intermediate
NADH:ubiquinone oxidoreductase 30kDa subunit
Bacterial type II secretion system protein E
Large ribosomal subunit protein uL30-like ferredoxin-like fold
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Cytochrome b561 bacterial/Ni-hydrogenase
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Heme-copper oxidase subunit III family profile
ABC-type glycine betaine transport system substrate-binding
Lipocalin-like domain-containing protein
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
TtsA-like Glycoside hydrolase family 108
Phosphoadenosine phosphosulphate reductase
Resolvase/invertase-type recombinase catalytic
NIF system FeS cluster assembly NifU N-terminal
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-96)
Electron transfer flavoprotein alpha/beta-subunit N-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Nitrite/Sulfite reductase ferredoxin-like
Plasmid replication protein C C-terminal
Plasmid replication protein C N-terminal
Peptide methionine sulphoxide reductase MsrA
Endolytic peptidoglycan transglycosylase RlpA
RlpA-like protein double-psi beta-barrel
Alginate export domain-containing protein
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Pyridoxamine 5'-phosphate oxidase putative
Shikimate dehydrogenase substrate binding N-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Ribosomal RNA adenine methylase transferase N-terminal
Glycosyl transferase family 3 N-terminal
Penicillin-binding protein transpeptidase
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Saccharopine dehydrogenase-like C-terminal
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Tryptophan synthase beta chain-like PALP
Large ribosomal subunit protein uL6 alpha-beta
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Cytochrome c-type biogenesis protein CcmF C-terminal
Glutamate synthase alpha subunit C-terminal
Polysaccharide chain length determinant N-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Mannose-6-phosphate isomerase type II C-terminal
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Glycosyltransferase subfamily 4-like N-terminal
Spermidine/putrescine transport system substrate-binding protein
Hedgehog/Intein (Hint) domain-containing protein
Flagella basal body P-ring formation protein FlgA
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Major facilitator superfamily associated
Phosphoethanolamine transferase N-terminal
Beta-hexosaminidase bacterial type N-terminal
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Large ribosomal subunit protein uL2 C-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Pyrroline-5-carboxylate reductase catalytic N-terminal
Adaptive response protein AidB N-terminal
Heat-inducible transcription repressor HrcA C-terminal
Flagellar motor switch protein FliN-like C-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Histidine phosphotransferase ChpT C-terminal
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Outer membrane protein assembly factor BamA
Prokaryotic-type class I peptide chain release factors
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Important for interaction with partner proteins
AlgX/AlgJ SGNH hydrolase-like domain-containing protein
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Endoribonuclease L-PSP/chorismate mutase-like
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Alpha-D-phosphohexomutase alpha/beta/alpha
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Survival protein SurE-like phosphatase/nucleotidase
Pseudouridine synthase I TruA alpha/beta
Poly-beta-hydroxybutyrate polymerase N-terminal
Proton acceptor; for glutaminase activity
Glyoxalase/fosfomycin resistance/dioxygenase
Required for zinc-mediated homotetramerization and catalytic activity
Beta-xylosidase C-terminal Concanavalin A-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Regulator of nucleoside diphosphate kinase N-terminal
Ionotropic glutamate receptor C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Na+/H+ antiporter MnhB subunit-related protein
Glycosyl-hydrolase family 116 catalytic region
CDP-alcohol phosphatidyltransferase C-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
NAD(P) transhydrogenase alpha subunit C-terminal
Reversibly protonated during proton transport
Small ribosomal subunit protein uS4 N-terminal
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
RNA binding; important for wobble base 34 recognition
Phosphoribosylformylglycinamidine synthase linker
Periplasmic copper-binding protein NosD beta helix
Chromosomal replication initiator protein DnaA
TonB-dependent receptor-like beta-barrel
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
ABC transporter substrate-binding protein
ABC transporter substrate-binding protein PnrA-like
Cobaltochelatase subunit CobS N-terminal
Cytochrome c oxidase subunit IV bacterial aa3 type
SUF system FeS cluster assembly SufBD N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Release factor glutamine methyltransferase N-terminal
Involved in tetramerization or stability of the tetramer
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Pyrroline-5-carboxylate reductase dimerisation
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
NADH:ubiquinone oxidoreductase-like 20kDa subunit
General stress protein FMN-binding split barrel
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Gamma-butyrobetaine hydroxylase-like N-terminal
Vanillate O-demethylase oxygenase-like C-terminal catalytic
Phosphogluconate dehydrogenase (decarboxylating) C-terminal
TRAP C4-dicarboxylate transport system permease DctM subunit
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Calcineurin-like phosphoesterase domain-containing protein
Polymerase/histidinol phosphatase N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Pyruvate phosphate dikinase AMP/ATP-binding
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
CagE TrbE VirB component of type IV transporter system central
Glycine zipper domain-containing protein
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Oxidoreductase molybdopterin-binding domain-containing protein
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Ribose-phosphate pyrophosphokinase N-terminal
AB hydrolase-1 domain-containing protein
N-end rule aminoacyl transferase C-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Pyrimidine nucleoside phosphorylase C-terminal
DNA topoisomerase I catalytic core eukaryotic-type
Cyclophilin-like domain-containing protein
Chromosomal replication initiator DnaA C-terminal
Serine/threonine specific protein phosphatases
Transcriptional regulator TetR C-terminal Proteobacteria type
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
ATP synthase F1 complex delta/epsilon subunit N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Aromatic amino acid beta-eliminating lyase/threonine aldolase
CobB/CobQ-like glutamine amidotransferase
C-type lysozyme inhibitor domain-containing protein
Anthranilate synthase component I N-terminal
Moves into active site upon enzyme activation, plays a role in electron transfer
Lysozyme inhibitor LprI N-terminal domain-containing protein
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Increases nucleophilicity of active site Cys
Glycine cleavage T-protein C-terminal barrel
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
High-affinity branched-chain amino acid transport system permease LivHM N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Molybdopterin cofactor biosynthesis C (MoaC)
DNA mismatch repair proteins mutS family
DNA replication/recombination mediator RecO N-terminal
2-oxoisovalerate dehydrogenase E1 alpha subunit N-terminal
Large ribosomal subunit protein uL15/eL18
Thymidylate synthase/dCMP hydroxymethylase
High-affinity zinc uptake system protein ZnuA
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Glycosyl transferase family 28 C-terminal
Right handed beta helix domain-containing protein
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Type IV conjugative transfer protein TrbJ/K C-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Carbamoyl-phosphate synthase small subunit N-terminal
Essential for prephenate dehydratase activity
Alanyl-transfer RNA synthetases family profile
PHA accumulation regulator DNA-binding N-terminal
Phosphodiester glycosidase domain-containing protein
Anaphase-promoting complex subunit 4-like WD40
Exonuclease VII large subunit C-terminal
Auto-transporter adhesin head GIN domain-containing protein
Glucose/Sorbosone dehydrogenase domain-containing protein
Transglycosylase SLT domain-containing protein
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Glycosyltransferase family 28 N-terminal
Plays an important role in substrate specificity
5-glutamyl coenzyme A thioester intermediate
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Terminase large subunit-like endonuclease
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Beta-lactamase hydrolase-like protein phosphatase-like
Extensin-like C-terminal domain-containing protein
Prepilin type IV endopeptidase peptidase
Cytochrome C biogenesis protein transmembrane
Phosphatidylglycerol lysyltransferase C-terminal
ABC-type transport auxiliary lipoprotein component
ABC-type transport auxiliary lipoprotein component domain-containing protein
NADH-rubredoxin oxidoreductase C-terminal
Translation elongation factor P/YeiP central
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Microcystin LR degradation protein MlrC C-terminal
Microcystin LR degradation protein MlrC N-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Involved in allosteric activation by GTP
Alpha-glycerophosphate oxidase C-terminal
Transcription regulator AsnC/Lrp ligand binding
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Aminoacyl-tRNA synthetase class I anticodon-binding
S-adenosyl-L-homocysteine hydrolase NAD binding
Nucleophile; cysteine thiosulfonate intermediate
Glycosyl hydrolases family 2 sugar binding
Tetrahydrodipicolinate-N-succinyltransferase chain A
Nitrile hydratase alpha /Thiocyanate hydrolase gamma
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Gamma-glutamylcyclotransferase AIG2-like
Sugar ABC transporter substrate-binding protein
Flagellar hook-length control protein-like C-terminal
Cob(I)alamin adenosyltransferase N-terminal
DNA primase/polymerase bifunctional N-terminal