Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Activator of Hsp90 ATPase homologue 1-like C-terminal
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Major facilitator superfamily (MFS) profile
6-phosphogluconate dehydrogenase NADP-binding
Glycosyltransferase subfamily 4-like N-terminal
ATP-dependent DNA helicase RecG C-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Sodium/calcium exchanger membrane region
Mandelate racemase/muconate lactonizing enzyme C-terminal
NIF system FeS cluster assembly NifU N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
1,4-alpha-glucan branching enzyme C-terminal
Glycoside hydrolase family 57 N-terminal
Peptidase M1 membrane alanine aminopeptidase
RNA polymerase sigma factor 70 region 4 type 2
Peptidase S9 prolyl oligopeptidase catalytic
ABC transporter substrate-binding protein PnrA-like
Actinobacteria/chloroflexi VLRF1 release factor
Cytochrome C biogenesis protein transmembrane
Translation elongation factor P/YeiP central
Ribose-phosphate pyrophosphokinase N-terminal
Pyridoxamine 5'-phosphate oxidase putative
Endoribonuclease L-PSP/chorismate mutase-like
Myo-inositol-1-phosphate synthase GAPDH-like
Beta-lactamase class A catalytic domain-containing protein
DNA primase/polymerase bifunctional N-terminal
Na+/H+ antiporter MnhB subunit-related protein
Solute-binding protein family 3/N-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Helix-hairpin-helix DNA-binding motif class 1
Pyridine nucleotide-disulphide oxidoreductase dimerisation
PsrA tetracyclin repressor-like C-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
N6 adenine-specific DNA methyltransferase N-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Pyruvate dehydrogenase E1 component middle
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
4'-phosphopantetheinyl transferase N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Glycoside-hydrolase family GH114 TIM-barrel
Glycoside-hydrolase family GH114 TIM-barrel domain-containing protein
Pyruvate phosphate dikinase AMP/ATP-binding
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Putative Flp pilus-assembly TadG-like N-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Tryptophan synthase beta chain-like PALP
Glucosamine/galactosamine-6-phosphate isomerase
Peptidoglycan recognition protein family
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Schiff-base intermediate with D-ribose 5-phosphate
Alpha-D-phosphohexomutase alpha/beta/alpha
Important for beta-aspartyl-AMP intermediate formation
Peptide methionine sulphoxide reductase MsrA
Penicillin-binding protein transpeptidase
Pyrimidine nucleoside phosphorylase C-terminal
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
SUF system FeS cluster assembly SufBD N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Cytochrome b/b6 N-terminal region profile
CobB/CobQ-like glutamine amidotransferase
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Lactate utilization protein B C-terminal
Large ribosomal subunit protein uL15/eL18
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Positions MEP for the nucleophilic attack
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Sigma 54 modulation/S30EA ribosomal protein C-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
ABC-type glycine betaine transport system substrate-binding
Microcin J25-processing protein McjB C-terminal
Small ribosomal subunit protein uS4 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Phosphotransferase system enzyme I N-terminal
Nitrite/Sulfite reductase ferredoxin-like
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Peptidase M15C domain-containing protein
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Cell envelope-related transcriptional attenuator
Glycosyl transferase family 3 N-terminal
Glycine cleavage T-protein C-terminal barrel
O-(5'-phospho-DNA)-tyrosine intermediate
Prokaryotic-type class I peptide chain release factors
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Schiff-base intermediate with substrate; via pyruvic acid
Removed in mature form; by autocatalysis
Carbamoyl-phosphate synthase small subunit N-terminal
N(4)-bis(aminopropyl)spermidine synthase C-terminal
Aspartate/homoserine dehydrogenase NAD-binding
Type I restriction modification DNA specificity
NADH-rubredoxin oxidoreductase C-terminal
Survival protein SurE-like phosphatase/nucleotidase
RNA 2-O ribose methyltransferase substrate binding
Large ribosomal subunit protein uL2 C-terminal
Large ribosomal subunit protein uL6 alpha-beta
Moves into active site upon enzyme activation, plays a role in electron transfer
Phosphocysteine intermediate; for EIIB activity
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Ribosomal RNA adenine methylase transferase N-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Glucose-methanol-choline oxidoreductase C-terminal
FAD-dependent oxidoreductase 2 FAD binding
Thiopeptide-type bacteriocin biosynthesis
Prepilin type IV endopeptidase peptidase
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Anthranilate synthase component I N-terminal
Glycoside hydrolase family 42 N-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Septum formation-related domain-containing protein
Alanyl-transfer RNA synthetases family profile
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Transcription regulator AsnC/Lrp ligand binding
DNA replication/recombination mediator RecO N-terminal
Threonine/serine exporter-like N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Glycosyl transferase family 28 C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
6-phosphogluconate dehydrogenase C-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Putative oxidoreductase/dehydrogenase Rossmann-like
DNA-directed DNA polymerase family A palm
Shikimate dehydrogenase substrate binding N-terminal
Sporulation transcription regulator WhiA N-terminal
Anti-sigma-D factor RsdA sigma factor binding region
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Styrene monooxygenase StyA putative substrate binding
Glutathionylspermidine synthase pre-ATP-grasp-like
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Alpha-L-rhamnosidase six-hairpin glycosidase
Bacterial alpha-L-rhamnosidase N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Chromosomal replication initiator DnaA C-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Nicotinate phosphoribosyltransferase N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Gp5/Type VI secretion system Vgr protein OB-fold
Heat-inducible transcription repressor HrcA C-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Ionotropic glutamate receptor C-terminal
Involved in ionization of N3 of dUMP, leading to its activation
S-adenosyl-L-homocysteine hydrolase NAD binding
Glycosyl hydrolase family 98 putative carbohydrate-binding module
Histidine-specific methyltransferase SAM-dependent
Essential for prephenate dehydratase activity
Methylguanine DNA methyltransferase ribonuclease-like
Beta-xylosidase C-terminal Concanavalin A-like
Release factor glutamine methyltransferase N-terminal
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Membrane insertase YidC/Oxa/ALB C-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Transition state stabilizer; via amide nitrogen