NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Major facilitator superfamily (MFS) profile
Cytochrome c-type biogenesis protein CcmF C-terminal
Heme-copper oxidase subunit III family profile
ABC-type glycine betaine transport system substrate-binding
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Transposase IS116/IS110/IS902 C-terminal
Histidine phosphotransferase ChpT C-terminal
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-98)
PHA accumulation regulator DNA-binding N-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
N-end rule aminoacyl transferase C-terminal
Glycosyltransferase 2-like prokaryotic type
Phosphoadenosine phosphosulphate reductase
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Small ribosomal subunit protein uS4 N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Aminoacyl-transfer RNA synthetases class-II family profile
Pyrimidine nucleoside phosphorylase C-terminal
Siroheme decarboxylase AsnC-like ligand binding
General stress protein FMN-binding split barrel
O-(3'-phospho-DNA)-tyrosine intermediate
Glucan biosynthesis periplasmic MdoG C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
RNA 2-O ribose methyltransferase substrate binding
Heat-inducible transcription repressor HrcA C-terminal
Flagellar motor switch protein FliN-like C-terminal
Survival protein SurE-like phosphatase/nucleotidase
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Ribosomal RNA adenine methylase transferase N-terminal
Glutathionylspermidine synthase pre-ATP-grasp-like
Anthranilate synthase component I N-terminal
Peptide methionine sulphoxide reductase MsrA
TonB-dependent receptor-like beta-barrel
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Peptidase propeptide and YPEB domain-containing protein
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Endoribonuclease L-PSP/chorismate mutase-like
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Positions MEP for the nucleophilic attack
DNA-directed DNA polymerase family A palm
RND efflux pump membrane fusion protein barrel-sandwich
Phosphatidylglycerol lysyltransferase C-terminal
Cytochrome C biogenesis protein transmembrane
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Bacterial bifunctional deaminase-reductase C-terminal
DNA-binding beta-propeller fold protein YncE
Sigma 54 modulation/S30EA ribosomal protein C-terminal
S-adenosylmethionine-dependent methyltransferase
Proton acceptor; for glutaminase activity
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Mannose-6-phosphate isomerase type II C-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Cob(I)alamin adenosyltransferase N-terminal
Tetrahydrodipicolinate-N-succinyltransferase chain A
Alpha-D-phosphohexomutase alpha/beta/alpha
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
Aconitase A/isopropylmalate dehydratase small subunit swivel
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Gly-cisPro motif, important for rejection of L-amino acids
Polymerase/histidinol phosphatase N-terminal
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Penicillin-binding protein transpeptidase
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Lysozyme inhibitor LprI N-terminal domain-containing protein
YbaK/aminoacyl-tRNA synthetase-associated
Glycosyltransferase subfamily 4-like N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Solute-binding protein family 3/N-terminal
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
DNA mismatch repair proteins mutS family
Periplasmic binding protein/LacI sugar binding
RNA polymerase sigma factor 70 region 4 type 2
Alanyl-transfer RNA synthetases family profile
Pyridine nucleotide-disulphide oxidoreductase dimerisation
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Na+/H+ antiporter MnhB subunit-related protein
DNA-directed RNA polymerase RpoA/D/Rpb3-type
SUF system FeS cluster assembly SufBD N-terminal
Transcription regulator AsnC/Lrp ligand binding
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Glutamate synthase alpha subunit C-terminal
Large ribosomal subunit protein uL6 alpha-beta
Cobaltochelatase subunit CobS N-terminal
Moybdenum cofactor oxidoreductase dimerisation
Terminase large subunit gp17-like C-terminal
Phage terminase large subunit GpA ATPase
Terminase large subunit GpA endonuclease
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Lipopolysaccharide export system protein LptA
Organic solvent tolerance-like N-terminal
Release factor glutamine methyltransferase N-terminal
Interacts with tRNA; defines subfamily-specific binding signature
Cytochrome c oxidase subunit IV bacterial aa3 type
Large ribosomal subunit protein uL15/eL18
Could play a key role in the communication between the regulatory and the substrate sites
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
TRAP C4-dicarboxylate transport system permease DctM subunit
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
S-adenosyl-L-homocysteine hydrolase NAD binding
N,N-dimethylformamidase beta subunit-like C-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Glucose-methanol-choline oxidoreductase N-terminal
Nitrite/Sulfite reductase ferredoxin-like
Methionyl-tRNA synthetase anticodon-binding
Signal recognition particle SRP54 helical bundle
Pseudouridine synthase I TruA alpha/beta
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Glycine cleavage T-protein C-terminal barrel
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
tRNA pseudouridylate synthase B C-terminal
Translation elongation factor P/YeiP central
Prokaryotic-type class I peptide chain release factors
Proline utilization A proline dehydrogenase N-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Glycosyl transferase family 3 N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Outer membrane protein beta-barrel domain-containing protein
Exonuclease VII large subunit C-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Interaction with polymerase core subunit RpoC
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Superoxide dismutase copper/zinc binding
TtsA-like Glycoside hydrolase family 108
Cysteine sulfenic acid (-SOH) intermediate
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Chromosomal replication initiator protein DnaA
Ionotropic glutamate receptor C-terminal
Phosphoribosylformylglycinamidine synthase linker
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Cytochrome b561 bacterial/Ni-hydrogenase
HTH-type transcriptional repressor KstR2 C-terminal
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
UDP N-acetylglucosamine O-acyltransferase C-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Alpha-glycerophosphate oxidase C-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Essential for prephenate dehydratase activity
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Involved in ionization of N3 of dUMP, leading to its activation
Helix-hairpin-helix DNA-binding motif class 1
Membrane fusion protein biotin-lipoyl like
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Glucose-methanol-choline oxidoreductase C-terminal
Important for interaction with partner proteins
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Involved in allosteric activation by GTP
Gfo/Idh/MocA-like oxidoreductase N-terminal
Shikimate dehydrogenase substrate binding N-terminal
Choloylglycine hydrolase/NAAA C-terminal
Bacteriophage tail tape measure C-terminal
ABC transporter substrate-binding protein PnrA-like
Activator of Hsp90 ATPase homologue 1-like C-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Invasion protein IalB, involved in pathogenesis
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Tryptophan synthase beta chain-like PALP
Reversibly protonated during proton transport
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
DNA replication/recombination mediator RecO N-terminal
Large ribosomal subunit protein uL2 C-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Ribonucleotide reductase large subunit C-terminal
Ribonucleotide reductase large subunit N-terminal
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Molybdopterin cofactor biosynthesis C (MoaC)
4'-phosphopantetheinyl transferase N-terminal
L-seryl-tRNA selenium transferase N-terminal
Involved in tetramerization or stability of the tetramer
Inosine/uridine-preferring nucleoside hydrolase
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Thiol:disulfide interchange protein DsbD N-terminal
Type I restriction modification DNA specificity
Membrane insertase YidC/Oxa/ALB C-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Mandelate racemase/muconate lactonizing enzyme C-terminal
ABC-type transport auxiliary lipoprotein component
ABC-type transport auxiliary lipoprotein component domain-containing protein
Gfo/Idh/MocA-like oxidoreductase C-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
YMGG-like Gly-zipper domain-containing protein
Chromosomal replication initiator DnaA C-terminal
Resolvase/invertase-type recombinase catalytic
Schiff-base intermediate with dihydroxyacetone-P
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Gp5/Type VI secretion system Vgr protein OB-fold
Probable periplasmic serine endoprotease DegP-like
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Saccharopine dehydrogenase-like C-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Type II secretion system protein GspE N-terminal
Adaptive response protein AidB N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Inner membrane protein YgaP-like transmembrane
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Malonate/sodium symporter MadM subunit N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Protocatechuate 3,4-dioxygenase beta subunit N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Ribose-phosphate pyrophosphokinase N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Excalibur calcium-binding domain-containing protein
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
ATP synthase F1 complex delta/epsilon subunit N-terminal
2-oxoisovalerate dehydrogenase E1 alpha subunit N-terminal
Signal transduction histidine kinase HWE region