TonB-dependent receptor-like beta-barrel
Major facilitator superfamily (MFS) profile
Probable periplasmic serine endoprotease DegP-like
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Glycosyltransferase subfamily 4-like N-terminal
S-adenosylmethionine-dependent methyltransferase
Activator of Hsp90 ATPase homologue 1-like C-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Glycine-rich cell wall structural protein
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Solute-binding protein family 3/N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
HicB-like antitoxin of toxin-antitoxin system
Aminoacyl-transfer RNA synthetases class-II family profile
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Resolvase/invertase-type recombinase catalytic
Large ribosomal subunit protein uL2 C-terminal
RNA polymerase sigma factor 70 region 4 type 2
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Pyrimidine nucleoside phosphorylase C-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
FAD-dependent oxidoreductase 2 FAD binding
Release factor glutamine methyltransferase N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Glycosyl-hydrolase 97 C-terminal oligomerisation
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
DNA topoisomerase I catalytic core eukaryotic-type
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Heat-inducible transcription repressor HrcA C-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Signal transduction histidine kinase dimerisation/phosphoacceptor
Aconitase A/isopropylmalate dehydratase small subunit swivel
Beta-lactamase hydrolase-like protein phosphatase-like
Alpha-D-phosphohexomutase alpha/beta/alpha
Outer membrane protein assembly factor BamA
RND efflux pump membrane fusion protein barrel-sandwich
Alginate export domain-containing protein
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Transcription factor NikR nickel binding C-terminal
Flagellar basal body rod protein N-terminal
Membrane fusion protein biotin-lipoyl like
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
CagE TrbE VirB component of type IV transporter system central
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Tryptophan synthase beta chain-like PALP
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Peptide methionine sulfoxide reductase MsrA
Peptide methionine sulphoxide reductase MsrA
Flagellar motor switch protein FliN-like C-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Heme-copper oxidase subunit III family profile
Small ribosomal subunit protein uS4 N-terminal
Type IV secretion system coupling protein TraD DNA-binding
Cytochrome c-type biogenesis protein CcmE
O-(3'-phospho-DNA)-tyrosine intermediate
NADH:ubiquinone oxidoreductase 30kDa subunit
Molybdopterin cofactor biosynthesis C (MoaC)
Methionyl-tRNA synthetase anticodon-binding
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Penicillin-binding protein transpeptidase
Antitoxin Xre/MbcA/ParS-like toxin-binding
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Electron transfer flavoprotein alpha/beta-subunit N-terminal
N-end rule aminoacyl transferase C-terminal
Important for interaction with partner proteins
Quercetin 2,3-dioxygenase C-terminal cupin
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Polysaccharide chain length determinant N-terminal
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Putative Flp pilus-assembly TadG-like N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Reversibly protonated during proton transport
O-(5'-phospho-DNA)-tyrosine intermediate
C-type lysozyme inhibitor domain-containing protein
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Alanyl-transfer RNA synthetases family profile
Organic solvent tolerance-like N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
General stress protein FMN-binding split barrel
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase
Pyridoxamine 5'-phosphate oxidase putative
Alpha-L-glutamate ligase-related protein ATP-grasp
Polymerase/histidinol phosphatase N-terminal
Polysaccharide biosynthesis protein CapD-like
Glucose-methanol-choline oxidoreductase N-terminal
Prokaryotic-type class I peptide chain release factors
Chromosomal replication initiator DnaA C-terminal
Putative auto-transporter adhesin head GIN
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Biopterin-dependent aromatic amino acid hydroxylase family profile
Cobaltochelatase subunit CobS N-terminal
CobB/CobQ-like glutamine amidotransferase
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
SUF system FeS cluster assembly SufBD N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Essential for prephenate dehydratase activity
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
DNA replication/recombination mediator RecO N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
PsrA tetracyclin repressor-like C-terminal
Bacterial type II secretion system protein E
Shikimate dehydrogenase substrate binding N-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Putative glycogen debranching enzyme N-terminal
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-100)
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Major facilitator superfamily associated
Phosphoribosylformylglycinamidine synthase linker
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Positions MEP for the nucleophilic attack
Type II secretion system protein TadB-like N-terminal
Alpha-glycerophosphate oxidase C-terminal
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Thymidylate synthase/dCMP hydroxymethylase
Nitrite/Sulfite reductase ferredoxin-like
Outer membrane protein assembly factor BamD
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Signal transduction histidine kinase subgroup 2 dimerisation and phosphoacceptor
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Histidine phosphotransferase ChpT C-terminal
DNA mismatch repair proteins mutS family
Cytochrome b561 bacterial/Ni-hydrogenase
Glucan biosynthesis periplasmic MdoG C-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Translation elongation factor P/YeiP central
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Flagellar basal-body/hook protein C-terminal
RlpA-like protein double-psi beta-barrel
Outer membrane protein beta-barrel domain-containing protein
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Ribosomal RNA adenine methylase transferase N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Large ribosomal subunit protein uL15/eL18
Histidine-specific methyltransferase SAM-dependent
Ribose-phosphate pyrophosphokinase N-terminal
Transposase IS116/IS110/IS902 C-terminal
Interaction with polymerase core subunit RpoC
tRNA pseudouridylate synthase B C-terminal
Quinohemoprotein amine dehydrogenase alpha subunit haem binding domain-containing protein
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Glucosamine/galactosamine-6-phosphate isomerase
2-oxoisovalerate dehydrogenase E1 alpha subunit N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Cysteine sulfenic acid (-SOH) intermediate
NAD(P) transhydrogenase alpha subunit C-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Glycosyl transferase family 3 N-terminal
Signal recognition particle SRP54 helical bundle
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Pyrroline-5-carboxylate reductase dimerisation
Saccharopine dehydrogenase-like C-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
YbaK/aminoacyl-tRNA synthetase-associated
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Terminase large subunit gp17-like C-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Mandelate racemase/muconate lactonizing enzyme C-terminal
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
Pseudouridine synthase I TruA alpha/beta
PHA accumulation regulator DNA-binding N-terminal
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
2-oxoacid dehydrogenase acyltransferase catalytic
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
CDP-alcohol phosphatidyltransferase C-terminal
Flagella basal body P-ring formation protein FlgA C-terminal
Acetyl-CoA dehydrogenase-like C-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Poly-beta-hydroxybutyrate polymerase N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Prepilin type IV endopeptidase peptidase
Endoribonuclease L-PSP/chorismate mutase-like
TtsA-like Glycoside hydrolase family 108
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
RNA binding; important for wobble base 34 recognition
Heavy metal-binding domain-containing protein
Increases nucleophilicity of active site Cys
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Signal transduction histidine kinase HWE region
ATP synthase F1 complex delta/epsilon subunit N-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
S-adenosyl-L-homocysteine hydrolase NAD binding
Anthranilate synthase component I N-terminal
RNA 2-O ribose methyltransferase substrate binding
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Survival protein SurE-like phosphatase/nucleotidase
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Ribonucleotide reductase large subunit C-terminal
Ribonucleotide reductase large subunit N-terminal
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Exonuclease VII large subunit C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Spore coat protein U domain-containing protein
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Cytochrome c oxidase subunit IV bacterial aa3 type
Mannose-6-phosphate isomerase type II C-terminal
Large ribosomal subunit protein uL6 alpha-beta
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Beta-xylosidase C-terminal Concanavalin A-like
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal