Aminoacyl-transfer RNA synthetases class-II family profile
Resolvase/invertase-type recombinase catalytic
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Sugar fermentation stimulation protein C-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
O-(phosphoribosyl dephospho-coenzyme A)serine
Membrane insertase YidC/Oxa/ALB C-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Polymerase/histidinol phosphatase N-terminal
RND efflux pump membrane fusion protein barrel-sandwich
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
5-glutamyl coenzyme A thioester intermediate
Dinitrogenase iron-molybdenum cofactor biosynthesis
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
DNA replication/recombination mediator RecO N-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
ABC transporter substrate-binding protein PnrA-like
Transcriptional coactivator p15 (PC4) C-terminal
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
RNA polymerase sigma factor 70 region 4 type 2
Flagellar basal body rod protein N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Alanyl-transfer RNA synthetases family profile
Large ribosomal subunit protein uL2 C-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Inner membrane protein YgaP-like transmembrane
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Major facilitator superfamily (MFS) profile
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
Prepilin type IV endopeptidase peptidase
Electron transfer flavoprotein alpha/beta-subunit N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Membrane fusion protein biotin-lipoyl like
Heat-inducible transcription repressor HrcA C-terminal
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Ribose-phosphate pyrophosphokinase N-terminal
Tryptophan synthase beta chain-like PALP
Schiff-base intermediate with substrate; via pyruvic acid
Flagellar hook-length control protein-like C-terminal
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Mandelate racemase/muconate lactonizing enzyme C-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Glycosyl transferase family 28 C-terminal
Succinate dehydogenase/fumarate reductase N-terminal
ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
6-hydroxymethylpterin diphosphokinase MptE-like
Phosphatidylglycerol lysyltransferase C-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
FAD-dependent oxidoreductase 2 FAD binding
Helix-hairpin-helix DNA-binding motif class 1
Flagellar basal-body/hook protein C-terminal
Formiminotransferase C-terminal subdomain
Formiminotransferase N-terminal subdomain
CO dehydrogenase/acetyl-CoA synthase complex beta subunit C-terminal
Carbon monoxide dehydrogenase subunit alpha ,N-terminal
Threonine/serine exporter-like N-terminal
Polysaccharide biosynthesis protein CapD-like
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Inosine/uridine-preferring nucleoside hydrolase
Manganese/iron superoxide dismutase C-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Anthranilate synthase component I N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Polysaccharide chain length determinant N-terminal
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Essential for prephenate dehydratase activity
Pyridoxamine 5'-phosphate oxidase putative
Methylene-tetrahydrofolate reductase C-terminal
DNA mismatch repair proteins mutS family
Penicillin-binding protein transpeptidase
NADH-ubiquinone oxidoreductase 51kDa subunit FMN-binding
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
NADH-rubredoxin oxidoreductase C-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
Type II secretion system protein GspE N-terminal
DNA-directed DNA polymerase family A palm
Positions MEP for the nucleophilic attack
Phosphatidylinositol-specific phospholipase C X
Glycosyltransferase subfamily 4-like N-terminal
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Chromosomal replication initiator DnaA C-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
NIF system FeS cluster assembly NifU C-terminal
Siroheme decarboxylase AsnC-like ligand binding
Prokaryotic-type class I peptide chain release factors
Probable transposase IS891/IS1136/IS1341
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Sulfonate/nitrate/taurine transporter substrate-binding protein
Global transcriptional regulator CodY C-terminal
Global transcriptional regulator CodY N-terminal
Phosphocysteine intermediate; for EIIB activity
Flagellar motor switch protein FliN-like C-terminal
Cation-transporting P-type ATPase N-terminal
CobB/CobQ-like glutamine amidotransferase
Polysaccharide biosynthesis protein C-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Methylaspartate ammonia-lyase C-terminal
Methylaspartate ammonia-lyase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
L-seryl-tRNA selenium transferase N-terminal
L,D-transpeptidase catalytic domain-containing protein
Increases nucleophilicity of active site Cys
Lysidine-tRNA(Ile) synthetase C-terminal
Cytochrome oxidase subunit II transmembrane region profile
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Small ribosomal subunit protein uS4 N-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Carbamoyl-phosphate synthase small subunit N-terminal
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
BAAT/Acyl-CoA thioester hydrolase C-terminal
DNA polymerase III delta subunit C-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Flagellar hook-associated protein 2 C-terminal
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Schiff-base intermediate with acetaldehyde
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Septum formation inhibitor MinC C-terminal
Peptidase M1 membrane alanine aminopeptidase
Metal ABC transporter substrate-binding protein
Important for beta-aspartyl-AMP intermediate formation
Phosphomannose isomerase type I catalytic
Pyruvate/ketoisovalerate oxidoreductase catalytic
Involved in ionization of N3 of dUMP, leading to its activation
PrcB C-terminal domain-containing protein
Cell envelope-related transcriptional attenuator
Fe/B12 periplasmic-binding domain-containing protein
Proton acceptor; for glutaminase activity
RNA binding; important for wobble base 34 recognition
Glycosyl transferase family 3 N-terminal
Sporulation stage IV protein A C-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Thiamine pyrophosphate enzyme TPP-binding
Choloylglycine hydrolase/NAAA C-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Nitrite/Sulfite reductase ferredoxin-like
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
CO dehydrogenase/acetyl-CoA synthase delta subunit TIM barrel
Survival protein SurE-like phosphatase/nucleotidase
Could be important to modulate the pK values of the two catalytic cysteine residues
Diacylglycerol glucosyltransferase N-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Lantibiotic immunity protein Spa1 C-terminal
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
O-(5'-phospho-DNA)-tyrosine intermediate
Bacterial type II secretion system protein E
Reversibly protonated during proton transport
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Could play a key role in the communication between the regulatory and the substrate sites
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Glycosyltransferase family 28 N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
ABC transporter substrate-binding protein
Glutathionylspermidine synthase pre-ATP-grasp-like
Formylmethanofuran dehydrogenase subunit E
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Translation elongation factor P/YeiP central
Signal transduction histidine kinase osmosensitive K+ channel sensor N-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Large ribosomal subunit protein uL6 alpha-beta
tRNA pseudouridylate synthase B C-terminal
Ribulose bisphosphate carboxylase large subunit C-terminal
Exonuclease VII large subunit C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Release factor glutamine methyltransferase N-terminal
RNA 2-O ribose methyltransferase substrate binding
4-hydroxyphenylacetate decarboxylase small gamma subunit C-terminal
4-hydroxyphenylacetate decarboxylase small gamma subunit N-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Aspartate/homoserine dehydrogenase NAD-binding
Sporulation stage II protein D amidase enhancer LytB N-terminal
Plays an important role in substrate specificity
ABC-type uncharacterised transport system
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Glycine cleavage T-protein C-terminal barrel
Sodium/calcium exchanger membrane region
Helix-turn-helix conjugative transposon-like
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
2,4-diaminopentanoate dehydrogenase C-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Transposase IS116/IS110/IS902 C-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Type III secretion system flagellar brake protein YcgR PilZN
Fibronectin type-III domain-containing protein
Gly-cisPro motif, important for rejection of L-amino acids
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Type II restriction enzyme and methyltransferase RM.Eco57I-like
Phosphotransferase system enzyme I N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Important for autoinhibition of adenylyltransferase activity
Stage III sporulation protein AA AAA+ ATPase
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Pyrimidine nucleoside phosphorylase C-terminal
General stress protein FMN-binding split barrel
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Thiamin pyrophosphokinase thiamin-binding
Aminoacyl-tRNA synthetase class I anticodon-binding
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Putative amidase domain-containing protein
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Bacterial transcription activator effector binding
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase N-terminal
Arsenosugar biosynthesis radical SAM protein ArsS-like C-terminal
2-oxoacid dehydrogenase acyltransferase catalytic
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Flagellar hook-associated protein 2 N-terminal
Translation initiation factor beta propellor-like
Large ribosomal subunit protein uL15/eL18
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal