2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Gfo/Idh/MocA-like oxidoreductase N-terminal
Gfo/Idh/MocA-like oxidoreductase bacterial type C-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Organic solvent tolerance-like N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
Cellulose-binding Sde182 nucleoside hydrolase-like
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
DNA topoisomerase I catalytic core eukaryotic-type
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
TonB-dependent receptor-like beta-barrel
Trigger factor ribosome-binding bacterial
Mandelate racemase/muconate lactonizing enzyme C-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Transcription elongation factor GreA/GreB C-terminal
Peptidase M1 membrane alanine aminopeptidase
Polysaccharide chain length determinant N-terminal
RND efflux pump membrane fusion protein barrel-sandwich
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
SusD/RagB family nutrient-binding outer membrane lipoprotein
DNA mismatch repair proteins mutS family
Na+/H+ antiporter MnhB subunit-related protein
Tryptophan synthase beta chain-like PALP
Gfo/Idh/MocA-like oxidoreductase C-terminal
3-keto-disaccharide hydrolase domain-containing protein
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Prokaryotic-type class I peptide chain release factors
RNA polymerase sigma factor 70 region 4 type 2
Aminoacyl-transfer RNA synthetases class-II family profile
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Cytochrome C biogenesis protein transmembrane
Thiol:disulfide interchange protein DsbD N-terminal
Major facilitator superfamily (MFS) profile
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
RNA 2-O ribose methyltransferase substrate binding
N-sulphoglucosamine sulphohydrolase C-terminal
Glycosyltransferase subfamily 4-like N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Histidine-specific methyltransferase SAM-dependent
Heme-copper oxidase subunit III family profile
Glycosyl transferase family 3 N-terminal
Na(+)-translocating NADH-quinone reductase subunit A C-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Outer membrane protein beta-barrel domain-containing protein
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
DNA-directed RNA polymerase RpoA/D/Rpb3-type
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Phosphoadenosine phosphosulphate reductase
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Peptidase S9 prolyl oligopeptidase catalytic
High potential iron-sulfur proteins family profile
Alpha-D-phosphohexomutase alpha/beta/alpha
Large ribosomal subunit protein uL6 alpha-beta
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Nickel transport complex protein, NikM subunit, transmembrane
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Outer membrane lipoprotein-sorting protein
Carbamoyl-phosphate synthase small subunit N-terminal
Neutral/alkaline non-lysosomal ceramidase N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Alpha-L-rhamnosidase six-hairpin glycosidase
Bacterial alpha-L-rhamnosidase N-terminal
Non-canonical purine NTP phosphatase/PRRC1
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Beta-hexosaminidase bacterial type N-terminal
Beta-hexosaminidase bacterial type N-terminal domain-containing protein
Survival protein SurE-like phosphatase/nucleotidase
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Glycosyl-hydrolase 97 C-terminal oligomerisation
Neutral/alkaline non-lysosomal ceramidase N-terminal domain-containing protein
Penicillin-binding protein transpeptidase
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Menaquinone biosynthesis protein MenD middle
Small ribosomal subunit protein uS4 N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
CASTOR/POLLUX/SYM8 ion channel conserved
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Purple acid phosphatase N-terminal domain-containing protein
PhoD-like phosphatase metallophosphatase
Ribose-phosphate pyrophosphokinase N-terminal
Polymerase/histidinol phosphatase N-terminal
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
Positions MEP for the nucleophilic attack
Glycosyl hydrolases family 2 sugar binding
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Glucosamine/galactosamine-6-phosphate isomerase
General stress protein FMN-binding split barrel
Gly-cisPro motif, important for rejection of L-amino acids
Secretion system C-terminal sorting domain-containing protein
Molybdopterin cofactor biosynthesis C (MoaC)
Cation-transporting P-type ATPase N-terminal
Endoribonuclease L-PSP/chorismate mutase-like
Peptidase M43 pregnancy-associated plasma-A
Activator of Hsp90 ATPase homologue 1-like C-terminal
Chemotaxis methyl-accepting receptor HlyB-like 4HB MCP
Transposase IS116/IS110/IS902 C-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Exonuclease VII large subunit C-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Schiff-base intermediate with acetaldehyde
TonB-dependent receptor plug domain-containing protein
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Right handed beta helix domain-containing protein
Moybdenum cofactor oxidoreductase dimerisation
S-adenosyl-L-homocysteine hydrolase NAD binding
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Glycogen debranching enzyme bacterial and archaeal type N-terminal
Membrane fusion protein biotin-lipoyl like
Polysaccharide pyruvyl transferase domain-containing protein
Electron transfer flavoprotein alpha/beta-subunit N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Large ribosomal subunit protein uL15/eL18
Phosphatidate phosphatase APP1 catalytic
N,N-dimethylformamidase beta subunit-like C-terminal
Mannose-6-phosphate isomerase type II C-terminal
Anthranilate synthase component I N-terminal
Restriction system protein Mrr-like N-terminal
Transcription elongation factor GreA/GreB N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Biopterin-dependent aromatic amino acid hydroxylase family profile
Alginate export domain-containing protein
Membrane protein insertion efficiency factor YidD
Haem-binding uptake Tiki superfamily ChaN
Pyridoxamine 5'-phosphate oxidase putative
Gp5/Type VI secretion system Vgr protein OB-fold
Polysaccharide biosynthesis protein C-terminal
SUF system FeS cluster assembly SufBD N-terminal
Proton acceptor; for glutaminase activity
Alpha-glycerophosphate oxidase C-terminal
Cell wall-active antibiotics response LiaF-like C-terminal
WD40-like beta Propeller containing protein
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Sodium/calcium exchanger membrane region
Electron transfer via tryptophanyl radical
Microcystin LR degradation protein MlrC C-terminal
Microcystin LR degradation protein MlrC N-terminal
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Signal transduction histidine kinase internal region
Polysaccharide lyase 8 N-terminal alpha-helical
Polysaccharide lyase family 8 C-terminal
Alanyl-transfer RNA synthetases family profile
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Gliding motility-associated C-terminal domain-containing protein
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Urease accessory protein UreH-like transmembrane
Pyrroline-5-carboxylate reductase catalytic N-terminal
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Pyridine nucleotide-disulphide oxidoreductase dimerisation
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Helix-hairpin-helix DNA-binding motif class 1
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Plays an important role in substrate specificity
TRAP C4-dicarboxylate transport system permease DctM subunit
Peptidase C45 hydrolase domain-containing protein
Lipocalin-like domain-containing protein
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Reversibly protonated during proton transport
ABC-type uncharacterised transport system
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Calcineurin-like phosphoesterase C-terminal
Calcineurin-like phosphoesterase N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Bacterial bifunctional deaminase-reductase C-terminal
NAD(P) transhydrogenase alpha subunit C-terminal
Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Bacterial transcription activator effector binding
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Mandelate racemase/muconate lactonizing enzyme N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Translation elongation factor P/YeiP central
Carbamoyl-phosphate synthetase large subunit-like ATP-binding
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Pyrroline-5-carboxylate reductase dimerisation
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Glycoside hydrolase family 57 N-terminal
6-phosphogluconate dehydrogenase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Peptide methionine sulphoxide reductase MsrA
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Chromosomal replication initiator DnaA C-terminal
Thymidylate synthase/dCMP hydroxymethylase
Tat (Twin-arginine translocation) pathway signal sequence domain protein
DNA replication/recombination mediator RecO N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
RNA binding; important for wobble base 34 recognition
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
Glycoside hydrolase family 5 domain-containing protein
Putative auto-transporter adhesin head GIN
Putative auto-transporter adhesin head GIN domain-containing protein
Chitobiase/beta-hexosaminidases N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Lysidine-tRNA(Ile) synthetase C-terminal
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Inosine/uridine-preferring nucleoside hydrolase
Nitrite/Sulfite reductase ferredoxin-like
Membrane insertase YidC/Oxa/ALB C-terminal
UDP N-acetylglucosamine O-acyltransferase C-terminal
Cytochrome c-type biogenesis protein CcmF C-terminal
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
DNA-directed DNA polymerase family A palm
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Pseudouridine synthase I TruA alpha/beta
Glycoside hydrolase family 31 N-terminal
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Glycine cleavage T-protein C-terminal barrel
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Tetrahydrodipicolinate-N-succinyltransferase chain A
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Shikimate dehydrogenase substrate binding N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
ATP-grasp fold succinyl-CoA synthetase-type
Large ribosomal subunit protein uL2 C-terminal
Nuclear transport factor 2 family protein
Carbohydrate-binding domain-containing protein
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Glycosyl transferase family 28 C-terminal
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
NIF system FeS cluster assembly NifU C-terminal
Tellurite resistance methyltransferase TehB-like
Periplasmic copper-binding protein NosD beta helix
Nicotinic acid mononucleotide adenyltransferase
Gliding motility-associated protein GldM C-terminal
Gliding motility-associated protein GldM N-terminal
tRNA pseudouridylate synthase B C-terminal
Type II restriction enzyme and methyltransferase RM.Eco57I-like
Could be important to modulate the pK values of the two catalytic cysteine residues