Interaction with polymerase core subunit RpoC
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Major facilitator superfamily (MFS) profile
YdgH/BhsA/McbA-like domain-containing protein
Gamma-glutamylcyclotransferase AIG2-like
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Integral membrane protein YccS N-terminal
Curli production assembly/transport component CsgG
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
Translation elongation factor P/YeiP central
Non-canonical purine NTP phosphatase/PRRC1
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Phosphotransferase system enzyme I N-terminal
Glucan biosynthesis periplasmic MdoG C-terminal
Chromosome partition protein MukF C-terminal
Chromosome partition protein MukF middle
Chromosome partition protein MukF winged-helix
Outer-membrane lipoprotein Wza C-terminal
Arginine decarboxylase C-terminal helical
O-(3'-phospho-DNA)-tyrosine intermediate
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Outer-membrane lipoprotein carrier protein
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Penicillin-binding protein transpeptidase
Could be important to modulate the pK values of the two catalytic cysteine residues
Aspartate/homoserine dehydrogenase NAD-binding
Exopolysaccharide production protein YjbE
SUF system FeS cluster assembly SufBD N-terminal
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Glycosyl transferase family 3 N-terminal
Appears to be important in orienting the phosphate for catalysis
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Large ribosomal subunit protein uL2 C-terminal
Schiff-base intermediate with substrate; via pyruvic acid
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Translocation and assembly module subunit TamA
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Aminoacyl-transfer RNA synthetases class-II family profile
Prokaryotic-type class I peptide chain release factors
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
O-(phosphoribosyl dephospho-coenzyme A)serine
Tryptophan synthase beta chain-like PALP
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
NIF system FeS cluster assembly NifU C-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Chromosomal replication initiator DnaA C-terminal
RND efflux pump membrane fusion protein barrel-sandwich
Phosphocysteine intermediate; for EIIB activity
Penicillin-binding protein activator LpoB
Important for substrate binding and specificity
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
Acyl-ester intermediate; for transpeptidase activity
Proton donor; for transglycosylase activity
Transglycosylase PBP1b N-terminal transmembrane
Membrane fusion protein biotin-lipoyl like
Arabinogalactan endo-beta-1,4-galactanase
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
NADH:ubiquinone oxidoreductase 30kDa subunit
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Membrane insertase YidC/Oxa/ALB C-terminal
Curli production assembly/transport component CsgE
Penicillin-insensitive murein endopeptidase
Phosphatidic acid phosphatase type 2/haloperoxidase
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Moves into active site upon enzyme activation, plays a role in electron transfer
Essential for degradation by Lon protease
Aconitase A/isopropylmalate dehydratase small subunit swivel
Glycosyltransferase subfamily 4-like N-terminal
Glutathionylspermidine synthase pre-ATP-grasp-like
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Quercetin 2,3-dioxygenase C-terminal cupin
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Major facilitator superfamily associated
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Interacts with tRNA; defines subfamily-specific binding signature
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Type III secretion system flagellar brake protein YcgR PilZN
Type VI secretion system IcmF C-terminal
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Common pilus major fimbrillin subunit EcpA
Proton acceptor; for decarboxylase activity
Proton donor; for decarboxylase activity
Proton donor; for formyltransferase activity
ABC-type transport auxiliary lipoprotein component
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Polysaccharide chain length determinant N-terminal
Important for beta-aspartyl-AMP intermediate formation
Outer membrane protein assembly factor BamD
Tetrahydrodipicolinate-N-succinyltransferase chain A
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
RNA 2-O ribose methyltransferase substrate binding
Ribosomal RNA adenine methylase transferase N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Tellurite resistance methyltransferase TehB-like
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Superoxide dismutase copper/zinc binding
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
RNA methyltransferase SpoU/TrmH type C-terminal
Regulator of nucleoside diphosphate kinase N-terminal
Helix-hairpin-helix DNA-binding motif class 1
Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with Met-252)
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-105)
Reversibly protonated during proton transport
Plays a key role in the stabilization of the transition state and positioning the aldehyde component
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Pyrimidine nucleoside phosphorylase C-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Mechanosensitive ion channel inner membrane
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Gly-cisPro motif, important for rejection of L-amino acids
Threonine/serine exporter-like N-terminal
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Polymerase/histidinol phosphatase N-terminal
Large ribosomal subunit protein bL25 L25
Alpha-D-phosphohexomutase alpha/beta/alpha
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Lipoprotein YgdI/YgdR-like SH3-like domain-containing protein
Flagellar motor switch protein FliN-like C-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Transcriptional regulator SgrR N-terminal HTH
Important for interaction with partner proteins
Could play a key role in the communication between the regulatory and the substrate sites
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Bacteriophage tail tape measure C-terminal
Bacteriophage tail tape measure N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
TRAP C4-dicarboxylate transport system permease DctM subunit
Involved in allosteric activation by GTP
Activator of Hsp90 ATPase homologue 1-like C-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Large ribosomal subunit protein uL6 alpha-beta
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Flagellar motor switch protein FliN N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Small ribosomal subunit protein uS4 N-terminal
Type II secretion system protein GspG C-terminal
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like domain-containing protein
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
TonB-dependent receptor-like beta-barrel
Phosphomannose isomerase type I C-terminal
Phosphomannose isomerase type I catalytic
Phosphomannose isomerase type I helical insertion
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Required for dimer formation and molybdate binding
Cytochrome b561 bacterial/Ni-hydrogenase
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Outer membrane protein assembly factor BamE
Ribose-phosphate pyrophosphokinase N-terminal
Large ribosomal subunit protein uL15/eL18
Sodium/calcium exchanger membrane region
Lipopolysaccharide export system protein LptA
Organic solvent tolerance-like N-terminal
Periplasmic binding protein/LacI sugar binding
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
D-galactose/methyl-galactoside binding periplasmic protein MglB
Negative modulator of initiation of replication SeqA N-terminal
Replication modulator SeqA C-terminal DNA-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
RNA polymerase sigma factor 70 region 4 type 2
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Curli production assembly/transport component CsgF
Involved in tetramerization or stability of the tetramer
ABC-type glycine betaine transport system substrate-binding
Heme-copper oxidase subunit III family profile
Thymidylate synthase/dCMP hydroxymethylase
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Peptide methionine sulphoxide reductase MsrA
Schiff-base intermediate with acetaldehyde
Pyruvate dehydrogenase E1 component middle
Sugar fermentation stimulation protein C-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Cysteine sulfenic acid (-SOH) intermediate
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Nucleoside-specific channel-forming protein Tsx
Outer membrane protein assembly factor BamA
Greasy slide, important in sugar transport
High-affinity branched-chain amino acid transport system permease LivHM N-terminal
Prepilin peptidase dependent protein C-like C-terminal
NIF system FeS cluster assembly NifU N-terminal