Acyl-CoA dehydrogenase/oxidase C-terminal
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
RNA polymerase sigma factor 70 region 4 type 2
Chromosomal replication initiator DnaA C-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Acyl-CoA dehydrogenase/oxidase N-terminal
Myo-inositol-1-phosphate synthase GAPDH-like
Lactate utilization protein B C-terminal
Shikimate dehydrogenase substrate binding N-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Bacterial bifunctional deaminase-reductase C-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Penicillin-binding protein transpeptidase
Major facilitator superfamily (MFS) profile
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Translation elongation factor P/YeiP central
RlpA-like protein double-psi beta-barrel
Pyridoxamine 5'-phosphate oxidase putative
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Helix-hairpin-helix DNA-binding motif class 1
Alpha-L-rhamnosidase six-hairpin glycosidase
Bacterial alpha-L-rhamnosidase N-terminal
Glycosyltransferase subfamily 4-like N-terminal
N(4)-bis(aminopropyl)spermidine synthase C-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
CobB/CobQ-like glutamine amidotransferase
Tryptophan synthase beta chain-like PALP
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
2,4-diaminopentanoate dehydrogenase C-terminal
Dihydrodipicolinate reductase N-terminal
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Mandelate racemase/muconate lactonizing enzyme C-terminal
Cytochrome C biogenesis protein transmembrane
Plays an important role in substrate specificity
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Aminoacyl-transfer RNA synthetases class-II family profile
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Leucine-binding protein domain-containing protein
TIGR04222 domain-containing membrane protein
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Erythromycin biosynthesis protein CIII-like central
CRISPR-associated protein Cas6 C-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Alpha-D-phosphohexomutase alpha/beta/alpha
RNA 2-O ribose methyltransferase substrate binding
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Release factor glutamine methyltransferase N-terminal
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
NAD(P) transhydrogenase alpha subunit C-terminal
Peptidase M1 membrane alanine aminopeptidase
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
FAD-dependent oxidoreductase 2 FAD binding
Polymerase/histidinol phosphatase N-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Positions MEP for the nucleophilic attack
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Glucose-methanol-choline oxidoreductase C-terminal
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Anthranilate synthase component I N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Right handed beta helix domain-containing protein
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Large ribosomal subunit protein uL2 C-terminal
Reversibly protonated during proton transport
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Cytochrome b/b6 N-terminal region profile
Quercetin 2,3-dioxygenase C-terminal cupin
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Periplasmic binding protein domain-containing protein
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Alpha-glycerophosphate oxidase C-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Schiff-base intermediate with substrate; via pyruvic acid
Solute-binding protein family 3/N-terminal
Gamma-butyrobetaine hydroxylase-like N-terminal
Thiopeptide-type bacteriocin biosynthesis
6-phosphogluconate dehydrogenase C-terminal
ABC-type glycine betaine transport system substrate-binding
Small ribosomal subunit protein uS4 N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Polysaccharide chain length determinant N-terminal
Histidine-specific methyltransferase SAM-dependent
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Large ribosomal subunit protein uL6 alpha-beta
NIF system FeS cluster assembly NifU N-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Cell envelope-related transcriptional attenuator
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Gfo/Idh/MocA-like oxidoreductase C-terminal
Phosphomannose isomerase type I catalytic
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
CD-NTase-associated protein 12/Pycsar effector protein TIR
Membrane insertase YidC/Oxa/ALB C-terminal
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Na+/H+ antiporter MnhB subunit-related protein
Putative oxidoreductase/dehydrogenase Rossmann-like
O-(5'-phospho-DNA)-tyrosine intermediate
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
S-adenosyl-L-homocysteine hydrolase NAD binding
Tetrahydrodipicolinate-N-succinyltransferase chain A
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Involved in ionization of N3 of dUMP, leading to its activation
Survival protein SurE-like phosphatase/nucleotidase
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Bacterial type II secretion system protein E
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Ribosome maturation factor RimP N-terminal
Polysaccharide biosynthesis protein CapD-like
Peptide methionine sulphoxide reductase MsrA
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
General stress protein FMN-binding split barrel
Essential for prephenate dehydratase activity
Putative Flp pilus-assembly TadG-like N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
ATP synthase F1 complex delta/epsilon subunit N-terminal
Inosine/uridine-preferring nucleoside hydrolase
PsrA tetracyclin repressor-like C-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Phosphatidic acid phosphatase type 2/haloperoxidase
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
4'-phosphopantetheinyl transferase N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Transposase IS116/IS110/IS902 C-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
NADH-ubiquinone oxidoreductase 51kDa subunit FMN-binding
Beta-xylosidase C-terminal Concanavalin A-like
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-110)
Molybdopterin cofactor biosynthesis C (MoaC)
Prokaryotic-type class I peptide chain release factors
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Bacterial transcription activator effector binding
Cysteine sulfenic acid (-SOH) intermediate
Large ribosomal subunit protein uL15/eL18
Resuscitation-promoting factor core lysozyme-like
Transcription regulator AsnC/Lrp ligand binding
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Alanyl-transfer RNA synthetases family profile
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Thiolase-like protein type 1 additional C-terminal
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
NADH:ubiquinone oxidoreductase chain 4 N-terminal
LPXTG-motif cell wall anchor domain protein
Aconitase A/isopropylmalate dehydratase small subunit swivel
NADH:ubiquinone oxidoreductase 30kDa subunit
Prepilin type IV endopeptidase peptidase
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Putative regulatory protein FmdB Zinc ribbon
Ribose 1,5-bisphosphate phosphokinase PhnN
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
WD40-like beta Propeller containing protein
Nitrite/Sulfite reductase ferredoxin-like
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-? in acceptor proteins)
Glycine cleavage T-protein C-terminal barrel
Moybdenum cofactor oxidoreductase dimerisation
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Glutamate synthase alpha subunit C-terminal
Dihydrodipicolinate reductase C-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Microcin J25-processing protein McjB C-terminal
Proton acceptor; for glutaminase activity
Styrene monooxygenase StyA putative substrate binding
DNA replication/recombination mediator RecO N-terminal
Interaction with polymerase core subunit RpoC
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
NitT/TauT family transport system substrate-binding protein
Endoribonuclease L-PSP/chorismate mutase-like
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
ABC transporter substrate-binding protein PnrA-like
Increases nucleophilicity of active site Cys
ATP-dependent DNA helicase RecG C-terminal
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Glycosyl transferase family 3 N-terminal
Superoxide dismutase copper/zinc binding
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Diacylglycerol glucosyltransferase N-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
SUF system FeS cluster assembly SufBD N-terminal
Polysaccharide biosynthesis protein C-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
2-oxoacid dehydrogenase acyltransferase catalytic
Resolvase/invertase-type recombinase catalytic
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Periplasmic copper-binding protein NosD beta helix
Gp5/Type VI secretion system Vgr protein OB-fold
Schiff-base intermediate with substrate; via topaquinone
Schiff-base intermediate with D-ribose 5-phosphate