Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Solute-binding protein family 3/N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
5'-Nucleotidase C-terminal domain-containing protein
TonB-dependent receptor-like beta-barrel
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Required for dimer formation and molybdate binding
Ribulose bisphosphate carboxylase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
glutathione gamma-glutamylcysteinyltransferase
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Flagellar basal-body/hook protein C-terminal
Putative Flp pilus-assembly TadG-like N-terminal
RNA polymerase sigma factor 70 region 4 type 2
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Schiff-base intermediate with dihydroxyacetone-P
Major facilitator superfamily (MFS) profile
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Penicillin-binding protein transpeptidase
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Membrane fusion protein biotin-lipoyl like
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Pyruvate phosphate dikinase AMP/ATP-binding
Ribose-phosphate pyrophosphokinase N-terminal
Could play a key role in the communication between the regulatory and the substrate sites
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Pyrimidine nucleoside phosphorylase C-terminal
Putative glycogen debranching enzyme N-terminal
Glycosyltransferase subfamily 4-like N-terminal
ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase
Myo-inositol-1-phosphate synthase GAPDH-like
TRAP C4-dicarboxylate transport system permease DctM subunit
Glycosyl hydrolases family 2 sugar binding
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Flagellar assembly protein FliH/Type III secretion system HrpE
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal domain-containing protein
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Lysozyme inhibitor LprI N-terminal domain-containing protein
Flagellar hook-length control protein-like C-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Putative regulatory protein FmdB Zinc ribbon
Sugar fermentation stimulation protein C-terminal
N-end rule aminoacyl transferase C-terminal
Pseudouridine synthase I TruA alpha/beta
Transposase IS116/IS110/IS902 C-terminal
Resolvase/invertase-type recombinase catalytic
Ribonucleotide reductase large subunit C-terminal
Ribonucleotide reductase large subunit N-terminal
RND efflux pump membrane fusion protein barrel-sandwich
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Thiol:disulfide interchange protein DsbD N-terminal
Anthranilate synthase component I N-terminal
Dinitrogenase iron-molybdenum cofactor biosynthesis
Right handed beta helix domain-containing protein
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Flagellar basal body rod protein N-terminal
Transcriptional coactivator p15 (PC4) C-terminal
ABC transporter substrate-binding protein PnrA-like
Rap1a immunity protein domain-containing protein
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
NIF system FeS cluster assembly NifU N-terminal
Release factor glutamine methyltransferase N-terminal
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Glycine cleavage T-protein C-terminal barrel
Lipid/polyisoprenoid-binding YceI-like domain-containing protein
Polysaccharide biosynthesis protein CapD-like
Interaction with polymerase core subunit RpoC
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Alanyl-transfer RNA synthetases family profile
Peptidase S9 prolyl oligopeptidase catalytic
Small-conductance mechanosensitive channel
Cobaltochelatase subunit CobS N-terminal
RND efflux pump membrane fusion protein barrel-sandwich domain-containing protein
Aminoacyl-transfer RNA synthetases class-II family profile
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
HicB-like antitoxin of toxin-antitoxin system
Important for substrate specificity; cannot use PPi as phosphoryl donor
Ionotropic glutamate receptor C-terminal
YbaK/aminoacyl-tRNA synthetase-associated
TRAP transporter substrate-binding protein
Nitrite/Sulfite reductase ferredoxin-like
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Endolytic peptidoglycan transglycosylase RlpA
RlpA-like protein double-psi beta-barrel
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Inner membrane protein YgaP-like transmembrane
UDP N-acetylglucosamine O-acyltransferase C-terminal
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Glycine-zipper-containing OmpA-like membrane
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Translation elongation factor P/YeiP central
Alpha-D-phosphohexomutase alpha/beta/alpha
Solute-binding protein family 5 domain-containing protein
Phage tail collar domain-containing protein
Could be important to modulate the pK values of the two catalytic cysteine residues
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Tetrahydrodipicolinate-N-succinyltransferase chain A
NADH-rubredoxin oxidoreductase C-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Proton acceptor; for glutaminase activity
Mannose-6-phosphate isomerase type II C-terminal
Large ribosomal subunit protein uL6 alpha-beta
Ribosomal RNA adenine methylase transferase N-terminal
Bacteriophage tail tape measure N-terminal
Schiff-base intermediate with substrate; via pyruvic acid
Tryptophan synthase beta chain-like PALP
Type 2A encapsulin shell protein SrpI-like
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Heme-copper oxidase subunit III family profile
Phage terminase large subunit N-terminal
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Glycosyl transferase family 3 N-terminal
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Magnesium transporter MgtE intracellular
CDP-alcohol phosphatidyltransferase C-terminal
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Cytochrome c-type biogenesis protein CcmF C-terminal
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Regulator of nucleoside diphosphate kinase N-terminal
ABC-type transport auxiliary lipoprotein component
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Prokaryotic-type class I peptide chain release factors
NADH:ubiquinone oxidoreductase 30kDa subunit
Survival protein SurE-like phosphatase/nucleotidase
Carbohydrate binding module xylan-binding
Abortive infection protein-like C-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
NAD(P) transhydrogenase alpha subunit C-terminal
SGNH hydrolase-type esterase domain-containing protein
S-adenosylmethionine-dependent methyltransferase
Phosphotransferase system enzyme I N-terminal
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Involved in ionization of N3 of dUMP, leading to its activation
Outer membrane protein assembly factor BamD
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Alginate export domain-containing protein
Alpha-glycerophosphate oxidase C-terminal
Prepilin type IV endopeptidase peptidase
Signal transduction histidine kinase subgroup 2 dimerisation and phosphoacceptor
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Probable periplasmic serine endoprotease DegP-like
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Glycogen debranching enzyme bacterial and archaeal type N-terminal
4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase-like C-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Gp5/Type VI secretion system Vgr protein OB-fold
Methylene-tetrahydromethanopterin dehydrogenase N-terminal
Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Mandelate racemase/muconate lactonizing enzyme C-terminal
Transcription regulator AsnC/Lrp ligand binding
DNA replication/recombination mediator RecO N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
ABC-type transport auxiliary lipoprotein component domain-containing protein
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Shikimate dehydrogenase substrate binding N-terminal
Cysteine sulfenic acid (-SOH) intermediate
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
Small ribosomal subunit protein uS4 N-terminal
Leucine-binding protein domain-containing protein
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Alpha-(1,3)-fucosyltransferase FucT N-terminal
Quinoprotein dehydrogenase-associated SoxYZ-like carrier
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
O-(3'-phospho-DNA)-tyrosine intermediate
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
Reversibly protonated during proton transport
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
TtsA-like Glycoside hydrolase family 108
Urease accessory protein UreH-like transmembrane
Polymerase/histidinol phosphatase N-terminal
Polysaccharide biosynthesis protein C-terminal
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Phosphatidic acid phosphatase type 2/haloperoxidase
Large ribosomal subunit protein uL2 C-terminal
Large ribosomal subunit protein uL15/eL18
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Histidine-specific methyltransferase SAM-dependent
RNA 2-O ribose methyltransferase substrate binding
Important for beta-aspartyl-AMP intermediate formation
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Polysaccharide chain length determinant N-terminal
Heat-inducible transcription repressor HrcA C-terminal
Flagellar motor switch protein FliN-like C-terminal
tRNA pseudouridylate synthase B C-terminal
Autotransporter domain-containing protein
Histidine phosphotransferase ChpT C-terminal
NIF system FeS cluster assembly NifU C-terminal
Saccharopine dehydrogenase-like C-terminal
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
Electron transfer via tryptophanyl radical
Cytochrome b561 bacterial/Ni-hydrogenase
Extradiol ring-cleavage dioxygenase LigAB LigA subunit
Invasion associated locus B family protein
Formylmethanofuran: tetrahydromethanopterin formyltransferase Ftr C-terminal
Formylmethanofuran: tetrahydromethanopterin formyltransferase Ftr N-terminal
Nitrogenase molybdenum-iron protein beta chain N-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Poly-beta-hydroxybutyrate polymerase N-terminal
Gamma-butyrobetaine hydroxylase-like N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Periplasmic nitrate reductase, electron transfer subunit
Quercetin 2,3-dioxygenase C-terminal cupin
Phosphogluconate dehydrogenase NAD-binding putative C-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Restriction system protein Mrr-like N-terminal
General stress protein FMN-binding split barrel
SUF system FeS cluster assembly SufBD N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Type VI secretion system IcmF C-terminal
Organic solvent tolerance-like N-terminal
Solute-binding protein family 3/N-terminal domain-containing protein
RNA polymerase sigma factor 70 region 1.1
Activator of Hsp90 ATPase homologue 1-like C-terminal
CobB/CobQ-like glutamine amidotransferase
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Involved in tetramerization or stability of the tetramer
Glycoside hydrolase family 31 N-terminal
High-affinity branched-chain amino acid transport system permease LivHM N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Chromosomal replication initiator DnaA C-terminal
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
PHA accumulation regulator DNA-binding N-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Helix-hairpin-helix DNA-binding motif class 1
RNA binding; important for wobble base 34 recognition
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Glycine zipper domain-containing protein
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Required for zinc-mediated homotetramerization and catalytic activity
Methionyl-tRNA synthetase anticodon-binding
Bacterial type II secretion system protein E
Endoribonuclease L-PSP/chorismate mutase-like
Chromosomal replication initiator protein DnaA
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
D-glutamate N-acetyltransferase-like C-terminal
D-glutamate N-acetyltransferase-like N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Na+/H+ antiporter MnhB subunit-related protein
Antitoxin Xre/MbcA/ParS-like toxin-binding
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Positions MEP for the nucleophilic attack
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Membrane insertase YidC/Oxa/ALB C-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding