Arabinogalactan endo-beta-1,4-galactanase
NIF system FeS cluster assembly NifU N-terminal
RlpA-like protein double-psi beta-barrel
Glycosyltransferase subfamily 4-like N-terminal
PhoD-like phosphatase metallophosphatase
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Alanyl-transfer RNA synthetases family profile
Beta-xylosidase C-terminal Concanavalin A-like
Cytochrome oxidase subunit II copper A binding
Glycogen debranching enzyme bacterial and archaeal type N-terminal
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Cell envelope-related transcriptional attenuator
Pyrroline-5-carboxylate reductase catalytic N-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
RNA polymerase sigma factor 70 region 4 type 2
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Myo-inositol-1-phosphate synthase GAPDH-like
DNA replication/recombination mediator RecO N-terminal
CobB/CobQ-like glutamine amidotransferase
Large ribosomal subunit protein uL15/eL18
Plays an important role in substrate specificity
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Solute-binding protein family 3/N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Tryptophan synthase beta chain-like PALP
Major facilitator superfamily (MFS) profile
Transcription regulator AsnC/Lrp ligand binding
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Membrane insertase YidC/Oxa/ALB C-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Gram-positive cocci surface proteins LPxTG
Polymerase/histidinol phosphatase N-terminal
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Large ribosomal subunit protein uL2 C-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
6-phosphogluconate dehydrogenase NADP-binding
Penicillin-binding protein transpeptidase
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Polysaccharide chain length determinant N-terminal
Polysaccharide biosynthesis protein C-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Bacterial bifunctional deaminase-reductase C-terminal
Mannose-6-phosphate isomerase type II C-terminal
FAD-dependent oxidoreductase 2 FAD binding
Large ribosomal subunit protein uL6 alpha-beta
Phosphatidic acid phosphatase type 2/haloperoxidase
RNA 2-O ribose methyltransferase substrate binding
Glycosyl transferase family 3 N-terminal
Small ribosomal subunit protein uS4 N-terminal
4'-phosphopantetheinyl transferase N-terminal
Lactate utilization protein B C-terminal
Pyrimidine nucleoside phosphorylase C-terminal
Pyridoxamine 5'-phosphate oxidase putative
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Alpha-L-arabinofuranosidase B arabinose-binding
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Cation-transporting P-type ATPase N-terminal
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
ATP synthase F1 complex delta/epsilon subunit N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Cell wall-active antibiotics response LiaF-like C-terminal
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Could be important to modulate the pK values of the two catalytic cysteine residues
Alpha-D-phosphohexomutase alpha/beta/alpha
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Proton acceptor; for glutaminase activity
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Pyruvate phosphate dikinase AMP/ATP-binding
Peptidase M1 membrane alanine aminopeptidase
Peptidoglycan recognition protein family
Reversibly protonated during proton transport
YbaK/aminoacyl-tRNA synthetase-associated
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
Acyltransferase MbtK/IucB-like conserved
Translation elongation factor P/YeiP central
SUF system FeS cluster assembly SufBD N-terminal
Polysaccharide biosynthesis protein CapD-like
Putative glycogen debranching enzyme N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Could play a key role in the communication between the regulatory and the substrate sites
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Activator of Hsp90 ATPase homologue 1-like C-terminal
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Gp5/Type VI secretion system Vgr protein OB-fold
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Thymidylate synthase/dCMP hydroxymethylase
Nicotinate phosphoribosyltransferase N-terminal
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Bacterial type II secretion system protein E
Endoribonuclease L-PSP/chorismate mutase-like
Ricin B lectin domain-containing protein
DNA topoisomerase I catalytic core eukaryotic-type
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Putative regulatory protein FmdB Zinc ribbon
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
6-phosphogluconate dehydrogenase C-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Schiff-base intermediate with D-ribose 5-phosphate
Schiff-base intermediate with substrate; via pyruvic acid
von Hippel-Lindau disease tumour suppressor beta
Glycosyl transferase family 28 C-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
ssDNA thymidine ADP-ribosyltransferase DarT
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Glycine cleavage T-protein C-terminal barrel
DNA-directed DNA polymerase family A palm
Peptide methionine sulphoxide reductase MsrA
Glycoside hydrolase family 42 N-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Anthranilate synthase component I N-terminal
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Histidine-specific methyltransferase SAM-dependent
Glycoside hydrolase family 31 N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
S-adenosyl-L-homocysteine hydrolase NAD binding
Ionotropic glutamate receptor C-terminal
Na+/H+ antiporter MnhB subunit-related protein
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
DnaJ homologue subfamily C member 28 conserved
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
HTH-type transcriptional regulator MT1864/Rv1816-like C-terminal
Saccharopine dehydrogenase-like C-terminal
Sodium/calcium exchanger membrane region
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Formamidopyrimidine-DNA glycosylase catalytic
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Shikimate dehydrogenase substrate binding N-terminal
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
Positions MEP for the nucleophilic attack
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Putative oxidoreductase/dehydrogenase Rossmann-like
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
L-seryl-tRNA selenium transferase N-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Glutathionylspermidine synthase pre-ATP-grasp-like
Phosphoribosylformylglycinamidine synthase linker
Carbamoyl-phosphate synthase small subunit N-terminal
Chromosomal replication initiator DnaA C-terminal
Glyoxalase/fosfomycin resistance/dioxygenase
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Homogentisate 1,2-dioxygenase C-terminal
N6 adenine-specific DNA methyltransferase N-terminal
Glycosyltransferase family 28 N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Sporulation transcription regulator WhiA N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Acetylserotonin O-methyltransferase dimerisation
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Cytochrome b/b6 N-terminal region profile
Ribose-phosphate pyrophosphokinase N-terminal
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
ABC-type glycine betaine transport system substrate-binding
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Helix-hairpin-helix DNA-binding motif class 1
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Peptidase M43 pregnancy-associated plasma-A
Phosphomannose isomerase type I catalytic
Adaptive response protein AidB N-terminal
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Prokaryotic-type class I peptide chain release factors
DNA primase/polymerase bifunctional N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Heat-inducible transcription repressor HrcA C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Involved in ionization of N3 of dUMP, leading to its activation
Aconitase A/isopropylmalate dehydratase small subunit swivel
Phthiocerol/phthiodiolone dimycocerosyl transferase C-terminal
General stress protein FMN-binding split barrel
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Cytochrome C biogenesis protein transmembrane
Electron transfer via tryptophanyl radical
Glycoside-hydrolase family GH114 TIM-barrel
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Heme-copper oxidase subunit III family profile
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
Methionyl-tRNA synthetase anticodon-binding
Pseudouridine synthase I TruA alpha/beta
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-128)
Trigger factor ribosome-binding bacterial
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase