Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
N6 adenine-specific DNA methyltransferase N-terminal
RND efflux pump membrane fusion protein barrel-sandwich
Resolvase/invertase-type recombinase catalytic
Membrane insertase YidC/Oxa/ALB C-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Flagellar motor switch protein FliN-like C-terminal
Urease accessory protein UreH-like transmembrane
Tetrahydrodipicolinate-N-succinyltransferase chain A
Probable transposase IS891/IS1136/IS1341
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Histidine-specific methyltransferase SAM-dependent
Lipoprotein SmpA/OmlA domain-containing protein
TonB-dependent receptor-like beta-barrel
Bacterial type II secretion system protein E
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
NIF system FeS cluster assembly NifU N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Sodium/calcium exchanger membrane region
Alpha-D-phosphohexomutase alpha/beta/alpha
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Putative regulatory protein FmdB Zinc ribbon
Translation elongation factor P/YeiP central
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Heme-copper oxidase subunit III family profile
Flagellar hook-length control protein-like C-terminal
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Large ribosomal subunit protein uL6 alpha-beta
Phosphoadenosine phosphosulphate reductase
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Glycosyltransferase subfamily 4-like N-terminal
RNA 2-O ribose methyltransferase substrate binding
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Aminoacyl-transfer RNA synthetases class-II family profile
Type I restriction modification DNA specificity
CD-NTase-associated protein 12/Pycsar effector protein TIR
Glycine cleavage T-protein C-terminal barrel
N-end rule aminoacyl transferase C-terminal
Alanyl-transfer RNA synthetases family profile
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Nitrite/Sulfite reductase ferredoxin-like
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Major facilitator superfamily (MFS) profile
Nucleophile; cysteine thiosulfonate intermediate
Peptidoglycan binding-like domain-containing protein
Gly-cisPro motif, important for rejection of L-amino acids
Inner membrane protein YgaP-like transmembrane
ATP synthase F1 complex delta/epsilon subunit N-terminal
Outer membrane protein assembly factor BamD
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Release factor glutamine methyltransferase N-terminal
Cysteine sulfenic acid (-SOH) intermediate
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
Leucine-binding protein domain-containing protein
Thymidylate synthase/dCMP hydroxymethylase
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Phosphorylase b kinase regulatory subunit alpha/beta C-terminal
Chromosomal replication initiator protein DnaA
RNA polymerase sigma factor 70 region 4 type 2
ABC-type uncharacterised transport system
Secretin N-terminal domain-containing protein
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Penicillin-binding protein transpeptidase
HupH hydrogenase expression protein C-terminal
Type II secretion system protein GspE N-terminal
Transglycosylase SLT domain-containing protein
Important for beta-aspartyl-AMP intermediate formation
Glucose-methanol-choline oxidoreductase N-terminal
High-affinity zinc uptake system protein ZnuA
Polymerase/histidinol phosphatase N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Aconitase A/isopropylmalate dehydratase small subunit swivel
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Signal transduction histidine kinase internal region
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Pseudouridine synthase I TruA alpha/beta
Gamma-butyrobetaine hydroxylase-like N-terminal
HicB-like antitoxin of toxin-antitoxin system
Important for interaction with partner proteins
ABC-type glycine betaine transport system substrate-binding
ABC-type glycine betaine transport system substrate-binding domain-containing protein
Phosphotransferase system enzyme I N-terminal
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
RND efflux pump membrane fusion protein barrel-sandwich domain-containing protein
Cytochrome oxidase subunit II copper A binding
NAD(P) transhydrogenase alpha subunit C-terminal
Tryptophan synthase beta chain-like PALP
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Positions MEP for the nucleophilic attack
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
S-adenosyl-L-homocysteine hydrolase NAD binding
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Arginine decarboxylase C-terminal helical
TraG N-terminal Proteobacteria domain-containing protein
Type IV secretion system coupling protein TraD DNA-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Large ribosomal subunit protein uL2 C-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Ribulose bisphosphate carboxylase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
Type III secretion system flagellar brake protein YcgR PilZN
Arsenosugar biosynthesis radical SAM protein ArsS-like C-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Essential for prephenate dehydratase activity
Transposase IS116/IS110/IS902 C-terminal
Proline utilization A proline dehydrogenase N-terminal
Antitoxin Xre/MbcA/ParS-like toxin-binding
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Helix-hairpin-helix DNA-binding motif class 1
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
SsuA/THI5-like domain-containing protein
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Molybdopterin cofactor biosynthesis C (MoaC)
Ribosomal RNA adenine methylase transferase N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
Bacteriophage T7 Gp4 DNA primase/helicase N-terminal
Peptide methionine sulphoxide reductase MsrA
Transposase IS204/IS1001/IS1096/IS1165 DDE
Outer membrane protein beta-barrel domain-containing protein
UDP N-acetylglucosamine O-acyltransferase C-terminal
Cathelicidin antimicrobial peptide C-terminal domain-containing protein
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Aromatic hydrocarbon degradation protein
Disulphide bond isomerase DsbC/G N-terminal
6-phosphogluconate dehydrogenase C-terminal
SMP-30/Gluconolactonase/LRE-like region domain-containing protein
Exonuclease VII large subunit C-terminal
ABC-type transport auxiliary lipoprotein component
Cytochrome C biogenesis protein transmembrane
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Cytochrome oxidase subunit II transmembrane region profile
Interacts with tRNA; defines subfamily-specific binding signature
Acetylserotonin O-methyltransferase dimerisation
D-galactarate/Altronate dehydratase C-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Serine/threonine specific protein phosphatases
Polysaccharide biosynthesis protein C-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Anthranilate synthase component I N-terminal
Prokaryotic-type class I peptide chain release factors
Flagellar assembly protein FliH/Type III secretion system HrpE
Glucan biosynthesis periplasmic MdoG C-terminal
Transposase IS204/IS1001/IS1096/IS1165 helix-turn-helix
Transposase IS204/IS1001/IS1096/IS1165 zinc-finger
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
TRAP C4-dicarboxylate transport system permease DctM subunit
Survival protein SurE-like phosphatase/nucleotidase
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Chromosomal replication initiator DnaA C-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
NADH:ubiquinone oxidoreductase chain 4 N-terminal
S-adenosylmethionine-dependent methyltransferase
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Interaction with polymerase core subunit RpoC
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
RNA binding; important for wobble base 34 recognition
NADH-rubredoxin oxidoreductase C-terminal
Plays an important role in substrate specificity
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Membrane fusion protein biotin-lipoyl like
Membrane fusion protein biotin-lipoyl like domain-containing protein
Shikimate dehydrogenase substrate binding N-terminal
Glycine zipper 2TM domain-containing protein
Blue (type 1) copper domain-containing protein
DNA polymerase III delta subunit C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Pyruvate dehydrogenase E1 component middle
DNA mismatch repair proteins mutS family
ATP-grasp fold succinyl-CoA synthetase-type
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
High potential iron-sulfur proteins family profile
Ribose-phosphate pyrophosphokinase N-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Could play a key role in the communication between the regulatory and the substrate sites
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Solute-binding protein family 3/N-terminal
Prepilin type IV endopeptidase peptidase
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Glycoside-hydrolase family GH114 TIM-barrel
Glycoside-hydrolase family GH114 TIM-barrel domain-containing protein
Small ribosomal subunit protein uS4 N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Proton acceptor; for glutaminase activity
Large ribosomal subunit protein uL15/eL18
Pyruvate phosphate dikinase AMP/ATP-binding
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-89)
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Glycosyl transferase family 3 N-terminal
Ribulose bisphosphate carboxylase small subunit
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Phosphonate ABC transporter substrate-binding protein
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Cation-transporting P-type ATPase N-terminal