Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Glycoside hydrolase family 42 N-terminal
Major facilitator superfamily (MFS) profile
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Involved in ionization of N3 of dUMP, leading to its activation
Phosphatidic acid phosphatase type 2/haloperoxidase
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
DNA-directed DNA polymerase family A palm
Pyrroline-5-carboxylate reductase catalytic N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Polymerase/histidinol phosphatase N-terminal
Phosphocysteine intermediate; for EIIB activity
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Mandelate racemase/muconate lactonizing enzyme C-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Reversibly protonated during proton transport
Acyl-CoA dehydrogenase/oxidase C-terminal
Adaptive response protein AidB N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
ABC transporter substrate-binding protein PnrA-like
Large ribosomal subunit protein uL2 C-terminal
LamG-like jellyroll fold domain-containing protein
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Gram-positive cocci surface proteins LPxTG
DNA primase/polymerase bifunctional N-terminal
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
Phosphomannose isomerase type I catalytic
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Threonine/serine exporter-like N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Lysyl-tRNA synthetase N-terminal transmembrane region
Phosphatidylglycerol lysyltransferase C-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Essential for prephenate dehydratase activity
RNA polymerase sigma factor 70 region 4 type 2
Carbamoyl-phosphate synthase small subunit N-terminal
MmyB-like transcription regulator ligand binding
Alpha-glycerophosphate oxidase C-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Pyridoxamine 5'-phosphate oxidase putative
Formamidopyrimidine-DNA glycosylase catalytic
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Aminoacyl-transfer RNA synthetases class-II family profile
Gly-cisPro motif, important for rejection of L-amino acids
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Type VII secretion system protein EssD-like
Type VII secretion system protein EssD-like domain-containing protein
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Bacterial bifunctional deaminase-reductase C-terminal
Solute-binding protein family 3/N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-108)
Saccharopine dehydrogenase-like C-terminal
ABC-type glycine betaine transport system substrate-binding
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Cyclophilin-like domain-containing protein
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Butirosin biosynthesis protein H N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Glycoside-hydrolase family GH114 TIM-barrel
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Tat pathway signal sequence domain protein
Erythromycin biosynthesis protein CIII-like central
Glycosyl transferase family 28 C-terminal
Tryptophan synthase beta chain-like PALP
Myo-inositol-1-phosphate synthase GAPDH-like
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Cytochrome C biogenesis protein transmembrane
PhoD-like phosphatase metallophosphatase
Gfo/Idh/MocA-like oxidoreductase N-terminal
Prokaryotic-type class I peptide chain release factors
Small ribosomal subunit protein uS4 N-terminal
Cytochrome oxidase subunit II copper A binding
CobB/CobQ-like glutamine amidotransferase
Glyoxalase/fosfomycin resistance/dioxygenase
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Histidine-specific methyltransferase SAM-dependent
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Acyl-CoA dehydrogenase/oxidase N-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Penicillin-binding protein transpeptidase
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Heat-inducible transcription repressor HrcA C-terminal
Transcription regulator AsnC/Lrp ligand binding
Tetracyclin repressor-like C-terminal group 31
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Nitrite/Sulfite reductase ferredoxin-like
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
N-acetylneuraminic acid synthase N-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
RNA 2-O ribose methyltransferase substrate binding
Release factor glutamine methyltransferase N-terminal
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Peptide methionine sulphoxide reductase MsrA
Activator of Hsp90 ATPase homologue 1-like C-terminal
Pyrroline-5-carboxylate reductase dimerisation
Peptidase S9 prolyl oligopeptidase catalytic
Gfo/Idh/MocA-like oxidoreductase C-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Beta-xylosidase C-terminal Concanavalin A-like
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Aspartate/homoserine dehydrogenase NAD-binding
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Phosphoadenosine phosphosulphate reductase
6-phosphogluconate dehydrogenase C-terminal
Shikimate dehydrogenase substrate binding N-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Transposase IS116/IS110/IS902 C-terminal
Putative glycogen debranching enzyme N-terminal
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
6-phosphogluconate dehydrogenase NADP-binding
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Involved in allosteric activation by GTP
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Heme-copper oxidase subunit III family profile
YbaK/aminoacyl-tRNA synthetase-associated
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Resuscitation-promoting factor core lysozyme-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Plays an important role in substrate specificity
Geranyl diphosphate 2-C-methyltransferase
N,N-dimethylformamidase beta subunit-like C-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Methionyl-tRNA synthetase anticodon-binding
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Positions MEP for the nucleophilic attack
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Proton acceptor; for glutaminase activity
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Glycosyltransferase family 28 N-terminal
Cell envelope-related transcriptional attenuator
Beta-hexosaminidase bacterial type N-terminal
non-reducing end alpha-L-arabinofuranosidase
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Gram-positive cocci surface proteins LPxTG domain-containing protein
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Pyruvate phosphate dikinase AMP/ATP-binding
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Translation elongation factor P/YeiP central
DNA replication/recombination mediator RecO N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Probable subtilase-type protease inhibitor
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Endoribonuclease L-PSP/chorismate mutase-like
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Sporulation transcription regulator WhiA N-terminal
Bacterial type II secretion system protein E
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Cytochrome b/b6 N-terminal region profile
Putative oxidoreductase/dehydrogenase Rossmann-like
Glycosyl hydrolase family 98 putative carbohydrate-binding module
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
DnaJ homologue subfamily C member 28 conserved
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Large ribosomal subunit protein uL6 alpha-beta
Moybdenum cofactor oxidoreductase dimerisation
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Peptidase S8/S53 domain-containing protein
SUF system FeS cluster assembly SufBD N-terminal
Glycerophosphoryl diester phosphodiesterase membrane
Styrene monooxygenase StyA putative substrate binding
Pyruvate dehydrogenase E1 component middle
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase C-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Could be important to modulate the pK values of the two catalytic cysteine residues
Na+/H+ antiporter MnhB subunit-related protein
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
S-adenosyl-L-homocysteine hydrolase NAD binding
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Gamma-glutamylcyclotransferase AIG2-like
Putative Flp pilus-assembly TadG-like N-terminal
Thiopeptide-type bacteriocin biosynthesis
ATP synthase F1 complex delta/epsilon subunit N-terminal
NADH-rubredoxin oxidoreductase C-terminal
Peptidase M1 membrane alanine aminopeptidase
Gp5/Type VI secretion system Vgr protein OB-fold
Cysteine sulfenic acid (-SOH) intermediate
Cation-transporting P-type ATPase C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Exonuclease VII large subunit C-terminal
Important for substrate specificity; cannot use PPi as phosphoryl donor
3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold
Alpha-N-acetylglucosaminidase C-terminal
Alpha-N-acetylglucosaminidase N-terminal
Alpha-N-acetylglucosaminidase tim-barrel
Large ribosomal subunit protein uL15/eL18
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
NIF system FeS cluster assembly NifU N-terminal
Phosphotransferase system enzyme I N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
4'-phosphopantetheinyl transferase N-terminal
Glycine cleavage T-protein C-terminal barrel
Ribose-phosphate pyrophosphokinase N-terminal
3-beta hydroxysteroid dehydrogenase/isomerase
Nucleophile; cysteine thiosulfonate intermediate
Schiff-base intermediate with substrate; via pyruvic acid
Cytochrome bc1 complex cytochrome c subunit
Damage-control phosphatase ARMT1-like metal-binding
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Inosine/uridine-preferring nucleoside hydrolase
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
Schiff-base intermediate with D-ribose 5-phosphate
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Lactate utilization protein B C-terminal
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
PsrA tetracyclin repressor-like C-terminal
N6 adenine-specific DNA methyltransferase N-terminal
Alanyl-transfer RNA synthetases family profile
Glycosyl transferase family 3 N-terminal
Alpha-L-rhamnosidase six-hairpin glycosidase
Bacterial alpha-L-rhamnosidase N-terminal
Helix-hairpin-helix DNA-binding motif class 1
AB hydrolase-1 domain-containing protein
Putative regulatory protein FmdB Zinc ribbon
Acyltransferase MbtK/IucB-like conserved
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Pseudouridine synthase I TruA alpha/beta
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Prepilin type IV endopeptidase peptidase
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Glutathionylspermidine synthase pre-ATP-grasp-like
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Glycoside hydrolase family 31 N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Interaction with polymerase core subunit RpoC