Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Glycine cleavage T-protein C-terminal barrel
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Nitrite/Sulfite reductase ferredoxin-like
RND efflux pump membrane fusion protein barrel-sandwich
Penicillin-binding protein transpeptidase
Electron transfer flavoprotein alpha/beta-subunit N-terminal
PhoD-like phosphatase metallophosphatase
Major facilitator superfamily (MFS) profile
Type III secretion system flagellar brake protein YcgR PilZN
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
RNA polymerase sigma factor 70 region 4 type 2
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Flagellar assembly protein FliH/Type III secretion system HrpE
Could be important to modulate the pK values of the two catalytic cysteine residues
YbaK/aminoacyl-tRNA synthetase-associated
Pyruvate dehydrogenase E1 component middle
RNA 2-O ribose methyltransferase substrate binding
ABC-type glycine betaine transport system substrate-binding
Water stress and hypersensitive response
Pyridoxamine 5'-phosphate oxidase putative
Solute-binding protein family 3/N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Mandelate racemase/muconate lactonizing enzyme C-terminal
Chromosomal replication initiator protein DnaA
Tryptophan synthase beta chain-like PALP
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Bacterial type II secretion system protein E
Reversibly protonated during proton transport
TonB-dependent receptor-like beta-barrel
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Phosphatidylglycerol lysyltransferase C-terminal
Mechanosensitive ion channel inner membrane
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Glycoside-hydrolase family GH114 TIM-barrel
Membrane fusion protein biotin-lipoyl like
DNA-3-methyladenine glycosylase AlkA N-terminal
Regulator of nucleoside diphosphate kinase N-terminal
Transcription elongation factor GreA/GreB C-terminal
Peptide methionine sulphoxide reductase MsrA
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Plays an important role in substrate specificity
Malonate/sodium symporter MadM subunit N-terminal
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Cysteine sulfenic acid (-SOH) intermediate
Alpha-glycerophosphate oxidase C-terminal
Polysaccharide biosynthesis protein CapD-like
Phosphocysteine intermediate; for EIIB activity
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Thymidylate synthase/dCMP hydroxymethylase
Helix-hairpin-helix DNA-binding motif class 1
DNA-directed DNA polymerase family B exonuclease
DNA-directed DNA polymerase family B multifunctional
S-adenosylmethionine-dependent methyltransferase
Molybdenum cofactor biosynthesis protein F N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Large ribosomal subunit protein uL30-like ferredoxin-like fold
NIF system FeS cluster assembly NifU N-terminal
HicB-like antitoxin of toxin-antitoxin system
Inosine/uridine-preferring nucleoside hydrolase
Outer-membrane lipoprotein Wza C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
DNA polymerase III delta subunit C-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Large ribosomal subunit protein uL2 C-terminal
Type II secretion system protein GspG C-terminal
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Bacterial bifunctional deaminase-reductase C-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Electron transfer via tryptophanyl radical
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Outer-membrane lipoprotein carrier protein
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Flagellar hook-length control protein-like C-terminal
Important for beta-aspartyl-AMP intermediate formation
Survival protein SurE-like phosphatase/nucleotidase
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
2-oxoisovalerate dehydrogenase E1 alpha subunit N-terminal
Moves into active site upon enzyme activation, plays a role in electron transfer
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Translation elongation factor P/YeiP central
Outer membrane protein assembly factor BamB
Gamma-butyrobetaine hydroxylase-like N-terminal
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
YMGG-like Gly-zipper domain-containing protein
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Phosphatidic acid phosphatase type 2/haloperoxidase
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Endolytic peptidoglycan transglycosylase RlpA
High-affinity branched-chain amino acid transport system permease LivHM N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Ionotropic glutamate receptor C-terminal
Transposase IS116/IS110/IS902 C-terminal
Prokaryotic-type class I peptide chain release factors
Transcription elongation factor GreA/GreB N-terminal
Pseudouridine synthase I TruA alpha/beta
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Aminoacyl-transfer RNA synthetases class-II family profile
Acyl-CoA dehydrogenase C-terminal bacterial-type
NIF system FeS cluster assembly NifU C-terminal
Guanylate kinase/L-type calcium channel beta subunit
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Involved in tetramerization or stability of the tetramer
Alanyl-transfer RNA synthetases family profile
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
O-(3'-phospho-DNA)-tyrosine intermediate
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Polymerase/histidinol phosphatase N-terminal
Important for interaction with partner proteins
4'-phosphopantetheinyl transferase N-terminal
Positions MEP for the nucleophilic attack
ABC-type transport auxiliary lipoprotein component
7 transmembrane helices usually fused to an inactive transglutaminase
Inactive transglutaminase fused to 7 transmembrane helices
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Large ribosomal subunit protein uL15/eL18
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
DNA replication/recombination mediator RecO N-terminal
6-phosphogluconate dehydrogenase C-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Organic solvent tolerance-like N-terminal
Release factor glutamine methyltransferase N-terminal
Alkaline proteinase inhibitor/ Outer membrane lipoprotein Omp19
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
O-(phosphoribosyl dephospho-coenzyme A)serine
NADH:ubiquinone oxidoreductase 30kDa subunit
Pyruvate phosphate dikinase AMP/ATP-binding
Nucleoside-binding outer membrane protein
ATP synthase F1 complex delta/epsilon subunit N-terminal
Exonuclease VII large subunit C-terminal
Biotin-protein ligase N-terminal domain-containing protein
Mannose-6-phosphate isomerase type II C-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Polyribonucleotide nucleotidyltransferase (Polynucleotide phosphorylase)
Acyl-ester intermediate; for transpeptidase activity
Proton donor; for transglycosylase activity
Biopterin-dependent aromatic amino acid hydroxylase family profile
Glycosyl transferase family 3 N-terminal
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Na+/H+ antiporter MnhB subunit-related protein
Glucose-methanol-choline oxidoreductase N-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
Important for substrate binding and specificity
Interaction with polymerase core subunit RpoC
Quercetin 2,3-dioxygenase C-terminal cupin
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Anthranilate synthase component I N-terminal
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Glucan biosynthesis periplasmic MdoG C-terminal
Large ribosomal subunit protein uL6 alpha-beta
Outer membrane protein assembly factor BamD
Flagellar motor switch protein FliN-like C-terminal
Outer membrane protein assembly factor BamA
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Proline utilization A proline dehydrogenase N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
NAD(P) transhydrogenase alpha subunit C-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Saccharopine dehydrogenase-like C-terminal
Methylguanine DNA methyltransferase ribonuclease-like
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Ribose-phosphate pyrophosphokinase N-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Calcium/calmodulin-dependent protein kinase II association-domain
Proton acceptor; for decarboxylase activity
Proton donor; for decarboxylase activity
Proton donor; for formyltransferase activity
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Glutamate synthase alpha subunit C-terminal
Heme-copper oxidase subunit III family profile
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Terminase large subunit gp17-like C-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
For 3-hydroxyacyl-CoA dehydrogenase activity
Gp5/Type VI secretion system Vgr protein OB-fold
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Periplasmic binding protein/LacI sugar binding
The binding site for the sugar molecule has not yet been established, but C-87 may be involved
Flagella basal body P-ring formation protein FlgA
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Inner membrane protein YgaP-like transmembrane
DNA topoisomerase I catalytic core eukaryotic-type
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Poly-beta-hydroxybutyrate polymerase N-terminal
Lysidine-tRNA(Ile) synthetase C-terminal
Required for dimer formation and molybdate binding
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Translocation and assembly module subunit TamA
Sugar fermentation stimulation protein C-terminal
TRAP C4-dicarboxylate transport system permease DctM subunit
Type 4 fimbrial biogenesis protein PilX N-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Type II secretion system protein GspI C-terminal
Lytic transglycosylase superhelical linker
DNA polymerase III subunit delta C-terminal
Polypeptide-transport-associated ShlB-type
Interacts with tRNA; defines subfamily-specific binding signature
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Chromosomal replication initiator DnaA C-terminal
Glucose-methanol-choline oxidoreductase C-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Adaptive response protein AidB N-terminal
Disulphide bond isomerase DsbC/G N-terminal
Cation-transporting P-type ATPase N-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Alpha-D-phosphohexomutase alpha/beta/alpha
Carbamoyl-phosphate synthase small subunit N-terminal
Transposase IS204/IS1001/IS1096/IS1165 DDE
RlpA-like protein double-psi beta-barrel
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Activator of Hsp90 ATPase homologue 1-like C-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Lipopolysaccharide export system protein LptA
Ribosomal RNA adenine methylase transferase N-terminal
Arginine decarboxylase C-terminal helical
Erythronate-4-phosphate dehydrogenase dimerisation
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Integral membrane protein YccS N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Small ribosomal subunit protein uS4 N-terminal
Peptidase C-terminal archaeal/bacterial domain-containing protein
Urease accessory protein UreH-like transmembrane
Molybdopterin cofactor biosynthesis C (MoaC)
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Type VI secretion system IcmF C-terminal
Acetyl-CoA hydrolase/transferase C-terminal
Putative beta-barrel assembly-enhancing protease
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Cob(I)alamin adenosyltransferase N-terminal
Schiff-base intermediate with acetaldehyde
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Thiol:disulfide interchange protein DsbD
Alginate biosynthesis protein AlgX C-terminal carbohydrate-binding module
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
N-end rule aminoacyl transferase C-terminal
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase N-terminal
Probable periplasmic serine endoprotease DegP-like
Peptidase M61 catalytic domain-containing protein
Bacterial transcription activator effector binding
Endoribonuclease L-PSP/chorismate mutase-like
DNA-directed DNA polymerase family A palm
UDP-glucose/GDP-mannose dehydrogenase C-terminal
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Prepilin type IV endopeptidase peptidase
Gly-cisPro motif, important for rejection of L-amino acids
Aminoacyl-tRNA synthetase class I anticodon-binding
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
UDP N-acetylglucosamine O-acyltransferase C-terminal
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Glutathionylspermidine synthase pre-ATP-grasp-like
Putative Flp pilus-assembly TadG-like N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Plays an important role in discriminating NADH against NADPH
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Sodium/calcium exchanger membrane region
Type II secretion system protein GspC N-terminal
Seems to be a necessary countercharge to the potassium cations
Curli production assembly/transport component CsgG
Putative regulatory protein FmdB Zinc ribbon