ATP-dependent Clp protease ATP-binding subunit ClpX 2
Inner membrane protein YgaP-like transmembrane
Thioredoxin-like fold domain-containing protein
Essential for prephenate dehydratase activity
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
S-adenosylmethionine-dependent methyltransferase
Interaction with polymerase core subunit RpoC
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG
Cysteine sulfenic acid (-SOH) intermediate
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Bacterial type II secretion system protein E
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Disulfide isomerase DsbG N-terminal domain-containing protein
O-(5'-phospho-DNA)-tyrosine intermediate
Ribosomal RNA small subunit methyltransferase G
Membrane fusion protein biotin-lipoyl like
Formate dehydrogenase iron-sulfur subunit
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
NIF system FeS cluster assembly NifU C-terminal
NIF system FeS cluster assembly NifU N-terminal
Quinone-reactive Ni/Fe-hydrogenase large chain
Glycosyltransferase subfamily 4-like N-terminal
ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase
Polymerase/histidinol phosphatase N-terminal
Holliday junction branch migration complex subunit RuvB
ATP-dependent Clp protease ATP-binding subunit ClpX 1
Ribosomal protein uS12 methylthiotransferase RimO
O-(3'-phospho-DNA)-tyrosine intermediate
3-isopropylmalate dehydratase small subunit
4-hydroxy-tetrahydrodipicolinate synthase
Electron transfer via tryptophanyl radical
Carbamoyl-phosphate synthase small subunit N-terminal
ABC-type transport auxiliary lipoprotein component
ABC-type transport auxiliary lipoprotein component domain-containing protein
Dual-specificity RNA methyltransferase RlmN
Thiamine pyrophosphate enzyme TPP-binding
N6 adenine-specific DNA methyltransferase N-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase
Glutathionylspermidine synthase pre-ATP-grasp-like
TonB-dependent receptor-like beta-barrel
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
8-methylmenaquinol:fumarate reductase iron-sulfur subunit
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
TRAP C4-dicarboxylate transport system permease DctM subunit
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
2,3-bisphosphoglycerate-independent phosphoglycerate mutase
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
N-end rule aminoacyl transferase C-terminal
L-2,4-diaminobutyric acid acetyltransferase
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Glutamate-1-semialdehyde 2,1-aminomutase
Crossover junction endodeoxyribonuclease RuvC
Phenylalanine--tRNA ligase alpha subunit
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Formate-dependent phosphoribosylglycinamide formyltransferase
Nitrogenase molybdenum-iron protein beta chain N-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Periplasmic nitrate reductase, electron transfer subunit
Diaminobutyrate--2-oxoglutarate transaminase
Major facilitator superfamily (MFS) profile
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Phosphatidylglycerol lysyltransferase C-terminal
Flagellar motor switch protein FliN-like C-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Cytochrome C biogenesis protein transmembrane
Resolvase/invertase-type recombinase catalytic
Ribosomal RNA small subunit methyltransferase E methyltransferase
UDP N-acetylglucosamine O-acyltransferase C-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Membrane iron-sulfur containing protein FtrD-like
3,4-dihydroxy-2-butanone 4-phosphate synthase
Reduces nitrite reductase activity by over 99%, but does not decrease the low sulfite reductase activity.
Ribosomal RNA large subunit methyltransferase H
Ribosomal RNA small subunit methyltransferase H
Tetrahydrodipicolinate-N-succinyltransferase chain A
SurA N-terminal domain-containing protein
RNA polymerase sigma factor 70 region 4 type 2
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
3-methyl-2-oxobutanoate hydroxymethyltransferase
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
NADPH-dependent 7-cyano-7-deazaguanine reductase
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Pyruvate/ketoisovalerate oxidoreductase catalytic
UDP-N-acetylenolpyruvoylglucosamine reductase C-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
Carboxy-S-adenosyl-L-methionine synthase
Pyruvate phosphate dikinase AMP/ATP-binding
6-hydroxymethylpterin diphosphokinase MptE-like
8-methylmenaquinol:fumarate reductase membrane anchor subunit
Dinitrogenase iron-molybdenum cofactor biosynthesis
Phosphoribosylformylglycinamidine synthase subunit PurQ
UDP-3-O-acylglucosamine N-acyltransferase
STT3 subunit PglB C-terminal beta-barrel
Cobalamin-independent methionine synthase MetE N-terminal
Exonuclease VII large subunit C-terminal
tRNA N6-adenosine threonylcarbamoyltransferase
Imidazole glycerol phosphate synthase subunit HisF
Protein-methionine-sulfoxide reductase catalytic subunit MsrP
Conserved virulence factor B-like winged helix
Aromatic hydrocarbon degradation protein
Polysaccharide biosynthesis protein CapD-like
Septum formation inhibitor MinC C-terminal
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Imidazole glycerol phosphate synthase subunit HisH
UDP-3-O-acyl-N-acetylglucosamine deacetylase
Saccharopine dehydrogenase-like C-terminal
Aldehyde ferredoxin oxidoreductase N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Glycerol-3-phosphate dehydrogenase [NAD(P)+]
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Macrolide export ATP-binding/permease protein MacB
No growth on fumarate, loss of FAD cofactor, no enzyme activity.
No growth on fumarate, retains FAD cofactor, 15-fold decreased enzyme activity in vitro.
Outer-membrane lipoprotein carrier protein
3-phosphoshikimate 1-carboxyvinyltransferase
Deoxyguanosinetriphosphate triphosphohydrolase-like protein
Phosphonates import ATP-binding protein PhnC
FAD-dependent oxidoreductase 2 FAD binding
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Probable transcriptional regulatory protein WS1016
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
Bifunctional DNA-directed RNA polymerase subunit beta-beta'
DNA-directed RNA polymerase subunit beta
DNA-directed RNA polymerase subunit beta'
Flagellar assembly protein FliH/Type III secretion system HrpE
Holliday junction branch migration complex subunit RuvA
Chromosomal replication initiator protein DnaA
Required for dimer formation and molybdate binding
Reduction in fumarate reductase activity.
Slight reduction in fumarate reductase activity.
Cell division topological specificity factor
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Plasminogen-binding protein PgbA N-terminal
Plasminogen-binding protein PgbA N-terminal domain-containing protein
Sodium/calcium exchanger membrane region
YbaK/aminoacyl-tRNA synthetase-associated
Leucyl/phenylalanyl-tRNA--protein transferase
Damage-control phosphatase ARMT1-like metal-binding
Glutamyl-tRNA(Gln) amidotransferase subunit A
Type I restriction modification DNA specificity
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C
4-hydroxy-tetrahydrodipicolinate reductase
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
DNA-directed DNA polymerase family A palm
DNA-directed RNA polymerase subunit alpha
Quinone-reactive Ni/Fe-hydrogenase B-type cytochrome subunit
Anthranilate synthase component I N-terminal
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Important for interaction with partner proteins
8-methylmenaquinol:fumarate reductase flavoprotein subunit
Highly decreases MFR activity in the periplasm due to the disruption of the signal peptide.
Leads to covalent attachment of FAD to the enzyme. Is still not able to catalyze succinate oxidation.
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Putative membrane protein insertion efficiency factor
Tryptophan synthase beta chain-like PALP
Release factor glutamine methyltransferase N-terminal
RNA binding; important for wobble base 34 recognition
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Phosphoribosylaminoimidazole-succinocarboxamide synthase
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Alpha-D-phosphohexomutase alpha/beta/alpha
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Arginine decarboxylase C-terminal helical
Involved in ionization of N3 of dUMP, leading to its activation
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase
DNA-directed RNA polymerase subunit omega
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Transcription antitermination protein NusB
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
Succinate--CoA ligase [ADP-forming] subunit beta
Nitrite/Sulfite reductase ferredoxin-like
Phosphoethanolamine transferase N-terminal
Plays an important role in substrate specificity
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Important for beta-aspartyl-AMP intermediate formation
ATP-dependent dethiobiotin synthetase BioD
ATP-dependent Clp protease proteolytic subunit
3-deoxy-manno-octulosonate cytidylyltransferase
Penicillin-binding protein transpeptidase
CagE TrbE VirB component of type IV transporter system central
3-isopropylmalate dehydratase large subunit
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Flagellar Assembly Protein A N-terminal region
Magnesium transporter MgtE intracellular
NADH:ubiquinone oxidoreductase 30kDa subunit
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
ATP-dependent Clp protease adapter protein ClpS
Signal transduction histidine kinase dimerisation/phosphoacceptor
Schiff-base intermediate with substrate; via pyruvic acid
Sec-independent protein translocase protein TatA
RND efflux pump membrane fusion protein barrel-sandwich domain-containing protein
tRNA/tmRNA (uracil-C(5))-methyltransferase
2-dehydro-3-deoxyphosphooctonate aldolase
Phosphate import ATP-binding protein PstB
Histidine biosynthesis bifunctional protein HisIE
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Positions MEP for the nucleophilic attack